IL128631A - Derivatives of acetylaminoalkenylene-amide as 1 NK and 2 NK antagonists - Google Patents
Derivatives of acetylaminoalkenylene-amide as 1 NK and 2 NK antagonistsInfo
- Publication number
- IL128631A IL128631A IL12863197A IL12863197A IL128631A IL 128631 A IL128631 A IL 128631A IL 12863197 A IL12863197 A IL 12863197A IL 12863197 A IL12863197 A IL 12863197A IL 128631 A IL128631 A IL 128631A
- Authority
- IL
- Israel
- Prior art keywords
- phenyl
- methyl
- hydrogen
- lower alkyl
- indol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH206196 | 1996-08-22 | ||
PCT/EP1997/004436 WO1998007694A1 (fr) | 1996-08-22 | 1997-08-13 | Derives d'acylaminoalkenylene comme antagonistes de nk1 et nk2 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL128631A0 IL128631A0 (en) | 2000-01-31 |
IL128631A true IL128631A (en) | 2002-09-12 |
Family
ID=4225003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12863197A IL128631A (en) | 1996-08-22 | 1997-08-13 | Derivatives of acetylaminoalkenylene-amide as 1 NK and 2 NK antagonists |
Country Status (32)
Country | Link |
---|---|
US (1) | US6319917B1 (fr) |
EP (1) | EP0923550B1 (fr) |
JP (1) | JP3654908B2 (fr) |
KR (1) | KR100467402B1 (fr) |
CN (1) | CN1119328C (fr) |
AR (1) | AR009266A1 (fr) |
AT (1) | ATE224875T1 (fr) |
AU (1) | AU721850B2 (fr) |
BR (1) | BR9711350A (fr) |
CA (1) | CA2264065C (fr) |
CO (1) | CO4900047A1 (fr) |
CZ (1) | CZ294233B6 (fr) |
DE (1) | DE69715886T2 (fr) |
DK (1) | DK0923550T3 (fr) |
ES (1) | ES2184083T3 (fr) |
HK (1) | HK1021372A1 (fr) |
HU (1) | HU226395B1 (fr) |
ID (1) | ID18059A (fr) |
IL (1) | IL128631A (fr) |
MY (1) | MY132550A (fr) |
NO (1) | NO312292B1 (fr) |
NZ (1) | NZ334736A (fr) |
PE (1) | PE107498A1 (fr) |
PL (1) | PL193731B1 (fr) |
PT (1) | PT923550E (fr) |
RU (1) | RU2185375C2 (fr) |
SI (1) | SI0923550T1 (fr) |
SK (1) | SK283991B6 (fr) |
TR (1) | TR199900363T2 (fr) |
TW (1) | TW438777B (fr) |
WO (1) | WO1998007694A1 (fr) |
ZA (1) | ZA977493B (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6281300B1 (en) * | 1998-03-20 | 2001-08-28 | Exxon Chemical Patents, Inc. | Continuous slurry polymerization volatile removal |
GB0010958D0 (en) * | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
GB0203061D0 (en) | 2002-02-08 | 2002-03-27 | Novartis Ag | Organic compounds |
GB2394417A (en) * | 2002-10-24 | 2004-04-28 | Novartis Ag | Solid dispersion comprising a piperidine substance P antagonist and a carrier |
GB0224788D0 (en) * | 2002-10-24 | 2002-12-04 | Novartis Ag | Organic compounds |
US7776851B2 (en) | 2003-10-27 | 2010-08-17 | Novartis Ag | Use of neurokinin antagonists in the treatment of urinary incontinence |
CA2547651C (fr) * | 2003-12-01 | 2015-06-23 | Cambridge University Technical Services Limited | Agents anti-inflammatoires |
GB0402679D0 (en) * | 2004-02-06 | 2004-03-10 | Novartis Ag | Organic compounds |
JO2630B1 (en) * | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
GB0607532D0 (en) * | 2006-04-13 | 2006-05-24 | Novartis Ag | Organic compounds |
EP1938804A1 (fr) * | 2006-12-22 | 2008-07-02 | Novartis AG | Préparation pharmaceutique comprenant un antagoniste de neurokinine |
BRPI0807972A2 (pt) | 2007-01-24 | 2014-06-10 | Glaxo Group Ltd | Composições farmacêuticas compreendendo 3,5-diamino-6-(2,3-diclofenil)-l,2,4-triazina ou r(-)-2,4-diamino-5-(2,3-diclorofenil)-6-fluorometilpirim idina e uma nk1 |
UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
US20120077803A1 (en) * | 2009-02-24 | 2012-03-29 | Novartis Ag | Uses Of NK Receptor Antagonists |
RU2697414C1 (ru) * | 2018-05-11 | 2019-08-14 | Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" | Новый антагонист тахикининовых рецепторов и его применение |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993001169A2 (fr) | 1991-07-05 | 1993-01-21 | Merck Sharp & Dohme Limited | Composes aromatiques, compositions pharmaceutiques les contenant et leur utilisation therapeutique |
MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
US5217996A (en) | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
EP0716077A1 (fr) * | 1994-12-08 | 1996-06-12 | Ciba-Geigy Ag | Amides d'acides oméga-amino alcanoiques et diamides alcanoiques ayant un substituant aromatique et leur application en tant qu'inhibiteurs de leur rénine |
EA002348B1 (ru) | 1995-02-22 | 2002-04-25 | Новартис Аг | Соединения 1-арил-2-ациламиноэтана и их применение в качестве антагонистов нейрокинина, в частности нейрокинина 1 |
-
1997
- 1997-08-08 MY MYPI97003625A patent/MY132550A/en unknown
- 1997-08-13 AU AU42993/97A patent/AU721850B2/en not_active Ceased
- 1997-08-13 WO PCT/EP1997/004436 patent/WO1998007694A1/fr active IP Right Grant
- 1997-08-13 PT PT97918984T patent/PT923550E/pt unknown
- 1997-08-13 NZ NZ334736A patent/NZ334736A/xx not_active IP Right Cessation
- 1997-08-13 CZ CZ1999581A patent/CZ294233B6/cs not_active IP Right Cessation
- 1997-08-13 EP EP97918984A patent/EP0923550B1/fr not_active Expired - Lifetime
- 1997-08-13 SI SI9730413T patent/SI0923550T1/xx unknown
- 1997-08-13 DK DK97918984T patent/DK0923550T3/da active
- 1997-08-13 AT AT97918984T patent/ATE224875T1/de active
- 1997-08-13 IL IL12863197A patent/IL128631A/en not_active IP Right Cessation
- 1997-08-13 SK SK221-99A patent/SK283991B6/sk not_active IP Right Cessation
- 1997-08-13 RU RU99106157/04A patent/RU2185375C2/ru not_active IP Right Cessation
- 1997-08-13 CA CA002264065A patent/CA2264065C/fr not_active Expired - Fee Related
- 1997-08-13 HU HU0001165A patent/HU226395B1/hu not_active IP Right Cessation
- 1997-08-13 DE DE69715886T patent/DE69715886T2/de not_active Expired - Lifetime
- 1997-08-13 KR KR10-1999-7001487A patent/KR100467402B1/ko not_active IP Right Cessation
- 1997-08-13 TR TR1999/00363T patent/TR199900363T2/xx unknown
- 1997-08-13 CN CN97198633A patent/CN1119328C/zh not_active Expired - Fee Related
- 1997-08-13 ES ES97918984T patent/ES2184083T3/es not_active Expired - Lifetime
- 1997-08-13 BR BR9711350A patent/BR9711350A/pt not_active IP Right Cessation
- 1997-08-13 JP JP51037198A patent/JP3654908B2/ja not_active Expired - Lifetime
- 1997-08-19 AR ARP970103747A patent/AR009266A1/es active IP Right Grant
- 1997-08-20 ID IDP972913A patent/ID18059A/id unknown
- 1997-08-20 PE PE1997000741A patent/PE107498A1/es not_active Application Discontinuation
- 1997-08-21 ZA ZA977493A patent/ZA977493B/xx unknown
- 1997-08-21 CO CO97048265A patent/CO4900047A1/es unknown
- 1997-08-22 TW TW086111854A patent/TW438777B/zh not_active IP Right Cessation
-
1999
- 1999-02-19 PL PL97331740A patent/PL193731B1/pl not_active IP Right Cessation
- 1999-02-19 NO NO19990786A patent/NO312292B1/no not_active IP Right Cessation
- 1999-12-21 HK HK99106019A patent/HK1021372A1/xx not_active IP Right Cessation
-
2000
- 2000-09-05 US US09/655,170 patent/US6319917B1/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |