IL136278A - Thermodynamically stable form of (r)-3-[[(4-fluorophenyl) sulphonyl]amino]-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban), process for its preparation and pharmaceutical compositions comprising it - Google Patents
Thermodynamically stable form of (r)-3-[[(4-fluorophenyl) sulphonyl]amino]-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban), process for its preparation and pharmaceutical compositions comprising itInfo
- Publication number
- IL136278A IL136278A IL13627898A IL13627898A IL136278A IL 136278 A IL136278 A IL 136278A IL 13627898 A IL13627898 A IL 13627898A IL 13627898 A IL13627898 A IL 13627898A IL 136278 A IL136278 A IL 136278A
- Authority
- IL
- Israel
- Prior art keywords
- ramatroban
- sulphonyl
- carbazole
- fluorophenyl
- tetrahydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19757983A DE19757983A1 (de) | 1997-12-24 | 1997-12-24 | Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban) |
| PCT/JP1998/005844 WO1999033803A1 (en) | 1997-12-24 | 1998-12-24 | Thermodynamically stable form of (r)-3-[ [(4-fluorophenyl) sulphonyl]amino] -1,2,3,4- tetrahydro -9h-carbazole -9-propanoic acid (ramatroban) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL136278A0 IL136278A0 (en) | 2001-05-20 |
| IL136278A true IL136278A (en) | 2005-03-20 |
Family
ID=7853457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13627898A IL136278A (en) | 1997-12-24 | 1998-12-24 | Thermodynamically stable form of (r)-3-[[(4-fluorophenyl) sulphonyl]amino]-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban), process for its preparation and pharmaceutical compositions comprising it |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US6362214B1 (zh) |
| EP (1) | EP1051398B1 (zh) |
| JP (2) | JP3817668B2 (zh) |
| KR (1) | KR100586350B1 (zh) |
| CN (1) | CN1140510C (zh) |
| AR (1) | AR013803A1 (zh) |
| AT (1) | ATE263152T1 (zh) |
| AU (1) | AU744242B2 (zh) |
| BG (1) | BG65024B1 (zh) |
| BR (1) | BR9814496A (zh) |
| CA (1) | CA2313230A1 (zh) |
| CO (1) | CO4970800A1 (zh) |
| DE (2) | DE19757983A1 (zh) |
| DK (1) | DK1051398T3 (zh) |
| ES (1) | ES2218874T3 (zh) |
| GT (1) | GT199800198A (zh) |
| HK (1) | HK1034517A1 (zh) |
| HN (1) | HN1998000186A (zh) |
| HU (1) | HUP0004432A3 (zh) |
| ID (1) | ID25446A (zh) |
| IL (1) | IL136278A (zh) |
| IN (1) | IN192932B (zh) |
| MY (1) | MY116312A (zh) |
| NO (1) | NO316618B1 (zh) |
| NZ (1) | NZ504741A (zh) |
| PE (1) | PE20000115A1 (zh) |
| PL (1) | PL341359A1 (zh) |
| PT (1) | PT1051398E (zh) |
| RU (1) | RU2220137C2 (zh) |
| SI (1) | SI1051398T1 (zh) |
| SK (1) | SK285109B6 (zh) |
| TR (1) | TR200001936T2 (zh) |
| TW (1) | TW552258B (zh) |
| UA (1) | UA66832C2 (zh) |
| UY (2) | UY25324A1 (zh) |
| WO (1) | WO1999033803A1 (zh) |
| ZA (1) | ZA9811817B (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE543501T1 (de) * | 2006-12-20 | 2012-02-15 | Cardoz Ab | Kombination von pemirolast und ramatroban zur verwendung bei der behandlung von entzündlichen erkrankungen |
| AU2007344274A1 (en) * | 2007-01-16 | 2008-07-24 | Cardoz Ab | New combination for use in the treatment of inflammatory disorders |
| WO2009007674A2 (en) * | 2007-07-11 | 2009-01-15 | Cardoz Ab | Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast |
| CN101434571B (zh) * | 2007-11-13 | 2012-05-30 | 杭州容立医药科技有限公司 | 环烷并[1,2-b]吲哚磺酰胺、其异构体或其盐的合成方法 |
| WO2011115069A1 (ja) * | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | 結晶の網羅的探索 |
| CN103054857A (zh) * | 2012-12-30 | 2013-04-24 | 北京阜康仁生物制药科技有限公司 | 一种以雷马曲班为活性成分的固体制剂 |
| US20180021302A1 (en) | 2015-02-13 | 2018-01-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1015711B (zh) * | 1986-02-21 | 1992-03-04 | 拜尔公司 | 制备环烷并[1，2-b]吲哚-磺酰胺类化合物的方法 |
| DE3631824A1 (de) | 1986-02-21 | 1988-03-31 | Bayer Ag | Cycloalkano(1.2-b)indol-sulfonamide |
| DE19506739A1 (de) | 1995-02-27 | 1996-08-29 | Bayer Ag | [3-Amino]-tetrahydrocarbazol-propansäureester |
-
1997
- 1997-12-24 DE DE19757983A patent/DE19757983A1/de not_active Withdrawn
-
1998
- 1998-12-09 HN HN1998000186A patent/HN1998000186A/es unknown
- 1998-12-11 AR ARP980106318A patent/AR013803A1/es unknown
- 1998-12-15 GT GT199800198A patent/GT199800198A/es unknown
- 1998-12-22 PE PE1998001272A patent/PE20000115A1/es not_active Application Discontinuation
- 1998-12-22 MY MYPI98005837A patent/MY116312A/en unknown
- 1998-12-23 ZA ZA9811817A patent/ZA9811817B/xx unknown
- 1998-12-23 TW TW087121479A patent/TW552258B/zh not_active IP Right Cessation
- 1998-12-23 UY UY25324A patent/UY25324A1/es not_active IP Right Cessation
- 1998-12-23 CO CO98076459A patent/CO4970800A1/es unknown
- 1998-12-24 UA UA2000074335A patent/UA66832C2/uk unknown
- 1998-12-24 IN IN43MU2000 patent/IN192932B/en unknown
- 1998-12-24 BR BR9814496-0A patent/BR9814496A/pt not_active Application Discontinuation
- 1998-12-24 NZ NZ504741A patent/NZ504741A/xx unknown
- 1998-12-24 US US09/582,250 patent/US6362214B1/en not_active Expired - Fee Related
- 1998-12-24 WO PCT/JP1998/005844 patent/WO1999033803A1/en not_active Application Discontinuation
- 1998-12-24 SK SK975-2000A patent/SK285109B6/sk unknown
- 1998-12-24 DE DE69822882T patent/DE69822882T2/de not_active Expired - Fee Related
- 1998-12-24 AU AU16874/99A patent/AU744242B2/en not_active Ceased
- 1998-12-24 EP EP98961506A patent/EP1051398B1/en not_active Expired - Lifetime
- 1998-12-24 IL IL13627898A patent/IL136278A/xx not_active IP Right Cessation
- 1998-12-24 TR TR2000/01936T patent/TR200001936T2/xx unknown
- 1998-12-24 KR KR1020007007031A patent/KR100586350B1/ko not_active IP Right Cessation
- 1998-12-24 PT PT98961506T patent/PT1051398E/pt unknown
- 1998-12-24 CN CNB98812405XA patent/CN1140510C/zh not_active Expired - Fee Related
- 1998-12-24 HU HU0004432A patent/HUP0004432A3/hu unknown
- 1998-12-24 PL PL98341359A patent/PL341359A1/xx not_active Application Discontinuation
- 1998-12-24 CA CA002313230A patent/CA2313230A1/en not_active Abandoned
- 1998-12-24 JP JP2000526487A patent/JP3817668B2/ja not_active Expired - Lifetime
- 1998-12-24 DK DK98961506T patent/DK1051398T3/da active
- 1998-12-24 AT AT98961506T patent/ATE263152T1/de not_active IP Right Cessation
- 1998-12-24 RU RU2000119741/04A patent/RU2220137C2/ru not_active IP Right Cessation
- 1998-12-24 ID IDW20001226A patent/ID25446A/id unknown
- 1998-12-24 SI SI9830656T patent/SI1051398T1/xx unknown
- 1998-12-24 ES ES98961506T patent/ES2218874T3/es not_active Expired - Lifetime
-
1999
- 1999-06-18 UY UY25575A patent/UY25575A1/es unknown
-
2000
- 2000-06-21 NO NO20003217A patent/NO316618B1/no unknown
- 2000-06-23 BG BG104554A patent/BG65024B1/bg unknown
-
2001
- 2001-07-27 HK HK01105260A patent/HK1034517A1/xx not_active IP Right Cessation
-
2005
- 2005-11-25 JP JP2005340586A patent/JP4411269B2/ja not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |