IL152384A0 - Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein - Google Patents
Modulators of receptors for parathyroid hormone and parathyroid hormone-related proteinInfo
- Publication number
- IL152384A0 IL152384A0 IL15238401A IL15238401A IL152384A0 IL 152384 A0 IL152384 A0 IL 152384A0 IL 15238401 A IL15238401 A IL 15238401A IL 15238401 A IL15238401 A IL 15238401A IL 152384 A0 IL152384 A0 IL 152384A0
- Authority
- IL
- Israel
- Prior art keywords
- parathyroid hormone
- modulators
- receptors
- related protein
- parathyroid
- Prior art date
Links
- 102000003982 Parathyroid hormone Human genes 0.000 title 1
- 108090000445 Parathyroid hormone Proteins 0.000 title 1
- 102000043299 Parathyroid hormone-related Human genes 0.000 title 1
- 101710123753 Parathyroid hormone-related protein Proteins 0.000 title 1
- 239000000199 parathyroid hormone Substances 0.000 title 1
- 229960001319 parathyroid hormone Drugs 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
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- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20005300P | 2000-04-27 | 2000-04-27 | |
US21486000P | 2000-06-28 | 2000-06-28 | |
US26667301P | 2001-02-06 | 2001-02-06 | |
US09/843,221 US6756480B2 (en) | 2000-04-27 | 2001-04-26 | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
PCT/US2001/013528 WO2001081415A2 (en) | 2000-04-27 | 2001-04-27 | Parathyroid hormone and parathyroid hormone-related protein antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
IL152384A0 true IL152384A0 (en) | 2003-05-29 |
Family
ID=27498365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15238401A IL152384A0 (en) | 2000-04-27 | 2001-04-27 | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
Country Status (18)
Country | Link |
---|---|
US (2) | US6756480B2 (xx) |
EP (1) | EP1276767A2 (xx) |
JP (1) | JP2004500838A (xx) |
KR (1) | KR20030004375A (xx) |
CN (1) | CN1439021A (xx) |
AU (2) | AU2001257321B2 (xx) |
BG (1) | BG107242A (xx) |
BR (1) | BR0110391A (xx) |
CA (1) | CA2407493A1 (xx) |
CZ (1) | CZ20023496A3 (xx) |
EA (1) | EA200201121A1 (xx) |
HK (1) | HK1052939A1 (xx) |
HU (1) | HUP0300465A3 (xx) |
IL (1) | IL152384A0 (xx) |
MX (1) | MXPA02010589A (xx) |
NO (1) | NO20025143L (xx) |
SK (1) | SK15202002A3 (xx) |
WO (1) | WO2001081415A2 (xx) |
Families Citing this family (159)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6495662B1 (en) * | 1998-10-22 | 2002-12-17 | The General Hospital Corporation | Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) |
US6689566B1 (en) * | 1999-01-14 | 2004-02-10 | Scantibodies Laboratory, Inc. | Methods, kits, and antibodies for detecting parathyroid hormone |
US7820393B2 (en) * | 1999-01-14 | 2010-10-26 | Scantibodies Laboratory, Inc. | Methods, kits and antibodies for detecting parathyroid hormone |
WO2001023521A2 (en) * | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
US20020090646A1 (en) * | 2000-05-03 | 2002-07-11 | Amgen Inc. | Calcitonin-related molecules |
JP4837888B2 (ja) * | 2001-07-23 | 2011-12-14 | ザ ジェネラル ホスピタル コーポレイション | コンホメーションが拘束された副甲状腺ホルモン(pth)類似体 |
EP1437141A4 (en) * | 2001-09-17 | 2009-05-27 | Chugai Pharmaceutical Co Ltd | TREATMENTS OF BONE LOSS |
US7247609B2 (en) | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
AU2003207512B2 (en) * | 2002-01-10 | 2008-06-12 | Osteotrophin Llc | Treatment of bone disorders with skeletal anabolic drugs |
EP1477496A4 (en) * | 2002-02-01 | 2006-08-02 | Chugai Pharmaceutical Co Ltd | PEG BINDING PTH OR PEG BINDING PTH DERIVATIVE |
US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
TW200307553A (en) * | 2002-05-24 | 2003-12-16 | Akzo Nobel Nv | Treatment of post-menopausal complaints in breast cancer patients |
US7378495B2 (en) | 2002-10-21 | 2008-05-27 | Pevion Biotech, Ltd. | PTH-rP related peptide cancer therapeutics |
EP1567178A4 (en) * | 2002-11-01 | 2009-07-15 | Amgen Inc | MODULATORS OF RECEPTORS FOR NEUTRAL THERAPY HORMONE AND SIDE-HORSE HORMONE-RELATED PROTEINS |
US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
EP1610813A4 (en) * | 2003-03-19 | 2009-07-01 | Gen Hospital Corp | PARATHYROIDAL HORMONES CONFORMALLY CONFORMALLY CONSTRAINED WITH PROPELLER STABILIZERS $ G (A) |
AU2016244273B2 (en) * | 2003-05-06 | 2018-10-18 | Bioverativ Therapeutics Inc. | Immunoglobulin Chimeric Monomer-Dimer Hybrids |
TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
PL2298347T3 (pl) | 2003-05-06 | 2016-03-31 | Bioverativ Therapeutics Inc | Białka chimeryczne czynnika krzepnięcia do leczenia zaburzenia hemostazy |
WO2005009358A2 (en) | 2003-07-17 | 2005-02-03 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
CN1838968A (zh) | 2003-08-08 | 2006-09-27 | 艾伯吉尼斯公司 | 针对甲状旁腺激素(pth)之抗体和其用途 |
US7318925B2 (en) * | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
EP1682584B1 (en) | 2003-11-13 | 2013-04-17 | Hanmi Science Co., Ltd. | A pharmaceutical composition comprising an immunoglobulin fc region as a carrier |
CA2562133A1 (en) * | 2004-03-19 | 2005-09-29 | Zelos Therapeutics, Inc. | Compositions and methods for detecting cyclic analogs of human parathyroid hormone (hpth) |
US20060127320A1 (en) * | 2004-05-10 | 2006-06-15 | Nastech Pharmaceutical Company Inc. | Method of delivering parathyroid hormone to a human |
CN101151048A (zh) * | 2004-05-10 | 2008-03-26 | 纳斯泰克制药公司 | 增强甲状旁腺激素粘膜递送的组合物和方法 |
US20060052305A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | Method of treating osteoporosis using intranasal parathyroid hormone |
JP5324781B2 (ja) * | 2004-06-14 | 2013-10-23 | ビーエーエスエフ、ビューティー、ケア、ソルーションズ、フランス、エスエーエス | Pth断片含有化粧品 |
KR100754667B1 (ko) * | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | 비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물 |
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JP2002541779A (ja) | 1999-02-24 | 2002-12-10 | ザ ジュネラル ホスピタル コーポレーション | シグナル伝達中間体のクローニング方法 |
WO2000077042A2 (en) | 1999-06-15 | 2000-12-21 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Parathyroid hormone receptor ligands |
ECSP003590A (es) | 1999-07-31 | 2002-02-25 | Smithkline Beecham Corp | Compuestos calcioliticos |
WO2001023521A2 (en) | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
ES2316354T3 (es) | 1999-09-29 | 2009-04-16 | The General Hospital Corporation | Derivados polipeptidos de la hormona paratiroidea (pth). |
-
2001
- 2001-04-26 US US09/843,221 patent/US6756480B2/en not_active Expired - Fee Related
- 2001-04-27 BR BR0110391-1A patent/BR0110391A/pt not_active IP Right Cessation
- 2001-04-27 CA CA002407493A patent/CA2407493A1/en not_active Abandoned
- 2001-04-27 WO PCT/US2001/013528 patent/WO2001081415A2/en active IP Right Grant
- 2001-04-27 AU AU2001257321A patent/AU2001257321B2/en not_active Ceased
- 2001-04-27 MX MXPA02010589A patent/MXPA02010589A/es active IP Right Grant
- 2001-04-27 EA EA200201121A patent/EA200201121A1/ru unknown
- 2001-04-27 HU HU0300465A patent/HUP0300465A3/hu unknown
- 2001-04-27 KR KR1020027014455A patent/KR20030004375A/ko not_active Application Discontinuation
- 2001-04-27 CZ CZ20023496A patent/CZ20023496A3/cs unknown
- 2001-04-27 SK SK1520-2002A patent/SK15202002A3/sk unknown
- 2001-04-27 CN CN01811719A patent/CN1439021A/zh active Pending
- 2001-04-27 EP EP01930822A patent/EP1276767A2/en not_active Withdrawn
- 2001-04-27 JP JP2001578502A patent/JP2004500838A/ja not_active Withdrawn
- 2001-04-27 AU AU5732101A patent/AU5732101A/xx active Pending
- 2001-04-27 IL IL15238401A patent/IL152384A0/xx unknown
-
2002
- 2002-10-25 NO NO20025143A patent/NO20025143L/no not_active Application Discontinuation
- 2002-11-01 BG BG107242A patent/BG107242A/xx unknown
-
2003
- 2003-07-18 HK HK03105225.3A patent/HK1052939A1/zh unknown
-
2004
- 2004-05-04 US US10/839,037 patent/US20040214996A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CZ20023496A3 (cs) | 2003-05-14 |
US20040214996A1 (en) | 2004-10-28 |
EA200201121A1 (ru) | 2003-06-26 |
US6756480B2 (en) | 2004-06-29 |
NO20025143L (no) | 2002-12-23 |
BR0110391A (pt) | 2003-02-25 |
AU5732101A (en) | 2001-11-07 |
HUP0300465A3 (en) | 2009-11-30 |
AU2001257321B2 (en) | 2007-05-17 |
WO2001081415A3 (en) | 2002-11-28 |
CN1439021A (zh) | 2003-08-27 |
HK1052939A1 (zh) | 2003-10-03 |
BG107242A (en) | 2003-06-30 |
WO2001081415A2 (en) | 2001-11-01 |
NO20025143D0 (no) | 2002-10-25 |
SK15202002A3 (sk) | 2003-06-03 |
CA2407493A1 (en) | 2001-11-01 |
WO2001081415A9 (en) | 2002-02-14 |
US20030039654A1 (en) | 2003-02-27 |
MXPA02010589A (es) | 2003-03-10 |
KR20030004375A (ko) | 2003-01-14 |
HUP0300465A2 (hu) | 2003-06-28 |
EP1276767A2 (en) | 2003-01-22 |
JP2004500838A (ja) | 2004-01-15 |
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