JP2000514427A - フィブリノーゲンレセプター拮抗薬プロドラッグ - Google Patents
フィブリノーゲンレセプター拮抗薬プロドラッグInfo
- Publication number
- JP2000514427A JP2000514427A JP10504262A JP50426298A JP2000514427A JP 2000514427 A JP2000514427 A JP 2000514427A JP 10504262 A JP10504262 A JP 10504262A JP 50426298 A JP50426298 A JP 50426298A JP 2000514427 A JP2000514427 A JP 2000514427A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- carboxy
- alkyloxy
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2097696P | 1996-06-28 | 1996-06-28 | |
GB9617983.3 | 1996-08-28 | ||
GB60/020,976 | 1996-08-28 | ||
GBGB9617983.3A GB9617983D0 (en) | 1996-08-28 | 1996-08-28 | Fibrinogen receptor antagonist prodrugs |
PCT/US1997/011037 WO1998000144A1 (fr) | 1996-06-28 | 1997-06-25 | Promedicaments antagonistes du recepteur de fibrinogene |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2000514427A true JP2000514427A (ja) | 2000-10-31 |
Family
ID=26309939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10504262A Pending JP2000514427A (ja) | 1996-06-28 | 1997-06-25 | フィブリノーゲンレセプター拮抗薬プロドラッグ |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0912182A4 (fr) |
JP (1) | JP2000514427A (fr) |
AU (1) | AU709631B2 (fr) |
CA (1) | CA2257937A1 (fr) |
WO (1) | WO1998000144A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008516897A (ja) * | 2004-10-01 | 2008-05-22 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | Hcv複製の調節 |
JP2008545770A (ja) * | 2005-06-06 | 2008-12-18 | エフ.ホフマン−ラ ロシュ アーゲー | 肝臓のカルニチンパルミトイルトランスフェラーゼ(l−cpt1)阻害剤として有用なスルホンアミド誘導体 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU721130B2 (en) * | 1996-06-28 | 2000-06-22 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
NL1006179C2 (nl) * | 1997-05-30 | 1998-12-01 | Alcoa Nederland Bv | Werkwijze voor het verwerken van materiaal uit aluminium en kunststof. |
GB0319150D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
AU2007221207A1 (en) | 2006-02-28 | 2007-09-07 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase |
DK2825541T3 (en) | 2012-03-16 | 2016-10-03 | Vitae Pharmaceuticals Inc | LIVER-X-receptor modulators |
BR112014022780A8 (pt) | 2012-03-16 | 2021-06-15 | Vitae Pharmaceuticals Inc | composto modulador de receptor de fígado x, composição farmacêutica que o compreende e seu uso |
CN107501202A (zh) * | 2017-09-26 | 2017-12-22 | 杨文浪 | 微波法制备1,4苯并噁嗪酮的合成工艺 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5256812A (en) * | 1989-01-31 | 1993-10-26 | Hoffmann-La Roche Inc. | Carboxamides and sulfonamides |
GB9406143D0 (en) * | 1993-03-29 | 1994-05-18 | Zeneca Ltd | Heterocyclic derivatives |
CA2155307A1 (fr) * | 1993-03-29 | 1994-10-13 | Michael Garth Wayne | Composes heterocycliques, inhibiteurs de l'agregation des plaquettes |
US5547671A (en) * | 1995-09-20 | 1996-08-20 | Duthinh; Phu | Anti-intoxication composition |
-
1997
- 1997-06-25 CA CA 2257937 patent/CA2257937A1/fr not_active Abandoned
- 1997-06-25 WO PCT/US1997/011037 patent/WO1998000144A1/fr not_active Application Discontinuation
- 1997-06-25 AU AU35033/97A patent/AU709631B2/en not_active Ceased
- 1997-06-25 JP JP10504262A patent/JP2000514427A/ja active Pending
- 1997-06-25 EP EP97931396A patent/EP0912182A4/fr not_active Withdrawn
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008516897A (ja) * | 2004-10-01 | 2008-05-22 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | Hcv複製の調節 |
JP2008545770A (ja) * | 2005-06-06 | 2008-12-18 | エフ.ホフマン−ラ ロシュ アーゲー | 肝臓のカルニチンパルミトイルトランスフェラーゼ(l−cpt1)阻害剤として有用なスルホンアミド誘導体 |
JP4880678B2 (ja) * | 2005-06-06 | 2012-02-22 | エフ.ホフマン−ラ ロシュ アーゲー | 肝臓のカルニチンパルミトイルトランスフェラーゼ(l−cpt1)阻害剤として有用なスルホンアミド誘導体 |
Also Published As
Publication number | Publication date |
---|---|
WO1998000144A1 (fr) | 1998-01-08 |
CA2257937A1 (fr) | 1998-01-08 |
EP0912182A1 (fr) | 1999-05-06 |
EP0912182A4 (fr) | 1999-12-29 |
AU709631B2 (en) | 1999-09-02 |
AU3503397A (en) | 1998-01-21 |
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