IL154305A0 - INHIBITION OF alpha4 MEDIATED CELL ADHESION - Google Patents
INHIBITION OF alpha4 MEDIATED CELL ADHESIONInfo
- Publication number
- IL154305A0 IL154305A0 IL15430501A IL15430501A IL154305A0 IL 154305 A0 IL154305 A0 IL 154305A0 IL 15430501 A IL15430501 A IL 15430501A IL 15430501 A IL15430501 A IL 15430501A IL 154305 A0 IL154305 A0 IL 154305A0
- Authority
- IL
- Israel
- Prior art keywords
- inhibition
- cell adhesion
- mediated cell
- alpha4
- alpha4 mediated
- Prior art date
Links
- 230000021164 cell adhesion Effects 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Psychology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22912800P | 2000-08-31 | 2000-08-31 | |
PCT/US2001/026594 WO2002018320A2 (fr) | 2000-08-31 | 2001-08-27 | Inhibiteurs de l'adhesion cellulaire induite par alpha 4 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL154305A0 true IL154305A0 (en) | 2003-09-17 |
Family
ID=22859926
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15430501A IL154305A0 (en) | 2000-08-31 | 2001-08-27 | INHIBITION OF alpha4 MEDIATED CELL ADHESION |
IL154305A IL154305A (en) | 2000-08-31 | 2003-02-05 | Phenylalanine derivatives, medicinal preparations contain them and methods for their preparation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL154305A IL154305A (en) | 2000-08-31 | 2003-02-05 | Phenylalanine derivatives, medicinal preparations contain them and methods for their preparation |
Country Status (28)
Country | Link |
---|---|
US (6) | US7026501B2 (fr) |
EP (1) | EP1315694B1 (fr) |
JP (1) | JP3899022B2 (fr) |
KR (1) | KR100528049B1 (fr) |
CN (1) | CN1229334C (fr) |
AR (1) | AR034556A1 (fr) |
AT (1) | ATE292615T1 (fr) |
AU (2) | AU8677801A (fr) |
BR (1) | BR0113629A (fr) |
CA (1) | CA2418054C (fr) |
CZ (1) | CZ303460B6 (fr) |
DE (1) | DE60109943T2 (fr) |
DK (1) | DK1315694T3 (fr) |
ES (1) | ES2240509T3 (fr) |
HK (1) | HK1052684B (fr) |
HU (1) | HUP0302693A3 (fr) |
IL (2) | IL154305A0 (fr) |
MX (1) | MXPA03001837A (fr) |
MY (1) | MY129000A (fr) |
NO (1) | NO327861B1 (fr) |
NZ (1) | NZ524043A (fr) |
PL (1) | PL206656B1 (fr) |
PT (1) | PT1315694E (fr) |
RU (1) | RU2250895C2 (fr) |
SI (1) | SI1315694T1 (fr) |
TW (1) | TWI224587B (fr) |
WO (1) | WO2002018320A2 (fr) |
ZA (1) | ZA200301039B (fr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU12203A (sh) | 2000-08-18 | 2006-03-03 | Ajinomoto Co.Inc. | Novi derivati fenilalanina |
TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
RU2308457C2 (ru) | 2001-04-27 | 2007-10-20 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Пиразоло [1, 5-а] пиридины и содержащие их лекарственные средства |
MY140707A (en) | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
CN1703395A (zh) * | 2002-08-09 | 2005-11-30 | 特兰斯泰克制药公司 | 芳基和杂芳基化合物以及调节凝血的方法 |
TWI283679B (en) | 2002-10-22 | 2007-07-11 | Eisai Co Ltd | 7-phenylpyrazolopyridine compounds |
US7176216B2 (en) | 2002-10-22 | 2007-02-13 | Eisai Co., Ltd. | 7-phenylpyrazolopyridine compounds |
US7459472B2 (en) | 2003-08-08 | 2008-12-02 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
AU2004263508A1 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
KR20110098980A (ko) * | 2003-12-22 | 2011-09-02 | 아지노모토 가부시키가이샤 | 신규한 페닐알라닌 유도체 |
MY140489A (en) | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
US7910734B2 (en) | 2004-12-20 | 2011-03-22 | Eisai R&D Management Co., Ltd. | Crystal and salt of 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine |
US7410971B2 (en) | 2004-12-24 | 2008-08-12 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic)substituted benzene compounds |
JP2008542407A (ja) | 2005-06-09 | 2008-11-27 | ユセベ ファルマ ソシエテ アノニム | 2,6キノリニル誘導体、それらを調製するための方法及び薬剤としてのそれらの使用 |
US20090137601A1 (en) * | 2005-11-23 | 2009-05-28 | Astrazeneca Ab | L-Phenylalanine Derivatives |
US7855291B2 (en) | 2005-12-29 | 2010-12-21 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
US7897763B2 (en) | 2005-12-29 | 2011-03-01 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
IL172896A0 (en) * | 2005-12-29 | 2006-06-11 | Yeda Res & Dev | Cxcr4 inhibition |
AU2006337137B2 (en) * | 2005-12-29 | 2012-06-14 | Tersera Therapeutics Llc | Multicyclic amino acid derivatives and methods of their use |
US8808698B2 (en) * | 2006-02-03 | 2014-08-19 | The Regents Of The University Of California | Methods for inhibition of lymphangiogenesis and tumor metastasis |
CN101379028A (zh) * | 2006-02-09 | 2009-03-04 | 阿斯利康(瑞典)有限公司 | 化学化合物 |
LT2676967T (lt) * | 2006-02-28 | 2019-09-10 | Biogen Ma Inc. | Uždegiminių ir autoimuninių ligų gydymo būdai su natalizumabu |
JP2009531304A (ja) * | 2006-02-28 | 2009-09-03 | エラン ファーマシューティカルズ,インコーポレイテッド | α−4阻害剤化合物を用いて炎症性疾患および自己免疫疾患を治療する方法 |
BRPI0708392A2 (pt) | 2006-03-03 | 2011-05-24 | Elan Pharm Inc | métodos de tratamento de um paciente com uma doença inflamatória ou autoimune com natalizumab e de uso de natalizumab para tratar um paciente com uma doença inflamatória ou autoimune |
WO2009029499A1 (fr) | 2007-08-24 | 2009-03-05 | Lexicon Pharmaceuticals, Inc. | Procédés de préparation de composés à base de 4-phényl-6-(2,2,2-trifluoro-1-phényléthoxy)pyrimidine |
NZ588376A (en) | 2008-04-15 | 2011-06-30 | Eisai R&D Man Co Ltd | 3-phenylpyrazolo[5,1-b]thiazole compound having antagonism against corticotropin-releasing factor (CRF) receptor |
AR078521A1 (es) | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
EP2491006A1 (fr) * | 2009-10-21 | 2012-08-29 | Glaxo Group Limited | Procédé pour préparer un dérivé de phénylalanine |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
PL2524060T3 (pl) | 2010-01-11 | 2018-05-30 | Biogen Ma Inc. | Test wykrywający przeciwciała przeciwko wirusowi jc |
KR102292563B1 (ko) | 2011-05-31 | 2021-08-24 | 바이오젠 엠에이 인코포레이티드 | Pml의 위험을 판단하는 방법 |
US20150010563A1 (en) * | 2012-02-21 | 2015-01-08 | Massachusetts Eye & Ear Infirmary | Methods for Treating Corneal and Conjunctival Inflammation and Inflammatory Disorders |
EP3004334A4 (fr) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | Méthodes d'évaluation de risque de développement d'une lemp |
WO2018085552A1 (fr) * | 2016-11-02 | 2018-05-11 | Saint Louis University | Antagonistes de l'intégrine |
EP3873900A1 (fr) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Dérivés d'imidazopyridine utilisés en tant qu'inhibiteurs de l'intégrine alpha4bêta7 |
EP3873897B1 (fr) | 2018-10-30 | 2024-08-14 | Gilead Sciences, Inc. | Dérivés de n-benzoyl-phénylalanine en tant qu'inhibiteurs d'integrin alpha4béta7 pour le traitement de maladies inflammatoires |
WO2020092375A1 (fr) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Dérivés de quinoléine utilisés en tant qu'inhibiteurs de l'intégrine alpha4bêta7 |
US11179383B2 (en) | 2018-10-30 | 2021-11-23 | Gilead Sciences, Inc. | Compounds for inhibition of α4β7 integrin |
CN114222730B (zh) | 2019-08-14 | 2024-09-10 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK148576A (da) | 1975-04-18 | 1976-10-19 | Boehringer Mannheim Gmbh | Fenylalkankarbonsyrederivater og fremgangsmade til deres fremstilling |
BR9407933A (pt) | 1993-11-01 | 1996-11-26 | Japat Ltd | Antagonistas de receptores de endotelina |
JPH09510720A (ja) | 1994-03-28 | 1997-10-28 | 日本チバガイギー株式会社 | エンドセリンレセプターのアンタゴニスト |
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
JPH11505522A (ja) | 1995-04-21 | 1999-05-21 | ノバルティス・アクチエンゲゼルシャフト | エンドセリン阻害剤としてのn−アロイルアミノ酸アミド |
DE69833654T2 (de) | 1997-05-29 | 2006-12-14 | Merck & Co., Inc. (A New Jersey Corp.) | Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren |
JP2002512625A (ja) | 1997-05-29 | 2002-04-23 | メルク エンド カンパニー インコーポレーテッド | 細胞接着阻害薬としての複素環アミド化合物 |
WO1998053818A1 (fr) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Sulfamides utilises en tant qu'inhibiteurs de l'adherence cellulaire |
AU7667498A (en) | 1997-05-30 | 1998-12-30 | Celltech Therapeutics Limited | Anti-inflammatory tyrosine derivatives |
ATE249421T1 (de) | 1997-06-23 | 2003-09-15 | Tanabe Seiyaku Co | Inhibitoren der alpha4-beta1 vermittelten zelladhäsion |
AR016133A1 (es) | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
CN1265670A (zh) | 1997-07-31 | 2000-09-06 | 伊兰药品公司 | 抑制vla-4介导的白细胞粘附的二肽和相关的化合物 |
JP2001512139A (ja) | 1997-07-31 | 2001-08-21 | エラン・ファーマシューティカルズ・インコーポレーテッド | Vla−4が介在する白血球接着を阻害するスルホニル化ジペプチド化合物 |
EP0994895A1 (fr) | 1997-07-31 | 2000-04-26 | Elan Pharmaceuticals, Inc. | Composes de dipeptides inhibant une adhesion de leucocytes regulee par vla-4 |
CN1265674A (zh) | 1997-07-31 | 2000-09-06 | 伊兰药品公司 | 能抑制由vla-4介导的白细胞粘连的4-氨基苯基丙氨酸化合物 |
CN1265669A (zh) | 1997-07-31 | 2000-09-06 | 伊兰药品公司 | 抑制由vla-4介导的白细胞粘着的化合物 |
IL133635A0 (en) | 1997-07-31 | 2001-04-30 | Elan Pharm Inc | Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4 |
CA2290747A1 (fr) | 1997-07-31 | 1999-02-11 | Elan Pharmaceuticals, Inc. | Composes de type phenylalanine substituee inhibant une adhesion de leucocytes regulee par vla-4 |
JP3555876B2 (ja) | 1997-08-22 | 2004-08-18 | エフ.ホフマン−ラ ロシュ アーゲー | N−アロイルフェニルアラニン誘導体 |
CN1276785A (zh) | 1997-08-22 | 2000-12-13 | 霍夫曼-拉罗奇有限公司 | N-烷酰基苯丙氨酸衍生物 |
US6191171B1 (en) * | 1997-11-20 | 2001-02-20 | Merck & Co., Inc. | Para-aminomethylaryl carboxamide derivatives |
AU1463499A (en) | 1997-11-21 | 1999-06-15 | Merck & Co., Inc. | Substituted pyrrole derivatives as cell adhesion inhibitors |
AU751950B2 (en) | 1997-11-24 | 2002-09-05 | Merck & Co., Inc. | Substituted beta-alanine derivatives as cell adhesion inhibitors |
EP1033983A1 (fr) | 1997-11-24 | 2000-09-13 | Merck & Co., Inc. | Derives d'acide amine cycliques utilises comme inhibiteurs de l'adhesion cellulaire |
US6197794B1 (en) | 1998-01-08 | 2001-03-06 | Celltech Therapeutics Limited | Phenylalanine derivatives |
MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
AU3260399A (en) | 1998-02-26 | 1999-09-15 | Celltech Therapeutics Limited | Phenylalanine derivatives as inhibitors of alpha4 integrins |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
GB9812088D0 (en) | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
WO1999064395A1 (fr) | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Composes d'amide heterocycliques utilises comme inhibiteurs d'adhesion cellulaire |
TW591026B (en) | 1998-06-23 | 2004-06-11 | Upjohn Co | Inhibitors of alpha4beta1 mediated cell adhesion |
DE69915692T2 (de) | 1998-12-22 | 2005-02-10 | Tanabe Seiyaku Co., Ltd. | Inhibitoren der alpha-4 beta-1 vermittelten zelladhäsion |
GB2354440A (en) | 1999-07-20 | 2001-03-28 | Merck & Co Inc | Aryl amides as cell adhesion inhibitors |
WO2001012183A1 (fr) * | 1999-08-16 | 2001-02-22 | Merck & Co., Inc. | Amides heterocycles comme inhibiteurs de l'adhesion cellulaire |
AU6909300A (en) * | 1999-08-20 | 2001-03-19 | Merck & Co., Inc. | Substituted ureas as cell adhesion inhibitors |
DK1214292T3 (da) * | 1999-09-24 | 2007-10-15 | Genentech Inc | Tyrosinderivater |
WO2002018329A1 (fr) | 2000-08-31 | 2002-03-07 | Eli Lilly And Company | Derives de sulfonamide acetylenique |
-
2001
- 2001-08-21 MY MYPI20013917A patent/MY129000A/en unknown
- 2001-08-27 PT PT01966246T patent/PT1315694E/pt unknown
- 2001-08-27 WO PCT/US2001/026594 patent/WO2002018320A2/fr active IP Right Grant
- 2001-08-27 DK DK01966246T patent/DK1315694T3/da active
- 2001-08-27 IL IL15430501A patent/IL154305A0/xx unknown
- 2001-08-27 AU AU8677801A patent/AU8677801A/xx active Pending
- 2001-08-27 BR BR0113629-1A patent/BR0113629A/pt active Search and Examination
- 2001-08-27 ZA ZA200301039A patent/ZA200301039B/xx unknown
- 2001-08-27 EP EP01966246A patent/EP1315694B1/fr not_active Expired - Lifetime
- 2001-08-27 US US10/333,985 patent/US7026501B2/en not_active Expired - Fee Related
- 2001-08-27 ES ES01966246T patent/ES2240509T3/es not_active Expired - Lifetime
- 2001-08-27 AU AU2001286778A patent/AU2001286778B2/en not_active Ceased
- 2001-08-27 PL PL365668A patent/PL206656B1/pl unknown
- 2001-08-27 MX MXPA03001837A patent/MXPA03001837A/es active IP Right Grant
- 2001-08-27 NZ NZ524043A patent/NZ524043A/en not_active IP Right Cessation
- 2001-08-27 HU HU0302693A patent/HUP0302693A3/hu unknown
- 2001-08-27 KR KR10-2003-7001993A patent/KR100528049B1/ko not_active IP Right Cessation
- 2001-08-27 RU RU2003105885/04A patent/RU2250895C2/ru not_active IP Right Cessation
- 2001-08-27 CN CNB018149871A patent/CN1229334C/zh not_active Expired - Fee Related
- 2001-08-27 DE DE60109943T patent/DE60109943T2/de not_active Expired - Lifetime
- 2001-08-27 JP JP2002523438A patent/JP3899022B2/ja not_active Expired - Fee Related
- 2001-08-27 CA CA 2418054 patent/CA2418054C/fr not_active Expired - Fee Related
- 2001-08-27 SI SI200130351T patent/SI1315694T1/xx unknown
- 2001-08-27 AT AT01966246T patent/ATE292615T1/de active
- 2001-08-27 CZ CZ20030487A patent/CZ303460B6/cs not_active IP Right Cessation
- 2001-08-31 AR ARP010104172A patent/AR034556A1/es active IP Right Grant
- 2001-08-31 TW TW090121581A patent/TWI224587B/zh not_active IP Right Cessation
-
2003
- 2003-02-05 IL IL154305A patent/IL154305A/en not_active IP Right Cessation
- 2003-02-25 NO NO20030885A patent/NO327861B1/no not_active IP Right Cessation
- 2003-07-11 HK HK03105043.3A patent/HK1052684B/zh not_active IP Right Cessation
-
2005
- 2005-07-13 US US11/179,729 patent/US7456217B2/en not_active Expired - Fee Related
-
2008
- 2008-10-07 US US12/247,129 patent/US7671090B2/en not_active Expired - Fee Related
-
2010
- 2010-01-07 US US12/683,648 patent/US7872151B2/en not_active Expired - Fee Related
- 2010-12-08 US US12/962,707 patent/US8501809B2/en not_active Expired - Fee Related
-
2013
- 2013-07-03 US US13/934,405 patent/US20130289109A1/en not_active Abandoned
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