EP0880511A4 - Antagonistes du recepteur integrine - Google Patents
Antagonistes du recepteur integrineInfo
- Publication number
- EP0880511A4 EP0880511A4 EP97902931A EP97902931A EP0880511A4 EP 0880511 A4 EP0880511 A4 EP 0880511A4 EP 97902931 A EP97902931 A EP 97902931A EP 97902931 A EP97902931 A EP 97902931A EP 0880511 A4 EP0880511 A4 EP 0880511A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- receptor antagonists
- integrin receptor
- integrin
- antagonists
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US996596P | 1996-01-16 | 1996-01-16 | |
US9965P | 1996-01-16 | ||
GBGB9603373.3A GB9603373D0 (en) | 1996-02-16 | 1996-02-16 | Integrin receptor antagonists |
GB9603373 | 1996-02-16 | ||
PCT/US1997/000572 WO1997026250A1 (fr) | 1996-01-16 | 1997-01-13 | Antagonistes du recepteur integrine |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0880511A1 EP0880511A1 (fr) | 1998-12-02 |
EP0880511A4 true EP0880511A4 (fr) | 1999-06-16 |
Family
ID=26308745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97902931A Withdrawn EP0880511A4 (fr) | 1996-01-16 | 1997-01-13 | Antagonistes du recepteur integrine |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0880511A4 (fr) |
JP (1) | JP2000516197A (fr) |
AU (1) | AU713676B2 (fr) |
CA (1) | CA2242877A1 (fr) |
WO (1) | WO1997026250A1 (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5981546A (en) * | 1996-08-29 | 1999-11-09 | Merck & Co., Inc. | Integrin antagonists |
US6211184B1 (en) | 1996-08-29 | 2001-04-03 | Merck & Co., Inc. | Integrin antagonists |
US5952341A (en) * | 1996-10-30 | 1999-09-14 | Merck & Co., Inc. | Integrin antagonists |
US5919792A (en) * | 1996-10-30 | 1999-07-06 | Merck & Co., Inc. | Integrin antagonists |
US6017925A (en) * | 1997-01-17 | 2000-01-25 | Merck & Co., Inc. | Integrin antagonists |
GB2327609A (en) * | 1997-07-23 | 1999-02-03 | Merck & Co Inc | A method for eliciting an avß5 or dual avß3/avß5 antagonizing effect |
US6294549B1 (en) | 1997-07-23 | 2001-09-25 | Merck & Co., Inc. | Method for eliciting an αvβ5 or dual αvβ3/αvβ5 antagonizing effect |
KR20010033248A (ko) * | 1997-12-17 | 2001-04-25 | 폴락 돈나 엘. | 인테그린 수용체 길항제 |
US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
US6001855A (en) * | 1998-01-02 | 1999-12-14 | Hoffman-La Roche Inc. | Thiazole derivatives |
CA2333927A1 (fr) | 1998-04-01 | 1999-10-07 | Dupont Pharmaceuticals Company | Antagonistes de l'integrine |
ES2381591T3 (es) | 1998-04-09 | 2012-05-29 | Meiji Seika Pharma Co., Ltd. | Derivados de aminopiperidina como antagonistas de integrina alfa v beta 3 |
DE19831710A1 (de) * | 1998-07-15 | 2000-01-20 | Merck Patent Gmbh | Diacylhydrazinderivate |
EP1153014B1 (fr) | 1999-02-20 | 2004-09-22 | MERCK PATENT GmbH | Derives de la beta-alanine |
AU5011300A (en) | 1999-05-14 | 2000-12-05 | Combichem, Inc. | Cyclic amine derivatives and their uses |
WO2000072801A2 (fr) | 1999-06-02 | 2000-12-07 | Merck & Co., Inc. | Antagonistes du recepteur de l'alpha v integrine |
EP1209152A4 (fr) | 1999-08-05 | 2003-03-12 | Meiji Seika Kaisha | Derives d'acide omega-amino-alpha-hydroxycarboxylique possedant un antagonisme alpha v beta 3 d'integrine |
DK1302461T3 (da) * | 2000-05-31 | 2008-01-28 | Santen Pharmaceutical Co Ltd | TNF-alfa-produktionsinhibitorer |
DE10041423A1 (de) * | 2000-08-23 | 2002-03-07 | Merck Patent Gmbh | Biphenylderivate |
EP1446418B1 (fr) * | 2001-10-22 | 2012-05-23 | The Scripps Research Institute | Composes de ciblage de l'integrine |
US7317019B2 (en) | 2003-08-21 | 2008-01-08 | Bristol Myers Squibb Co. | N-alkylated diaminopropane derivatives as modulators of chemokine receptor activity |
HUE063437T2 (hu) | 2013-09-24 | 2024-01-28 | Fujifilm Corp | Nitrogént tartalmazó vegyületet vagy sóját vagy fémkomplexét tartalmazó gyógyászati készítmény |
US20180244648A1 (en) | 2017-02-28 | 2018-08-30 | Lazuli, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
US11046685B2 (en) | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
CR20210109A (es) | 2018-08-29 | 2021-06-24 | Morphic Therapeutic Inc | INHIBICIÓN DE LA INTEGRINA av ß6 |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0384362A2 (fr) * | 1989-02-23 | 1990-08-29 | F. Hoffmann-La Roche Ag | Dérivés de la glycine |
WO1991005562A1 (fr) * | 1989-10-10 | 1991-05-02 | Rorer International (Holdings), Inc. | Peptides et pseudopeptides anti-thrombotiques |
EP0512831A1 (fr) * | 1991-05-07 | 1992-11-11 | Merck & Co. Inc. | Antagonistes des récepteurs fibrinogeniques |
EP0565896A2 (fr) * | 1992-04-13 | 1993-10-20 | Hoechst Aktiengesellschaft | Dérivés d'acide aspartique et leur préparation et utilisation |
EP0578535A1 (fr) * | 1992-06-30 | 1994-01-12 | Adir Et Compagnie | Nouveaux dérivés peptidiques actifs dans les processus d'adhesion cellulaire, leur procédé de préparation et les compositions pharmaceutiques qui les renferment |
WO1994014775A1 (fr) * | 1992-12-29 | 1994-07-07 | Smithkline Beecham Corporation | Composes inhibant l'aggregation des plaquettes |
US5332726A (en) * | 1989-09-29 | 1994-07-26 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Antithrombotic peptides and pseudopeptides |
WO1994022907A1 (fr) * | 1993-03-26 | 1994-10-13 | Hoechst Aktiengesellschaft | Nouveaux derives d'uree, leur preparation et leur utilisation |
WO1994022835A2 (fr) * | 1993-03-29 | 1994-10-13 | Zeneca Limited | Composes heterocycliques en tant qu'inhibiteurs de l'agregation plaquettaire |
EP0725059A1 (fr) * | 1993-10-19 | 1996-08-07 | Sumitomo Pharmaceuticals Company, Limited | Derive d'acide 2,3-diaminopropionique |
WO1997024122A1 (fr) * | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Antagonistes du recepteur de vitronectine |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3553227A (en) * | 1968-08-05 | 1971-01-05 | Parke Davis & Co | S-2-((2-(2-thiazolylcarbamoyl)ethyl)amino)ethyl thiosulfate, salts thereof, and methods for their production |
US4684722A (en) * | 1986-01-06 | 1987-08-04 | E. R. Squibb & Sons, Inc. | Monosulfactams |
-
1997
- 1997-01-13 EP EP97902931A patent/EP0880511A4/fr not_active Withdrawn
- 1997-01-13 WO PCT/US1997/000572 patent/WO1997026250A1/fr not_active Application Discontinuation
- 1997-01-13 CA CA002242877A patent/CA2242877A1/fr not_active Abandoned
- 1997-01-13 AU AU16990/97A patent/AU713676B2/en not_active Ceased
- 1997-01-13 JP JP09526121A patent/JP2000516197A/ja active Pending
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0384362A2 (fr) * | 1989-02-23 | 1990-08-29 | F. Hoffmann-La Roche Ag | Dérivés de la glycine |
US5332726A (en) * | 1989-09-29 | 1994-07-26 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Antithrombotic peptides and pseudopeptides |
WO1991005562A1 (fr) * | 1989-10-10 | 1991-05-02 | Rorer International (Holdings), Inc. | Peptides et pseudopeptides anti-thrombotiques |
EP0512831A1 (fr) * | 1991-05-07 | 1992-11-11 | Merck & Co. Inc. | Antagonistes des récepteurs fibrinogeniques |
EP0565896A2 (fr) * | 1992-04-13 | 1993-10-20 | Hoechst Aktiengesellschaft | Dérivés d'acide aspartique et leur préparation et utilisation |
EP0578535A1 (fr) * | 1992-06-30 | 1994-01-12 | Adir Et Compagnie | Nouveaux dérivés peptidiques actifs dans les processus d'adhesion cellulaire, leur procédé de préparation et les compositions pharmaceutiques qui les renferment |
WO1994014775A1 (fr) * | 1992-12-29 | 1994-07-07 | Smithkline Beecham Corporation | Composes inhibant l'aggregation des plaquettes |
WO1994022907A1 (fr) * | 1993-03-26 | 1994-10-13 | Hoechst Aktiengesellschaft | Nouveaux derives d'uree, leur preparation et leur utilisation |
WO1994022835A2 (fr) * | 1993-03-29 | 1994-10-13 | Zeneca Limited | Composes heterocycliques en tant qu'inhibiteurs de l'agregation plaquettaire |
EP0725059A1 (fr) * | 1993-10-19 | 1996-08-07 | Sumitomo Pharmaceuticals Company, Limited | Derive d'acide 2,3-diaminopropionique |
WO1997024122A1 (fr) * | 1995-12-29 | 1997-07-10 | Smithkline Beecham Corporation | Antagonistes du recepteur de vitronectine |
Non-Patent Citations (1)
Title |
---|
See also references of WO9726250A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU1699097A (en) | 1997-08-11 |
WO1997026250A1 (fr) | 1997-07-24 |
CA2242877A1 (fr) | 1997-07-24 |
JP2000516197A (ja) | 2000-12-05 |
AU713676B2 (en) | 1999-12-09 |
EP0880511A1 (fr) | 1998-12-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1047425A4 (fr) | Antagonistes du recepteur de l'integrine | |
EP0934305A4 (fr) | Antagonistes de l'integrine | |
EP1100506A4 (fr) | Antagonistes des recepteurs de l'integrine | |
EP1105389A4 (fr) | Antagonistes de recepteurs d'integrine | |
EP1007051A4 (fr) | Antagonistes du recepteur de l'integrine | |
CY2576B1 (en) | Vitronectin receptor antagonists | |
EP0946164A4 (fr) | Antagonistes de l'integrine | |
EP1007026A4 (fr) | Antagonistes d'integrine | |
EP0880511A4 (fr) | Antagonistes du recepteur integrine | |
HU9603525D0 (en) | Vironectin receptor antagonists | |
EP0912175A4 (fr) | Antagonistes du recepteur de fibrinogene | |
EP0763035A4 (fr) | Antagonistes du recepteur de l'endotheline | |
IL130760A0 (en) | Vitronectin receptor antagonists | |
EP0885205A4 (fr) | Antagonistes des recepteurs de fibrinogenes | |
EP0885213A4 (fr) | Antagonistes du recepteur du fibrinogene | |
IL135797A0 (en) | Thrombin receptor antagonists | |
IL135028A0 (en) | Vitronectin receptor antagonists | |
EP1027337A4 (fr) | Antagonistes des recepteurs d'integrines | |
EP0929218A4 (fr) | Antagonistes des recepteurs p2y | |
GB9820014D0 (en) | Receptor antagonists and uses thereof | |
IL119820A0 (en) | Integrin receptor antagonists | |
GB9603373D0 (en) | Integrin receptor antagonists | |
ZA986930B (en) | Integrin receptor antagonists | |
ZA9811500B (en) | Integrin receptor antagonists | |
ZA9610690B (en) | Integrin receptor antagonists. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19980817 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19990503 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 19990922 |
|
17Q | First examination report despatched |
Effective date: 20030731 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20031211 |