IL157546A0 - Compounds useful as intermediates for 4-aminoquinoline derivatives - Google Patents

Compounds useful as intermediates for 4-aminoquinoline derivatives

Info

Publication number
IL157546A0
IL157546A0 IL15754602A IL15754602A IL157546A0 IL 157546 A0 IL157546 A0 IL 157546A0 IL 15754602 A IL15754602 A IL 15754602A IL 15754602 A IL15754602 A IL 15754602A IL 157546 A0 IL157546 A0 IL 157546A0
Authority
IL
Israel
Prior art keywords
intermediates
compounds useful
aminoquinoline derivatives
aminoquinoline
derivatives
Prior art date
Application number
IL15754602A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of IL157546A0 publication Critical patent/IL157546A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL15754602A 2001-04-30 2002-04-08 Compounds useful as intermediates for 4-aminoquinoline derivatives IL157546A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28752201P 2001-04-30 2001-04-30
PCT/IB2002/001217 WO2002088069A2 (en) 2001-04-30 2002-04-08 Compounds useful as intermediates for 4-aminoquinoline derivatives

Publications (1)

Publication Number Publication Date
IL157546A0 true IL157546A0 (en) 2004-03-28

Family

ID=23103272

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15754602A IL157546A0 (en) 2001-04-30 2002-04-08 Compounds useful as intermediates for 4-aminoquinoline derivatives
IL15754402A IL157544A0 (en) 2001-04-30 2002-04-08 Methods and intermediates for preparing 4-aminoquinoline cetp inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL15754402A IL157544A0 (en) 2001-04-30 2002-04-08 Methods and intermediates for preparing 4-aminoquinoline cetp inhibitors

Country Status (25)

Country Link
US (3) US6600045B2 (ja)
EP (2) EP1383734B1 (ja)
JP (2) JP3924251B2 (ja)
KR (2) KR100639745B1 (ja)
CN (3) CN1297541C (ja)
AR (3) AR035963A1 (ja)
AT (2) ATE316957T1 (ja)
AU (1) AU2002253448B2 (ja)
BR (2) BR0209238A (ja)
CA (2) CA2445693A1 (ja)
CZ (2) CZ20032898A3 (ja)
DE (2) DE60209004T2 (ja)
DK (2) DK1425270T3 (ja)
ES (2) ES2256461T3 (ja)
HK (1) HK1062294A1 (ja)
HU (2) HUP0304039A3 (ja)
IL (2) IL157546A0 (ja)
MX (2) MXPA03009935A (ja)
PL (2) PL366700A1 (ja)
PT (1) PT1425270E (ja)
RU (2) RU2259355C2 (ja)
TW (1) TWI250974B (ja)
WO (2) WO2002088085A2 (ja)
YU (2) YU84403A (ja)
ZA (2) ZA200306599B (ja)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
JP2006021999A (ja) * 2002-07-12 2006-01-26 Kaneka Corp 光学活性β−アミノニトリル化合物およびその対掌体アミド化合物の製造方法
KR20050055747A (ko) 2002-10-04 2005-06-13 밀레니엄 파머슈티컬스 인코퍼레이티드 염증 질환 치료용의 ｐｇｄ2 수용체 길항제
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
AU2003283769A1 (en) 2002-12-20 2004-07-14 Pfizer Products Inc. Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor
EP1594843B1 (en) 2003-02-18 2013-05-22 Takasago International Corporation METHOD FOR PRODUCING AN OPTICALLY ACTIVE beta-amino acid derivative
CA2515789A1 (en) * 2003-03-17 2004-09-30 Kaneka Corporation Method for producing(r)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative
US7223859B2 (en) 2003-03-17 2007-05-29 Pfizer Inc. Method for producing (R)-3-[4-(trifluoromethyl) phenylamino]-pentanoic acid amide derivative
CA2554982A1 (en) 2003-09-26 2005-04-07 Japan Tobacco Inc. Method of inhibiting remnant lipoprotein production
PL1670768T3 (pl) * 2003-10-08 2010-01-29 Lilly Co Eli Związki i sposoby leczenia dyslipidemii
EP1680099B1 (en) * 2003-11-07 2009-04-15 JJ Pharma, Inc. Hdl-boosting combination therapy complexes
KR20070002085A (ko) * 2004-04-07 2007-01-04 밀레니엄 파머슈티컬스 인코퍼레이티드 염증 질병을 치료하기 위한 ｐｇｄ２ 수용체 길항제
KR20070041452A (ko) * 2004-06-24 2007-04-18 일라이 릴리 앤드 캄파니 이상지혈증 치료를 위한 화합물 및 방법
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
US7700774B2 (en) 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
MX2007010215A (es) 2005-02-24 2007-11-07 Millennium Pharm Inc Antagonistas del receptor pgd2 para el tratamiento de enfermedades inflamatorias.
CA2610205A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the production of (alkoxycarbonylamino)alkyl sulfonates
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
DE102006032391A1 (de) * 2006-07-04 2008-01-17 Merck Patent Gmbh Fluortenside
DE102006031149A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031262A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031151A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031143A1 (de) * 2006-07-04 2008-01-24 Merck Patent Gmbh Fluortenside
AR065670A1 (es) 2007-03-09 2009-06-24 Indigene Pharmaceuticals Inc Combinacion de metformina r-(+) lipoato y agentes antihiperlipidemicos para el tratamiento de hiperglucemia diabetica y complicaciones diabeticas
JP2011256110A (ja) * 2008-09-30 2011-12-22 Takeda Chem Ind Ltd ヘキサヒドロピロロキノリンの製造法
AR077208A1 (es) * 2009-06-30 2011-08-10 Lilly Co Eli Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam
ES2617221T3 (es) 2011-04-12 2017-06-15 Chong Kun Dang Pharmaceutical Corp. Derivados de 3-(2-aril-cicloalquenilmetil)-oxazolidin-2-ona como inhibidores de la proteína de transferencia de ésteres de colesterol (CETP)
ES2683350T3 (es) * 2011-07-08 2018-09-26 Novartis Ag Método para tratar la aterosclerosis en sujetos con alto nivel de triglicéridos
DK2943474T3 (en) 2013-01-31 2017-08-21 Chong Kun Dang Pharmaceutical Corp BIARYL- OR HETEROCYCLIC BIARYL-SUBSTITUTED CYCLOHEXE DERIVATE COMPOUNDS AS CETP INHIBITORS
WO2015067405A1 (en) * 2013-11-11 2015-05-14 Lonza Ltd Method for preparation of cyano compounds of the 13th group with a lewis acid
LT3180314T (lt) * 2014-08-12 2022-11-10 Newamsterdam Pharma B.V. Sintetinių tarpinių junginių, skirtų tetrahidrochinolino darinių gamybai, gavimo būdas
CN105294559B (zh) * 2015-06-24 2017-11-14 厦门法茉维特动物药业有限公司 一种医药中间体4‑氨基喹啉类化合物的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1097158T3 (da) 1998-07-10 2006-05-29 Massachusetts Inst Technology Ligander til metaller og metalkatalyserede metoder
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.

Also Published As

Publication number Publication date
DK1425270T3 (da) 2006-07-03
WO2002088069A2 (en) 2002-11-07
KR100591998B1 (ko) 2006-06-22
AR036331A1 (es) 2004-09-01
BR0209238A (pt) 2004-06-15
HUP0304039A3 (en) 2005-10-28
CZ20032900A3 (cs) 2004-06-16
JP2004531541A (ja) 2004-10-14
WO2002088085A3 (en) 2004-03-25
US20020177716A1 (en) 2002-11-28
DE60210265T2 (de) 2006-10-12
JP3924250B2 (ja) 2007-06-06
DK1383734T3 (da) 2006-05-15
CN1297541C (zh) 2007-01-31
ZA200306600B (en) 2004-08-25
DE60209004D1 (de) 2006-04-13
YU84303A (sh) 2006-05-25
CN1505609A (zh) 2004-06-16
CA2445623A1 (en) 2002-11-07
BR0209291A (pt) 2004-07-13
KR20040030603A (ko) 2004-04-09
RU2259355C2 (ru) 2005-08-27
PT1425270E (pt) 2006-07-31
RU2003131871A (ru) 2005-04-10
US6600045B2 (en) 2003-07-29
CA2445693A1 (en) 2002-11-07
EP1383734A2 (en) 2004-01-28
CZ20032898A3 (cs) 2004-07-14
JP3924251B2 (ja) 2007-06-06
TWI250974B (en) 2006-03-11
CN1267411C (zh) 2006-08-02
ES2256461T3 (es) 2006-07-16
PL366700A1 (en) 2005-02-07
AU2002253448B2 (en) 2007-07-05
EP1425270A2 (en) 2004-06-09
ATE316957T1 (de) 2006-02-15
AR044706A2 (es) 2005-09-21
HK1062294A1 (en) 2004-10-29
DE60210265D1 (de) 2006-05-18
KR100639745B1 (ko) 2006-10-30
IL157544A0 (en) 2004-03-28
RU2003131870A (ru) 2005-01-27
US20030073843A1 (en) 2003-04-17
ES2259080T3 (es) 2006-09-16
WO2002088069A9 (en) 2003-12-04
MXPA03009935A (es) 2004-01-29
ZA200306599B (en) 2004-10-22
CN1529696A (zh) 2004-09-15
US20030216576A1 (en) 2003-11-20
HUP0304041A2 (hu) 2004-04-28
ATE321755T1 (de) 2006-04-15
HUP0304039A2 (hu) 2004-03-29
MXPA03009936A (es) 2004-01-29
JP2004527556A (ja) 2004-09-09
EP1425270B1 (en) 2006-03-29
WO2002088069A3 (en) 2003-02-20
US6706881B2 (en) 2004-03-16
CN1680292A (zh) 2005-10-12
HU225777B1 (en) 2007-08-28
AR035963A1 (es) 2004-07-28
US6689897B2 (en) 2004-02-10
YU84403A (sh) 2006-08-17
DE60209004T2 (de) 2006-09-28
PL366584A1 (en) 2005-02-07
RU2265010C2 (ru) 2005-11-27
CN100357265C (zh) 2007-12-26
HUP0304041A3 (en) 2005-08-29
WO2002088085A2 (en) 2002-11-07
EP1383734B1 (en) 2006-02-01
KR20040015200A (ko) 2004-02-18

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