IL138829A0 - Method for increasing bone toughness and stiffness and reducing fractures - Google Patents

Method for increasing bone toughness and stiffness and reducing fractures

Info

Publication number
IL138829A0
IL138829A0 IL13882999A IL13882999A IL138829A0 IL 138829 A0 IL138829 A0 IL 138829A0 IL 13882999 A IL13882999 A IL 13882999A IL 13882999 A IL13882999 A IL 13882999A IL 138829 A0 IL138829 A0 IL 138829A0
Authority
IL
Israel
Prior art keywords
stiffness
increasing bone
reducing fractures
bone toughness
toughness
Prior art date
Application number
IL13882999A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26792729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL138829(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL138829A0 publication Critical patent/IL138829A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Steroid Compounds (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
IL13882999A 1998-08-19 1999-08-19 Method for increasing bone toughness and stiffness and reducing fractures IL138829A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9715198P 1998-08-19 1998-08-19
US9974698P 1998-09-10 1998-09-10
PCT/US1999/018961 WO2000010596A1 (en) 1998-08-19 1999-08-19 Method of increasing bone toughness and stiffness and reducing fractures

Publications (1)

Publication Number Publication Date
IL138829A0 true IL138829A0 (en) 2001-10-31

Family

ID=26792729

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13882999A IL138829A0 (en) 1998-08-19 1999-08-19 Method for increasing bone toughness and stiffness and reducing fractures
IL138829A IL138829A (en) 1998-08-19 2000-10-03 Use of a parathyroid hormone containing the 34-1 amino acid sequence of human parathyroid hormone in the preparation of a drug to increase bone strength and reduce the risk of bone fracture

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL138829A IL138829A (en) 1998-08-19 2000-10-03 Use of a parathyroid hormone containing the 34-1 amino acid sequence of human parathyroid hormone in the preparation of a drug to increase bone strength and reduce the risk of bone fracture

Country Status (33)

Country Link
US (2) US6977077B1 (ja)
EP (3) EP1059933B1 (ja)
JP (5) JP2002523375A (ja)
KR (1) KR100454207B1 (ja)
CN (1) CN1205997C (ja)
AR (1) AR033639A1 (ja)
AT (1) ATE231000T1 (ja)
AU (1) AU746277B2 (ja)
BR (1) BR9909445A (ja)
CA (1) CA2325371C (ja)
CO (1) CO5130020A1 (ja)
CY (2) CY1113343T1 (ja)
CZ (1) CZ301017B6 (ja)
DE (2) DE15152726T1 (ja)
DK (4) DK2266598T3 (ja)
DZ (1) DZ2873A1 (ja)
EA (1) EA003362B1 (ja)
ES (4) ES2621653T3 (ja)
HK (3) HK1030545A1 (ja)
HR (1) HRP20000755A2 (ja)
HU (2) HU230697B1 (ja)
ID (1) ID29039A (ja)
IL (2) IL138829A0 (ja)
MY (1) MY129227A (ja)
NO (2) NO323984B1 (ja)
NZ (1) NZ507056A (ja)
PE (1) PE20001089A1 (ja)
PL (1) PL201688B1 (ja)
PT (4) PT1059933E (ja)
TR (1) TR200003455T2 (ja)
TW (1) TW576747B (ja)
UA (1) UA72205C2 (ja)
WO (1) WO2000010596A1 (ja)

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US6770623B1 (en) * 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
US20040033950A1 (en) * 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
DZ2873A1 (fr) * 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
EP1222465A1 (en) * 1999-09-20 2002-07-17 Eli Lilly And Company Method for monitoring treatment with a parathyroid hormone
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
CA2472472A1 (en) * 2002-01-10 2003-07-24 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
RU2006108557A (ru) * 2003-09-19 2007-09-27 Пфайзер Продактс Инк. (Us) Фармацевтические композиции, включающие в себя сочетания производных 2-алкилиден-19-нор-витамина d и паратиреоидного гормона, и способы (лечения)
US20060052305A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. Method of treating osteoporosis using intranasal parathyroid hormone
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human
JP2007537274A (ja) * 2004-05-10 2007-12-20 ナステック ファーマスーティカル カンパニー インク． 副甲状腺ホルモンの粘膜送達を増強するための組成物及び方法
US20060189533A1 (en) * 2004-05-10 2006-08-24 Nastech Pharmaceutical Company Inc. Stable pharmaceutical dosage forms of teriparatide
BRPI0509788A (pt) 2004-05-13 2007-10-23 Alza Corp aparato e método para liberação transdérmica de agentes de hormÈnio paratireóides
US7648965B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20060069021A1 (en) * 2004-08-13 2006-03-30 Nastech Pharmaceutical Company Inc. Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
WO2006073711A2 (en) * 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
CA2608016A1 (en) * 2005-05-11 2006-11-23 Unigene Laboratories, Inc. Improving bone formation and preservation by surgically inducing an increase in osteoblast activity coupled with the effect of administering pthrp or cgrp
US20070173447A1 (en) * 2005-10-25 2007-07-26 Nastech Pharmaceutical Company Inc. Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent
AU2006315132A1 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US20080051332A1 (en) * 2005-11-18 2008-02-28 Nastech Pharmaceutical Company Inc. Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone
US20080119408A1 (en) * 2006-07-07 2008-05-22 Nastech Pharmaceutical Company Inc. Pth formulations for intranasal delivery
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
JP2010523243A (ja) 2007-04-13 2010-07-15 クロス・バイオサージェリー・アクチェンゲゼルシャフト 高分子組織シーラント
US20110137243A1 (en) * 2007-09-06 2011-06-09 Abbott Cardiovascular Systems Inc. Coating On A Balloon Device
US9457056B2 (en) * 2007-12-04 2016-10-04 Ben-Gurion University Of The Negev Research And Development Authority Peptides comprising alternating hydrophobic and anionic amino acids for treatment of osteoporosis
JP2012512812A (ja) 2007-12-28 2012-06-07 クロス・バイオサージェリー・アクチェンゲゼルシャフト フィブリンフォームに組込まれたｐｄｇｆ融合タンパク質
CN102470164B (zh) 2009-09-09 2014-04-09 旭化成制药株式会社 以每周给药1次每次为100单位～200单位的pth为特征的、含有pth的骨质疏松症治疗/预防剂
EP2509996A1 (en) 2009-12-07 2012-10-17 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US9295663B2 (en) 2010-07-14 2016-03-29 Abbott Cardiovascular Systems Inc. Drug coated balloon with in-situ formed drug containing microspheres
WO2012111852A1 (ja) * 2011-02-17 2012-08-23 帝人ファーマ株式会社 椎体骨折治療剤及びその評価方法
ES2882852T3 (es) 2011-03-16 2021-12-02 Kuros Biosurgery Ag Formulación farmacéutica para la utilización en la fusión espinal
CN108195965B (zh) 2011-06-07 2021-02-23 旭化成制药株式会社 含pth肽冷冻干燥制剂的检査方法及包含该含pth肽冷冻干燥制剂的医药品的制造方法
US9700485B2 (en) 2013-04-24 2017-07-11 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
CA3013443C (en) * 2016-02-01 2021-06-15 Eli Lilly And Company Parathyroid hormone - anti-rankl antibody fusion compounds
JP2020506926A (ja) * 2017-02-01 2020-03-05 ザ・ジョンズ・ホプキンス・ユニバーシティ 副甲状腺ホルモンと変性椎間板疾患の再生
CA3075977A1 (en) * 2017-09-22 2019-03-28 Asahi Kasei Pharma Corporation Teriparatide-containing liquid pharmaceutical composition having excellent stability
CN111447943A (zh) 2018-10-29 2020-07-24 旭化成制药株式会社 以按每周2次的频率给予特立帕肽或其盐为特征的骨质疏松症的预防或治疗方法
WO2021030222A1 (en) 2019-08-09 2021-02-18 Flagship Pioneering Innovations Vi, Llc Modulators of parathyroid hormone receptor (pthr1)
GB2590692A (en) * 2019-12-24 2021-07-07 Corthotec Ltd Composition for improved bone fracture healing

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US4086196A (en) 1975-03-28 1978-04-25 Armour Pharmaceutical Company Parathyroid hormone
IL78342A (en) 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
DE3935738A1 (de) 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5208041A (en) 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
CA2126299C (en) 1994-06-20 2000-12-12 Gordon E. Willick Parathyroid hormone analogues for the treatment of osteoporosis
JPH0873376A (ja) * 1994-09-07 1996-03-19 Asahi Chem Ind Co Ltd 骨粗鬆症治療薬
US5747456A (en) 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
EP0800405A4 (en) * 1994-12-19 1998-11-11 Beth Israel Hospital CONTINUOUS ADMINISTRATION OF LOW DOSES OF HORMONE PARATHYRO DIENNE OR ITS AGONIST
AU703532B2 (en) * 1994-12-22 1999-03-25 Astra Aktiebolag Therapeutic preparation for inhalation containing parathyroid hormone, PTH
JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
CZ298701B6 (cs) 1997-09-09 2007-12-27 F. Hoffman-La Roche Ag Lécivo pro hojení kostí a reparaci zlomenin
MY120063A (en) 1997-12-09 2005-08-30 Lilly Co Eli Stabilized teriparatide solutions
US20040033950A1 (en) * 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
DZ2873A1 (fr) 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
US6907597B1 (en) 2000-10-13 2005-06-14 Ati International Srl Method and apparatus for constructing an executable program in memory
US6967759B2 (en) 2001-12-31 2005-11-22 Texas Instruments Incorporated Pulse width modulation sequence generation
JP5796714B2 (ja) 2012-01-13 2015-10-21 株式会社リコー 定着装置及び画像形成装置
EP2949301B1 (en) 2014-05-27 2018-04-18 The Procter and Gamble Company Absorbent core with curved and straight absorbent material areas

Also Published As

Publication number Publication date
CA2325371C (en) 2004-08-17
ES2549551T3 (es) 2017-11-27
ES2549551T1 (es) 2015-10-29
HU230697B1 (hu) 2017-09-28
PT1059933E (pt) 2003-06-30
PE20001089A1 (es) 2000-11-04
ID29039A (id) 2001-07-26
EP2266598A1 (en) 2010-12-29
DK2266598T3 (en) 2017-05-15
CA2325371A1 (en) 2000-03-02
HUP0101594A3 (en) 2002-01-28
CY1113343T1 (el) 2016-06-22
EP2266598B1 (en) 2017-02-22
CO5130020A1 (es) 2002-02-27
NO20005947L (no) 2000-11-24
CN1205997C (zh) 2005-06-15
DK1769804T3 (da) 2012-10-15
PL201688B1 (pl) 2009-04-30
DZ2873A1 (fr) 2003-12-15
JP2011021035A (ja) 2011-02-03
JP6177718B2 (ja) 2017-08-09
WO2000010596A1 (en) 2000-03-02
EA200001015A1 (ru) 2001-02-26
CZ301017B6 (cs) 2009-10-14
CN1308545A (zh) 2001-08-15
NO20072983L (no) 2000-11-24
KR100454207B1 (ko) 2004-10-26
HK1102496A1 (en) 2007-11-23
UA72205C2 (uk) 2005-02-15
HUP0101594A2 (hu) 2001-11-28
ES2190244T3 (es) 2003-07-16
DE15152726T1 (de) 2015-12-10
JP2015028065A (ja) 2015-02-12
DK2907522T3 (en) 2017-10-23
AU746277B2 (en) 2002-04-18
JP2002523375A (ja) 2002-07-30
AU5575099A (en) 2000-03-14
HRP20000755A2 (en) 2001-02-28
JP2014139220A (ja) 2014-07-31
DE69904918D1 (de) 2003-02-20
DK1059933T3 (da) 2003-04-07
AR033639A1 (es) 2004-01-07
NO20005947D0 (no) 2000-11-24
US7163684B2 (en) 2007-01-16
HU1200430D0 (hu) 2001-11-28
NO323984B1 (no) 2007-07-30
KR20010072763A (ko) 2001-07-31
PT1769804E (pt) 2012-11-13
DE69904918T2 (de) 2003-11-13
PL343595A1 (en) 2001-08-27
HK1212602A1 (zh) 2016-06-17
EA003362B1 (ru) 2003-04-24
PT2266598T (pt) 2017-05-02
EP1059933A1 (en) 2000-12-20
CZ20004134A3 (cs) 2001-08-15
DK2907522T1 (da) 2015-10-19
NZ507056A (en) 2003-10-31
JP2017190332A (ja) 2017-10-19
TR200003455T2 (tr) 2001-06-21
EP2907522B1 (en) 2017-08-02
US6977077B1 (en) 2005-12-20
EP1059933B1 (en) 2003-01-15
BR9909445A (pt) 2000-12-12
PT2907522T (pt) 2017-10-23
ES2393200T3 (es) 2012-12-19
EP2907522A1 (en) 2015-08-19
ATE231000T1 (de) 2003-02-15
HK1030545A1 (en) 2001-05-11
TW576747B (en) 2004-02-21
US20050197294A1 (en) 2005-09-08
CY1119552T1 (el) 2018-03-07
IL138829A (en) 2011-01-31
MY129227A (en) 2007-03-30
ES2621653T3 (es) 2017-07-04

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