IL105206A - Indole derivatives and pharmaceutical compositions comprising them - Google Patents

Indole derivatives and pharmaceutical compositions comprising them

Info

Publication number
IL105206A
IL105206A IL10520693A IL10520693A IL105206A IL 105206 A IL105206 A IL 105206A IL 10520693 A IL10520693 A IL 10520693A IL 10520693 A IL10520693 A IL 10520693A IL 105206 A IL105206 A IL 105206A
Authority
IL
Israel
Prior art keywords
compound
alkyl
hydrogen
aryl
formula
Prior art date
Application number
IL10520693A
Other languages
English (en)
Other versions
IL105206A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to IL12132693A priority Critical patent/IL121326A/en
Publication of IL105206A0 publication Critical patent/IL105206A0/xx
Priority to IL12132697A priority patent/IL121326A0/xx
Publication of IL105206A publication Critical patent/IL105206A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL10520693A 1992-04-07 1993-03-29 Indole derivatives and pharmaceutical compositions comprising them IL105206A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL12132693A IL121326A (en) 1992-04-07 1993-03-29 N-substituted pyrolidin-2-yl methyl indole derivatives
IL12132697A IL121326A0 (en) 1992-04-07 1997-07-16 Indole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86473792A 1992-04-07 1992-04-07

Publications (2)

Publication Number Publication Date
IL105206A0 IL105206A0 (en) 1993-07-08
IL105206A true IL105206A (en) 1999-04-11

Family

ID=25343950

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10520693A IL105206A (en) 1992-04-07 1993-03-29 Indole derivatives and pharmaceutical compositions comprising them

Country Status (26)

Country Link
US (7) US5747501A (cs)
EP (1) EP0635017A1 (cs)
JP (1) JP2644088B2 (cs)
KR (1) KR0179072B1 (cs)
CN (2) CN1050841C (cs)
AU (1) AU670579B2 (cs)
BR (1) BR9306201A (cs)
CA (1) CA2133413C (cs)
CZ (1) CZ281763B6 (cs)
EG (1) EG20226A (cs)
FI (1) FI931558L (cs)
HR (1) HRP930752A2 (cs)
HU (1) HUT64062A (cs)
IL (1) IL105206A (cs)
MX (1) MX9302011A (cs)
MY (1) MY108909A (cs)
NO (1) NO303388B1 (cs)
NZ (1) NZ251086A (cs)
PL (1) PL172405B1 (cs)
RU (1) RU2101283C1 (cs)
SK (1) SK280193B6 (cs)
TW (1) TW341565B (cs)
UA (1) UA27467C2 (cs)
WO (1) WO1993020073A1 (cs)
YU (1) YU48931B (cs)
ZA (1) ZA932440B (cs)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
JP2644088B2 (ja) * 1992-04-07 1997-08-25 フアイザー・インコーポレイテツド ５−ｈｔ１作動薬としてのインドール誘導体
ES2070087B1 (es) * 1993-08-13 1996-02-16 Pfizer Derivados de indol
AU686654B2 (en) * 1993-08-31 1998-02-12 Pfizer Inc. 5-arylindole derivatives
AU694226B2 (en) * 1994-05-19 1998-07-16 Merck Sharp & Dohme Limited Piperazine, piperidine and tetrahydropyridine derivatives ofindol-3-ylalkyl as 5-HT1D-alpha agonists
GB9415575D0 (en) * 1994-08-02 1994-09-21 Merck Sharp & Dohme Therapeutic agents
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
EP0796258A1 (en) * 1994-12-06 1997-09-24 MERCK SHARP & DOHME LTD. Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
TR199800157T1 (xx) * 1995-07-31 1998-06-22 Shionogi & Co.,Ltd. Fosfolipaz A2 inhibit�r� aktivitesi olan pirolidin t�revleri.
GB9519558D0 (en) * 1995-09-26 1995-11-29 Merck Sharp & Dohme Therapeutic agents
US6051593A (en) * 1997-06-20 2000-04-18 Sugen, Inc. 3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors
AU4850199A (en) * 1998-06-30 2000-01-17 Eli Lilly And Company Pyrrolidine and pyrroline derivatives having effects on serotonin related systems
CA2339662A1 (en) * 1998-08-07 2000-02-17 Takeda Chemical Industries, Ltd. Benzothiepin derivatives, their production and use
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
US6326388B1 (en) * 1999-12-21 2001-12-04 Celgene Corporation Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
JP4335684B2 (ja) * 2001-12-20 2009-09-30 ワイス ５−ヒドロキシトリプタミン−６リガンドとしてのインドリルアルキルアミン誘導体
RU2218189C1 (ru) * 2002-05-28 2003-12-10 Нижегородская государственная медицинская академия Способ лечения мигрени в межприступном периоде заболевания
US7041697B2 (en) * 2002-09-12 2006-05-09 Wyeth Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
CA2635010A1 (en) * 2005-12-30 2007-07-19 Amjad Ali Oxazolidinone derivatives as cetp inhibitors
CN102186477B (zh) * 2008-10-16 2013-07-17 奥梅-杨森制药有限公司 作为代谢型谷氨酸受体调节剂的吲哚和苯并吗啉衍生物
US20100217013A1 (en) * 2008-12-15 2010-08-26 Wenge Li Enantioselective process for the preparation of zolmitriptan
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CA3021471A1 (en) * 2016-04-28 2017-11-02 Guaili Wu Method for preparing tyrosine kinase inhibitor and derivative thereof
BR112022015379A2 (pt) * 2020-02-04 2022-09-27 Mindset Pharma Inc Derivados de 3-pirrolidino-indol como agentes psicodélicos serotonérgicos para o tratamento de distúrbios do snc
WO2025104491A1 (en) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto

Family Cites Families (28)

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ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
US4689336A (en) * 1981-01-02 1987-08-25 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine 2,4-diones
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
FR2601008B1 (fr) * 1986-07-03 1990-03-30 Sanofi Sa Procede de synthese stereospecifique de derives de l'indole
HU203330B (en) * 1987-06-10 1991-07-29 Pfizer Process for producing oxazolidin-2-one derivatives and hypoglychemic pharmaceutical compositions containing them
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
HU219974B (hu) * 1990-06-07 2001-10-28 Astrazeneca Ab, Heterociklusos csoporttal helyettesített indolszármazék, előállítása és a vegyületet hatóanyagként tartalmazó gyógyszerkészítmények
US5607951A (en) 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5545644A (en) 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
BR9106978A (pt) * 1990-10-15 1993-09-28 Pfizer Derivados de indol
US5559129A (en) 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5559246A (en) 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5578612A (en) 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
TW263508B (cs) * 1991-02-12 1995-11-21 Pfizer
DK0619805T3 (da) 1991-11-25 2000-06-05 Pfizer 5-(Hetero-eller carbocyclylamino)-indolderivater, deres fremstilling og anvendelse som 5-HT1-agonister
CA2083891A1 (en) * 1991-12-03 1993-06-04 Angus Murray Macleod Heterocyclic compounds, compositions containing them and their use in therapy
US5409941A (en) 1992-02-03 1995-04-25 Pfizer Inc. 5-heteroyl indole derivatives
TW288010B (cs) 1992-03-05 1996-10-11 Pfizer
JP2644088B2 (ja) * 1992-04-07 1997-08-25 フアイザー・インコーポレイテツド ５−ｈｔ１作動薬としてのインドール誘導体
ATE148465T1 (de) 1992-04-10 1997-02-15 Pfizer Acylaminoindolderivate als 5-ht1 agonisten
JP7121942B2 (ja) 2018-04-10 2022-08-19 アサヒビール株式会社 発泡性飲料移充填方法
JP7121943B2 (ja) 2018-04-27 2022-08-19 日本ゼオン株式会社 レジストパターン形成方法

Also Published As

Publication number Publication date
WO1993020073A1 (en) 1993-10-14
NZ251086A (en) 1996-09-25
ZA932440B (en) 1994-10-05
CZ246494A3 (en) 1995-06-14
YU23893A (sh) 1996-10-09
NO943762D0 (no) 1994-10-06
US6150388A (en) 2000-11-21
SK120694A3 (en) 1995-05-10
CN1083443C (zh) 2002-04-24
TW341565B (en) 1998-10-01
SK280193B6 (sk) 1999-09-10
CA2133413A1 (en) 1993-10-14
NO943762L (no) 1994-10-06
CZ281763B6 (cs) 1997-01-15
AU3789893A (en) 1993-11-08
FI931558A7 (fi) 1993-10-08
NO303388B1 (no) 1998-07-06
MX9302011A (es) 1994-03-31
CN1225362A (zh) 1999-08-11
BR9306201A (pt) 1998-06-23
CA2133413C (en) 2001-04-10
CN1082543A (zh) 1994-02-23
EP0635017A1 (en) 1995-01-25
CN1050841C (zh) 2000-03-29
HUT64062A (en) 1993-11-29
JP2644088B2 (ja) 1997-08-25
US5747501A (en) 1998-05-05
MY108909A (en) 1996-11-30
KR950700906A (ko) 1995-02-20
IL105206A0 (en) 1993-07-08
EG20226A (en) 1997-12-31
US6387937B1 (en) 2002-05-14
FI931558A0 (fi) 1993-04-06
US6387941B1 (en) 2002-05-14
JPH07504919A (ja) 1995-06-01
YU48931B (sh) 2002-12-10
RU94045897A (ru) 1996-09-10
US6436957B1 (en) 2002-08-20
AU670579B2 (en) 1996-07-25
HU9301003D0 (en) 1993-06-28
US6465500B1 (en) 2002-10-15
US6410739B1 (en) 2002-06-25
UA27467C2 (uk) 2000-09-15
FI931558L (fi) 1993-10-08
RU2101283C1 (ru) 1998-01-10
KR0179072B1 (ko) 1999-03-20
HRP930752A2 (en) 1994-10-31
PL172405B1 (en) 1997-09-30

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Legal Events

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