IL134081A - History - 6 Aril 1, 2, 4 - Triazolo b] - 3, 4] Pyrido d] -2, 3] Pyridazine, their preparation and pharmaceutical preparations containing them - Google Patents

History - 6 Aril 1, 2, 4 - Triazolo b] - 3, 4] Pyrido d] -2, 3] Pyridazine, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL134081A
IL134081A IL13408198A IL13408198A IL134081A IL 134081 A IL134081 A IL 134081A IL 13408198 A IL13408198 A IL 13408198A IL 13408198 A IL13408198 A IL 13408198A IL 134081 A IL134081 A IL 134081A
Authority
IL
Israel
Prior art keywords
group
pyrido
compound according
pyridazine
triazolo
Prior art date
Application number
IL13408198A
Other languages
English (en)
Hebrew (he)
Other versions
IL134081A0 (en
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of IL134081A0 publication Critical patent/IL134081A0/xx
Publication of IL134081A publication Critical patent/IL134081A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13408198A 1997-07-29 1998-07-13 History - 6 Aril 1, 2, 4 - Triazolo b] - 3, 4] Pyrido d] -2, 3] Pyridazine, their preparation and pharmaceutical preparations containing them IL134081A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009701670A ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.
PCT/EP1998/004340 WO1999006404A1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
IL134081A0 IL134081A0 (en) 2001-04-30
IL134081A true IL134081A (en) 2004-02-08

Family

ID=8300216

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13408198A IL134081A (en) 1997-07-29 1998-07-13 History - 6 Aril 1, 2, 4 - Triazolo b] - 3, 4] Pyrido d] -2, 3] Pyridazine, their preparation and pharmaceutical preparations containing them

Country Status (36)

Country Link
US (2) US6407108B1 (bg)
EP (1) EP1001955B1 (bg)
JP (1) JP4320118B2 (bg)
KR (1) KR20010022353A (bg)
CN (1) CN1135231C (bg)
AR (1) AR015927A1 (bg)
AT (1) ATE207069T1 (bg)
AU (1) AU737709B2 (bg)
BG (1) BG64448B1 (bg)
BR (1) BR9810829B1 (bg)
CA (1) CA2298935A1 (bg)
CO (1) CO4970780A1 (bg)
CZ (1) CZ290208B6 (bg)
DE (1) DE69802100T2 (bg)
DK (1) DK1001955T3 (bg)
EE (1) EE04313B1 (bg)
EG (1) EG24041A (bg)
ES (2) ES2137113B1 (bg)
HK (1) HK1024914A1 (bg)
HU (1) HUP0004708A3 (bg)
ID (1) ID24506A (bg)
IL (1) IL134081A (bg)
MY (1) MY118796A (bg)
NO (1) NO315118B1 (bg)
NZ (1) NZ502356A (bg)
PE (1) PE111099A1 (bg)
PL (1) PL191031B1 (bg)
PT (1) PT1001955E (bg)
RU (1) RU2202552C2 (bg)
SI (1) SI1001955T1 (bg)
SK (1) SK284046B6 (bg)
TR (1) TR200000243T2 (bg)
TW (1) TW542837B (bg)
UA (1) UA60339C2 (bg)
WO (1) WO1999006404A1 (bg)
ZA (1) ZA986248B (bg)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2792938B1 (fr) * 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
AU777012B2 (en) 1999-08-21 2004-09-30 Takeda Gmbh Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist
WO2002080974A1 (fr) * 2001-04-04 2002-10-17 Sankyo Company, Limited Utilisation medicale d'inhibiteur de production de cytokine
MXPA04002562A (es) * 2001-09-19 2004-05-31 Altana Pharma Ag Combinacion de un pde-4 y nsaid.
FR2832711B1 (fr) * 2001-11-26 2004-01-30 Warner Lambert Co Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
US7608716B2 (en) 2002-11-06 2009-10-27 Aska Pharmaceutical Co., Ltd. Pyrazolonaphthyridine derivative
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
RU2246496C1 (ru) * 2003-09-12 2005-02-20 Тец Виктор Вениаминович Вещество с противовирусной и антибактериальной активностью на основе производных 2,8-дитиоксо-1h-пирано[2,3-d, 6,5-d`] дипиримидина и их 10-аза-аналогов
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
CA2610888C (en) * 2005-06-10 2011-02-08 Merck & Co., Inc. Inhibitors of akt activity
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CN101268073B (zh) 2005-09-15 2011-10-19 Aska制药株式会社 杂环化合物、制备方法及其用途
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249435A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 HT receptor mediated neurogenesis
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
TW200817410A (en) 2006-08-07 2008-04-16 Incyte Corp Triazolotriazines as kinase inhibitors
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
ME02372B (me) 2006-11-22 2016-06-20 Incyte Holdings Corp Imidazotriazini i imidazopiramidini kao inhibitori kinaze
US20110112079A1 (en) * 2008-01-09 2011-05-12 Thomas Craig J Phosphodiesterase inhibitors
CN108586463A (zh) 2008-05-21 2018-09-28 因西特控股公司 2-氟-N-甲基-4-[7-(喹啉-6-基甲基)咪唑并[1,2-b][1,2,4]三嗪-2-基]苯甲酰胺的盐及与其相关的制备方法
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
CN102791715B (zh) 2009-12-31 2016-04-27 卡洛斯三世国家癌症研究中心基金会 用作激酶抑制剂的三环化合物
EP2531509B1 (en) 2010-02-03 2016-10-05 Incyte Holdings Corporation Imidazo[1,2-b][1,2,4]triazines as c-met inhibitors
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3122670A1 (de) 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
PH21834A (en) * 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
WO1991012251A1 (en) * 1990-02-19 1991-08-22 Chugai Seiyaku Kabushiki Kaisha Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom
ES2135416T3 (es) * 1991-10-09 1999-11-01 Syntex Inc Compuestos de piridopiridazinonas y piridazintionas con actividad inhibidora de la pde iv.
GB9514465D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds

Also Published As

Publication number Publication date
EP1001955B1 (en) 2001-10-17
CA2298935A1 (en) 1999-02-11
ZA986248B (en) 1999-02-05
EE04313B1 (et) 2004-06-15
SK862000A3 (en) 2000-07-11
NO315118B1 (no) 2003-07-14
NZ502356A (en) 2001-03-30
MY118796A (en) 2005-01-31
UA60339C2 (uk) 2003-10-15
EG24041A (en) 2008-04-03
NO20000394D0 (no) 2000-01-26
US6407108B1 (en) 2002-06-18
HUP0004708A2 (hu) 2001-07-30
DE69802100T2 (de) 2002-03-14
AU8861298A (en) 1999-02-22
CZ290208B6 (cs) 2002-06-12
NO20000394L (no) 2000-03-27
ES2137113B1 (es) 2000-09-16
BG64448B1 (en) 2005-02-28
AR015927A1 (es) 2001-05-30
BG104112A (bg) 2001-01-31
IL134081A0 (en) 2001-04-30
SK284046B6 (sk) 2004-08-03
JP2001512121A (ja) 2001-08-21
KR20010022353A (ko) 2001-03-15
TR200000243T2 (tr) 2000-07-21
PT1001955E (pt) 2002-02-28
EE200000052A (et) 2000-10-16
DK1001955T3 (da) 2001-11-19
CO4970780A1 (es) 2000-11-07
CN1266434A (zh) 2000-09-13
HK1024914A1 (en) 2000-10-27
SI1001955T1 (en) 2002-02-28
BR9810829A (pt) 2000-07-25
EP1001955A1 (en) 2000-05-24
ES2137113A1 (es) 1999-12-01
PL338214A1 (en) 2000-10-09
BR9810829B1 (pt) 2009-08-11
ATE207069T1 (de) 2001-11-15
CZ2000333A3 (cs) 2000-05-17
JP4320118B2 (ja) 2009-08-26
US20020183326A1 (en) 2002-12-05
ES2162466T3 (es) 2001-12-16
CN1135231C (zh) 2004-01-21
RU2202552C2 (ru) 2003-04-20
DE69802100D1 (de) 2001-11-22
PL191031B1 (pl) 2006-03-31
AU737709B2 (en) 2001-08-30
PE111099A1 (es) 1999-11-18
WO1999006404A1 (en) 1999-02-11
HUP0004708A3 (en) 2002-11-28
TW542837B (en) 2003-07-21
ID24506A (id) 2000-07-20

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