EP0912182A4 - Promedicaments antagonistes du recepteur de fibrinogene - Google Patents

Promedicaments antagonistes du recepteur de fibrinogene

Info

Publication number
EP0912182A4
EP0912182A4 EP97931396A EP97931396A EP0912182A4 EP 0912182 A4 EP0912182 A4 EP 0912182A4 EP 97931396 A EP97931396 A EP 97931396A EP 97931396 A EP97931396 A EP 97931396A EP 0912182 A4 EP0912182 A4 EP 0912182A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonist
fibrinogen receptor
antagonist prodrugs
prodrugs
fibrinogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97931396A
Other languages
German (de)
English (en)
Other versions
EP0912182A1 (fr
Inventor
Melissa S Egbertson
George D Hartman
William C Lumma
John S Wai
Steven D Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617983.3A external-priority patent/GB9617983D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0912182A1 publication Critical patent/EP0912182A1/fr
Publication of EP0912182A4 publication Critical patent/EP0912182A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP97931396A 1996-06-28 1997-06-25 Promedicaments antagonistes du recepteur de fibrinogene Withdrawn EP0912182A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2097696P 1996-06-28 1996-06-28
US20976P 1996-06-28
GBGB9617983.3A GB9617983D0 (en) 1996-08-28 1996-08-28 Fibrinogen receptor antagonist prodrugs
GB9617983 1996-08-28
PCT/US1997/011037 WO1998000144A1 (fr) 1996-06-28 1997-06-25 Promedicaments antagonistes du recepteur de fibrinogene

Publications (2)

Publication Number Publication Date
EP0912182A1 EP0912182A1 (fr) 1999-05-06
EP0912182A4 true EP0912182A4 (fr) 1999-12-29

Family

ID=26309939

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97931396A Withdrawn EP0912182A4 (fr) 1996-06-28 1997-06-25 Promedicaments antagonistes du recepteur de fibrinogene

Country Status (5)

Country Link
EP (1) EP0912182A4 (fr)
JP (1) JP2000514427A (fr)
AU (1) AU709631B2 (fr)
CA (1) CA2257937A1 (fr)
WO (1) WO1998000144A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU721130B2 (en) * 1996-06-28 2000-06-22 Merck & Co., Inc. Fibrinogen receptor antagonists
NL1006179C2 (nl) * 1997-05-30 1998-12-01 Alcoa Nederland Bv Werkwijze voor het verwerken van materiaal uit aluminium en kunststof.
GB0319150D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
GB0421908D0 (en) * 2004-10-01 2004-11-03 Angeletti P Ist Richerche Bio New uses
KR100956703B1 (ko) * 2005-06-06 2010-05-06 에프. 호프만-라 로슈 아게 간 카르니틴 팔미토일 전이효소(ｌ-ｃｐｔ1) 저해제로서유용한 설폰아마이드 유도체
EP1991226B1 (fr) 2006-02-28 2013-03-20 Merck Sharp & Dohme Corp. Inhibiteurs de l'histone désacétylase
DK2825542T3 (en) 2012-03-16 2017-01-09 Vitae Pharmaceuticals Inc LIVER-X-receptor modulators
AU2013232066B2 (en) 2012-03-16 2017-07-06 Vitae Pharmaceuticals, Inc. Liver X receptor modulators
CN107501202A (zh) * 2017-09-26 2017-12-22 杨文浪 微波法制备1,4苯并噁嗪酮的合成工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256812A (en) * 1989-01-31 1993-10-26 Hoffmann-La Roche Inc. Carboxamides and sulfonamides
SK120895A3 (en) * 1993-03-29 1996-06-05 Zeneca Ltd Pyridine derivatives, process for preparing the same and intermediate products in this process and pharmaceutical compositions containing them
NZ262942A (en) * 1993-03-29 1997-07-27 Zeneca Ltd Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions
US5547671A (en) * 1995-09-20 1996-08-20 Duthinh; Phu Anti-intoxication composition

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9800144A1 *

Also Published As

Publication number Publication date
JP2000514427A (ja) 2000-10-31
AU709631B2 (en) 1999-09-02
EP0912182A1 (fr) 1999-05-06
AU3503397A (en) 1998-01-21
CA2257937A1 (fr) 1998-01-08
WO1998000144A1 (fr) 1998-01-08

Similar Documents

Publication Publication Date Title
AU3503797A (en) Fibrinogen receptor antagonist prodrugs
EP0912175A4 (fr) Antagonistes du recepteur de fibrinogene
HU9603525D0 (en) Vironectin receptor antagonists
PL348375A1 (en) Pyrrolidine derivatives-ccr-3 receptor antagonists
HU9601529D0 (en) Pyrimidinedion-, pyrimidinetrion-, triazinedion-, tetrahydro-quinazolinedion- derivatives as alpha-adrenerg receptor antagonists
EP0810994A4 (fr) Antagonistes des recepteurs de fibrinogene
EP0885205A4 (fr) Antagonistes des recepteurs de fibrinogenes
EP0866705A4 (fr) Antagonistes du recepteur de fibrinogene
CY2576B1 (en) Vitronectin receptor antagonists
EP0885213A4 (fr) Antagonistes du recepteur du fibrinogene
GB9625843D0 (en) Phenyl spiroethercycloalkyl tachykinn receptor antagonists
EP0796098A4 (fr) Antagonistes des recepteurs du fibrinogene
ZA951345B (en) Adhesion receptor antagonist
HK1031726A1 (en) Thrombin receptor antagonists
EP0929218A4 (fr) Antagonistes des recepteurs p2y
EP0912182A4 (fr) Promedicaments antagonistes du recepteur de fibrinogene
IL134301A0 (en) 2-acylaminopropanamines as tachykinin receptor antagonists
EP0794779A4 (fr) Antagonistes des recepteurs du fibrinogene
EP1023295A4 (fr) Promedicaments antagonistes de recepteur de fibrinogene
GB9515852D0 (en) Fibrinogen receptor antagonists
IL134155A0 (en) 2-acylaminopropanamines as tachykinin receptor antagonists
EP0800395A4 (fr) Antagonistes des recepteurs du fibrinogene
GB9819420D0 (en) Novel receptor
EP0781133A4 (fr) Antagonistes du recepteur de fibrinogene
GB9617983D0 (en) Fibrinogen receptor antagonist prodrugs

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990128

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19991112

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20030103