EP0957908A4 - Antagonistes de recepteurs du fibrinogene - Google Patents

Antagonistes de recepteurs du fibrinogene

Info

Publication number
EP0957908A4
EP0957908A4 EP97952350A EP97952350A EP0957908A4 EP 0957908 A4 EP0957908 A4 EP 0957908A4 EP 97952350 A EP97952350 A EP 97952350A EP 97952350 A EP97952350 A EP 97952350A EP 0957908 A4 EP0957908 A4 EP 0957908A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonists
fibrinogen receptor
fibrinogen
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97952350A
Other languages
German (de)
English (en)
Other versions
EP0957908A1 (fr
Inventor
Melissa S Egbertson
Laura M Vassallo
George D Hartman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9702834.4A external-priority patent/GB9702834D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0957908A1 publication Critical patent/EP0957908A1/fr
Publication of EP0957908A4 publication Critical patent/EP0957908A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
EP97952350A 1996-12-13 1997-12-09 Antagonistes de recepteurs du fibrinogene Withdrawn EP0957908A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3288896P 1996-12-13 1996-12-13
US32888P 1996-12-13
GB9702834 1997-02-12
GBGB9702834.4A GB9702834D0 (en) 1997-02-12 1997-02-12 Fibrinogen receptor antagonists
PCT/US1997/022622 WO1998025601A1 (fr) 1996-12-13 1997-12-09 Antagonistes de recepteurs du fibrinogene

Publications (2)

Publication Number Publication Date
EP0957908A1 EP0957908A1 (fr) 1999-11-24
EP0957908A4 true EP0957908A4 (fr) 2003-03-12

Family

ID=26310974

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97952350A Withdrawn EP0957908A4 (fr) 1996-12-13 1997-12-09 Antagonistes de recepteurs du fibrinogene

Country Status (5)

Country Link
EP (1) EP0957908A4 (fr)
JP (1) JP2001506633A (fr)
AU (1) AU719495B2 (fr)
CA (1) CA2274029A1 (fr)
WO (1) WO1998025601A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
WO1994012181A1 (fr) * 1992-12-01 1994-06-09 Merck & Co., Inc. Antagonistes des recepteurs du fibrinogene
US5563158A (en) * 1993-12-28 1996-10-08 The Dupont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9825601A1 *

Also Published As

Publication number Publication date
AU5598198A (en) 1998-07-03
EP0957908A1 (fr) 1999-11-24
WO1998025601A1 (fr) 1998-06-18
JP2001506633A (ja) 2001-05-22
CA2274029A1 (fr) 1998-06-18
AU719495B2 (en) 2000-05-11

Similar Documents

Publication Publication Date Title
EP0912175A4 (fr) Antagonistes du recepteur de fibrinogene
EP0885205A4 (fr) Antagonistes des recepteurs de fibrinogenes
EP0810994A4 (fr) Antagonistes des recepteurs de fibrinogene
HU9603525D0 (en) Vironectin receptor antagonists
GB9405317D0 (en) Fibrinogen receptor antagonists
EP0866705A4 (fr) Antagonistes du recepteur de fibrinogene
CY2576B1 (en) Vitronectin receptor antagonists
EP0885213A4 (fr) Antagonistes du recepteur du fibrinogene
GB9625843D0 (en) Phenyl spiroethercycloalkyl tachykinn receptor antagonists
EP0796098A4 (fr) Antagonistes des recepteurs du fibrinogene
EP0880511A4 (fr) Antagonistes du recepteur integrine
IL135797A0 (en) Thrombin receptor antagonists
EP0801650A4 (fr) Antagonistes des recepteurs du fibrinogene
HU9502028D0 (en) Fibrinogen receptor antagonists
EP0794779A4 (fr) Antagonistes des recepteurs du fibrinogene
GB9320799D0 (en) Fibrinogen receptor antagonists
GB9515852D0 (en) Fibrinogen receptor antagonists
EP0912182A4 (fr) Promedicaments antagonistes du recepteur de fibrinogene
GB9600344D0 (en) Benzimidzolyl neuropeptide y receptor antagonists
HRP960237A2 (en) Improved isoxazoline fibrinogen receptor antagonists
EP0800395A4 (fr) Antagonistes des recepteurs du fibrinogene
EP0781133A4 (fr) Antagonistes du recepteur de fibrinogene
GB9516643D0 (en) Fibrinogen receptor antagonists
EP0957908A4 (fr) Antagonistes de recepteurs du fibrinogene
GB9708766D0 (en) Fibrinogen receptor antagonist

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990713

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20030127

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 45/06 B

Ipc: 7C 07D 333/34 B

Ipc: 7C 07C 311/19 B

Ipc: 7C 07C 311/14 B

Ipc: 7C 07C 311/27 A

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20030415