IL132273A - -5 [(- 4-methyl-1-piperazinylsulfonyl) -2-benazamidomethmer] -1-methyl-3-profile-H1-ferrous-5-carboxamides, their preparation and process for the preparation of sildenafil from them - Google Patents

-5 [(- 4-methyl-1-piperazinylsulfonyl) -2-benazamidomethmer] -1-methyl-3-profile-H1-ferrous-5-carboxamides, their preparation and process for the preparation of sildenafil from them

Info

Publication number
IL132273A
IL132273A IL13227399A IL13227399A IL132273A IL 132273 A IL132273 A IL 132273A IL 13227399 A IL13227399 A IL 13227399A IL 13227399 A IL13227399 A IL 13227399A IL 132273 A IL132273 A IL 132273A
Authority
IL
Israel
Prior art keywords
compound
tertiary
formula
alkanol
methyl
Prior art date
Application number
IL13227399A
Other languages
English (en)
Hebrew (he)
Other versions
IL132273A0 (en
Original Assignee
Pfizer Ireland Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL132273(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to IL15292399A priority Critical patent/IL152923A/en
Priority to IL15292499A priority patent/IL152924A/en
Priority to IL15292699A priority patent/IL152926A/en
Priority to IL15292799A priority patent/IL152927A/en
Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
Publication of IL132273A0 publication Critical patent/IL132273A0/xx
Priority to IL15292602A priority patent/IL152926A0/xx
Priority to IL15292302A priority patent/IL152923A0/xx
Priority to IL15292702A priority patent/IL152927A0/xx
Priority to IL15292802A priority patent/IL152928A0/xx
Priority to IL15292402A priority patent/IL152924A0/xx
Publication of IL132273A publication Critical patent/IL132273A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13227399A 1998-10-12 1999-10-07 -5 [(- 4-methyl-1-piperazinylsulfonyl) -2-benazamidomethmer] -1-methyl-3-profile-H1-ferrous-5-carboxamides, their preparation and process for the preparation of sildenafil from them IL132273A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IL15292399A IL152923A (en) 1998-10-12 1999-10-07 Acids-5 (–4 methyl –– 1-piperazinylsulfonyl) position-converted benzoic acids in position 2
IL15292499A IL152924A (en) 1998-10-12 1999-10-07 Acids-5 (-4-ethyl-1-piperazinylsulfonyl) position-converted benzoic acids in position 2
IL15292699A IL152926A (en) 1998-10-12 1999-10-07 Process for the preparation of 11 ethyl – 4 [–3 {3 ethyl 66, 77 dihydro - 7 - oxo - 2 - (pyridylmethyl) H2 - pyrazolo [4, 3 - [d pyrimidine - 5 - ile] propoxysulfonyl} - piperazine and intermediates –4 [2 Transformed –– 5 (–4 ethyl –– 1 piperazinylsulfonyl) - benzamide] - 5 - ethyl –– 1 (–2 pyridylmethyl) - H1 - pyrazole - 3 - carboxamide for it
IL15292799A IL152927A (en) 1998-10-12 1999-10-07 1- [3- (7,6-Dihydro-1-methyl-7-oxo-3-profile-1H-pyrazolo [3,4-d] pyrimidin-5-yl) - (Phenyl converted at position 4) Sulfonyl] -4-methyl piperazines
IL15292402A IL152924A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292602A IL152926A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292802A IL152928A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292302A IL152923A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292702A IL152927A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (2)

Publication Number Publication Date
IL132273A0 IL132273A0 (en) 2001-03-19
IL132273A true IL132273A (en) 2004-06-20

Family

ID=10840421

Family Applications (11)

Application Number Title Priority Date Filing Date
IL13227399A IL132273A (en) 1998-10-12 1999-10-07 -5 [(- 4-methyl-1-piperazinylsulfonyl) -2-benazamidomethmer] -1-methyl-3-profile-H1-ferrous-5-carboxamides, their preparation and process for the preparation of sildenafil from them
IL15292499A IL152924A (en) 1998-10-12 1999-10-07 Acids-5 (-4-ethyl-1-piperazinylsulfonyl) position-converted benzoic acids in position 2
IL15292699A IL152926A (en) 1998-10-12 1999-10-07 Process for the preparation of 11 ethyl – 4 [–3 {3 ethyl 66, 77 dihydro - 7 - oxo - 2 - (pyridylmethyl) H2 - pyrazolo [4, 3 - [d pyrimidine - 5 - ile] propoxysulfonyl} - piperazine and intermediates –4 [2 Transformed –– 5 (–4 ethyl –– 1 piperazinylsulfonyl) - benzamide] - 5 - ethyl –– 1 (–2 pyridylmethyl) - H1 - pyrazole - 3 - carboxamide for it
IL15292799A IL152927A (en) 1998-10-12 1999-10-07 1- [3- (7,6-Dihydro-1-methyl-7-oxo-3-profile-1H-pyrazolo [3,4-d] pyrimidin-5-yl) - (Phenyl converted at position 4) Sulfonyl] -4-methyl piperazines
IL152928A IL152928A (en) 1998-10-12 1999-10-07 1 - ethyl - 4 - [3 - [3 - ethyl - 6, 7 - dihydro - 7 oxo - 2 - (2 - pyridylmethyl) - 2H - pyrazolo [4, 3 - d] pyramidine - 5 - ile] (4 - Transformed phenyl (sulfonyl) piperazines
IL15292399A IL152923A (en) 1998-10-12 1999-10-07 Acids-5 (–4 methyl –– 1-piperazinylsulfonyl) position-converted benzoic acids in position 2
IL15292302A IL152923A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292402A IL152924A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292702A IL152927A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292602A IL152926A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292802A IL152928A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof

Family Applications After (10)

Application Number Title Priority Date Filing Date
IL15292499A IL152924A (en) 1998-10-12 1999-10-07 Acids-5 (-4-ethyl-1-piperazinylsulfonyl) position-converted benzoic acids in position 2
IL15292699A IL152926A (en) 1998-10-12 1999-10-07 Process for the preparation of 11 ethyl – 4 [–3 {3 ethyl 66, 77 dihydro - 7 - oxo - 2 - (pyridylmethyl) H2 - pyrazolo [4, 3 - [d pyrimidine - 5 - ile] propoxysulfonyl} - piperazine and intermediates –4 [2 Transformed –– 5 (–4 ethyl –– 1 piperazinylsulfonyl) - benzamide] - 5 - ethyl –– 1 (–2 pyridylmethyl) - H1 - pyrazole - 3 - carboxamide for it
IL15292799A IL152927A (en) 1998-10-12 1999-10-07 1- [3- (7,6-Dihydro-1-methyl-7-oxo-3-profile-1H-pyrazolo [3,4-d] pyrimidin-5-yl) - (Phenyl converted at position 4) Sulfonyl] -4-methyl piperazines
IL152928A IL152928A (en) 1998-10-12 1999-10-07 1 - ethyl - 4 - [3 - [3 - ethyl - 6, 7 - dihydro - 7 oxo - 2 - (2 - pyridylmethyl) - 2H - pyrazolo [4, 3 - d] pyramidine - 5 - ile] (4 - Transformed phenyl (sulfonyl) piperazines
IL15292399A IL152923A (en) 1998-10-12 1999-10-07 Acids-5 (–4 methyl –– 1-piperazinylsulfonyl) position-converted benzoic acids in position 2
IL15292302A IL152923A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292402A IL152924A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292702A IL152927A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292602A IL152926A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292802A IL152928A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof

Country Status (48)

Country Link
US (3) US6207829B1 (cs)
EP (1) EP0994115B1 (cs)
JP (1) JP3721021B2 (cs)
KR (1) KR100380954B1 (cs)
CN (2) CN1473831A (cs)
AP (1) AP1233A (cs)
AR (1) AR019244A1 (cs)
AT (1) ATE290003T1 (cs)
AU (1) AU756463B2 (cs)
BG (1) BG63205B1 (cs)
BR (1) BR9905092A (cs)
CA (1) CA2285733C (cs)
CO (1) CO5150214A1 (cs)
CR (1) CR6118A (cs)
CU (1) CU22928A3 (cs)
CZ (1) CZ296816B6 (cs)
DE (1) DE69923906T2 (cs)
DK (1) DK0994115T3 (cs)
DZ (1) DZ2912A1 (cs)
EA (1) EA003774B1 (cs)
EE (1) EE04192B1 (cs)
EG (1) EG22630A (cs)
ES (1) ES2237049T3 (cs)
GB (1) GB9822238D0 (cs)
GE (1) GEP20022700B (cs)
GT (1) GT199900172A (cs)
HR (1) HRP990318B1 (cs)
HU (1) HU226162B1 (cs)
ID (1) ID23351A (cs)
IL (11) IL132273A (cs)
IS (1) IS1951B (cs)
MA (1) MA25007A1 (cs)
MY (1) MY124620A (cs)
NO (1) NO313700B1 (cs)
OA (1) OA11165A (cs)
PE (1) PE20001086A1 (cs)
PL (1) PL198150B1 (cs)
PT (1) PT994115E (cs)
RS (1) RS49762B (cs)
SG (1) SG118060A1 (cs)
SI (1) SI0994115T1 (cs)
SK (1) SK285215B6 (cs)
TN (1) TNSN99189A1 (cs)
TR (1) TR199902541A2 (cs)
TW (1) TW589314B (cs)
UA (1) UA66787C2 (cs)
UY (1) UY25750A1 (cs)
ZA (1) ZA996412B (cs)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
WO2001098284A1 (en) * 2000-06-22 2001-12-27 Pfizer Limited Process for the preparation of pyrazolopyrimidinones
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
YU51701A (sh) * 2000-07-28 2003-12-31 Pfizer Inc. Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
US7335680B2 (en) * 2001-12-20 2008-02-26 Laboratoires Serono Sa Pyrrolidine derivatives as prostaglandin modulators
US6908923B2 (en) * 2001-12-21 2005-06-21 Cytokinetics, Inc. Compositions and methods for treating heart failure
EP1719772A1 (en) 2002-05-31 2006-11-08 Schering Corporation Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
EP1605752B1 (en) * 2003-03-27 2011-09-14 Cytokinetics, Inc. Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
WO2007141805A2 (en) * 2006-06-05 2007-12-13 Matrix Laboratories Limited Novel process for the preparation of sildenafil citrate
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

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US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
BR9810233A (pt) * 1997-04-25 2000-10-17 Pfizer Pirozolpirimidinonas que inibem fosfodiesterase da guanosina 3`, 5`- monosfofato cìclico do tipo 5 (cgmp pde5) para o tratamento da disfunção sexual.

Also Published As

Publication number Publication date
IL152923A (en) 2004-02-08
SK285215B6 (sk) 2006-09-07
EP0994115A3 (en) 2000-05-24
EG22630A (en) 2003-05-31
IL152928A (en) 2007-07-04
PL198150B1 (pl) 2008-05-30
IL152926A (en) 2004-02-19
CN1207295C (zh) 2005-06-22
CZ353299A3 (cs) 2000-05-17
BR9905092A (pt) 2000-08-08
DE69923906D1 (de) 2005-04-07
TW589314B (en) 2004-06-01
BG63205B1 (bg) 2001-06-29
SI0994115T1 (cs) 2005-08-31
GT199900172A (es) 2001-03-28
EP0994115B1 (en) 2005-03-02
CA2285733C (en) 2004-08-24
IS5209A (is) 2000-04-13
IL152927A0 (en) 2003-06-24
JP3721021B2 (ja) 2005-11-30
ATE290003T1 (de) 2005-03-15
HUP9903469A3 (en) 2000-10-30
RS49762B (sr) 2008-04-04
IL152927A (en) 2004-06-01
CU22928A3 (es) 2004-02-20
GEP20022700B (en) 2002-05-27
NO313700B1 (no) 2002-11-18
AP1233A (en) 2003-12-18
US20030069422A1 (en) 2003-04-10
CR6118A (es) 2005-09-16
EA003774B1 (ru) 2003-08-28
PE20001086A1 (es) 2000-10-18
AU5358199A (en) 2000-04-13
JP2000119273A (ja) 2000-04-25
UY25750A1 (es) 2001-08-27
NO994943D0 (no) 1999-10-11
IL152924A (en) 2004-02-19
AU756463B2 (en) 2003-01-16
DZ2912A1 (fr) 2004-03-01
AP9901672A0 (en) 1999-12-31
US6207829B1 (en) 2001-03-27
ID23351A (id) 2000-04-13
EP0994115A2 (en) 2000-04-19
GB9822238D0 (en) 1998-12-09
NO994943L (no) 2000-04-13
SK138599A3 (en) 2000-05-16
HK1027559A1 (en) 2001-01-19
CZ296816B6 (cs) 2006-06-14
CN1473831A (zh) 2004-02-11
CA2285733A1 (en) 2000-04-12
US20010009962A1 (en) 2001-07-26
ES2237049T3 (es) 2005-07-16
DK0994115T3 (da) 2005-06-20
IL152923A0 (en) 2003-06-24
EA199900822A2 (ru) 2000-04-24
HRP990318A2 (en) 2000-06-30
KR20000028987A (ko) 2000-05-25
UA66787C2 (en) 2004-06-15
IL132273A0 (en) 2001-03-19
YU48999A (sh) 2002-06-19
HU9903469D0 (en) 1999-12-28
EA199900822A3 (ru) 2000-08-28
CN1255497A (zh) 2000-06-07
MA25007A1 (fr) 2000-07-01
HUP9903469A2 (hu) 2000-08-28
PL335959A1 (en) 2000-04-25
TR199902541A2 (xx) 2000-07-21
BG103794A (en) 2000-09-29
IL152926A0 (en) 2003-06-24
EE04192B1 (et) 2003-12-15
IS1951B (is) 2004-10-13
MY124620A (en) 2006-06-30
IL152928A0 (en) 2003-06-24
EE9900507A (et) 2000-06-15
IL152924A0 (en) 2003-06-24
ZA996412B (en) 2001-04-11
SG118060A1 (en) 2006-01-27
KR100380954B1 (ko) 2003-04-21
DE69923906T2 (de) 2006-04-06
HU226162B1 (en) 2008-05-28
HRP990318B1 (en) 2004-06-30
TNSN99189A1 (fr) 2005-11-10
AR019244A1 (es) 2001-12-26
OA11165A (en) 2003-04-22
CO5150214A1 (es) 2002-04-29
PT994115E (pt) 2005-06-30

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