DE60024651D1 - Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten - Google Patents
Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthaltenInfo
- Publication number
- DE60024651D1 DE60024651D1 DE60024651T DE60024651T DE60024651D1 DE 60024651 D1 DE60024651 D1 DE 60024651D1 DE 60024651 T DE60024651 T DE 60024651T DE 60024651 T DE60024651 T DE 60024651T DE 60024651 D1 DE60024651 D1 DE 60024651D1
- Authority
- DE
- Germany
- Prior art keywords
- optionally substituted
- chain
- substituted
- active
- denotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP27390599 | 1999-09-28 | ||
JP27390599 | 1999-09-28 | ||
JP2000179352 | 2000-06-15 | ||
JP2000179352 | 2000-06-15 | ||
PCT/JP2000/006665 WO2001023383A1 (fr) | 1999-09-28 | 2000-09-27 | Composes de quinuclidine et medicaments contenant ces composes comme principe actif |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60024651D1 true DE60024651D1 (de) | 2006-01-12 |
DE60024651T2 DE60024651T2 (de) | 2006-09-28 |
Family
ID=26550809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60024651T Expired - Lifetime DE60024651T2 (de) | 1999-09-28 | 2000-09-27 | Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten |
Country Status (20)
Country | Link |
---|---|
US (1) | US6599917B1 (de) |
EP (1) | EP1217001B1 (de) |
JP (1) | JP4206212B2 (de) |
KR (1) | KR100694687B1 (de) |
CN (1) | CN100334085C (de) |
AT (1) | ATE312100T1 (de) |
AU (1) | AU782114B2 (de) |
BR (1) | BR0014331A (de) |
CA (1) | CA2385995C (de) |
DE (1) | DE60024651T2 (de) |
DK (1) | DK1217001T3 (de) |
ES (1) | ES2252063T3 (de) |
HU (1) | HUP0203514A3 (de) |
IL (2) | IL148631A0 (de) |
MX (1) | MXPA02003167A (de) |
NO (1) | NO328218B1 (de) |
NZ (1) | NZ517788A (de) |
RU (1) | RU2266905C2 (de) |
TW (1) | TWI282794B (de) |
WO (1) | WO2001023383A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0010955D0 (en) * | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
JP4225787B2 (ja) * | 2001-03-27 | 2009-02-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | N−アリール環状アミン誘導体およびそれを有効成分として含有する医薬 |
EP1256573A1 (de) | 2001-05-09 | 2002-11-13 | Eisai Co., Ltd. | Verfahren zur Herstellung eines Stereoisomers von Pyrrolidinderivat |
EP1438309A1 (de) * | 2001-10-17 | 2004-07-21 | Ucb, S.A. | Chinuclidine-derivate, verfahren zu ihrer herstellung und ihre verwendung als m2 und/oder m3 muskarinerge inhibitoren |
US7361671B2 (en) * | 2001-11-15 | 2008-04-22 | The Institute For Pharmaceutical Discovery, Inc. | Substituted heteroarylalkanoic acids |
DE10225537A1 (de) * | 2002-06-10 | 2003-12-18 | Bayer Ag | N-alkylierte Thiazoliumsalze und Verfahren zu deren Herstellung |
GB0218876D0 (en) * | 2002-08-13 | 2002-09-25 | Merck Sharp & Dohme | Therapeutic agents |
PL210065B1 (pl) | 2002-09-25 | 2011-11-30 | Memory Pharm Corp | Związki indazole, benzotiazole i benzoizotiazole, kompozycje farmaceutyczne je zawierające oraz zastosowanie związków |
DE10334724A1 (de) * | 2003-07-30 | 2005-02-24 | Bayer Healthcare Ag | N-Biarylamide |
EP1680109A4 (de) * | 2003-10-07 | 2009-05-06 | Renovis Inc | Amid-derivate als ionenkanal-liganden und pharmazeutische zusammensetzungen und anwendungsverfahren |
