HK1021372A1 - Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists - Google Patents

Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists

Info

Publication number
HK1021372A1
HK1021372A1 HK99106019A HK99106019A HK1021372A1 HK 1021372 A1 HK1021372 A1 HK 1021372A1 HK 99106019 A HK99106019 A HK 99106019A HK 99106019 A HK99106019 A HK 99106019A HK 1021372 A1 HK1021372 A1 HK 1021372A1
Authority
HK
Hong Kong
Prior art keywords
acylaminoalkenylene
antagonists
amide derivatives
amide
derivatives
Prior art date
Application number
HK99106019A
Other languages
English (en)
Inventor
Marc Gerspacher
Sprecher Andreas Von
Robert Mah
Silvio Roggo
Stefan Stutz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1021372A1 publication Critical patent/HK1021372A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK99106019A 1996-08-22 1999-12-21 Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists HK1021372A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH206196 1996-08-22
PCT/EP1997/004436 WO1998007694A1 (fr) 1996-08-22 1997-08-13 Derives d'acylaminoalkenylene comme antagonistes de nk1 et nk2

Publications (1)

Publication Number Publication Date
HK1021372A1 true HK1021372A1 (en) 2000-06-09

Family

ID=4225003

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99106019A HK1021372A1 (en) 1996-08-22 1999-12-21 Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists

Country Status (32)

Country Link
US (1) US6319917B1 (fr)
EP (1) EP0923550B1 (fr)
JP (1) JP3654908B2 (fr)
KR (1) KR100467402B1 (fr)
CN (1) CN1119328C (fr)
AR (1) AR009266A1 (fr)
AT (1) ATE224875T1 (fr)
AU (1) AU721850B2 (fr)
BR (1) BR9711350A (fr)
CA (1) CA2264065C (fr)
CO (1) CO4900047A1 (fr)
CZ (1) CZ294233B6 (fr)
DE (1) DE69715886T2 (fr)
DK (1) DK0923550T3 (fr)
ES (1) ES2184083T3 (fr)
HK (1) HK1021372A1 (fr)
HU (1) HU226395B1 (fr)
ID (1) ID18059A (fr)
IL (1) IL128631A (fr)
MY (1) MY132550A (fr)
NO (1) NO312292B1 (fr)
NZ (1) NZ334736A (fr)
PE (1) PE107498A1 (fr)
PL (1) PL193731B1 (fr)
PT (1) PT923550E (fr)
RU (1) RU2185375C2 (fr)
SI (1) SI0923550T1 (fr)
SK (1) SK283991B6 (fr)
TR (1) TR199900363T2 (fr)
TW (1) TW438777B (fr)
WO (1) WO1998007694A1 (fr)
ZA (1) ZA977493B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281300B1 (en) * 1998-03-20 2001-08-28 Exxon Chemical Patents, Inc. Continuous slurry polymerization volatile removal
GB0010958D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
GB0203061D0 (en) 2002-02-08 2002-03-27 Novartis Ag Organic compounds
GB0224788D0 (en) * 2002-10-24 2002-12-04 Novartis Ag Organic compounds
GB2394417A (en) * 2002-10-24 2004-04-28 Novartis Ag Solid dispersion comprising a piperidine substance P antagonist and a carrier
AU2004283038B9 (en) * 2003-10-27 2008-04-24 Novartis Ag Use of neurokinin antagonists in the treatment of urinary incontinence
SI1691814T1 (sl) * 2003-12-01 2012-11-30 Cambridge Entpr Ltd Protivnetna zdravila
GB0402679D0 (en) * 2004-02-06 2004-03-10 Novartis Ag Organic compounds
GB0607532D0 (en) * 2006-04-13 2006-05-24 Novartis Ag Organic compounds
JO2630B1 (en) * 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
EP1938804A1 (fr) * 2006-12-22 2008-07-02 Novartis AG Préparation pharmaceutique comprenant un antagoniste de neurokinine
US8093268B2 (en) 2007-01-24 2012-01-10 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-)
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
AU2010217615C1 (en) * 2009-02-24 2013-05-23 Novartis Ag Uses of NK receptor antagonists
RU2697414C1 (ru) * 2018-05-11 2019-08-14 Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" Новый антагонист тахикининовых рецепторов и его применение

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472978A (en) 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
US5217996A (en) 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
EP0716077A1 (fr) * 1994-12-08 1996-06-12 Ciba-Geigy Ag Amides d'acides oméga-amino alcanoiques et diamides alcanoiques ayant un substituant aromatique et leur application en tant qu'inhibiteurs de leur rénine
CA2213080C (fr) 1995-02-22 2007-11-13 Novartis Ag Composes 1-aryl-2-acylamino-ethane et leur utilisation en tant qu'antagonistes des neurokinines et notamment des neurokinines 1

Also Published As

Publication number Publication date
ID18059A (id) 1998-02-26
CN1119328C (zh) 2003-08-27
RU2185375C2 (ru) 2002-07-20
TR199900363T2 (xx) 1999-04-21
AR009266A1 (es) 2000-04-12
EP0923550B1 (fr) 2002-09-25
EP0923550A1 (fr) 1999-06-23
DK0923550T3 (da) 2003-01-06
US6319917B1 (en) 2001-11-20
NO312292B1 (no) 2002-04-22
JP3654908B2 (ja) 2005-06-02
ATE224875T1 (de) 2002-10-15
IL128631A (en) 2002-09-12
ES2184083T3 (es) 2003-04-01
CN1233238A (zh) 1999-10-27
NO990786D0 (no) 1999-02-19
WO1998007694A1 (fr) 1998-02-26
PL331740A1 (en) 1999-08-02
DE69715886D1 (de) 2002-10-31
SI0923550T1 (en) 2003-02-28
CA2264065C (fr) 2008-02-05
HUP0001165A2 (hu) 2000-11-28
PL193731B1 (pl) 2007-03-30
NZ334736A (en) 2000-09-29
ZA977493B (en) 1998-08-03
KR100467402B1 (ko) 2005-01-24
HU226395B1 (en) 2008-11-28
SK283991B6 (sk) 2004-07-07
KR20000068325A (ko) 2000-11-25
BR9711350A (pt) 1999-08-17
AU4299397A (en) 1998-03-06
CZ294233B6 (cs) 2004-11-10
CZ58199A3 (cs) 1999-06-16
CA2264065A1 (fr) 1998-02-26
IL128631A0 (en) 2000-01-31
PT923550E (pt) 2003-01-31
TW438777B (en) 2001-06-07
DE69715886T2 (de) 2003-05-15
HUP0001165A3 (en) 2002-02-28
CO4900047A1 (es) 2000-03-27
JP2001503387A (ja) 2001-03-13
MY132550A (en) 2007-10-31
PE107498A1 (es) 1999-01-28
AU721850B2 (en) 2000-07-13
SK22199A3 (en) 2000-02-14
NO990786L (no) 1999-03-25

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120813