IL116018A0 - Cyanine dyes and diagnostic agents containing the same - Google Patents

Cyanine dyes and diagnostic agents containing the same

Info

Publication number
IL116018A0
IL116018A0 IL11601895A IL11601895A IL116018A0 IL 116018 A0 IL116018 A0 IL 116018A0 IL 11601895 A IL11601895 A IL 11601895A IL 11601895 A IL11601895 A IL 11601895A IL 116018 A0 IL116018 A0 IL 116018A0
Authority
IL
Israel
Prior art keywords
formula
alkyl
ch2cooh
cooh
dyestuffs
Prior art date
Application number
IL11601895A
Other languages
English (en)
Original Assignee
Diagnostikforschung Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagnostikforschung Inst filed Critical Diagnostikforschung Inst
Publication of IL116018A0 publication Critical patent/IL116018A0/xx
Priority to IL14138401A priority Critical patent/IL141384A0/xx
Priority to IL15374502A priority patent/IL153745A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00Dyes not provided for by a single group of this subclass
    • C09B69/10Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/105Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a methine or polymethine dye

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Studio Devices (AREA)
  • Laminated Bodies (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11601895A 1994-12-07 1995-11-16 Cyanine dyes and diagnostic agents containing the same IL116018A0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL14138401A IL141384A0 (en) 1994-12-07 2001-02-12 Diagnostic compositions containing cyanine dyes and their conjugates as contrast agents fro in-vivo nir diagnostic methods
IL15374502A IL153745A0 (en) 1994-12-07 2002-12-30 Cyanine dyes and diagnostic methods utilizing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4445065A DE4445065A1 (de) 1994-12-07 1994-12-07 Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung

Publications (1)

Publication Number Publication Date
IL116018A0 true IL116018A0 (en) 1996-01-31

Family

ID=6536117

Family Applications (4)

Application Number Title Priority Date Filing Date
IL11601895A IL116018A0 (en) 1994-12-07 1995-11-16 Cyanine dyes and diagnostic agents containing the same
IL141384A IL141384A (en) 1994-12-07 1995-11-16 A diagnostic method that uses a preparation containing cyanine dye or its salts as a contrast agent for NIR radiation
IL14138401A IL141384A0 (en) 1994-12-07 2001-02-12 Diagnostic compositions containing cyanine dyes and their conjugates as contrast agents fro in-vivo nir diagnostic methods
IL15374502A IL153745A0 (en) 1994-12-07 2002-12-30 Cyanine dyes and diagnostic methods utilizing the same

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL141384A IL141384A (en) 1994-12-07 1995-11-16 A diagnostic method that uses a preparation containing cyanine dye or its salts as a contrast agent for NIR radiation
IL14138401A IL141384A0 (en) 1994-12-07 2001-02-12 Diagnostic compositions containing cyanine dyes and their conjugates as contrast agents fro in-vivo nir diagnostic methods
IL15374502A IL153745A0 (en) 1994-12-07 2002-12-30 Cyanine dyes and diagnostic methods utilizing the same

Country Status (18)

Country Link
US (10) US6083485A (da)
EP (2) EP1181940B1 (da)
JP (4) JPH10510250A (da)
KR (2) KR100340290B1 (da)
CN (1) CN1089008C (da)
AT (2) ATE238071T1 (da)
AU (1) AU709152B2 (da)
CA (1) CA2205906C (da)
DE (3) DE4445065A1 (da)
DK (2) DK1181940T3 (da)
ES (2) ES2198446T3 (da)
HU (1) HUT77378A (da)
IL (4) IL116018A0 (da)
NO (2) NO319741B1 (da)
NZ (1) NZ294568A (da)
PT (2) PT1181940E (da)
WO (1) WO1996017628A1 (da)
ZA (1) ZA959707B (da)

Families Citing this family (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
US5804389A (en) * 1995-12-29 1998-09-08 Phanos Technologies, Inc. Method for detecting abnormal epithelial cell shedding
US5709845A (en) * 1996-05-13 1998-01-20 Rajagopalan; Raghavan Tricyclic functional dyes for contrast enhancement in optical imaging
US5688966A (en) * 1996-07-26 1997-11-18 E. I. Du Pont De Nemours And Company Compounds and method for synthesizing sulfoindocyanine dyes
DE19649971A1 (de) * 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
US6228344B1 (en) * 1997-03-13 2001-05-08 Mallinckrodt Inc. Method of measuring physiological function
US6280703B1 (en) 1997-03-13 2001-08-28 Mallinckrodt Inc. Simultaneous multimodal measurement of physiological function
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
GB9712524D0 (en) 1997-06-16 1997-08-20 Nycomed Imaging As Method
US6393315B1 (en) * 1997-09-12 2002-05-21 Communaute Europeenne Detecting and mapping of inflamed zones in a living tissue
WO1999013916A2 (en) * 1997-09-18 1999-03-25 Nycomed Imaging As Methods and compositions for medical imaging
US6133445A (en) * 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
US6685895B1 (en) 1997-12-17 2004-02-03 Ethicon, Inc. Method and apparatus for processing device with reduced occlusion
US6645430B1 (en) 1997-12-17 2003-11-11 Ethicon, Inc. Method and apparatus for processing device with fluid submersion
US6596232B1 (en) 1997-12-17 2003-07-22 Ethicon, Inc. Device processing apparatus and method having positive pressure with two partitions to minimize leakage
US6423547B1 (en) * 1998-04-03 2002-07-23 Mallinckrodt Inc. Non-covalent bioconjugates useful for diagnosis and therapy
US20030235846A1 (en) * 1998-04-08 2003-12-25 Terpetschnig Ewald A. Luminescent compounds
US7411068B2 (en) * 1998-04-08 2008-08-12 Terpetschnig Ewald A Luminescent compounds
US7250517B2 (en) * 1998-04-08 2007-07-31 Ewald A. Terpetschnig Luminescent compounds
US20030176663A1 (en) * 1998-05-11 2003-09-18 Eidgenossische Technische Hochscule Specific binding molecules for scintigraphy
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
JP2000095758A (ja) * 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
US20030180221A1 (en) * 1998-09-18 2003-09-25 Schering Ag Near infrared fluorescent contrast agent and fluorescence imaging
US6284223B1 (en) 1998-10-15 2001-09-04 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
US6652836B2 (en) 1998-10-15 2003-11-25 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
US6299860B1 (en) 1998-10-15 2001-10-09 Fluoro Probe, Inc. Method for viewing diseased tissue located within a body cavity
SE9804328D0 (sv) * 1998-12-15 1998-12-15 Christer Busch Contrast agent for facilitating ocular identification and inspection of lymph nodes
JP2002534218A (ja) * 1999-01-15 2002-10-15 ライト サイエンシーズ コーポレイション 非侵襲性の脈管療法
CA2358662A1 (en) * 1999-01-15 2000-07-20 James Chen Therapeutic compositions for metabolic bone disorders or bone metastases
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
AU3855499A (en) * 1999-02-12 2000-08-29 Mikhail Leonidovich Stakhanov Method for diagnosing proliferation regions and device for realising the same
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
US20030114434A1 (en) * 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
DE19948650A1 (de) * 1999-09-29 2001-07-19 Diagnostikforschung Inst Galenische Formulierungen
EP1267935A2 (en) * 2000-01-12 2003-01-02 Light Sciences Corporation Novel treatment for eye disease
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
US6180087B1 (en) 2000-01-18 2001-01-30 Mallinckrodt Inc. Tunable indocyanine dyes for biomedical applications
US7198778B2 (en) * 2000-01-18 2007-04-03 Mallinckrodt Inc. Tumor-targeted optical contrast agents
US6395257B1 (en) 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US6939532B2 (en) * 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
US7790144B2 (en) 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US6180086B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Hydrophilic cyanine dyes
CA2400622A1 (en) * 2000-02-24 2001-08-30 Eidgenossische Technische Hochschule Zurich Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis
US7575761B2 (en) * 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
EP1381629B1 (de) * 2000-09-07 2008-09-10 Bayer Schering Pharma Aktiengesellschaft REZEPTOR DER EDb-FIBRONEKTIN-DOMÄNE (II)
DE10046215B4 (de) * 2000-09-19 2004-04-15 Institut für Chemo- und Biosensorik Münster e.V. i.Ins. Fluorochrome und deren Verwendung
US7597878B2 (en) 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
DE60116510T2 (de) * 2000-09-19 2006-07-13 Li-Cor, Inc., Lincoln Cyaninfarbstoffe
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
WO2002026891A1 (en) 2000-09-29 2002-04-04 Molecular Probes, Inc. Modified carbocyanine dyes and their conjugates
EP1770129B1 (en) 2000-09-29 2012-07-25 Life Technologies Corporation Modified carbocyanine dyes and their conjugates
US6663847B1 (en) * 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US6669926B1 (en) 2000-10-16 2003-12-30 Mallinckrodt, Inc. Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
US6733744B1 (en) * 2000-10-16 2004-05-11 Mallinckrodt Inc. Indole compounds as minimally invasive physiological function monitoring agents
US20070092450A1 (en) * 2000-10-16 2007-04-26 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US7556797B2 (en) * 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US6716413B1 (en) * 2000-10-16 2004-04-06 Mallinckrodt, Inc. Indole compounds as tissue-specific exogenous optical agents
US20040180809A1 (en) * 2000-10-16 2004-09-16 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US6656451B1 (en) * 2000-10-16 2003-12-02 Mallinckrodt, Inc. Indole compounds as novel dyes for organ function monitoring
AU2002236683A1 (en) 2000-10-27 2002-05-21 Beth Israel Deaconess Medical Center Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
AU2006200164B2 (en) * 2001-04-09 2007-03-08 Oncofluor, Inc. Method for viewing tumor tissue located within a body cavity
US20030031627A1 (en) * 2001-07-31 2003-02-13 Mallinckrodt Inc. Internal image antibodies for optical imaging and therapy
US20030105300A1 (en) 2001-10-17 2003-06-05 Mallinckrodt Inc. Tumor targeted photodiagnostic-phototherapeutic agents
US6761878B2 (en) * 2001-10-17 2004-07-13 Mallinckrodt, Inc. Pathological tissue detection and treatment employing targeted benzoindole optical agents
US20030152577A1 (en) * 2002-02-07 2003-08-14 Mallinckrodt Inc. Dye-bioconjugates for simultaneous optical diagnostic and therapeutic applications
CA2513044A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
EP2301587B1 (en) 2002-03-01 2014-06-25 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2004006963A1 (en) * 2002-07-12 2004-01-22 Beth Israel Deaconess Medical Center Conjugated infrared fluorescent substances for detection of cell death
US20040132092A1 (en) * 2003-01-03 2004-07-08 Stetson Christopher M. Determining the density of functional moieties on polymer reagents
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
PL376459A1 (en) * 2003-01-24 2005-12-27 Schering Ag Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
US20050214859A1 (en) 2003-03-03 2005-09-29 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
US7850946B2 (en) 2003-05-31 2010-12-14 Washington University In St. Louis Macrocyclic cyanine and indocyanine bioconjugates provide improved biomedical applications
US7803624B2 (en) * 2003-09-30 2010-09-28 Cytyc Corporation Automated cytological sample classification
ATE522580T1 (de) * 2003-10-31 2011-09-15 Ge Healthcare Ltd Cyaninfarbstoffe als markieragenzien
WO2005082423A2 (en) * 2003-11-18 2005-09-09 Beth Israel Deaconess Medical Center Serum albumin conjugated to fluorescent substances for imaging
JP2005145921A (ja) * 2003-11-19 2005-06-09 Konica Minolta Medical & Graphic Inc 診断用蛍光造影剤及び蛍光造影診断方法
JP2005170812A (ja) * 2003-12-09 2005-06-30 Konica Minolta Medical & Graphic Inc 蛍光造影剤及び蛍光造影方法
US7682602B2 (en) * 2003-12-19 2010-03-23 Konica Minolta Medical & Graphic, Inc. Near-infrared fluorescent contrast medium
JP4487180B2 (ja) * 2004-03-18 2010-06-23 ソニー株式会社 情報生成装置及び情報生成方法
RU2393167C2 (ru) * 2004-06-16 2010-06-27 Джи-И Хелткер АС Пептидные соединения
US7465810B2 (en) * 2004-10-25 2008-12-16 Anaspec, Inc. Reactive 1,3′-crosslinked carbocyanine
ITMI20050328A1 (it) 2005-03-03 2006-09-04 Univ Degli Studi Milano Composti peptidomimetrici e preparazione di derivati biologicamente attivi
CN101203248A (zh) * 2005-06-21 2008-06-18 马林克罗特公司 光学成像造影剂
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
JP5416970B2 (ja) 2005-09-02 2014-02-12 ビセン メディカル, インコーポレイテッド ニコチン酸及びピコリン酸誘導近赤外線蛍光団
CA2621137C (en) * 2005-09-02 2014-07-29 Visen Medical, Inc. Biocompatible n,n-disubstituted sulfonamide-containing fluorescent dye labels
ES2612738T3 (es) * 2005-09-02 2017-05-18 Visen Medical, Inc. Agentes de formación de imágenes fluorescentes biocompatibles
DE102006029454A1 (de) * 2005-12-05 2007-06-06 Dyomics Gmbh Hydrophile Marker auf Basis von diasteromeren
ATE480596T1 (de) * 2005-12-05 2010-09-15 Dyomics Gmbh Hydrophile marker auf der basis von diastereomeren cyaninen
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
US20070148094A1 (en) * 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
DOP2007000020A (es) 2006-01-31 2007-09-15 Bayer Schering Pharma Ag Modulación de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
EP1815870A1 (en) * 2006-02-01 2007-08-08 DKFZ Deutsches Krebsforschungszentrum Cyanine dye compounds linked to metal chelator for bi-modal diagnostic imaging
US8735177B2 (en) 2006-02-23 2014-05-27 Adeka Corporation Diagnostic marker
US20100022449A1 (en) * 2006-03-09 2010-01-28 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
ES2374507T3 (es) 2006-03-31 2012-02-17 Wako Pure Chemical Industries, Ltd. Colorante de cianina a base de pirazol.
US20070281363A1 (en) * 2006-04-13 2007-12-06 Ewald Terpetschnig Luminescent compounds
US20080076188A1 (en) * 2006-06-19 2008-03-27 Patsenker Leonid D Luminescent compounds
US7993927B2 (en) 2006-07-03 2011-08-09 Beth Israel Deaconess Medical Center, Inc. Histology methods
WO2008060833A2 (en) 2006-10-24 2008-05-22 The Research Foundation Of State University Of New York Composition, method, system, and kit for optical electrophysiology
JP5364589B2 (ja) 2006-12-11 2013-12-11 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 診断および治療適用用フィブリン結合ペプチドコンジュゲート
DE102007002726A1 (de) * 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
WO2008094637A2 (en) 2007-01-30 2008-08-07 Seta Biomedicals. Llc Luminescent compounds
JP5476989B2 (ja) 2007-01-31 2014-04-23 和光純薬工業株式会社 ゲノムdna断片の増幅または欠失の検出方法
JP5643514B2 (ja) 2007-02-09 2014-12-17 ビセン メディカル, インコーポレイテッド ポリシクロ染料およびその使用
WO2008109832A2 (en) * 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
JP2008261784A (ja) * 2007-04-13 2008-10-30 Olympus Corp 生体観察方法
EP2005970A1 (de) 2007-06-22 2008-12-24 Berlin Science Partners GmbH i.V. Bildgebende Diagnostik durch Kombination von Kontrastmitteln
EP2197340A4 (en) 2007-09-19 2015-10-21 Oncofluor Inc METHOD FOR THE PRESENTATION AND TREATMENT OF ORGANS AND WOVEN FABRICS
DE102007059752A1 (de) 2007-12-10 2009-06-18 Bayer Schering Pharma Aktiengesellschaft Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone
CN101946171B (zh) 2007-12-14 2014-03-12 拜奥蒂乌姆股份有限公司 荧光化合物
US8253725B2 (en) * 2007-12-28 2012-08-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Method and system for generating surface models of geometric structures
CA2749108C (en) 2008-01-18 2017-06-27 Visen Medical, Inc. Intramolecularly-quenched fluorescent imaging agents
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
WO2009104741A1 (ja) 2008-02-22 2009-08-27 和光純薬工業株式会社 β-グルカン及び/又はエンドトキシン測定用基質並びに測定方法
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
US7951959B2 (en) 2008-09-17 2011-05-31 Thermo Fisher Scientific (Milwaukee) LLC Hydrophilic labels for biomolecules
EP2362884B1 (en) * 2008-10-27 2017-08-02 Sony Corporation A dye comprising a chromophore to which an acyloin group is attached
WO2010057944A1 (en) * 2008-11-20 2010-05-27 Ge Healthcare As Dye conjugate imaging agents
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
US20100143258A1 (en) * 2008-12-05 2010-06-10 General Electric Company Tumor margin imaging agents
GB0823315D0 (en) 2008-12-22 2009-01-28 Ge Healthcare As Fluorescent Probes
JP5500875B2 (ja) * 2009-01-30 2014-05-21 キヤノン株式会社 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤
WO2010106169A1 (en) 2009-03-19 2010-09-23 General Electric Company Optical imaging agents
CA2758952C (en) * 2009-04-17 2016-01-12 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
DK2470887T3 (da) 2009-08-28 2020-04-06 Visen Medical Inc Systemer til tomografisk billeddannelse i diffuse medier ved at anvende en hybrid inversionsteknik
US8401619B2 (en) 2009-09-22 2013-03-19 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
DE102010022110A1 (de) * 2010-05-31 2011-12-01 LMU Universität München Department Chemie Cyaninfarbstoffe als Kontrastmittel zur Unterstützung der Augenchirurgie
US8623324B2 (en) 2010-07-21 2014-01-07 Aat Bioquest Inc. Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
ES2732832T3 (es) * 2010-07-30 2019-11-26 Smartdyelivery Gmbh Procedimiento de medición para determinar una función de un órgano
GB201015806D0 (en) 2010-09-21 2010-10-27 Ge Healthcare As Vascular imaging agents
EP2630196B1 (en) 2010-10-20 2017-09-06 Li-Cor, Inc. Cyanine dyes and their conjugates
EP3029027B1 (en) 2010-12-21 2018-06-27 Pierce Biotechnology, Inc. Fluorescent compounds
US10221159B2 (en) 2011-05-09 2019-03-05 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
GB201116733D0 (en) 2011-09-28 2011-11-09 Ge Healthcare As Peptide margin imaging agents
EP2806781B1 (en) 2012-01-23 2018-03-21 Washington University Goggle imaging systems and methods
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
US20140072515A9 (en) 2012-03-02 2014-03-13 Greg Hermanson Cyanine compounds
US9932625B2 (en) 2012-03-22 2018-04-03 Wako Pure Chemical Industries, Ltd. Method for identification and detection of mutant gene using intercalator
EP2840136B1 (en) 2012-03-22 2017-02-08 Wako Pure Chemical Industries, Ltd. Method for detecting dna having microsatellite region
US9375493B2 (en) 2012-03-30 2016-06-28 Visen Medical, Inc. Bacterial imaging agents and methods of using same
JP6398093B2 (ja) * 2012-04-13 2018-10-03 ベイカー ハート アンド ダイアベーツ インスティテュート アテローム斑の検出
CN104470546B (zh) * 2012-07-20 2018-02-27 佳能株式会社 化合物和含有所述化合物的光声成像造影剂
EP2885006B1 (en) 2012-08-15 2018-08-08 VisEn Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
WO2014035712A1 (en) 2012-08-28 2014-03-06 Pierce Biotechnology, Inc. Benzopyrylium compounds
EP2906106B1 (en) 2012-10-15 2023-06-14 VisEn Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
EP2970674B1 (en) 2013-03-15 2018-12-12 VisEn Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
AU2014228504C1 (en) 2013-03-15 2019-10-03 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
SG11201507287SA (en) 2013-03-15 2015-10-29 Univ California Peptides having reduced toxicity that stimulate cholesterol efflux
US9353092B2 (en) 2013-06-27 2016-05-31 University Of Notre Dame Du Lac Synthesis and use of croconaine compounds
US10471163B2 (en) 2013-09-13 2019-11-12 The General Hospital Corporation Activatable fibrin-binding probes
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
CA2929116C (en) 2013-10-31 2024-02-27 Beth Israel Deaconess Medical Center Near-infrared fluorescent contrast bioimaging agents and methods of use thereof
US10022189B2 (en) 2013-12-16 2018-07-17 Stryker Sustainability Solutions, Inc. Apparatus and method for cleaning an instrument
CN113349707A (zh) 2013-12-31 2021-09-07 纪念斯隆-凯特琳癌症中心 用于荧光源实时多通道成像的系统、方法和设备
KR20150145468A (ko) 2014-06-19 2015-12-30 김영미 숯 성형물의 제조방법 및 이에 의해 제조된 숯 성형물
UA109751C2 (uk) * 2014-09-26 2015-09-25 Спосіб визначення гідрогелю в біологічних тканинах
US10335501B2 (en) 2014-12-15 2019-07-02 Memorial Sloan Kettering Cancer Center Cyclic peptides with enhanced nerve-binding selectively, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging
WO2016179350A1 (en) 2015-05-06 2016-11-10 Washington University Compounds having rd targeting motifs and methods of use thereof
US9670318B2 (en) 2015-05-28 2017-06-06 Miltenyi Biotec Gmbh Bright fluorochromes based on multimerization of fluorescent dyes
EP3098269B1 (en) 2015-05-28 2022-04-06 Miltenyi Biotec B.V. & Co. KG Bright fluorochromes based on multimerization of fluorescent dyes on branched polyether scaffolds
US20190090750A1 (en) 2015-12-15 2019-03-28 Memorial Sloan Kettering Cancer Center Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
EP3450963A4 (en) * 2016-04-28 2020-01-29 National University Corporation Nagoya University FLUORESCENCE PROBE, FLUORESCENCE DETECTION METHOD AND METHOD FOR USING A FLUORESCENCE PROBE
KR101855395B1 (ko) * 2016-09-26 2018-05-09 부경대학교 산학협력단 근적외선을 이용한 폐종양 스크리닝 방법
US11660354B2 (en) 2016-11-30 2023-05-30 Memorial Sloan Kettering Cancer Center Inhibitor-functionalized ultrasmall nanoparticles and methods thereof
EP3412303A1 (en) 2017-06-08 2018-12-12 Medizinische Universität Innsbruck Improved pharmacokinetics and cholecystokinin-2 receptor (cck2r) targeting for diagnosis and therapy
US11091646B2 (en) 2017-08-14 2021-08-17 Seta Biomedicals, Llc Luminescent squaraine rotaxane compounds
CA3095410A1 (en) 2018-03-30 2019-10-03 Perkinelmer Health Sciences, Inc. Systems and methods for 3d reconstruction of anatomical organs and inclusions using short-wave infrared (swir) projection tomography
FI3969063T3 (fi) 2019-05-13 2023-09-15 Bracco Imaging Spa Muunnettuja syaniiniväriaineita ja niiden konjugaatteja
KR20210069945A (ko) 2019-12-04 2021-06-14 삼성전자주식회사 생체정보 추산 장치 및 방법
WO2021119423A1 (en) 2019-12-13 2021-06-17 Washington University Near infrared fluorescent dyes, formulations and related methods
EP4015004A1 (en) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglycan specific branched peptides

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1522421A1 (de) * 1967-01-17 1969-07-31 Agfa Gevaert Ag Optisch sensibilisiertes lichtempfindliches Material
JPS5552750A (en) * 1978-10-12 1980-04-17 Mochida Pharm Co Ltd Laser knife* which can be detected* of tumor portion
JPS55116259A (en) * 1979-03-01 1980-09-06 Fuji Photo Film Co Ltd Microimmunoassay method
US4541438A (en) * 1983-06-02 1985-09-17 The Johns Hopkins University Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light
WO1989010758A1 (en) * 1988-05-02 1989-11-16 Zynaxis Technologies, Inc. Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles
DE3828360A1 (de) * 1988-08-20 1990-02-22 Stanowsky Alexander Dr Farbstoff-markierter antitumor-antikoerper und verfahren zu seiner herstellung
DE3912046B4 (de) * 1988-09-02 2004-03-25 Carnegie Mellon University Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt
US5153112A (en) * 1988-09-05 1992-10-06 Konica Corporation Method of processing silver halide photographic materials
SE8900612D0 (sv) * 1989-02-22 1989-02-22 Jonas Johansson Vaevnadskarakterisering utnyttjande ett blodfritt fluorescenskriterium
US4945239A (en) * 1989-03-29 1990-07-31 Center For Innovative Technology Early detection of breast cancer using transillumination
US5098379A (en) * 1990-01-10 1992-03-24 Rochester Medical Corporation Catheter having lubricated outer sleeve and methods for making and using same
ES2163393T3 (es) * 1990-05-15 2002-02-01 Hyperion Inc Porfirina fluorescente y ftalocianina fluorescente - derivados de polietilenglicol, poliol y sacaridos como sondas fluorescentes.
US5880287A (en) * 1990-05-15 1999-03-09 Hyperion, Inc. Polyoxyhydrocarbyl related products and methods for fluorescence assays
WO1992000748A1 (en) * 1990-07-06 1992-01-23 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
DE4136769A1 (de) * 1991-11-05 1993-05-06 Humboldt-Universitaet Zu Berlin, O-1086 Berlin, De Verfahren zum diagnostizieren von mit fluoreszierenden substanzen angereicherten, insbesondere tumoroesen gewebebereichen
US5298379A (en) 1992-06-30 1994-03-29 Eastman Kodak Company Radiation sensitive element with absorber dye to enhance spectral sensitivity range
DE4323368C2 (de) * 1993-07-13 1998-01-15 Domschke Wolfram Verwendung einer Markersubstanz zur Unterscheidung von verändertem Gewebe in einer Umgebung von unverändertem Gewebe
US6238931B1 (en) * 1993-09-24 2001-05-29 Biosite Diagnostics, Inc. Fluorescence energy transfer in particles
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
CN1173954C (zh) * 1996-01-16 2004-11-03 鲁米根公司 与磷酸酶反应产生化学发光的化合物、组合物和方法
DE19649971A1 (de) * 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US7175953B2 (en) * 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6630570B1 (en) * 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
EP1088559A3 (de) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
JP2003261464A (ja) * 2002-03-07 2003-09-16 Fuji Photo Film Co Ltd 近赤外蛍光造影剤および蛍光造影法
US20060239916A1 (en) * 2005-01-07 2006-10-26 Kai Licha Use of cyanine dyes for the diagnosis of proliferative diseases
EP1743658A1 (en) * 2005-07-14 2007-01-17 Schering Aktiengesellschaft Optical imaging of rheumatoid arthritis

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