AU2005227324A1 (en) | 2004-03-25 | 2005-10-06 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
EP2132196A1 (de) | 2007-02-26 | 2009-12-16 | Pfizer Products Inc. | Nicotinamid-derivate als h-pgds-hemmer und ihre verwendung zur behandlung prostaglandin-d2-vermittelter erkrankungen |
TW201111385A (en) | 2009-08-27 | 2011-04-01 | Biocryst Pharm Inc | Heterocyclic compounds as janus kinase inhibitors |
US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
MX2012013824A (es) | 2010-05-28 | 2013-03-12 | Biocryst Pharm Inc | Compuestos heterociclicos como inhibidores de cinasa janus. |
EP2797597B1 (de) | 2011-12-28 | 2020-02-26 | Global Blood Therapeutics, Inc. | Substituierte heteroarylaldehydverbindungen und verfahren zu deren verwendung bei der erhöhung einer gewebeoxigenierung |
PE20221914A1 (es) | 2011-12-28 | 2022-12-23 | Global Blood Therapeutics Inc | Compuestos de benzaldehido sustituidos y metodos para su uso en incrementar la oxigenacion del tejido |
WO2014060381A1 (de) | 2012-10-18 | 2014-04-24 | Bayer Cropscience Ag | Heterocyclische verbindungen als schädlingsbekämpfungsmittel |
BR112015009751A2 (pt) | 2012-10-31 | 2017-07-11 | Bayer Cropscience Ag | novos compostos heterocíclicos como pesticidas |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
CN112500338A (zh) | 2013-03-15 | 2021-03-16 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
KR101971385B1 (ko) | 2013-03-15 | 2019-04-22 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
AU2014237330A1 (en) | 2013-03-15 | 2015-09-17 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
AU2015214182B2 (en) | 2014-02-07 | 2020-04-30 | Global Blood Therapeutics, Inc. | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
UA120309C2 (uk) | 2015-06-03 | 2019-11-11 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні |
MA43373A (fr) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics Inc | Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde |
TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
JP7337174B2 (ja) | 2018-09-18 | 2023-09-01 | ニカング セラピューティクス, インコーポレイテッド | Srcホモロジー-2ホスファターゼ阻害剤としての三置換ヘテロアリール誘導体 |
WO2020072377A1 (en) | 2018-10-01 | 2020-04-09 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992015579A1 (en) | 1991-03-08 | 1992-09-17 | Rhone-Poulenc Rorer International (Holdings) Inc. | Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors |
US5135935A (en) * | 1991-05-17 | 1992-08-04 | Merck & Co., Inc. | Squalene synthetase inhibitors |
GB9127279D0 (en) | 1991-12-23 | 1992-02-19 | Ici Plc | Heterocyclic derivatives |
JPH05310732A (ja) * | 1992-03-12 | 1993-11-22 | Mitsubishi Kasei Corp | シンノリン−3−カルボン酸誘導体 |
GB9207961D0 (en) | 1992-04-10 | 1992-05-27 | Ici Plc | Heterocyclic derivatives |
GB9218334D0 (en) | 1992-08-28 | 1992-10-14 | Ici Plc | Heterocyclic compounds |
WO1995031458A1 (en) | 1992-10-13 | 1995-11-23 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | 3-hydroxyquinuclidin-3-ylphenylquinolines as squalene synthase inhibitors |
GB9226573D0 (en) * | 1992-12-21 | 1993-02-17 | Ici Plc | Heterocyclic compounds |
IL109451A0 (en) | 1993-04-29 | 1994-07-31 | Zeneca Ltd | Heterocyclic derivatives |
GB9412145D0 (en) | 1994-06-17 | 1994-08-10 | Zeneca Ltd | Heterocycles |
JPH08134067A (ja) | 1994-11-11 | 1996-05-28 | Yamanouchi Pharmaceut Co Ltd | キヌクリジン誘導体 |
JPH08269056A (ja) | 1995-03-29 | 1996-10-15 | Chugai Pharmaceut Co Ltd | スクアレンシンセターゼ阻害作用を有するキヌクリジン誘導体 |
US5712270A (en) * | 1995-11-06 | 1998-01-27 | American Home Products Corporation | 2-arylamidothiazole derivatives with CNS activity |
JP2000511532A (ja) * | 1996-05-20 | 2000-09-05 | メルク エンド カンパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモンのアンタゴニスト |
-
2000
- 2000-09-27 US US10/088,554 patent/US6599917B1/en not_active Expired - Fee Related
- 2000-09-27 KR KR1020027003952A patent/KR100694687B1/ko not_active IP Right Cessation
- 2000-09-27 DK DK00962889T patent/DK1217001T3/da active
- 2000-09-27 AU AU74464/00A patent/AU782114B2/en not_active Ceased
- 2000-09-27 AT AT00962889T patent/ATE312100T1/de not_active IP Right Cessation
- 2000-09-27 JP JP2001526535A patent/JP4206212B2/ja not_active Expired - Fee Related
- 2000-09-27 NZ NZ517788A patent/NZ517788A/en not_active IP Right Cessation
- 2000-09-27 HU HU0203514A patent/HUP0203514A3/hu unknown
- 2000-09-27 WO PCT/JP2000/006665 patent/WO2001023383A1/ja active IP Right Grant
- 2000-09-27 DE DE60024651T patent/DE60024651T2/de not_active Expired - Lifetime
- 2000-09-27 TW TW089119958A patent/TWI282794B/zh not_active IP Right Cessation
- 2000-09-27 IL IL14863100A patent/IL148631A0/xx unknown
- 2000-09-27 MX MXPA02003167A patent/MXPA02003167A/es active IP Right Grant
- 2000-09-27 CN CNB00813541XA patent/CN100334085C/zh not_active Expired - Fee Related
- 2000-09-27 EP EP00962889A patent/EP1217001B1/de not_active Expired - Lifetime
- 2000-09-27 ES ES00962889T patent/ES2252063T3/es not_active Expired - Lifetime
- 2000-09-27 CA CA002385995A patent/CA2385995C/en not_active Expired - Fee Related
- 2000-09-27 RU RU2002111344/04A patent/RU2266905C2/ru not_active IP Right Cessation
- 2000-09-27 BR BR0014331-6A patent/BR0014331A/pt not_active Application Discontinuation
-
2002
- 2002-03-12 IL IL148631A patent/IL148631A/en not_active IP Right Cessation
- 2002-03-26 NO NO20021528A patent/NO328218B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MXPA02003167A (es) | 2003-10-06 |
WO2001023383A1 (fr) | 2001-04-05 |
US6599917B1 (en) | 2003-07-29 |
CN100334085C (zh) | 2007-08-29 |
KR20020034197A (ko) | 2002-05-08 |
JP4206212B2 (ja) | 2009-01-07 |
NZ517788A (en) | 2003-11-28 |
NO328218B1 (no) | 2010-01-11 |
CN1377349A (zh) | 2002-10-30 |
EP1217001A1 (de) | 2002-06-26 |
EP1217001B1 (de) | 2005-12-07 |
BR0014331A (pt) | 2003-06-10 |
NO20021528L (no) | 2002-05-28 |
RU2266905C2 (ru) | 2005-12-27 |
DE60024651T2 (de) | 2006-09-28 |
IL148631A (en) | 2010-04-29 |
HUP0203514A2 (hu) | 2003-03-28 |
AU7446400A (en) | 2001-04-30 |
IL148631A0 (en) | 2002-09-12 |
KR100694687B1 (ko) | 2007-03-13 |
CA2385995C (en) | 2009-06-16 |
HUP0203514A3 (en) | 2004-01-28 |
CA2385995A1 (en) | 2001-04-05 |
DK1217001T3 (da) | 2006-03-20 |
NO20021528D0 (no) | 2002-03-26 |
AU782114B2 (en) | 2005-07-07 |
ES2252063T3 (es) | 2006-05-16 |
TWI282794B (en) | 2007-06-21 |
ATE312100T1 (de) | 2005-12-15 |
EP1217001A4 (de) | 2002-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: EISAI R&D MANAGEMENT CO., LTD., TOKYO, JP |