IL136278A - Thermodynamically stable form of (r)-3-[[(4-fluorophenyl) sulphonyl]amino]-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban), process for its preparation and pharmaceutical compositions comprising it - Google Patents
Thermodynamically stable form of (r)-3-[[(4-fluorophenyl) sulphonyl]amino]-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban), process for its preparation and pharmaceutical compositions comprising itInfo
- Publication number
- IL136278A IL136278A IL13627898A IL13627898A IL136278A IL 136278 A IL136278 A IL 136278A IL 13627898 A IL13627898 A IL 13627898A IL 13627898 A IL13627898 A IL 13627898A IL 136278 A IL136278 A IL 136278A
- Authority
- IL
- Israel
- Prior art keywords
- ramatroban
- sulphonyl
- carbazole
- fluorophenyl
- tetrahydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19757983A DE19757983A1 (de) | 1997-12-24 | 1997-12-24 | Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban) |
PCT/JP1998/005844 WO1999033803A1 (fr) | 1997-12-24 | 1998-12-24 | Forme thermodynamiquement stable d'un acide (r)-3-[ [(4-fluorophenyl) sulfonyl]amino] -1,2,3,4-tetrahydro -9h-carbazole -9-propionique (ramatrobane) |
Publications (2)
Publication Number | Publication Date |
---|---|
IL136278A0 IL136278A0 (en) | 2001-05-20 |
IL136278A true IL136278A (en) | 2005-03-20 |
Family
ID=7853457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13627898A IL136278A (en) | 1997-12-24 | 1998-12-24 | Thermodynamically stable form of (r)-3-[[(4-fluorophenyl) sulphonyl]amino]-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid (ramatroban), process for its preparation and pharmaceutical compositions comprising it |
Country Status (37)
Country | Link |
---|---|
US (1) | US6362214B1 (fr) |
EP (1) | EP1051398B1 (fr) |
JP (2) | JP3817668B2 (fr) |
KR (1) | KR100586350B1 (fr) |
CN (1) | CN1140510C (fr) |
AR (1) | AR013803A1 (fr) |
AT (1) | ATE263152T1 (fr) |
AU (1) | AU744242B2 (fr) |
BG (1) | BG65024B1 (fr) |
BR (1) | BR9814496A (fr) |
CA (1) | CA2313230A1 (fr) |
CO (1) | CO4970800A1 (fr) |
DE (2) | DE19757983A1 (fr) |
DK (1) | DK1051398T3 (fr) |
ES (1) | ES2218874T3 (fr) |
GT (1) | GT199800198A (fr) |
HK (1) | HK1034517A1 (fr) |
HN (1) | HN1998000186A (fr) |
HU (1) | HUP0004432A3 (fr) |
ID (1) | ID25446A (fr) |
IL (1) | IL136278A (fr) |
IN (1) | IN192932B (fr) |
MY (1) | MY116312A (fr) |
NO (1) | NO316618B1 (fr) |
NZ (1) | NZ504741A (fr) |
PE (1) | PE20000115A1 (fr) |
PL (1) | PL341359A1 (fr) |
PT (1) | PT1051398E (fr) |
RU (1) | RU2220137C2 (fr) |
SI (1) | SI1051398T1 (fr) |
SK (1) | SK285109B6 (fr) |
TR (1) | TR200001936T2 (fr) |
TW (1) | TW552258B (fr) |
UA (1) | UA66832C2 (fr) |
UY (2) | UY25324A1 (fr) |
WO (1) | WO1999033803A1 (fr) |
ZA (1) | ZA9811817B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2395120T3 (es) * | 2006-12-20 | 2013-02-08 | Cardoz Ab | Combinación de pemirolast y ramotrobán para su uso en el tratamiento de transtornos inflamatorios |
WO2008087371A1 (fr) * | 2007-01-16 | 2008-07-24 | Cardoz Ab | Nouvelle combinaison à utiliser dans le traitement des troubles inflammatoires |
WO2009007674A2 (fr) * | 2007-07-11 | 2009-01-15 | Cardoz Ab | Nouvelle association pour une utilisation dans le traitement de troubles inflammatoires |
CN101434571B (zh) * | 2007-11-13 | 2012-05-30 | 杭州容立医药科技有限公司 | 环烷并[1,2-b]吲哚磺酰胺、其异构体或其盐的合成方法 |
WO2011115069A1 (fr) * | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | Recherche exhaustive de cristaux |
CN103054857A (zh) * | 2012-12-30 | 2013-04-24 | 北京阜康仁生物制药科技有限公司 | 一种以雷马曲班为活性成分的固体制剂 |
EP3256121B1 (fr) | 2015-02-13 | 2024-08-07 | INSERM - Institut National de la Santé et de la Recherche Médicale | Antagonistes ptgdr-1 et/ou ptgdr-2 pour la prévention et/ou le traitement du lupus érythémateux systémique |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3631824A1 (de) * | 1986-02-21 | 1988-03-31 | Bayer Ag | Cycloalkano(1.2-b)indol-sulfonamide |
CN1015711B (zh) | 1986-02-21 | 1992-03-04 | 拜尔公司 | 制备环烷并[1,2-b]吲哚-磺酰胺类化合物的方法 |
DE19506739A1 (de) * | 1995-02-27 | 1996-08-29 | Bayer Ag | [3-Amino]-tetrahydrocarbazol-propansäureester |
-
1997
- 1997-12-24 DE DE19757983A patent/DE19757983A1/de not_active Withdrawn
-
1998
- 1998-12-09 HN HN1998000186A patent/HN1998000186A/es unknown
- 1998-12-11 AR ARP980106318A patent/AR013803A1/es unknown
- 1998-12-15 GT GT199800198A patent/GT199800198A/es unknown
- 1998-12-22 MY MYPI98005837A patent/MY116312A/en unknown
- 1998-12-22 PE PE1998001272A patent/PE20000115A1/es not_active Application Discontinuation
- 1998-12-23 CO CO98076459A patent/CO4970800A1/es unknown
- 1998-12-23 ZA ZA9811817A patent/ZA9811817B/xx unknown
- 1998-12-23 UY UY25324A patent/UY25324A1/es not_active IP Right Cessation
- 1998-12-23 TW TW087121479A patent/TW552258B/zh not_active IP Right Cessation
- 1998-12-24 HU HU0004432A patent/HUP0004432A3/hu unknown
- 1998-12-24 PT PT98961506T patent/PT1051398E/pt unknown
- 1998-12-24 TR TR2000/01936T patent/TR200001936T2/xx unknown
- 1998-12-24 EP EP98961506A patent/EP1051398B1/fr not_active Expired - Lifetime
- 1998-12-24 ES ES98961506T patent/ES2218874T3/es not_active Expired - Lifetime
- 1998-12-24 AU AU16874/99A patent/AU744242B2/en not_active Ceased
- 1998-12-24 NZ NZ504741A patent/NZ504741A/xx unknown
- 1998-12-24 JP JP2000526487A patent/JP3817668B2/ja not_active Expired - Lifetime
- 1998-12-24 ID IDW20001226A patent/ID25446A/id unknown
- 1998-12-24 DE DE69822882T patent/DE69822882T2/de not_active Expired - Fee Related
- 1998-12-24 WO PCT/JP1998/005844 patent/WO1999033803A1/fr not_active Application Discontinuation
- 1998-12-24 CN CNB98812405XA patent/CN1140510C/zh not_active Expired - Fee Related
- 1998-12-24 RU RU2000119741/04A patent/RU2220137C2/ru not_active IP Right Cessation
- 1998-12-24 PL PL98341359A patent/PL341359A1/xx not_active Application Discontinuation
- 1998-12-24 UA UA2000074335A patent/UA66832C2/uk unknown
- 1998-12-24 SK SK975-2000A patent/SK285109B6/sk unknown
- 1998-12-24 IL IL13627898A patent/IL136278A/xx not_active IP Right Cessation
- 1998-12-24 BR BR9814496-0A patent/BR9814496A/pt not_active Application Discontinuation
- 1998-12-24 DK DK98961506T patent/DK1051398T3/da active
- 1998-12-24 KR KR1020007007031A patent/KR100586350B1/ko not_active IP Right Cessation
- 1998-12-24 CA CA002313230A patent/CA2313230A1/fr not_active Abandoned
- 1998-12-24 US US09/582,250 patent/US6362214B1/en not_active Expired - Fee Related
- 1998-12-24 AT AT98961506T patent/ATE263152T1/de not_active IP Right Cessation
- 1998-12-24 IN IN43MU2000 patent/IN192932B/en unknown
- 1998-12-24 SI SI9830656T patent/SI1051398T1/xx unknown
-
1999
- 1999-06-18 UY UY25575A patent/UY25575A1/es unknown
-
2000
- 2000-06-21 NO NO20003217A patent/NO316618B1/no unknown
- 2000-06-23 BG BG104554A patent/BG65024B1/bg unknown
-
2001
- 2001-07-27 HK HK01105260A patent/HK1034517A1/xx not_active IP Right Cessation
-
2005
- 2005-11-25 JP JP2005340586A patent/JP4411269B2/ja not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |