IL150798A0 - Water soluble prodrugs of azole compounds - Google Patents
Water soluble prodrugs of azole compoundsInfo
- Publication number
- IL150798A0 IL150798A0 IL15079801A IL15079801A IL150798A0 IL 150798 A0 IL150798 A0 IL 150798A0 IL 15079801 A IL15079801 A IL 15079801A IL 15079801 A IL15079801 A IL 15079801A IL 150798 A0 IL150798 A0 IL 150798A0
- Authority
- IL
- Israel
- Prior art keywords
- water soluble
- azole compounds
- soluble prodrugs
- triazole antifungal
- prodrugs
- Prior art date
Links
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 239000000651 prodrug Substances 0.000 title abstract 2
- 150000003851 azoles Chemical class 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 3
- 229940121375 antifungal agent Drugs 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 150000003852 triazoles Chemical class 0.000 abstract 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polymerization Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17716900P | 2000-01-20 | 2000-01-20 | |
| US24996900P | 2000-11-20 | 2000-11-20 | |
| PCT/US2001/001284 WO2001052852A1 (en) | 2000-01-20 | 2001-01-16 | Water soluble prodrugs of azole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL150798A0 true IL150798A0 (en) | 2003-02-12 |
Family
ID=26873001
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15079801A IL150798A0 (en) | 2000-01-20 | 2001-01-16 | Water soluble prodrugs of azole compounds |
| IL150798A IL150798A (en) | 2000-01-20 | 2002-07-17 | Water-soluble pro-drugs of azole compounds |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL150798A IL150798A (en) | 2000-01-20 | 2002-07-17 | Water-soluble pro-drugs of azole compounds |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6362172B2 (no) |
| EP (1) | EP1284737B1 (no) |
| JP (1) | JP3766804B2 (no) |
| KR (1) | KR100748299B1 (no) |
| CN (1) | CN1178665C (no) |
| AT (1) | ATE300946T1 (no) |
| AU (1) | AU782177C (no) |
| BR (1) | BR0107618A (no) |
| CA (1) | CA2397734C (no) |
| CZ (1) | CZ20022822A3 (no) |
| DE (1) | DE60112433T2 (no) |
| DK (1) | DK1284737T5 (no) |
| ES (1) | ES2247131T3 (no) |
| HU (1) | HU229226B1 (no) |
| IL (2) | IL150798A0 (no) |
| MX (1) | MXPA02007120A (no) |
| NO (1) | NO330352B1 (no) |
| NZ (1) | NZ519354A (no) |
| PL (1) | PL206024B1 (no) |
| PT (1) | PT1284737E (no) |
| RU (1) | RU2266909C2 (no) |
| WO (1) | WO2001052852A1 (no) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6448401B1 (en) * | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
| HUP0303249A3 (en) | 2001-02-22 | 2007-03-28 | Sankyo Co | Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| CN1678321A (zh) | 2002-07-29 | 2005-10-05 | 里格尔药品股份有限公司 | 用2,4－嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| PT1856135E (pt) | 2005-01-19 | 2010-02-26 | Rigel Pharmaceuticals Inc | Pró-fármacos de compostos 2,4-pirimidinodiamina e suas utilizações |
| JO2691B1 (en) | 2005-05-03 | 2013-03-03 | ايساي آر آند دي مانجمنت كو.، ليمتد | Monolysine salts for azole compounds |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| US7803949B2 (en) * | 2005-12-20 | 2010-09-28 | Eisai R&D Management Co., Ltd. | Process for preparation of water-soluble azole prodrugs |
| EP2043446A2 (en) * | 2006-02-08 | 2009-04-08 | Phibro-Tech Inc. | Biocidal azole emulsion concentrates having high active ingredient content |
| CN101389333A (zh) | 2006-02-22 | 2009-03-18 | 卫材R&D管理有限公司 | 稳定化药物组合物 |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| NZ619413A (en) | 2006-05-04 | 2015-08-28 | Boehringer Ingelheim Int | Polymorphs of a dpp-iv enzyme inhibitor |
| AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
| AU2009249067A1 (en) * | 2008-05-20 | 2009-11-26 | Neurogesx, Inc. | Water-soluble acetaminophen analogs |
| MX2010012649A (es) | 2008-05-20 | 2010-12-21 | Neurogesx Inc | Profarmacos de carbonato y metodos para usar los mismos. |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| BRPI0919288A2 (pt) | 2008-09-10 | 2015-12-15 | Boehring Ingelheim Internat Gmbh | teriapia de combinação para tratamento de diabetes e condições relacionadas. |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| CN102256976A (zh) | 2008-12-23 | 2011-11-23 | 贝林格尔.英格海姆国际有限公司 | 有机化合物的盐形式 |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| KR20210033559A (ko) | 2009-11-27 | 2021-03-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| CN102946875A (zh) | 2010-05-05 | 2013-02-27 | 贝林格尔.英格海姆国际有限公司 | 组合疗法 |
| EP3124041A1 (en) | 2010-06-24 | 2017-02-01 | Boehringer Ingelheim International GmbH | Diabetes therapy |
| US20130288956A1 (en) | 2010-11-05 | 2013-10-31 | Eisai R&D Management Co., Ltd. | Combined pharmaceutical composition as antifungal agent |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| AU2011343576B2 (en) * | 2010-12-16 | 2016-09-08 | Platform Brightworks Two, Ltd. | Azole pharmaceutical formulations for parenteral administration and methods for preparing and using the same as treatment of diseases sensitive to azole compounds |
| EP2723452A2 (en) | 2011-06-22 | 2014-04-30 | Vyome Biosciences Pvt Ltd | Conjugate-based antifungal and antibacterial prodrugs |
| AU2012285904C1 (en) | 2011-07-15 | 2017-08-31 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
| US8426450B1 (en) * | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| KR102061137B1 (ko) * | 2012-01-20 | 2019-12-31 | 마이코비아 파마슈티컬즈, 인코포레이티드 | 금속효소 억제제 화합물 |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| CA2869882C (en) * | 2012-04-20 | 2019-09-10 | Eisai R&D Management Co., Ltd. | Capsule formulation |
| EP2849755A1 (en) | 2012-05-14 | 2015-03-25 | Boehringer Ingelheim International GmbH | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| US20160128944A1 (en) | 2013-06-04 | 2016-05-12 | Vyome Biosciences Pvt. Ltd. | Coated particles and compositions comprising same |
| AU2015212312A1 (en) | 2014-01-29 | 2016-08-18 | Vyome Therapeutics Limited | Treatments for resistant acne |
| US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
| CN104926870B (zh) * | 2014-03-21 | 2017-02-08 | 合肥久诺医药科技有限公司 | 一种福司氟康唑的精制方法 |
| WO2017019875A1 (en) * | 2015-07-28 | 2017-02-02 | Beta Cat Pharmaceuticals, Inc. | Anthracene-9, 10-dione dioxime compounds prodrugs and their uses |
| WO2017211979A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
| CN107501255B (zh) * | 2017-09-12 | 2019-08-23 | 成都施贝康生物医药科技有限公司 | 一种艾沙康唑衍生物及其用途 |
| CN108676031A (zh) * | 2018-05-29 | 2018-10-19 | 重庆威鹏药业有限公司 | 水溶性三唑类抗真菌膦酸化合物及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9308012A (es) | 1992-12-24 | 1994-08-31 | Bristol Myers Squibb Co | Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen. |
| CA2129288C (en) | 1993-08-17 | 2000-05-16 | Jerzy Golik | Phosphonooxymethyl esters of taxane derivatives |
| US5714490A (en) * | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| ATE204875T1 (de) | 1993-12-21 | 2001-09-15 | Schering Corp | Fungizide tetrahydrofurane |
| PL181947B1 (en) | 1994-01-24 | 2001-10-31 | Janssen Pharmaceutica Nv | Water-soluble azole-type antimycotic agents |
| NZ270418A (en) | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
| MX9701229A (es) | 1995-06-02 | 1997-05-31 | Schering Corp | Antifungicos de tetrahidrofurano. |
| TW354293B (en) * | 1995-06-06 | 1999-03-11 | Bristol Myers Squibb Co | Prodrugs of paclitaxel derivatives |
| GB9602080D0 (en) | 1996-02-02 | 1996-04-03 | Pfizer Ltd | Pharmaceutical compounds |
| EP0829478A3 (en) | 1996-09-09 | 1998-03-25 | F. Hoffmann-La Roche Ag | N-Benzylimidazolium and N-benzyltriazolium derivatives, their preparation and their use as antifungal and antimycotic agents |
| JP2002501926A (ja) | 1998-01-29 | 2002-01-22 | ブリストル−マイヤーズ スクイブ カンパニー | ジアリール１、３、４−オキサジアゾロンのホスフェート誘導体 |
| US5883097A (en) | 1998-04-16 | 1999-03-16 | Schering Corporation | Soluble azole antifungal salt |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| AU1915500A (en) * | 1998-11-20 | 2000-06-13 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| US6448401B1 (en) * | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
-
2001
- 2001-01-10 US US09/757,438 patent/US6362172B2/en not_active Expired - Lifetime
- 2001-01-16 WO PCT/US2001/001284 patent/WO2001052852A1/en active IP Right Grant
- 2001-01-16 PT PT01942553T patent/PT1284737E/pt unknown
- 2001-01-16 AU AU29485/01A patent/AU782177C/en not_active Expired
- 2001-01-16 MX MXPA02007120A patent/MXPA02007120A/es active IP Right Grant
- 2001-01-16 CZ CZ20022822A patent/CZ20022822A3/cs unknown
- 2001-01-16 RU RU2002118606/04A patent/RU2266909C2/ru active
- 2001-01-16 EP EP01942553A patent/EP1284737B1/en not_active Expired - Lifetime
- 2001-01-16 CN CNB018038581A patent/CN1178665C/zh not_active Expired - Lifetime
- 2001-01-16 NZ NZ519354A patent/NZ519354A/en not_active IP Right Cessation
- 2001-01-16 JP JP2001552899A patent/JP3766804B2/ja not_active Expired - Lifetime
- 2001-01-16 DK DK01942553T patent/DK1284737T5/da active
- 2001-01-16 HU HU0204405A patent/HU229226B1/hu not_active IP Right Cessation
- 2001-01-16 DE DE60112433T patent/DE60112433T2/de not_active Expired - Lifetime
- 2001-01-16 IL IL15079801A patent/IL150798A0/xx active IP Right Grant
- 2001-01-16 AT AT01942553T patent/ATE300946T1/de active
- 2001-01-16 CA CA2397734A patent/CA2397734C/en not_active Expired - Lifetime
- 2001-01-16 KR KR1020027009320A patent/KR100748299B1/ko active IP Right Grant
- 2001-01-16 ES ES01942553T patent/ES2247131T3/es not_active Expired - Lifetime
- 2001-01-16 BR BR0107618-3A patent/BR0107618A/pt active Search and Examination
- 2001-01-16 PL PL356164A patent/PL206024B1/pl not_active IP Right Cessation
-
2002
- 2002-07-17 IL IL150798A patent/IL150798A/en unknown
- 2002-07-19 NO NO20023468A patent/NO330352B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |