ES2163393T3 - Porfirina fluorescente y ftalocianina fluorescente - derivados de polietilenglicol, poliol y sacaridos como sondas fluorescentes. - Google Patents
Porfirina fluorescente y ftalocianina fluorescente - derivados de polietilenglicol, poliol y sacaridos como sondas fluorescentes.Info
- Publication number
- ES2163393T3 ES2163393T3 ES91912121T ES91912121T ES2163393T3 ES 2163393 T3 ES2163393 T3 ES 2163393T3 ES 91912121 T ES91912121 T ES 91912121T ES 91912121 T ES91912121 T ES 91912121T ES 2163393 T3 ES2163393 T3 ES 2163393T3
- Authority
- ES
- Spain
- Prior art keywords
- fluorescent
- sacarids
- porfirina
- ftalocianine
- polyol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002202 Polyethylene glycol Substances 0.000 title 1
- 239000007850 fluorescent dye Substances 0.000 title 1
- 229920001223 polyethylene glycol Polymers 0.000 title 1
- 229920005862 polyol Polymers 0.000 title 1
- 150000003077 polyols Chemical class 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0036—Porphyrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0015—Phosphorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B47/00—Porphines; Azaporphines
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B47/00—Porphines; Azaporphines
- C09B47/04—Phthalocyanines abbreviation: Pc
- C09B47/06—Preparation from carboxylic acids or derivatives thereof, e.g. anhydrides, amides, mononitriles, phthalimide, o-cyanobenzamide
- C09B47/073—Preparation from isoindolenines, e.g. pyrrolenines
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B47/00—Porphines; Azaporphines
- C09B47/04—Phthalocyanines abbreviation: Pc
- C09B47/08—Preparation from other phthalocyanine compounds, e.g. cobaltphthalocyanineamine complex
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B47/00—Porphines; Azaporphines
- C09B47/04—Phthalocyanines abbreviation: Pc
- C09B47/08—Preparation from other phthalocyanine compounds, e.g. cobaltphthalocyanineamine complex
- C09B47/24—Obtaining compounds having —COOH or —SO3H radicals, or derivatives thereof, directly bound to the phthalocyanine radical
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
- G01N2333/19—Rubella virus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
SE PRESENTAN COMPONENTES MARCADORES QUE SON COMPATIBLES CON SOLUCIONES ACUOSAS, EXHIBEN PROPIEDADES FAVORABLES DE FLUORESCENCIA Y EXHIBEN UNA CAPACIDAD DE UNION NO ESPECIFICA DISMINUIDA CON LAS MACROMOLECULAS EN LA SOLUCION. ESTOS COMPONENTES MARCADORES SON UTILES EN APLICACIONES TALES COMO INMUNOENSAYOS DE FLUORESCENCIA, FORMACION DE IMAGENES IN VIVO Y TERAPIA DE TUMORES IN VIVO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52360190A | 1990-05-15 | 1990-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2163393T3 true ES2163393T3 (es) | 2002-02-01 |
Family
ID=24085661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91912121T Expired - Lifetime ES2163393T3 (es) | 1990-05-15 | 1991-05-15 | Porfirina fluorescente y ftalocianina fluorescente - derivados de polietilenglicol, poliol y sacaridos como sondas fluorescentes. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5403928A (es) |
EP (1) | EP0529002B1 (es) |
JP (1) | JP3224538B2 (es) |
AT (1) | ATE206395T1 (es) |
DE (1) | DE69132750T2 (es) |
ES (1) | ES2163393T3 (es) |
WO (1) | WO1991018006A1 (es) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5648270A (en) * | 1995-02-06 | 1997-07-15 | Molecular Probes, Inc. | Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles |
US5880287A (en) * | 1990-05-15 | 1999-03-09 | Hyperion, Inc. | Polyoxyhydrocarbyl related products and methods for fluorescence assays |
US5919922A (en) * | 1990-05-15 | 1999-07-06 | Hyperion, Inc. | Fluorescent dyes free of aggregation and serum binding |
US5641878A (en) * | 1991-05-15 | 1997-06-24 | Diatron Corporation | Porphyrin, azaporphyrin, and related fluorescent dyes free of aggregation and serum binding |
US6060598A (en) * | 1990-05-15 | 2000-05-09 | Hyperion, Inc. | Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding |
US5606045A (en) * | 1990-05-15 | 1997-02-25 | Diatron Corporation | Nucleic acid probes and methods |
US5846703A (en) * | 1990-05-15 | 1998-12-08 | Diatron Corporation | Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding |
FR2680787B1 (fr) * | 1991-08-30 | 1994-11-04 | Cis Bio Int | Complexes macrocycliques de terres rares et leur utilisation pour reduire les interferences dans un dosage par fluorescence. |
TW235298B (es) * | 1992-02-27 | 1994-12-01 | Ciba Geigy | |
EP0632893A4 (en) * | 1992-03-23 | 1997-01-02 | Diatron Corp | FLUORESCENCE IMMUNOASSAYS USING FLUORESCENT MATRICES FREE OF AGGREGATE AND SERUM BINDER. |
US5493017A (en) * | 1992-08-14 | 1996-02-20 | The Trustees Of The University Of Pennsylvania | Ring-metalated porphyrins |
US5371199B1 (en) * | 1992-08-14 | 1995-12-26 | Univ Pennsylvania | Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor |
US5817830A (en) * | 1992-08-14 | 1998-10-06 | Trustees Of The University Of Pennsylvania | Pyrrolic compounds |
US5599924A (en) * | 1992-08-14 | 1997-02-04 | Trustees Of The University Of Pennsylvania | Electron-deficient porphyrins and processes and intermediates for preparing same |
JP3218770B2 (ja) * | 1993-01-14 | 2001-10-15 | 富士ゼロックス株式会社 | 電子写真感光体とそのためのフタロシアニン顔料および顔料分散液 |
US5824799A (en) * | 1993-09-24 | 1998-10-20 | Biosite Diagnostics Incorporated | Hybrid phthalocyanine derivatives and their uses |
US6238931B1 (en) * | 1993-09-24 | 2001-05-29 | Biosite Diagnostics, Inc. | Fluorescence energy transfer in particles |
US7322927B2 (en) | 1993-09-24 | 2008-01-29 | Biosite, Inc. | Hybrid phthalocyanine derivatives and their uses |
EP0649667B1 (en) * | 1993-10-20 | 2001-02-28 | Antonella Aprile Carpenter | Quantum energy therapeutic biostimulation apparatus |
DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
US5679661A (en) * | 1995-07-25 | 1997-10-21 | The Procter & Gamble Company | Low hue photodisinfectants |
US5916481A (en) * | 1995-07-25 | 1999-06-29 | The Procter & Gamble Company | Low hue photobleaches |
US5763602A (en) * | 1996-10-01 | 1998-06-09 | Li; Ying-Syi | Methods of syntheses of phthalocyanine compounds |
WO1998032825A2 (en) | 1997-01-24 | 1998-07-30 | The Procter & Gamble Company | Photochemical singlet oxygen generators having enhanced singlet oxygen yields |
CN1250472A (zh) | 1997-01-24 | 2000-04-12 | 普罗格特-甘布尔公司 | 光化学超氧化物发生剂 |
BR9807536A (pt) | 1997-01-24 | 2000-03-21 | Procter & Gamble | Composições de fotoalvejamento eficazes em tecido com mancha escura. |
ZA98526B (en) | 1997-01-24 | 1998-07-29 | Procter & Gamble | Photochemical singlet oxgen generators having cationic substantivity modifiers |
CN1250473A (zh) | 1997-01-24 | 2000-04-12 | 普罗格特-甘布尔公司 | 低色度光漂白剂 |
WO1998032824A2 (en) | 1997-01-24 | 1998-07-30 | The Procter & Gamble Company | Singlet oxygen generators having enhanced heavy atom effect |
BR9807510A (pt) | 1997-01-24 | 2000-03-21 | Procter & Gamble | Composições de fotoalvejamento compreendendo metalocianinas mistas |
US6544797B1 (en) * | 1997-04-09 | 2003-04-08 | Biosite Diagnostics, Inc. | Compositions and methods for inhibiting light-induced inactivation of biological reagents |
US6165741A (en) * | 1997-05-30 | 2000-12-26 | The Trustees Of The University Of Pennsylvania | Method for rapid detection of bacterial growth in cultures |
US7745142B2 (en) * | 1997-09-15 | 2010-06-29 | Molecular Devices Corporation | Molecular modification assays |
US7632651B2 (en) * | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
US20050227294A1 (en) * | 1997-09-15 | 2005-10-13 | Molecular Devices Corporation | Molecular modification assays involving lipids |
US6033918A (en) * | 1997-11-10 | 2000-03-07 | Bayer Corporation | Method and device for the detection of analyte in a fluid sample |
US5990486A (en) * | 1997-11-21 | 1999-11-23 | University Of Massachusetts | Apparatus and method for measuring components of a solute stream |
EP2283872A3 (en) * | 1998-04-03 | 2011-02-23 | Mallinckrodt Inc. | Non-covalent bioconjugates useful for diagnosis and therapy |
GB2337523A (en) * | 1998-04-29 | 1999-11-24 | Nycomed Imaging As | Light imaging contrast agents |
US6592847B1 (en) | 1998-05-14 | 2003-07-15 | The General Hospital Corporation | Intramolecularly-quenched near infrared flourescent probes |
US6083486A (en) * | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
EP1107971B1 (en) | 1998-08-28 | 2004-11-24 | Destiny Pharma Limited | Porphyrin derivatives, their use in photodynamic therapy and medical devices containing them |
US7547721B1 (en) | 1998-09-18 | 2009-06-16 | Bayer Schering Pharma Ag | Near infrared fluorescent contrast agent and fluorescence imaging |
JP2000095758A (ja) | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
EA200200635A1 (ru) * | 1999-12-15 | 2002-12-26 | Шеринг Акциенгезельшафт | Флуоресцентный контрастный агент для ближней инфракрасной области спектра и способ флуоресцентной визуализации |
US7383076B2 (en) * | 2000-11-27 | 2008-06-03 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
US20030044353A1 (en) * | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
EP1412749A4 (en) * | 2001-06-28 | 2006-12-13 | Ia Inc | OPTICAL FIBER SENSOR ARRAY |
JP5000050B2 (ja) | 2001-08-31 | 2012-08-15 | 浩 前田 | 抗腫瘍剤及びその製造方法 |
WO2003079015A1 (en) * | 2002-03-11 | 2003-09-25 | Visen Medical, Inc. | Optical imaging probes |
US7005518B2 (en) * | 2002-10-25 | 2006-02-28 | Li-Cor, Inc. | Phthalocyanine dyes |
US7371524B2 (en) * | 2003-06-17 | 2008-05-13 | Hannjorg Hereth | Substituted azaporphyrins as fluorescence labels |
US20070238921A1 (en) * | 2004-11-01 | 2007-10-11 | Weirich John P | Capsule imaging device using fluorescent light |
US7776567B2 (en) | 2005-03-17 | 2010-08-17 | Biotium, Inc. | Dimeric and trimeric nucleic acid dyes, and associated systems and methods |
US7601498B2 (en) | 2005-03-17 | 2009-10-13 | Biotium, Inc. | Methods of using dyes in association with nucleic acid staining or detection and associated technology |
EP1901781A2 (en) * | 2005-06-21 | 2008-03-26 | Mallinckrodt, Inc. | Optical imaging contrast agents |
EP1780213A1 (en) * | 2005-10-27 | 2007-05-02 | 3M Innovative Properties Company | Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups |
WO2007100392A2 (en) | 2005-11-30 | 2007-09-07 | Biotium, Inc. | Enzyme substrate comprising a functional dye and associated technology and methods |
US20080003694A1 (en) * | 2006-04-18 | 2008-01-03 | Swanson Basil I | Robust, self-assembled, biocompatible films |
US9193746B2 (en) * | 2006-12-07 | 2015-11-24 | Biotium, Inc. | Luminescent metal complexes and associated technology |
CA2749108C (en) * | 2008-01-18 | 2017-06-27 | Visen Medical, Inc. | Intramolecularly-quenched fluorescent imaging agents |
DK2250223T3 (en) * | 2008-02-06 | 2017-02-06 | Barry J Noar | Method of incorporating compound into matrices |
US9632094B2 (en) * | 2008-08-22 | 2017-04-25 | Norbert Gretz | Transcutaneous organ function measurement |
DE102009018688B4 (de) | 2009-04-23 | 2017-03-02 | Knauf Insulation | Mineralwolleprodukt |
US8877437B1 (en) | 2009-12-23 | 2014-11-04 | Biotium, Inc. | Methods of using dyes in association with nucleic acid staining or detection |
CN102676154B (zh) * | 2011-03-11 | 2014-01-29 | 清华大学 | 磷类酞菁及其衍生物作为荧光探针的应用 |
CN102757437B (zh) * | 2012-06-12 | 2014-10-15 | 中国科学院化学研究所 | 酞菁纳米棒阵列薄膜及其制备方法与应用 |
WO2018140978A1 (en) | 2017-01-30 | 2018-08-02 | Medibeacon Inc. | Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections |
WO2022216978A1 (en) * | 2021-04-09 | 2022-10-13 | Rakuten Medical, Inc. | Phthalocyanine dye compounds, conjugates and methods of use thereof |
EP4299761A1 (en) * | 2022-06-30 | 2024-01-03 | betaSENSE GmbH | Surface-functionalized optical element |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2951797A (en) * | 1957-11-13 | 1960-09-06 | Monsanto Chemicals | Photosensitizers in photoxidation |
US3116256A (en) * | 1961-08-24 | 1963-12-31 | Lawter Chem Inc | Daylight fluorescent compositions |
US3287470A (en) * | 1962-07-10 | 1966-11-22 | Geigy Ag J R | Metal phthalocyanine dyestuffs |
US4104466A (en) * | 1974-03-13 | 1978-08-01 | Eishun Tsuchida | Polymeric metal complex and method of manufacturing the same |
US4404366A (en) * | 1980-05-06 | 1983-09-13 | Miles Laboratories, Inc. | Beta-galactosyl-umbelliferone-labeled hapten conjugates |
US4707454A (en) * | 1981-08-10 | 1987-11-17 | Bio-Diagnostics, Inc. | Fluorescent chlorophyll labeled assay reagents |
EP0127797B1 (de) * | 1983-06-03 | 1987-06-16 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Markermoleküle für Fluoreszenz-Immuno-Assays sowie Verfahren und Zwischenprodukte zu deren Herstellung |
US5059510A (en) * | 1985-02-04 | 1991-10-22 | Hoechst Celanese Corp. | Media for optical information storage comprising an organic macrocyclic chromophore substituted with a film conferring organic substituent |
US4822733A (en) * | 1985-05-28 | 1989-04-18 | Amoco Corporation | Lifetime-resolved assay procedures |
US4732570A (en) * | 1985-09-13 | 1988-03-22 | Milliken Research Corporation | Colored thermoplastic resin |
US4849207A (en) * | 1985-10-23 | 1989-07-18 | Nihon Medi-Physics Co., Ltd. | Porphyrin derivatives |
JPH0645681B2 (ja) * | 1986-02-05 | 1994-06-15 | 美浜 久春 | 修飾ヘム |
JPS62249986A (ja) * | 1986-04-21 | 1987-10-30 | Hamari Yakuhin Kogyo Kk | ポルフイリン誘導体 |
US4877872A (en) * | 1986-06-24 | 1989-10-31 | The University Of Toledo | Production and use of dimers of hematoporophyrin, purpurins, chlorines and purpurin- and chlorin-complexes |
US4814098A (en) * | 1986-09-06 | 1989-03-21 | Bellex Corporation | Magnetic material-physiologically active substance conjugate |
US5135717A (en) * | 1986-12-24 | 1992-08-04 | British Technology Group Usa Inc. | Tetrabenztriazaporphyrin reagents and kits containing the same |
JPH07100714B2 (ja) * | 1987-03-03 | 1995-11-01 | 株式会社三和化学研究所 | ランプテロフラビン及びその製法 |
JPH0778180B2 (ja) * | 1987-04-22 | 1995-08-23 | 東洋インキ製造株式会社 | 顔料組成物 |
DE3809671A1 (de) * | 1988-03-18 | 1989-09-28 | Schering Ag | Porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US5177200A (en) * | 1989-05-19 | 1993-01-05 | Milliken Research Corporation | Poly(oxyalkylene) modified phthalocyanine colorants |
US5053423A (en) * | 1990-03-22 | 1991-10-01 | Quadra Logic Technologies Inc. | Compositions for photodynamic therapy |
-
1991
- 1991-05-15 DE DE69132750T patent/DE69132750T2/de not_active Expired - Fee Related
- 1991-05-15 AT AT91912121T patent/ATE206395T1/de not_active IP Right Cessation
- 1991-05-15 ES ES91912121T patent/ES2163393T3/es not_active Expired - Lifetime
- 1991-05-15 WO PCT/US1991/003424 patent/WO1991018006A1/en active IP Right Grant
- 1991-05-15 US US07/701,449 patent/US5403928A/en not_active Expired - Lifetime
- 1991-05-15 EP EP91912121A patent/EP0529002B1/en not_active Expired - Lifetime
- 1991-05-15 JP JP51118091A patent/JP3224538B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH05508015A (ja) | 1993-11-11 |
EP0529002A1 (en) | 1993-03-03 |
ATE206395T1 (de) | 2001-10-15 |
DE69132750D1 (de) | 2001-11-08 |
WO1991018006A1 (en) | 1991-11-28 |
US5403928A (en) | 1995-04-04 |
EP0529002A4 (en) | 1995-09-13 |
JP3224538B2 (ja) | 2001-10-29 |
DE69132750T2 (de) | 2002-06-20 |
EP0529002B1 (en) | 2001-10-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2163393T3 (es) | Porfirina fluorescente y ftalocianina fluorescente - derivados de polietilenglicol, poliol y sacaridos como sondas fluorescentes. | |
ES2068202T3 (es) | Composicion liquida suavizante para prendas de ropa. | |
ES2132253T3 (es) | Lipidos cationicos. | |
ATE368054T1 (de) | Verbindungen und methoden zur modulierung von occludin-abhängiger gewebepermeabilität | |
ES2185991T3 (es) | Esteres de acido hialuronico, hilos y materiales que los contienen y su uso en cirugia. | |
BR9907042A (pt) | Composição para tintura de oxidação das fibras queratìnicas, processo de tintura das fibras queratìnicas e dispositivo com diversos compartimentos | |
ES2106857T3 (es) | Mejoras en o relacionadas con agentes de contraste. | |
ES2164043T3 (es) | Marcador detectablemente marcado, que comprende un grupo fluoroforo, una sonda fluorescente que comprende el marcador y aplicaciones de los mismos. | |
ES2101499T3 (es) | Fibras. | |
ATE303412T1 (de) | Nicht antigen wirkende verzweigte polymerkonjugate | |
ES2052645T3 (es) | Acidos poliinsaturados con accion vasocinetica y formulaciones farmaceuticas y cosmeticas que los contienen. | |
IT8167730A0 (it) | Carta valori dotata di segni di autenticita realizzati con sostanze luminescenti procedimento per la determinazione dell autenticita ed apparecchio per l attuazione di questo procedimento | |
NO971643D0 (no) | Eter liptid-liposomer og terapeutisk anvendelse derav | |
AR022236A1 (es) | Citoquinas mamiferas purificadas; reactivos y metodos relacionados | |
CA2082936A1 (en) | Fluorescent porphyrin, and fluorescent phthalocyanine-polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes | |
ES2054699T3 (es) | Pigmentos que contienen grupos de piperidilo. | |
GT200200038A (es) | Conjugados peg de hgf-nk4 | |
ES2126145T3 (es) | Redireccionamiento de anticuerpos. | |
FI893428A0 (fi) | Eliminering av toxiska egenskaper in vitro och in vivo hos tnf-a medelst monoklonala antikroppar och fragment haerledda fraon dessa. | |
DE50112841D1 (de) | Verwendung von verzweigten polysäuren in dentalmassen | |
AR022890A1 (es) | Citoquinas mamiferas; reactivos relacionados y metodos | |
ATE115864T1 (de) | Polyethersubstituierte tumormittel. | |
ES2088633T3 (es) | Estabilizantes polisiloxanicos que contienen grupos fenol y grupos oxamidicos estericamente impedidos. | |
FI852730A0 (fi) | (pyrrol-1-yl) -fenyl-dihydropyridazinoner, deras framstaellning och anvaendning. | |
ES2154370T3 (es) | Alquenil-benzoilguanidinas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 529002 Country of ref document: ES |