IL153502A0 - 2,2-disubstituted 1,3-dioxolanes as antitussive agents - Google Patents

2,2-disubstituted 1,3-dioxolanes as antitussive agents

Info

Publication number
IL153502A0
IL153502A0 IL15350201A IL15350201A IL153502A0 IL 153502 A0 IL153502 A0 IL 153502A0 IL 15350201 A IL15350201 A IL 15350201A IL 15350201 A IL15350201 A IL 15350201A IL 153502 A0 IL153502 A0 IL 153502A0
Authority
IL
Israel
Prior art keywords
dioxolanes
disubstituted
antitussive agents
piperazinyl
phenyl
Prior art date
Application number
IL15350201A
Other languages
English (en)
Original Assignee
Dompe Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Spa filed Critical Dompe Spa
Publication of IL153502A0 publication Critical patent/IL153502A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Holo Graphy (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Fats And Perfumes (AREA)
  • Liquid Crystal Substances (AREA)
  • Glass Compositions (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Secondary Cells (AREA)
IL15350201A 2000-07-28 2001-07-18 2,2-disubstituted 1,3-dioxolanes as antitussive agents IL153502A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI001735A IT1318651B1 (it) 2000-07-28 2000-07-28 Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.
PCT/EP2001/008305 WO2002010150A1 (en) 2000-07-28 2001-07-18 2,2-disubstituted 1,3-dioxolanes as antitussive agents

Publications (1)

Publication Number Publication Date
IL153502A0 true IL153502A0 (en) 2003-07-06

Family

ID=11445592

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15350201A IL153502A0 (en) 2000-07-28 2001-07-18 2,2-disubstituted 1,3-dioxolanes as antitussive agents
IL153502A IL153502A (en) 2000-07-28 2002-12-17 1,3 - Dioxolanes - 2,2 - Imaging as cough suppressants

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL153502A IL153502A (en) 2000-07-28 2002-12-17 1,3 - Dioxolanes - 2,2 - Imaging as cough suppressants

Country Status (24)

Country Link
US (1) US6916926B2 (de)
EP (1) EP1307440B1 (de)
JP (1) JP5015403B2 (de)
KR (1) KR100788532B1 (de)
CN (1) CN1216053C (de)
AT (1) ATE290533T1 (de)
AU (1) AU2001281992A1 (de)
BR (1) BR0112802A (de)
CZ (1) CZ301039B6 (de)
DE (1) DE60109299T2 (de)
EE (1) EE05159B1 (de)
ES (1) ES2237589T3 (de)
HU (1) HU229801B1 (de)
IL (2) IL153502A0 (de)
IT (1) IT1318651B1 (de)
MX (1) MXPA02012922A (de)
PL (1) PL206308B1 (de)
PT (1) PT1307440E (de)
RS (1) RS50862B (de)
RU (1) RU2269522C2 (de)
SI (1) SI21041B (de)
SK (1) SK286795B6 (de)
UA (1) UA73790C2 (de)
WO (1) WO2002010150A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1318650B1 (it) * 2000-07-28 2003-08-27 Dompe Spa 1,3-diossolani ad attivita' antitosse.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049660A (en) * 1971-06-18 1977-09-20 Delalande S.A. N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics
IT1210639B (it) * 1981-02-25 1989-09-14 Menarini Sas Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione
IT1203721B (it) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
SE449516B (sv) * 1984-10-16 1987-05-04 Skf Nova Ab Klemring med reglerbar halomkrets
IT1254452B (it) * 1992-02-14 1995-09-25 Dompe Farmaceutici Spa N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
DE69722360T2 (de) * 1996-06-29 2003-11-27 Samjin Pharm, Co. Piperazin-derivate und verfahren zu ihrer herstellung
IT1318650B1 (it) * 2000-07-28 2003-08-27 Dompe Spa 1,3-diossolani ad attivita' antitosse.

Also Published As

Publication number Publication date
HUP0301473A2 (hu) 2003-08-28
BR0112802A (pt) 2003-07-01
DE60109299T2 (de) 2005-07-21
RU2269522C2 (ru) 2006-02-10
SI21041B (en) 2005-08-31
MXPA02012922A (es) 2003-10-06
ITMI20001735A0 (it) 2000-07-28
JP2004505074A (ja) 2004-02-19
EP1307440A1 (de) 2003-05-07
CN1444579A (zh) 2003-09-24
HU229801B1 (en) 2014-07-28
WO2002010150A1 (en) 2002-02-07
EP1307440B1 (de) 2005-03-09
IL153502A (en) 2006-12-10
YU3103A (sh) 2006-05-25
US20030176446A1 (en) 2003-09-18
ATE290533T1 (de) 2005-03-15
KR20030016424A (ko) 2003-02-26
SI21041A (sl) 2003-04-30
CZ301039B6 (cs) 2009-10-21
UA73790C2 (uk) 2005-09-15
EE200300035A (et) 2004-10-15
PT1307440E (pt) 2005-05-31
JP5015403B2 (ja) 2012-08-29
SK902003A3 (en) 2003-09-11
PL206308B1 (pl) 2010-07-30
RS50862B (sr) 2010-08-31
DE60109299D1 (de) 2005-04-14
US6916926B2 (en) 2005-07-12
AU2001281992A1 (en) 2002-02-13
HK1058798A1 (en) 2004-06-04
ITMI20001735A1 (it) 2002-01-28
EE05159B1 (et) 2009-04-15
ES2237589T3 (es) 2005-08-01
KR100788532B1 (ko) 2007-12-24
CZ2003269A3 (cs) 2003-06-18
SK286795B6 (sk) 2009-05-07
PL361173A1 (en) 2004-09-20
IT1318651B1 (it) 2003-08-27
CN1216053C (zh) 2005-08-24

Similar Documents

Publication Publication Date Title
EA200300459A1 (ru) Новые, применяемые в качестве медикаментов антихолинергические средства, а также способ их получения
MX9603050A (es) Derivados de la 1-h-3-aril-pirrolidin-2,4-diona como agentes pesticidas.
DK0776324T3 (da) Endothelin-antagonister
NO870241L (no) Hypoglykemiske tiazolidindioner.
DK0565549T3 (da) Anvendelse af 1,3-oxathiolannucleosidanaloger til fremstilling af et præparat til behandling af hepatitis B
DE69525354D1 (de) Eine neuartige medizinische verwendung eines 5ht 3-antagonisten
FI922806A0 (fi) Substituerade 4-fenyl-4 -piperidinkarboxamider med baode lokalbedoevande och smaertstillande effekt samt foerfaranden foer deras framstaellning.
EP1411052A4 (de) Benzokondensierte 5gliedrige heterocyclische verbindungen, verfahren zu deren herstellung und deren verwendung
ATE419228T1 (de) Herstellung von fluoromethyl-2,2,2-trifluoro-1- (trifluoromethyl)ethylether
TR200402546T4 (tr) Taksan türevleri hazırlamak için işlem.
BR0114380A (pt) Derivados-1-aminobutan-3-ol-substituìdos
MXPA02012922A (es) 1,3 dioxolanos 2,2-disubstituidos como agentes antitusigenos.
PL344696A1 (en) Hyperforin derivatives, the use thereof and formulations containing them
EA200201003A1 (ru) Аморфная модификация торасемида
IL153515A0 (en) 1,3-dioxolanes with antitussive activity
ATE298336T1 (de) Verfahren zur herstellung von thiazolidinedion- derivaten und zwischenprodukte
EP1561744A3 (de) Aminderivate, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
EA200200741A1 (ru) Способ получения эфиров арилиминометилкарбаминовой кислоты
EA200200090A1 (ru) Способ получения замещенных бензизотиазоловых соединений
ATE98628T1 (de) 2-amino-7-hydroxytetralin-ether.
IT9020200A0 (it) Procedimento per la fabbricazione di spazzole, nonche' macchina per la fabbricazione di spazzole per l'esecuzione del procedimento
ES2037667T3 (es) Procedimiento para la obtencion de indolinas.

Legal Events

Date Code Title Description
KB Patent renewed
FF Patent granted
KB Patent renewed