AU709631B2 - Fibrinogen receptor antagonist prodrugs - Google Patents
Fibrinogen receptor antagonist prodrugs Download PDFInfo
- Publication number
- AU709631B2 AU709631B2 AU35033/97A AU3503397A AU709631B2 AU 709631 B2 AU709631 B2 AU 709631B2 AU 35033/97 A AU35033/97 A AU 35033/97A AU 3503397 A AU3503397 A AU 3503397A AU 709631 B2 AU709631 B2 AU 709631B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- aryl
- carboxy
- alkyloxy
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2097696P | 1996-06-28 | 1996-06-28 | |
US60/020976 | 1996-06-28 | ||
GBGB9617983.3A GB9617983D0 (en) | 1996-08-28 | 1996-08-28 | Fibrinogen receptor antagonist prodrugs |
GB9617983 | 1996-08-28 | ||
PCT/US1997/011037 WO1998000144A1 (fr) | 1996-06-28 | 1997-06-25 | Promedicaments antagonistes du recepteur de fibrinogene |
Publications (2)
Publication Number | Publication Date |
---|---|
AU3503397A AU3503397A (en) | 1998-01-21 |
AU709631B2 true AU709631B2 (en) | 1999-09-02 |
Family
ID=26309939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU35033/97A Ceased AU709631B2 (en) | 1996-06-28 | 1997-06-25 | Fibrinogen receptor antagonist prodrugs |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0912182A4 (fr) |
JP (1) | JP2000514427A (fr) |
AU (1) | AU709631B2 (fr) |
CA (1) | CA2257937A1 (fr) |
WO (1) | WO1998000144A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2258093A1 (fr) * | 1996-06-28 | 1998-01-08 | Mark E. Duggan | Antagonistes du recepteur de fibrinogene |
NL1006179C2 (nl) * | 1997-05-30 | 1998-12-01 | Alcoa Nederland Bv | Werkwijze voor het verwerken van materiaal uit aluminium en kunststof. |
GB0319150D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
GB0421908D0 (en) * | 2004-10-01 | 2004-11-03 | Angeletti P Ist Richerche Bio | New uses |
WO2006131452A1 (fr) * | 2005-06-06 | 2006-12-14 | F. Hoffmann-La Roche Ag | Derives de sulfonamide utiles comme inhibiteurs de la carnitine palmitoyl transferase du foie (l-cpt1) |
WO2007100657A2 (fr) | 2006-02-28 | 2007-09-07 | Merck & Co., Inc. | Inhibiteurs de l'histone désacétylase |
IN2014DN07636A (fr) | 2012-03-16 | 2015-05-15 | Vitae Pharmaceuticals Inc | |
RS55532B1 (sr) | 2012-03-16 | 2017-05-31 | Vitae Pharmaceuticals Inc | Modulatori jetrenog x receptora |
CN107501202A (zh) * | 2017-09-26 | 2017-12-22 | 杨文浪 | 微波法制备1,4苯并噁嗪酮的合成工艺 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5256812A (en) * | 1989-01-31 | 1993-10-26 | Hoffmann-La Roche Inc. | Carboxamides and sulfonamides |
DE69411900T2 (de) * | 1993-03-29 | 1998-12-10 | Zeneca Ltd., London | Heterozyklische derivate als plätchenaggregationsinhibitoren |
ZW4194A1 (en) * | 1993-03-29 | 1994-12-21 | Zeneca Ltd | Heterocyclic compounds |
US5547671A (en) * | 1995-09-20 | 1996-08-20 | Duthinh; Phu | Anti-intoxication composition |
-
1997
- 1997-06-25 JP JP10504262A patent/JP2000514427A/ja active Pending
- 1997-06-25 WO PCT/US1997/011037 patent/WO1998000144A1/fr not_active Application Discontinuation
- 1997-06-25 AU AU35033/97A patent/AU709631B2/en not_active Ceased
- 1997-06-25 CA CA 2257937 patent/CA2257937A1/fr not_active Abandoned
- 1997-06-25 EP EP97931396A patent/EP0912182A4/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2000514427A (ja) | 2000-10-31 |
EP0912182A4 (fr) | 1999-12-29 |
CA2257937A1 (fr) | 1998-01-08 |
EP0912182A1 (fr) | 1999-05-06 |
AU3503397A (en) | 1998-01-21 |
WO1998000144A1 (fr) | 1998-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |