KR980700091A - 근적외선 조사에 의한 생체내 진단 방법(In-Vivo Diagnostic Process by Near Infrared Radiation) - Google Patents
근적외선 조사에 의한 생체내 진단 방법(In-Vivo Diagnostic Process by Near Infrared Radiation)Info
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- KR980700091A KR980700091A KR1019970703597A KR19970703597A KR980700091A KR 980700091 A KR980700091 A KR 980700091A KR 1019970703597 A KR1019970703597 A KR 1019970703597A KR 19970703597 A KR19970703597 A KR 19970703597A KR 980700091 A KR980700091 A KR 980700091A
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- 238000001727 in vivo Methods 0.000 title claims abstract 5
- 238000002405 diagnostic procedure Methods 0.000 title claims 2
- 230000005855 radiation Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 12
- 125000003118 aryl group Chemical group 0.000 claims abstract 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 9
- 239000000975 dye Substances 0.000 claims abstract 9
- 150000003839 salts Chemical class 0.000 claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 7
- 229920002521 macromolecule Polymers 0.000 claims abstract 6
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims abstract 6
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 5
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract 4
- 125000004181 carboxyalkyl group Chemical group 0.000 claims abstract 4
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 3
- 239000008280 blood Substances 0.000 claims abstract 3
- 210000004369 blood Anatomy 0.000 claims abstract 3
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 3
- 206010028980 Neoplasm Diseases 0.000 claims abstract 2
- 238000010521 absorption reaction Methods 0.000 claims abstract 2
- 238000003745 diagnosis Methods 0.000 claims abstract 2
- HGASFNYMVGEKTF-UHFFFAOYSA-N octan-1-ol;hydrate Chemical compound O.CCCCCCCCO HGASFNYMVGEKTF-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000005192 partition Methods 0.000 claims abstract 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 26
- 239000012634 fragment Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- -1 hapten Proteins 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 159000000000 sodium salts Chemical class 0.000 claims 3
- 125000004964 sulfoalkyl group Chemical group 0.000 claims 3
- 125000000542 sulfonic acid group Chemical group 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004999 nitroaryl group Chemical group 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- DMTLQZRCRZTIRL-UHFFFAOYSA-N CC[N+](C1=C(C2(C)C)C3=CC=CC=C3C=C1)=C2C=C1C(O)=C(C=C2N(CCCCS([O-])(=O)=O)C3=CC=CC=C3C2(C)CCCC(O)=O)C1=O Chemical compound CC[N+](C1=C(C2(C)C)C3=CC=CC=C3C=C1)=C2C=C1C(O)=C(C=C2N(CCCCS([O-])(=O)=O)C3=CC=CC=C3C2(C)CCCC(O)=O)C1=O DMTLQZRCRZTIRL-UHFFFAOYSA-N 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000002867 asparto group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000005026 carboxyaryl group Chemical group 0.000 claims 1
- 235000021466 carotenoid Nutrition 0.000 claims 1
- 150000001747 carotenoids Chemical class 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000004986 diarylamino group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000005027 hydroxyaryl group Chemical group 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- DZVCFNFOPIZQKX-LTHRDKTGSA-M merocyanine Chemical compound [Na+].O=C1N(CCCC)C(=O)N(CCCC)C(=O)C1=C\C=C\C=C/1N(CCCS([O-])(=O)=O)C2=CC=CC=C2O\1 DZVCFNFOPIZQKX-LTHRDKTGSA-M 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- BDRTVPCFKSUHCJ-UHFFFAOYSA-N molecular hydrogen;potassium Chemical class [K].[H][H] BDRTVPCFKSUHCJ-UHFFFAOYSA-N 0.000 claims 1
- 239000000712 neurohormone Substances 0.000 claims 1
- 102000008434 neuropeptide hormone activity proteins Human genes 0.000 claims 1
- 108040002669 neuropeptide hormone activity proteins Proteins 0.000 claims 1
- 239000002858 neurotransmitter agent Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 125000005504 styryl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 229910052714 tellurium Inorganic materials 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/105—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a methine or polymethine dye
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Studio Devices (AREA)
- Laminated Bodies (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
본 발명은 근적외선 범위에서 형광 및 투시 진단을 위한 조영제로서, 각각 특이적인 광물리적 및 약리-화학 성질을 갖는 수용성 염료 및 그들의 생물학적 부가물을 사용하는 근적외선 조사(NIR 조사)에 기초한 생체내 진단 방법. 신규의 염료 및 이러한 염료를 함유하는 약제에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 일반식(Ⅰ)의 화합물 및 그의 생리학적으로 허용되는 염을 사용하는 NIR 조사에 기초한 생체내 진단 방법 :B1-(F-Wn)m (Ⅰ)상기식에서, 1은 0 내지 6의 수를 나타내고, n은 0 내지 10의 수를 나타내며, m은 1 내지 100의 수를 나타내고, B는 특정 세포군에 결합하거나 수용체에 선택적으로 결합하거나, 조직 또는 종양에 축적하거나, 또는 일반적으로 혈액중에 잔류하는 30000 이하의 분자량을 갖는 생물학적 검출 유니트, 또는 비선택적으로 결합하는 거대 분자이며, F는 650 내지 1200㎚의 범위에서 최대 흡수를 보이는 염료를 나타내고, W는 수용해성을 개선하는 친수성 기를 나타내며, 1이 0인 경우에 일반식 (Ⅰ)의 화합물의 n-옥탄올-물 분배 계수는 2.0 이하이다.
- 제 1항에 있어서, 일반식 (Ⅰ)에서 B가 아미노산, 펩타이드, CDR(상보성 결정 영역), 항원, 합텐, 효소 기질, 효소 보조인자, 비오틴, 카로티노이드, 호르몬, 신경 호르몬, 신경 전달물질, 성장 인자, 림포킨, 렉틴, 독소, 탄수화물, 올리고당류, 다당류, 덱스트란, 올리고뉴클레오타이드 또는 수용체-결합 약제를 함유함을 특징으로 하는 방법.
- 제1항 또는 제2항에 있어서, 일반식 (Ⅰ)에 MF가 일반식(Ⅱa)의 시아닌 염료, 일반식(Ⅱb)의 스쿠아라인 염료, 일반식(Ⅱc)의 스티릴 염료 또는 일반식(Ⅱd)의 메로시아닌 염료를 나타냄을 특징으로 하는 방법 :상기 식에서, r은 0.1 또는 2의 수를 나타내고, 단 r이 2인 경우에 이중으로 존재하는 각각의 단편 L6과 L7은 동일하거나 상이 할 수 있으며, L1내지 L7은 동이하거나 상이하고, 각각은 독립적으로 단편 CH 또는 CR을 나타내고, 여기에서 R은 할로겐 원자, 하이드록시, 카복시, 아세톡시, 아미노, 니트로, 시아노 또는 설폰산 기 또는 6개 이하의 탄소 원자를 갖는 알킬, 알케닐, 하이드로시알킬, 카복시알킬, 알콕시, 알콕시카보닐, 설포알킬, 알킬아미노, 디알킬아미노 또는 할로게노알킬 잔기, 9개 이하의 탄소 원자를 갖는 아릴, 알킬아릴, 하이드록시아릴, 카복시아릴, 설포아릴, 아릴아미노, 디아릴아미노, 니트로아릴 또는 할로게노아릴 잔기를 나타내거나, R은 또다른 잔기 R에 결합하여 산재된 잔기 L1내지 L7과 함께 4-내지 6-원 환올 형성하는 결합을 나타내거나, R은 -CO- 단편을 통해 연결된 두개의 상이한 위치에서 각각 하나의 결합을 나타내며, R3내지 R12는 동일하거나 상이하고, 각각은 독립적으로 수소 원자, 상기 정의된 바와 같은 B 또는 W 잔기, 또는 6개 이하의 탄소 원자를 갖는 알킬 또는 알케닐 잔기, 또는 9개 이하의 탄소 원자를 갖는 아릴 또는 아르알킬 잔기를 나타내며, 여기에서 상기 알킬, 알케닐, 아릴 또는 아르알킬 잔기는 임의로 상기 정의된 바와 같은 추가의 W 잔기를 수반하거나, 인접한 잔기 R3내지 R12의 각 쌍은 개재된 탄소 원자와 함께 연결되어 포화, 불포화 또는 방향족일 수 있고, 임의로 상기 정의된 바와 같은 추가의 R 잔기를 수반할 수 있는 5- 내지 6-원 환을 형성하고, X 및 Y는 동일하거나 상이하며, 각각 독립적으로 O, S, Se, Te 또는 -C(CH3)2-, -CH=CH- 또는 -CR13R14- 단편을 나타내며, 여기에서, R13및 R14는 독립적으로 수소 원자, 상기 정의된 바와 같은 B 또는 W잔기, 또는 6개 이하의 탄소 원자를 갖는 알킬 또는 알케닐 잔기, 또는 9개 이하의 탄소원자를 갖는 아릴 또는 아르알킬 잔기를 나타내고, 여기에서 알킬, 알케닐, 아릴 또는 아르알킬 잔기는 임의로 상기 정의된 바와 같은 추가의 W 잔기를 수반하거나, s 및 t는 독립적으로 0 또는 1의 수를 나타내고, 단 s 및 t는 동시에 1을 나타내지 않으며, G는 산소 또는 황 원자를 나타냄을 특징으로 하는 방법.
- 제1항 내지 제3항중 어느 한항에 있어서, 일반식(Ⅰ)에서 W가 카복시 또는 설폰산기 또는 12개 이하의 탄소원자를 갖는 카복시알킬기 또는 알콕시카보닐기 또는 알콕시옥소알킬기이거나 일반식 (Ⅲ)의 잔기를 나타내며,-(CH2-O-Z 또는 (-CH2-CHO )a-Z (Ⅲ)여기에서, a는 0 내지 6의 수를 나타내고, Z는 수소 원자 또는 2 내지 n-1개(n은 탄소 원자의 수이다)개의 하이드록시기를 갖고 3 내지 6개의 탄소 원자를 함유하는 아르알킬 잔기, 6개 내지 10개의 탄소 원자를 갖고 2 내지 4개의 추가의 하이드록시기를 수반하는 아릴 또는 아르알킬 잔기, 또는 1 내지 6개의 탄소원자를 갖고 1 내지 3개의 추가의 카복시기를 수반하는 알킬 잔기, 또는 6 내지 9개의 탄소원자를 갖고 1 내지 3개의 추가의 카복시기를 수반하는 아릴 잔기, 또는 6 내지 15개의 탄소원자를 갖는 아르알킬 잔기 또는 니트로아릴 또는 니트로아르알킬, 또는 2 내지 4개의 탄소원자를 갖고 1 내지 3개의 추가의 카복시기를 수반하는 설포알킬 잔기를 포함하거나, 구조식(Ⅲa) 또는 (Ⅲb)의 잔기,또는 일반식(Ⅲc)의 잔기를 나타내며,-(CH2)o-(CO)p-NR1-(CH2)s-(NH-CO)q-R2(Ⅲc)여기에서, o 및 s는 0, 1, 2, 3, 4, 6 또는 6의 수를 나타내고, p 및 q는 독립적으로 0 또는 1을 나타내며, R1및 R2는 독립적으로 구조식(Ⅲa) 및 (Ⅲb)의 치환체를 제외하고는 상기 정의된 바와 같은 Z 잔기를 나타내거나, p 및 q가 1인 경우에는 독립적으로 구조식 (Ⅲd) 또는 (Ⅲe)의 잔기를 나타내거나,또는 W가 상기 정의된 바와 같은 일반식 (Ⅲc)의 잔기를 나타냄을 특징으로 하는 방법.
- 일반식(Ⅴ)의 시아닌 염료 및 그의 생리학적으로 허용되는 염 :상기 식에서, Q는 단편여기에서, R30은 수소 원자, 하이드록시 기, 카복시 기, 1 내지 4개의 탄소 원자를 갖는 알콕시 잔기 또는 염소 원자를 나타내고, b는 정수 2 또는 3이며, R31은 할로겐 원자 또는 1 내지 4개의 탄소 원자를 갖는 알킬 잔기이고, X 및 Y는 독립적으로 각각 -O-, -S-, -CH=CH- 또는 -C(CH2R32)(CH2R33)-의 단편을 나타내며 R20내지 R29, R32및 R33은 독립적으로 수소 원자, 하이드록시 기, 카복시-, 설폰산 잔기 또는 10개 이하의 탄소 원자를 갖는 카복시알킬-, 알콕시카보닐 또는 알콕시옥소알킬 잔기, 또는 4개 이하의 탄소 원자를 갖는 설포알킬 잔기를 나타내거나, 비선택적으로 결합하는 거대분자를 나타내거나, 일반식(Ⅵ)의 잔기를 나타내며, 단 X 및 Y가 O, S, -CH=CH- 또는 -C(CH3)2-의 경우에 R20내지 R29중의 적어도 하나는 비선택적으로 결합하는 거대분자 도는 일반식(Ⅵ)의 화합물을 나타내며,-(O)v-(CH2)o-CO-NR34-(CH2)s-(NR-CO)q-R35(Ⅵ)[여기에서, o 및 s는 0이거나 독립적으로 1 내지 6의 정수를 나타내고, q 및 v는 독립적으로 0 또는 1을 나타내며, R34는 수소 원자 또는 메틸 잔기를 나타내고, R35는 3 내지 6개의 탄소 원자를 갖고, 2 내지 n-1개(n은 탄소 원자의 수)의 하이드록시 기를 갖는 알킬 잔기, 또는 1 내지 6개의 탄소 원자를 갖고 1 내지 3개의 추가의 카복시기를 수반하는 아킬 잔기, 6 내지 9개의 탄소 원자를 갖는 알릴 잔기 또는 7 내지 15개의 탄소 원자를 갖는 아릴알킬 잔기, 또는 구조식(Ⅲd) 또는 (Ⅲe)의 잔기(단, 이 경우에 q는 1이다).또는 비선택적으로 결합하는 거대분자를 나타낸다]. R20및 R21, R21및 R22, R22및 R23, R24및 R25, R25및 R26, R26및 R27은 또한 개재되어 있는 원자와 함께 5- 또는 6-원 방향족 또는 포화 연결된 환을 형성한다.
- 제5항에 있어서, 5-[2-[(1,2-디카복시에틸)아미노]-2-옥소에틸]-2-[7-[5-[2-(1,2-디카복시에틸)아미노]-2-옥소에틸]-1,3-디하이드로-3,3-디메틸-1-(4-설포부틸)-2H-인돌-2-일리덴]-1,3,5-헵타트리에닐]-3,3-디메틸-1-(4-설포부틸)-3H-인돌리움, 내부염, 칼륨수소 염, 2-[7-[5-[2-[-[(11-카복시-2-옥소-1,4,7,10-테트라아자-4,7,10-트리(카복시메틸)-1-운데실)아미노]-2-옥소에틸]-1,3-디하이드로-3,3-디메틸-1-에틸-2H-인돌-2-일리덴]-1,3,5-헵타트리에닐]-3,3-디메틸-1-(4-설포부틸)-3H-인돌리움, 내부염, 2-[7-[1,3-디하이드로-3,3-디메틸-5-[2-[(메톡시폴리옥시에틸렌)-아미노]-2-옥소에틸]-1-(4-설포부틸)-3H-인돌리움, 내부염, 2-[7-[1,3-디하이드로-3,3-디메틸-1-(4-설포부틸)-2H-인돌-2-일리덴]-1,3,5-헵타트리에닐]-3,3-디메틸-5-(메톡시폴리옥시에틸렌)아미노카보닐-1-(4-설포부틸)-3H-인돌리움, 나트륨염, 3-(3-카복시프로필)-2-[7-[3-(3-카복시프로필)-2-[7-[3(3-카복시프로필)-1,3-디하이드로-3-메틸-1-(4-설포부틸)-2H-인돌-2-일리덴]-1,3,5-헵타트리에닐]-3-메틸-1-(4-설포부틸)-3H-인돌리움, 나트륨염, 2-[[3-[[3-(3-카복시프로필)-1,3-디하이드로 -3-메틸-1-(4-설포부틸)2H-인돌2-일리덴]메틸]2-하이드록시-4-옥소-2-사이클로부텐-1-일리덴]메틸]-1,1-디메틸-3-에틸-1H-벤즈(e)인돌리움, 내부염, 2-[7-[1,3-디하이드로-5-[2-[2,3-디하이드록시프로필)아미노]-2-옥소에틸]-3,3-디메틸-1-(4-설포부틸)-2H-인돌-2-일리덴]-1,3,5-헵타트리에닐]-5-[2-[(2,3-디하이드록시프로필)아미노]-2-옥소에틸]-3,3-디메틸-1-(4-설포부틸)-3H-인도리움, 나트륨염인 시아닌 염료.
- 제5항 또는 제6항에 따르는 시아닌 염료의 NIR 조사에 의한 생체내 진단에서의 용도.
- 공통 보강제, 기질, 및 희석제와 함께 제5항 또는 제6항에 따르는 시아닌 염료의 적어도 하나를 함유함을 특징으로 하는 생체내 진단제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
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1994
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1995
- 1995-10-10 DE DE59510982T patent/DE59510982D1/de not_active Expired - Lifetime
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- 1995-10-10 PT PT95935348T patent/PT796111E/pt unknown
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- 1995-10-10 WO PCT/DE1995/001465 patent/WO1996017628A1/de active IP Right Grant
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1997
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2000
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2001
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2002
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2003
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2006
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2009
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