IL125194A - Process for the production of flodipine - Google Patents

Process for the production of flodipine

Info

Publication number
IL125194A
IL125194A IL12519496A IL12519496A IL125194A IL 125194 A IL125194 A IL 125194A IL 12519496 A IL12519496 A IL 12519496A IL 12519496 A IL12519496 A IL 12519496A IL 125194 A IL125194 A IL 125194A
Authority
IL
Israel
Prior art keywords
felodipine
ethyl
aminocrotonate
methylester
ethanol
Prior art date
Application number
IL12519496A
Other languages
English (en)
Hebrew (he)
Other versions
IL125194A0 (en
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IL125194A0 publication Critical patent/IL125194A0/xx
Publication of IL125194A publication Critical patent/IL125194A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • General Factory Administration (AREA)
IL12519496A 1996-01-10 1996-12-13 Process for the production of flodipine IL125194A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9600086A SE9600086D0 (sv) 1996-01-10 1996-01-10 New manufacturing process
PCT/SE1996/001649 WO1997025313A1 (fr) 1996-01-10 1996-12-13 Nouveau procede de production

Publications (2)

Publication Number Publication Date
IL125194A0 IL125194A0 (en) 1999-03-12
IL125194A true IL125194A (en) 2002-09-12

Family

ID=20400982

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12519496A IL125194A (en) 1996-01-10 1996-12-13 Process for the production of flodipine

Country Status (34)

Country Link
US (1) US5942624A (fr)
EP (1) EP0874822B1 (fr)
JP (1) JP4587497B2 (fr)
KR (1) KR100488384B1 (fr)
CN (1) CN1105104C (fr)
AR (1) AR005342A1 (fr)
AT (1) ATE249436T1 (fr)
AU (1) AU706989B2 (fr)
BR (1) BR9612457A (fr)
CA (1) CA2240201C (fr)
CZ (1) CZ291063B6 (fr)
DE (1) DE69629942T2 (fr)
DK (1) DK0874822T3 (fr)
EE (1) EE03438B1 (fr)
EG (1) EG24197A (fr)
ES (1) ES2206617T3 (fr)
HK (1) HK1014941A1 (fr)
HU (1) HU227384B1 (fr)
IL (1) IL125194A (fr)
IS (1) IS1826B (fr)
MY (1) MY116842A (fr)
NO (1) NO310233B1 (fr)
NZ (1) NZ325967A (fr)
PL (1) PL188308B1 (fr)
PT (1) PT874822E (fr)
RU (1) RU2171251C2 (fr)
SE (1) SE9600086D0 (fr)
SI (1) SI0874822T1 (fr)
SK (1) SK281989B6 (fr)
TR (1) TR199801283T2 (fr)
TW (1) TW343194B (fr)
UA (1) UA44914C2 (fr)
WO (1) WO1997025313A1 (fr)
ZA (1) ZA9610937B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
KR101369207B1 (ko) 2007-04-11 2014-03-04 한국과학기술원 (ｓ)-(-)-펠로디핀의 제조방법
CN102143948B (zh) * 2008-09-04 2013-07-31 安国药品株式会社 (s)-(-)-非洛地平的制备方法
CN101613280B (zh) * 2009-05-13 2012-10-17 合肥立方制药股份有限公司 非洛地平合成中间体2,3-二氯亚苄基乙酰乙酸甲酯的制备方法
CN101735042B (zh) * 2009-12-15 2013-10-09 浙江大学 2-烷基-4,4-二芳基反-2-丁烯酸乙酯的合成方法
WO2012123966A1 (fr) 2011-03-04 2012-09-20 Arch Pharmalabs Limited Procédé pour la préparation de 1,4-dihydropyridines substituées en position 4
CN102304079B (zh) * 2011-09-29 2013-09-25 合肥立方制药股份有限公司 一种非洛地平环合反应液直接水析纯化方法
CN103373956B (zh) * 2012-04-23 2015-07-01 黑龙江省格润药业有限责任公司 一种制备丁酸氯维地平的方法
CN104557679A (zh) * 2013-10-23 2015-04-29 丹阳恒安化学科技研究所有限公司 一种西尼地平的合成方法
CN108840819B (zh) * 2018-04-02 2021-07-30 常州瑞明药业有限公司 一种非洛地平的制备方法
CN115201379B (zh) * 2022-07-26 2023-10-20 常州瑞明药业有限公司 非洛地平中基因毒性杂质的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
US5310917A (en) * 1991-09-13 1994-05-10 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropydrines

Also Published As

Publication number Publication date
NO310233B1 (no) 2001-06-11
DE69629942T2 (de) 2004-07-15
JP2000503647A (ja) 2000-03-28
EG24197A (en) 2008-10-14
HUP9901392A2 (hu) 1999-08-30
HK1014941A1 (en) 1999-10-08
CN1105104C (zh) 2003-04-09
TW343194B (en) 1998-10-21
CA2240201A1 (fr) 1997-07-17
EP0874822B1 (fr) 2003-09-10
AU706989B2 (en) 1999-07-01
CN1207726A (zh) 1999-02-10
NZ325967A (en) 2000-01-28
IS4779A (is) 1998-06-19
UA44914C2 (uk) 2002-03-15
SE9600086D0 (sv) 1996-01-10
SK281989B6 (sk) 2001-09-11
BR9612457A (pt) 1999-07-13
CZ218098A3 (cs) 1998-10-14
EP0874822A1 (fr) 1998-11-04
RU2171251C2 (ru) 2001-07-27
CZ291063B6 (cs) 2002-12-11
ATE249436T1 (de) 2003-09-15
KR100488384B1 (ko) 2006-03-23
ZA9610937B (en) 1997-07-10
IS1826B (is) 2002-10-01
EE03438B1 (et) 2001-06-15
TR199801283T2 (xx) 1998-10-21
DE69629942D1 (de) 2003-10-16
HUP9901392A3 (en) 1999-11-29
CA2240201C (fr) 2006-08-29
WO1997025313A1 (fr) 1997-07-17
IL125194A0 (en) 1999-03-12
DK0874822T3 (da) 2003-12-08
EE9800201A (et) 1998-12-15
JP4587497B2 (ja) 2010-11-24
ES2206617T3 (es) 2004-05-16
AU1323097A (en) 1997-08-01
HU227384B1 (en) 2011-05-30
SI0874822T1 (en) 2004-02-29
SK87898A3 (en) 1998-12-02
NO983166L (no) 1998-07-09
PL327946A1 (en) 1999-01-04
US5942624A (en) 1999-08-24
PL188308B1 (pl) 2005-01-31
PT874822E (pt) 2004-02-27
AR005342A1 (es) 1999-04-28
MY116842A (en) 2004-04-30
KR19990076972A (ko) 1999-10-25

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