AU719495B2 - Fibrinogen receptor antagonists - Google Patents

Fibrinogen receptor antagonists Download PDF

Info

Publication number
AU719495B2
AU719495B2 AU55981/98A AU5598198A AU719495B2 AU 719495 B2 AU719495 B2 AU 719495B2 AU 55981/98 A AU55981/98 A AU 55981/98A AU 5598198 A AU5598198 A AU 5598198A AU 719495 B2 AU719495 B2 AU 719495B2
Authority
AU
Australia
Prior art keywords
alkyl
aryl
compound
combination
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU55981/98A
Other languages
English (en)
Other versions
AU5598198A (en
Inventor
Melissa S. Egbertson
George D. Hartman
Laura M Vassallo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9702834.4A external-priority patent/GB9702834D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU5598198A publication Critical patent/AU5598198A/en
Application granted granted Critical
Publication of AU719495B2 publication Critical patent/AU719495B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU55981/98A 1996-12-13 1997-12-09 Fibrinogen receptor antagonists Ceased AU719495B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3288896P 1996-12-13 1996-12-13
US60/032888 1996-12-13
GB9702834 1997-02-12
GBGB9702834.4A GB9702834D0 (en) 1997-02-12 1997-02-12 Fibrinogen receptor antagonists
PCT/US1997/022622 WO1998025601A1 (fr) 1996-12-13 1997-12-09 Antagonistes de recepteurs du fibrinogene

Publications (2)

Publication Number Publication Date
AU5598198A AU5598198A (en) 1998-07-03
AU719495B2 true AU719495B2 (en) 2000-05-11

Family

ID=26310974

Family Applications (1)

Application Number Title Priority Date Filing Date
AU55981/98A Ceased AU719495B2 (en) 1996-12-13 1997-12-09 Fibrinogen receptor antagonists

Country Status (5)

Country Link
EP (1) EP0957908A4 (fr)
JP (1) JP2001506633A (fr)
AU (1) AU719495B2 (fr)
CA (1) CA2274029A1 (fr)
WO (1) WO1998025601A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
CA2150550A1 (fr) * 1992-12-01 1994-06-09 Melissa S. Egbertson Antagonistes du recepteur du fibrinogene
US5563158A (en) * 1993-12-28 1996-10-08 The Dupont Merck Pharmaceutical Company Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists

Also Published As

Publication number Publication date
WO1998025601A1 (fr) 1998-06-18
EP0957908A1 (fr) 1999-11-24
JP2001506633A (ja) 2001-05-22
AU5598198A (en) 1998-07-03
CA2274029A1 (fr) 1998-06-18
EP0957908A4 (fr) 2003-03-12

Similar Documents

Publication Publication Date Title
AU719102B2 (en) Fibrinogen receptor antagonist prodrugs
EP0810994A1 (fr) Antagonistes des recepteurs de fibrinogene
EP0698023B1 (fr) Antagonistes du recepteur de fibrinogene
EP0714295B1 (fr) Antagonistes du recepteur du fibrinogene
WO1994009029A1 (fr) Antagonistes des recepteurs de fibrinogene
US5358956A (en) Fibrinogen receptor antagonists
AU709631B2 (en) Fibrinogen receptor antagonist prodrugs
AU747293B2 (en) Fibrinogen receptor antagonist prodrugs
AU719495B2 (en) Fibrinogen receptor antagonists
US5945545A (en) Fibrinogen receptor antagonists
US6117842A (en) Fibrinogen receptor antagonists
AU742197B2 (en) Fibrinogen receptor antagonists
AU689961B2 (en) Fibrinogen receptor antagonists
US5981584A (en) Fibrinogen receptor antagonist prodrugs
US5990107A (en) Fibrinogen receptor antagonist prodrugs
AU702025B2 (en) Fibrinogen receptor antagonist
US5789421A (en) Fibrinogen receptor antagonist
GB2292558A (en) Fibrinogen receptor antagonists

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired