AU709631B2 - Fibrinogen receptor antagonist prodrugs - Google Patents

Fibrinogen receptor antagonist prodrugs Download PDF

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Publication number
AU709631B2
AU709631B2 AU35033/97A AU3503397A AU709631B2 AU 709631 B2 AU709631 B2 AU 709631B2 AU 35033/97 A AU35033/97 A AU 35033/97A AU 3503397 A AU3503397 A AU 3503397A AU 709631 B2 AU709631 B2 AU 709631B2
Authority
AU
Australia
Prior art keywords
alkyl
aryl
carboxy
alkyloxy
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU35033/97A
Other languages
English (en)
Other versions
AU3503397A (en
Inventor
Melissa S. Egbertson
George D. Hartman
William C. Lumma
John S. Wai
Steven D. Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617983.3A external-priority patent/GB9617983D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU3503397A publication Critical patent/AU3503397A/en
Application granted granted Critical
Publication of AU709631B2 publication Critical patent/AU709631B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU35033/97A 1996-06-28 1997-06-25 Fibrinogen receptor antagonist prodrugs Ceased AU709631B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2097696P 1996-06-28 1996-06-28
US60/020976 1996-06-28
GB9617983 1996-08-28
GBGB9617983.3A GB9617983D0 (en) 1996-08-28 1996-08-28 Fibrinogen receptor antagonist prodrugs
PCT/US1997/011037 WO1998000144A1 (fr) 1996-06-28 1997-06-25 Promedicaments antagonistes du recepteur de fibrinogene

Publications (2)

Publication Number Publication Date
AU3503397A AU3503397A (en) 1998-01-21
AU709631B2 true AU709631B2 (en) 1999-09-02

Family

ID=26309939

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35033/97A Ceased AU709631B2 (en) 1996-06-28 1997-06-25 Fibrinogen receptor antagonist prodrugs

Country Status (5)

Country Link
EP (1) EP0912182A4 (fr)
JP (1) JP2000514427A (fr)
AU (1) AU709631B2 (fr)
CA (1) CA2257937A1 (fr)
WO (1) WO1998000144A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2258093A1 (fr) * 1996-06-28 1998-01-08 Mark E. Duggan Antagonistes du recepteur de fibrinogene
NL1006179C2 (nl) * 1997-05-30 1998-12-01 Alcoa Nederland Bv Werkwijze voor het verwerken van materiaal uit aluminium en kunststof.
GB0319150D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
GB0421908D0 (en) * 2004-10-01 2004-11-03 Angeletti P Ist Richerche Bio New uses
JP4880678B2 (ja) * 2005-06-06 2012-02-22 エフ．ホフマン−ラ ロシュ アーゲー 肝臓のカルニチンパルミトイルトランスフェラーゼ（ｌ−ｃｐｔ１）阻害剤として有用なスルホンアミド誘導体
US8168658B2 (en) 2006-02-28 2012-05-01 Merck Sharp & Dohme Corp. Inhibitors of histone deacetylase
HUE030785T2 (en) 2012-03-16 2017-06-28 Vitae Pharmaceuticals Inc Liver X receptor modulators
HUE029402T2 (en) 2012-03-16 2017-02-28 Vitae Pharmaceuticals Inc Liver X receptor modulators
CN107501202A (zh) * 2017-09-26 2017-12-22 杨文浪 微波法制备1,4苯并噁嗪酮的合成工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256812A (en) * 1989-01-31 1993-10-26 Hoffmann-La Roche Inc. Carboxamides and sulfonamides
US5563141A (en) * 1993-03-29 1996-10-08 Zeneca Limited Heterocyclic compounds
CZ250995A3 (en) * 1993-03-29 1996-01-17 Zeneca Ltd Pyridine derivatives, process of their preparation and intermediates employed in this process as well as pharmaceutical compositions containing thereof
US5547671A (en) * 1995-09-20 1996-08-20 Duthinh; Phu Anti-intoxication composition

Also Published As

Publication number Publication date
WO1998000144A1 (fr) 1998-01-08
EP0912182A1 (fr) 1999-05-06
EP0912182A4 (fr) 1999-12-29
JP2000514427A (ja) 2000-10-31
CA2257937A1 (fr) 1998-01-08
AU3503397A (en) 1998-01-21

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired