IL148631A0 - Quinuclidine derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof - Google Patents

Quinuclidine derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof

Info

Publication number
IL148631A0
IL148631A0 IL14863100A IL14863100A IL148631A0 IL 148631 A0 IL148631 A0 IL 148631A0 IL 14863100 A IL14863100 A IL 14863100A IL 14863100 A IL14863100 A IL 14863100A IL 148631 A0 IL148631 A0 IL 148631A0
Authority
IL
Israel
Prior art keywords
optionally substituted
chain
substituted
denotes
preparation
Prior art date
Application number
IL14863100A
Other languages
English (en)
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of IL148631A0 publication Critical patent/IL148631A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL14863100A 1999-09-28 2000-09-27 Quinuclidine derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof IL148631A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27390599 1999-09-28
JP2000179352 2000-06-15
PCT/JP2000/006665 WO2001023383A1 (fr) 1999-09-28 2000-09-27 Composes de quinuclidine et medicaments contenant ces composes comme principe actif

Publications (1)

Publication Number Publication Date
IL148631A0 true IL148631A0 (en) 2002-09-12

Family

ID=26550809

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14863100A IL148631A0 (en) 1999-09-28 2000-09-27 Quinuclidine derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
IL148631A IL148631A (en) 1999-09-28 2002-03-12 History of quinocladin, pharmaceutical preparations containing them and processes for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL148631A IL148631A (en) 1999-09-28 2002-03-12 History of quinocladin, pharmaceutical preparations containing them and processes for their preparation

Country Status (20)

Country Link
US (1) US6599917B1 (pt)
EP (1) EP1217001B1 (pt)
JP (1) JP4206212B2 (pt)
KR (1) KR100694687B1 (pt)
CN (1) CN100334085C (pt)
AT (1) ATE312100T1 (pt)
AU (1) AU782114B2 (pt)
BR (1) BR0014331A (pt)
CA (1) CA2385995C (pt)
DE (1) DE60024651T2 (pt)
DK (1) DK1217001T3 (pt)
ES (1) ES2252063T3 (pt)
HU (1) HUP0203514A3 (pt)
IL (2) IL148631A0 (pt)
MX (1) MXPA02003167A (pt)
NO (1) NO328218B1 (pt)
NZ (1) NZ517788A (pt)
RU (1) RU2266905C2 (pt)
TW (1) TWI282794B (pt)
WO (1) WO2001023383A1 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0010955D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
ATE366248T1 (de) * 2001-03-27 2007-07-15 Eisai R&D Man Co Ltd N-aryl-substituiertes cyclisches aminderivat und medizin, die dieses als wirkstoff enthält
EP1256573A1 (en) 2001-05-09 2002-11-13 Eisai Co., Ltd. Process for producing stereoisomer of pyrrolidine derivative
EP1438309A1 (en) 2001-10-17 2004-07-21 Ucb, S.A. Quinuclidine derivatives, processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
US7361671B2 (en) * 2001-11-15 2008-04-22 The Institute For Pharmaceutical Discovery, Inc. Substituted heteroarylalkanoic acids
DE10225537A1 (de) * 2002-06-10 2003-12-18 Bayer Ag N-alkylierte Thiazoliumsalze und Verfahren zu deren Herstellung
GB0218876D0 (en) * 2002-08-13 2002-09-25 Merck Sharp & Dohme Therapeutic agents
CA2499128C (en) 2002-09-25 2012-07-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
DE10334724A1 (de) * 2003-07-30 2005-02-24 Bayer Healthcare Ag N-Biarylamide
CA2541949A1 (en) * 2003-10-07 2005-05-26 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
RU2417225C2 (ru) 2004-03-25 2011-04-27 Мемори Фармасьютиклз Корпорейшн Индазолы, бензотиазолы, бензоизотиазолы, бензизоксазолы и их получение и применение
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
EP2132196A1 (en) 2007-02-26 2009-12-16 Pfizer Products Inc. Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases
TW201111385A (en) 2009-08-27 2011-04-01 Biocryst Pharm Inc Heterocyclic compounds as janus kinase inhibitors
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
US20130071415A1 (en) 2010-05-28 2013-03-21 Biocryst Pharmaceuticals, Inc. Heterocyclic Compounds as Janus Kinase Inhibitors
WO2013102145A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
CN104135859B (zh) 2011-12-28 2017-06-27 全球血液疗法公司 取代的苯甲醛化合物及其用于增加组织氧合的方法
WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
CN104884449A (zh) 2012-10-31 2015-09-02 拜尔农作物科学股份公司 作为害虫防治剂的新的杂环化合物
JP6463327B2 (ja) 2013-03-15 2019-01-30 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
JP6426694B2 (ja) 2013-03-15 2018-11-21 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
SG11201507453VA (en) 2013-03-15 2015-10-29 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
DK3102208T4 (da) 2014-02-07 2024-08-26 Global Blood Therapeutics Inc Krystallinsk polymorph af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
MA42508B1 (fr) 2015-06-03 2020-05-29 Hoffmann La Roche Dérivés d'éthynyle
EP3383392A1 (en) 2015-12-04 2018-10-10 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI752307B (zh) 2016-05-12 2022-01-11 美商全球血液治療公司 新穎化合物及製造化合物之方法
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
SG11202102679QA (en) 2018-09-18 2021-04-29 Nikang Therapeutics Inc Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors
EP3860975B1 (en) 2018-10-01 2023-10-18 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992015579A1 (en) * 1991-03-08 1992-09-17 Rhone-Poulenc Rorer International (Holdings) Inc. Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5135935A (en) * 1991-05-17 1992-08-04 Merck & Co., Inc. Squalene synthetase inhibitors
GB9127279D0 (en) 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
JPH05310732A (ja) 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
GB9207961D0 (en) 1992-04-10 1992-05-27 Ici Plc Heterocyclic derivatives
GB9218334D0 (en) 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
WO1995031458A1 (en) 1992-10-13 1995-11-23 Rhone-Poulenc Rorer Pharmaceuticals Inc. 3-hydroxyquinuclidin-3-ylphenylquinolines as squalene synthase inhibitors
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
IL109451A0 (en) 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
GB9412145D0 (en) 1994-06-17 1994-08-10 Zeneca Ltd Heterocycles
JPH08134067A (ja) 1994-11-11 1996-05-28 Yamanouchi Pharmaceut Co Ltd キヌクリジン誘導体
JPH08269056A (ja) 1995-03-29 1996-10-15 Chugai Pharmaceut Co Ltd スクアレンシンセターゼ阻害作用を有するキヌクリジン誘導体
US5712270A (en) * 1995-11-06 1998-01-27 American Home Products Corporation 2-arylamidothiazole derivatives with CNS activity
EP0901489A1 (en) * 1996-05-20 1999-03-17 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone

Also Published As

Publication number Publication date
DK1217001T3 (da) 2006-03-20
DE60024651T2 (de) 2006-09-28
ATE312100T1 (de) 2005-12-15
HUP0203514A3 (en) 2004-01-28
AU7446400A (en) 2001-04-30
NO328218B1 (no) 2010-01-11
US6599917B1 (en) 2003-07-29
RU2266905C2 (ru) 2005-12-27
NO20021528L (no) 2002-05-28
KR20020034197A (ko) 2002-05-08
EP1217001A4 (en) 2002-12-18
ES2252063T3 (es) 2006-05-16
DE60024651D1 (de) 2006-01-12
EP1217001A1 (en) 2002-06-26
IL148631A (en) 2010-04-29
WO2001023383A1 (fr) 2001-04-05
EP1217001B1 (en) 2005-12-07
CN100334085C (zh) 2007-08-29
CA2385995A1 (en) 2001-04-05
NZ517788A (en) 2003-11-28
TWI282794B (en) 2007-06-21
HUP0203514A2 (hu) 2003-03-28
MXPA02003167A (es) 2003-10-06
KR100694687B1 (ko) 2007-03-13
AU782114B2 (en) 2005-07-07
BR0014331A (pt) 2003-06-10
JP4206212B2 (ja) 2009-01-07
CN1377349A (zh) 2002-10-30
CA2385995C (en) 2009-06-16
NO20021528D0 (no) 2002-03-26

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