IL125076A - Aza compounds, diazole cycloheptane and converted cyclooctane compounds and pharmaceutical preparations containing them - Google Patents

Aza compounds, diazole cycloheptane and converted cyclooctane compounds and pharmaceutical preparations containing them

Info

Publication number
IL125076A
IL125076A IL12507697A IL12507697A IL125076A IL 125076 A IL125076 A IL 125076A IL 12507697 A IL12507697 A IL 12507697A IL 12507697 A IL12507697 A IL 12507697A IL 125076 A IL125076 A IL 125076A
Authority
IL
Israel
Prior art keywords
alkyl
compound
halogen
substituted
phenyl
Prior art date
Application number
IL12507697A
Other languages
English (en)
Hebrew (he)
Other versions
IL125076A0 (en
Inventor
Hansjoerg Treiber
Stefan Blank
Dorothea Starck
Liliane Unger
Hansjuergen Teschedorf
Karsten Wicke
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of IL125076A0 publication Critical patent/IL125076A0/xx
Publication of IL125076A publication Critical patent/IL125076A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
IL12507697A 1996-01-12 1997-01-10 Aza compounds, diazole cycloheptane and converted cyclooctane compounds and pharmaceutical preparations containing them IL125076A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19600934A DE19600934A1 (de) 1996-01-12 1996-01-12 Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
PCT/EP1997/000106 WO1997025324A1 (de) 1996-01-12 1997-01-10 Substituierte aza- und diazacycloheptan- und -cyclooctanverbindungen und deren verwendung

Publications (2)

Publication Number Publication Date
IL125076A0 IL125076A0 (en) 1999-01-26
IL125076A true IL125076A (en) 2001-05-20

Family

ID=7782613

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12507697A IL125076A (en) 1996-01-12 1997-01-10 Aza compounds, diazole cycloheptane and converted cyclooctane compounds and pharmaceutical preparations containing them

Country Status (26)

Country Link
US (2) US6214822B1 (ko)
EP (1) EP0877744B1 (ko)
JP (1) JP4349657B2 (ko)
KR (1) KR100441073B1 (ko)
CN (2) CN1075070C (ko)
AR (1) AR005868A1 (ko)
AT (1) ATE273301T1 (ko)
AU (1) AU717726B2 (ko)
BG (1) BG64098B1 (ko)
CA (1) CA2241787C (ko)
CO (1) CO4790173A1 (ko)
CZ (1) CZ297981B6 (ko)
DE (2) DE19600934A1 (ko)
ES (1) ES2225947T3 (ko)
HR (1) HRP970021A2 (ko)
HU (1) HU228457B1 (ko)
IL (1) IL125076A (ko)
MX (1) MX9805499A (ko)
NO (1) NO316753B1 (ko)
NZ (1) NZ326332A (ko)
PL (1) PL327692A1 (ko)
SK (1) SK284987B6 (ko)
TR (1) TR199801302T2 (ko)
TW (1) TW475929B (ko)
WO (1) WO1997025324A1 (ko)
ZA (1) ZA97209B (ko)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19728996A1 (de) * 1997-07-07 1999-01-14 Basf Ag Triazolverbindungen und deren Verwendung
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
ID28385A (id) 1998-10-08 2001-05-17 Smithkline Beecham Plc Turunan-turunan tetrahidrobenzazepina yang berguna sebagai modulator reseptor d3 dopamina (bahan antipsikotik)
AR022228A1 (es) 1999-01-12 2002-09-04 Abbott Gmbh & Co Kg Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para la preparar dicha composicion
DE19922443A1 (de) * 1999-05-07 2000-11-09 Basf Ag Verwendung von Dopamin-D3-Rezeptorliganden zur Herstellung von Arzneimittel für die Behandlung von Nierenfunktionsstörungen
US7037916B2 (en) 1999-07-15 2006-05-02 Pharmacopeia Drug Discovery, Inc. Pyrimidine derivatives as IL-8 receptor antagonists
EP1272187B1 (de) * 2000-03-27 2008-07-30 Abbott GmbH & Co. KG Dopamin-d3-rezeptor-liganden zur behandlung von sucht
CA2438264A1 (en) 2001-02-16 2002-08-29 Aventis Pharmaceuticals Inc. Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands
DE10109866A1 (de) * 2001-03-01 2002-09-05 Abbott Gmbh & Co Kg Triazolverbindungen und deren Verwendung zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie
DE10131543A1 (de) * 2001-06-29 2003-01-16 Abbott Lab Pyrimidinoxyalkylpiperazine und ihre therapeutische Verwendung
CN100462359C (zh) * 2001-11-28 2009-02-18 科学研究和应用咨询公司 5-硫烷基-4h-1,2,4-三唑衍生物及其作为药物的应用
ES2290436T3 (es) * 2002-03-15 2008-02-16 Ciba Specialty Chemicals Holding Inc. Uso de 4-aminopiridinas para el tratamiento antimicrobiano de superficies.
DE10304870A1 (de) * 2003-02-06 2004-08-19 Abbott Gmbh & Co. Kg Triazolverbindungen und ihre therapeutische Verwendung
TW200507841A (en) * 2003-03-27 2005-03-01 Glaxo Group Ltd Antibacterial agents
DE10358004A1 (de) * 2003-12-11 2005-07-14 Abbott Gmbh & Co. Kg Ketolactam-Verbindungen und ihre Verwendung
DE102004027358A1 (de) * 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
JP2008528604A (ja) * 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP2007106746A (ja) * 2005-09-13 2007-04-26 Tosoh Corp 新規アリールホモピペラジン類、またはその塩と製造方法
WO2007099828A1 (ja) * 2006-02-23 2007-09-07 Shionogi & Co., Ltd. 環式基で置換された含窒素複素環誘導体
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
EP1882688A1 (en) * 2006-07-25 2008-01-30 EPFL Ecole Polytechnique Fédérale de Lausanne Labelling of fusion proteins with synthetic probes
JP4840440B2 (ja) * 2008-12-24 2011-12-21 ソニー株式会社 画像処理装置およびその方法、並びにプログラム
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
CN102811620B (zh) * 2010-01-25 2015-03-25 Chdi基金会股份有限公司 一些犬尿氨酸-3-单加氧酶抑制剂、药物组合物及其使用方法
US9156822B2 (en) * 2010-07-02 2015-10-13 The University Of North Carolina At Chapel Hill Functionally selective ligands of dopamine D2 receptors
EP2640705A2 (en) 2010-11-15 2013-09-25 Katholieke Universiteit Leuven Novel antiviral compounds
AU2012300246A1 (en) 2011-08-30 2014-03-06 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
EA027451B1 (ru) 2011-08-30 2017-07-31 Схди Фаундейшн, Инк. Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и их применение
MX2016008359A (es) 2013-12-24 2016-12-07 Oncotartis Inc Compuestos de benzamida y nicotinamida y metodos para usar los mismos.
SG11201700341PA (en) 2014-07-17 2017-02-27 Chdi Foundation Inc Methods and compositions for treating hiv-related disorders

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE628766A (ko) 1962-12-26
BE792206A (ko) 1971-12-02 1973-06-01 Byk Gulden Lomberg Chem Fab
US5139998A (en) 1988-08-31 1992-08-18 Superconductor Technologies, Inc. Controlled thallous oxide evaporation for thallium superconductor films and reactor design
SE8803429D0 (sv) 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
US5008267A (en) 1988-10-29 1991-04-16 Mitsui Toatsu Chemicals, Incorporated Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same
JP2815218B2 (ja) 1990-04-13 1998-10-27 三井化学株式会社 ピリミジンジオン誘導体、およびそれを含有する抗不整脈剤
FR2663638B2 (fr) 1990-04-06 1995-02-10 Institut Nal Sante Recherc Medic Polypeptides ayant une activite de recepteur dopaminergique, acides nucleiques codant pour ces polypeptides et utilisation de ces polypeptides pour le criblage de substances actives sur ces polypeptides.
JP2518965B2 (ja) 1990-09-21 1996-07-31 三井東圧化学株式会社 新規ピリジン誘導体及びそれを有効成分として含有する制癌剤効果増強剤
FR2668771B1 (fr) 1990-11-06 1995-03-17 Inst Nat Sante Rech Med Acides nucleiques codant pour des polypeptides ayant une activite de recepteur dopaminergique humain et utilisation de ces polypeptides pour le criblage de substances actives sur ces polypeptides.
DE4425143A1 (de) 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
DE4425144A1 (de) 1994-07-15 1996-01-18 Basf Ag Triazolverbindungen und deren Verwendung
DE4425146A1 (de) 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
DE4425145A1 (de) 1994-07-15 1996-01-18 Basf Ag Verwendung von Thiazol- und Thiadiazolverbindungen
US5635503A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Company Dihydropyridine npy antagonists: piperazine derivatives
FR2742149B1 (fr) 1995-12-11 1998-02-13 Inst Nat Sante Rech Med Nouveaux derives de 2-naphtamides et leurs applications therapeutiques

Also Published As

Publication number Publication date
PL327692A1 (en) 1998-12-21
BG64098B1 (bg) 2003-12-31
TR199801302T2 (xx) 1998-11-23
US6352981B1 (en) 2002-03-05
KR19990077127A (ko) 1999-10-25
CN1348956A (zh) 2002-05-15
AR005868A1 (es) 1999-07-21
HU228457B1 (en) 2013-03-28
CN1075070C (zh) 2001-11-21
AU717726B2 (en) 2000-03-30
MX9805499A (es) 1998-11-30
CN1146551C (zh) 2004-04-21
ATE273301T1 (de) 2004-08-15
ES2225947T3 (es) 2005-03-16
BG102616A (en) 1999-04-30
ZA97209B (en) 1998-07-10
HRP970021A2 (en) 1998-04-30
NO983187L (no) 1998-09-09
HUP9901590A2 (hu) 1999-08-30
SK284987B6 (sk) 2006-04-06
CN1212692A (zh) 1999-03-31
DE59711847D1 (de) 2004-09-16
IL125076A0 (en) 1999-01-26
CA2241787C (en) 2006-04-04
AU1440797A (en) 1997-08-01
TW475929B (en) 2002-02-11
KR100441073B1 (ko) 2004-11-16
CO4790173A1 (es) 1999-05-31
NO316753B1 (no) 2004-04-26
SK94198A3 (en) 1999-03-12
EP0877744B1 (de) 2004-08-11
CZ215998A3 (cs) 1999-05-12
CA2241787A1 (en) 1997-07-17
CZ297981B6 (cs) 2007-05-16
US6214822B1 (en) 2001-04-10
HUP9901590A3 (en) 2002-01-28
EP0877744A1 (de) 1998-11-18
DE19600934A1 (de) 1997-07-17
JP4349657B2 (ja) 2009-10-21
JP2000505072A (ja) 2000-04-25
NZ326332A (en) 1999-04-29
WO1997025324A1 (de) 1997-07-17

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