IL101312A - Aminoguanidines, their preparation and pharmaceutical compositions containing them - Google Patents
Aminoguanidines, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL101312A IL101312A IL101312A IL10131292A IL101312A IL 101312 A IL101312 A IL 101312A IL 101312 A IL101312 A IL 101312A IL 10131292 A IL10131292 A IL 10131292A IL 101312 A IL101312 A IL 101312A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- hydrogen
- aryl
- carbonyl
- hydroxy
- Prior art date
Links
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical class NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 22
- 229910052739 hydrogen Inorganic materials 0.000 abstract 20
- 239000001257 hydrogen Substances 0.000 abstract 20
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 14
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- -1 piperidino, pyrazinyl Chemical group 0.000 abstract 4
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 208000017228 Gastrointestinal motility disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- JYNZIOFUHBJABQ-UHFFFAOYSA-N allyl-{6-[3-(4-bromo-phenyl)-benzofuran-6-yloxy]-hexyl-}-methyl-amin Chemical group C=1OC2=CC(OCCCCCCN(C)CC=C)=CC=C2C=1C1=CC=C(Br)C=C1 JYNZIOFUHBJABQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- SYGWYBOJXOGMRU-UHFFFAOYSA-N chembl233051 Chemical group C1=CC=C2C3=CC(C(N(CCN(C)C)C4=O)=O)=C5C4=CC=CC5=C3SC2=C1 SYGWYBOJXOGMRU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000004929 pyrrolidonyl group Chemical group N1(C(CCC1)=O)* 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid Fuels And Fuel-Associated Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919106179A GB9106179D0 (en) | 1991-03-22 | 1991-03-22 | Improvements in or relating to organic compounds |
| GB919107927A GB9107927D0 (en) | 1991-04-15 | 1991-04-15 | Improvements in or relating to organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL101312A0 IL101312A0 (en) | 1992-11-15 |
| IL101312A true IL101312A (en) | 1997-03-18 |
Family
ID=26298625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL101312A IL101312A (en) | 1991-03-22 | 1992-03-20 | Aminoguanidines, their preparation and pharmaceutical compositions containing them |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5510353A (sk) |
| EP (1) | EP0505322B1 (sk) |
| JP (1) | JP2593022B2 (sk) |
| KR (1) | KR100198018B1 (sk) |
| AT (1) | ATE170838T1 (sk) |
| AU (1) | AU651442B2 (sk) |
| CA (1) | CA2063671C (sk) |
| CZ (1) | CZ284339B6 (sk) |
| DE (1) | DE69226894T2 (sk) |
| DK (1) | DK0505322T3 (sk) |
| ES (1) | ES2121836T3 (sk) |
| FI (2) | FI102371B1 (sk) |
| HK (1) | HK1011028A1 (sk) |
| HU (2) | HUT64023A (sk) |
| IE (1) | IE920895A1 (sk) |
| IL (1) | IL101312A (sk) |
| MX (1) | MX9201244A (sk) |
| MY (1) | MY108158A (sk) |
| NO (1) | NO179171C (sk) |
| NZ (1) | NZ242069A (sk) |
| RO (1) | RO109194B1 (sk) |
| SG (1) | SG43221A1 (sk) |
| SK (1) | SK279214B6 (sk) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993024117A2 (en) * | 1992-05-23 | 1993-12-09 | Smithkline Beecham Plc | Medicaments for the treatment of anxiety |
| WO1994000113A2 (en) * | 1992-06-27 | 1994-01-06 | Smithkline Beecham Plc | Medicaments containing 5-ht4 receptor antagonists |
| GB9226532D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| JP3035818B2 (ja) * | 1997-10-21 | 2000-04-24 | 日本精工株式会社 | 玉軸受 |
| WO1999054906A1 (fr) | 1998-04-16 | 1999-10-28 | Toshiba Lighting & Technology Corporation | Lampe a decharge electrique a haute pression et dispositif d'eclairage |
| EE05054B1 (et) * | 1998-08-21 | 2008-08-15 | Novartis Ag | 5-HT4 agonisti v?i antagonisti peroraalne ravimkoostis ja selle kasutamine meditsiinis |
| US20040092511A1 (en) * | 1999-12-10 | 2004-05-13 | Billstein Stephan Anthony | Pharmaceutical combinations and their use in treating gastrointestinal and abdominal viscera disorders |
| TWI263496B (en) * | 1999-12-10 | 2006-10-11 | Novartis Ag | Pharmaceutical combinations and their use in treating gastrointestinal disorders |
| GB0019357D0 (en) | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0019359D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel guanidines |
| CN1330641C (zh) | 2001-08-10 | 2007-08-08 | 日本化学医药株式会社 | 过氧化物酶体增殖剂响应受体δ活化剂 |
| JP4276074B2 (ja) | 2001-10-12 | 2009-06-10 | 日本ケミファ株式会社 | ペルオキシソーム増殖剤応答性受容体δの活性化剤 |
| AU2003209114A1 (en) * | 2002-02-14 | 2003-09-04 | Wyeth | Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands |
| US6951881B2 (en) | 2002-05-10 | 2005-10-04 | Wyeth | (1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands |
| US6906095B2 (en) | 2002-05-10 | 2005-06-14 | Wyeth | Indolylalkylidenehydrazine-carboximidamide derivatives as 5-hydroxytryptamine-6 ligands |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CN101787073B (zh) | 2003-01-28 | 2013-12-25 | 艾恩伍德医药品股份有限公司 | 治疗胃肠病的方法和组合物 |
| PE20050253A1 (es) * | 2003-07-24 | 2005-06-03 | Novartis Ag | Modificaciones estables de maleato de hidrogeno de tegaserod |
| WO2005058819A2 (en) * | 2003-12-16 | 2005-06-30 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of tegaserod base and salts thereof |
| CA2562627A1 (en) * | 2004-04-26 | 2005-11-10 | Santiago Ini | Preparation of tegaserod and tegaserod maleate |
| WO2006002212A1 (en) * | 2004-06-23 | 2006-01-05 | Dr. Reddy's Laboratories Ltd. | Tegaserod hemimaleate |
| EP1723106A2 (en) * | 2004-10-19 | 2006-11-22 | Teva Pharmaceutical Industries Ltd. | Purification of tegaserod maleate |
| WO2006083710A2 (en) * | 2005-01-31 | 2006-08-10 | Novartis Ag | Use of 5-ht4 agonist for treating delayed gastric emptying which may be induced by a proton pump inhibitor |
| WO2006116953A1 (en) * | 2005-05-02 | 2006-11-09 | Zentiva, A.S. | A method for the preparation of tegaserod and slected salts thereof |
| CZ298399B6 (cs) * | 2005-05-02 | 2007-09-19 | Zentiva, A. S. | Zpusob prípravy 2-[(5-methoxy-1 H-indol-3-yl) methylen]-N-pentylkarbazimidamidu (tegaserodu) |
| JP2007145827A (ja) * | 2005-10-27 | 2007-06-14 | Teijin Pharma Ltd | ベンゾ［ｂ］チオフェン誘導体およびその製造方法 |
| GB0524668D0 (en) * | 2005-12-02 | 2006-01-11 | Novartis Ag | Organic compounds |
| GB0601953D0 (en) * | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| MX2008013292A (es) | 2006-04-18 | 2008-11-14 | Nippon Chemiphar Co | Agente activador para el receptor ? activado por el proliferador de peroxisoma. |
| CN100412059C (zh) * | 2006-06-06 | 2008-08-20 | 江苏奥赛康药业有限公司 | 一种替加色罗的制备方法 |
| WO2008055994A1 (en) * | 2006-11-09 | 2008-05-15 | Generics [Uk] Limited | Novel process |
| EP1939176A1 (en) * | 2006-12-22 | 2008-07-02 | Novartis AG | Salts of Tegaserod |
| WO2008149137A2 (en) * | 2007-06-04 | 2008-12-11 | Generics [Uk] Limited | Tegazerod benzoate and polymorphic forms |
| US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2008149140A2 (en) * | 2007-06-04 | 2008-12-11 | Generics [Uk] Limited | Tegaserod oxalate and polymorphic forms |
| CA3089569C (en) | 2007-06-04 | 2023-12-05 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2008149136A1 (en) * | 2007-06-04 | 2008-12-11 | Generics [Uk] Limited | Tegaserod besylate and polymorphic forms |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| WO2008149139A2 (en) * | 2007-06-04 | 2008-12-11 | Generics [Uk] Limited | Tegaserod fumarate and polymorphic forms |
| WO2008149138A1 (en) * | 2007-06-04 | 2008-12-11 | Generics [Uk] Limited | Tegaserod malate and polymorphic forms |
| WO2008149154A2 (en) * | 2007-06-05 | 2008-12-11 | Generics [Uk] Limited | Tegaserod succinate and polymorphic forms |
| US20090082419A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched tegaserod |
| WO2009053732A1 (en) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Novel salt |
| WO2009053733A2 (en) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Novel crystalline forms |
| WO2009053754A2 (en) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Novel crystalline forms |
| WO2009053750A2 (en) | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Novel crystalline and amorphous forms |
| BRPI0911197A2 (pt) | 2008-04-15 | 2015-10-13 | Nippon Chemiphar Co | composto, ativador de receptor ativado pelo proliferador de peroxissoma, e, medicamento para o tratamento e /ou profilaxia de uma doença. |
| CA2930674A1 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| BRPI0918468A2 (pt) * | 2008-09-19 | 2015-11-24 | Cytokine Pharmasciences Inc | prevenção de poi |
| JP6265583B2 (ja) | 2008-10-17 | 2018-01-24 | ウィスコンシン アルムニ リサーチ ファンデイション | 生理活性アルファベータペプチドを作製する方法 |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| LT2384318T (lt) | 2008-12-31 | 2018-02-26 | Ardelyx, Inc. | Junginiai ir būdai, skirti nhe-medijuoto antiporto slopinimui, gydant sutrikimus, susijusius su skysčių kaupimusi ir druskų pertekliumi, bei virškinamojo trakto sutrikimus |
| WO2011014520A2 (en) | 2009-07-29 | 2011-02-03 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
| HUE024874T2 (en) | 2009-09-03 | 2016-02-29 | Bioenergenix | Heterocyclic compounds for inhibiting PASK |
| BR112012008004A2 (pt) | 2009-10-09 | 2016-03-29 | Irm Llc | compostos e composições como moduladores da atividade de gpr119 |
| US8394858B2 (en) | 2009-12-03 | 2013-03-12 | Novartis Ag | Cyclohexane derivatives and uses thereof |
| US8697739B2 (en) | 2010-07-29 | 2014-04-15 | Novartis Ag | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof |
| CA2827030C (en) | 2011-02-25 | 2019-01-08 | Yuhan Corporation | Diaminopyrimidine derivatives and processes for the preparation thereof |
| CA2828349C (en) | 2011-03-02 | 2019-05-21 | John M. Mccall | Heterocyclic compounds for the inhibition of pask |
| WO2014019092A1 (en) | 2012-08-01 | 2014-02-06 | The Hospital For Sick Children | Inhibitors of peptidyl arginine deiminase (pad) enzymes and uses thereof |
| US20150336892A1 (en) | 2012-08-21 | 2015-11-26 | Ardelyx, Inc | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2014052619A1 (en) | 2012-09-27 | 2014-04-03 | Irm Llc | Piperidine derivatives and compositions as modulators of gpr119 activity |
| EP2724723A1 (en) | 2012-10-25 | 2014-04-30 | Universitätsklinikum Hamburg-Eppendorf | Tegaserod for use in the treatment of nerve injuries |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
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| AU2018205400B2 (en) | 2017-01-09 | 2022-07-14 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
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| CN113801052B (zh) * | 2021-10-28 | 2023-06-27 | 西安交通大学 | 一种含有芳香酸酯的吲哚胍类化合物及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB842325A (en) * | 1956-10-01 | 1960-07-27 | Ici Ltd | Pharmaceutical compositions containing aminoguanidine derivatives |
| GB842322A (en) * | 1956-10-01 | 1960-07-27 | Ici Ltd | Aminoguanidine derivatives |
| GB842323A (en) * | 1956-10-01 | 1960-07-27 | Ici Ltd | Aminoguanidine derivatives |
| GB842324A (en) * | 1956-10-01 | 1960-07-27 | Ici Ltd | Aminoguanidine derivatives |
| US2855398A (en) * | 1956-11-19 | 1958-10-07 | Searle & Co | Amidines of the indole series |
| US3317560A (en) * | 1963-01-03 | 1967-05-02 | Philips Corp | Indol-3-yl alkylguanidine derivatives |
| EP0087218B1 (en) * | 1982-02-10 | 1985-05-02 | Beecham Group Plc | Guanidine derivatives |
| US5095031A (en) * | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
| FR2669927B1 (fr) * | 1990-11-29 | 1994-04-08 | Adir Cie | Nouveaux derives de guanidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
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1992
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- 1992-03-17 EP EP92810191A patent/EP0505322B1/en not_active Expired - Lifetime
- 1992-03-17 DE DE69226894T patent/DE69226894T2/de not_active Expired - Lifetime
- 1992-03-17 SG SG1996005765A patent/SG43221A1/en unknown
- 1992-03-17 AT AT92810191T patent/ATE170838T1/de active
- 1992-03-17 DK DK92810191T patent/DK0505322T3/da active
- 1992-03-17 ES ES92810191T patent/ES2121836T3/es not_active Expired - Lifetime
- 1992-03-18 MY MYPI92000449A patent/MY108158A/en unknown
- 1992-03-20 NO NO921104A patent/NO179171C/no not_active IP Right Cessation
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- 1992-03-20 IL IL101312A patent/IL101312A/xx active Protection Beyond IP Right Term
- 1992-03-20 RO RO92-200369A patent/RO109194B1/ro unknown
- 1992-03-20 FI FI921222A patent/FI102371B1/fi not_active IP Right Cessation
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- 1992-03-20 CZ CS92858A patent/CZ284339B6/cs not_active IP Right Cessation
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- 1992-03-20 AU AU13092/92A patent/AU651442B2/en not_active Expired
- 1992-03-20 NZ NZ242069A patent/NZ242069A/en not_active IP Right Cessation
- 1992-03-21 KR KR1019920004680A patent/KR100198018B1/ko not_active IP Right Cessation
- 1992-03-21 JP JP4064281A patent/JP2593022B2/ja not_active Expired - Lifetime
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1995
- 1995-01-09 US US08/370,038 patent/US5510353A/en not_active Expired - Lifetime
- 1995-06-21 HU HU95P/P00315P patent/HU211510A9/hu unknown
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1998
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2001
- 2001-01-11 FI FI20010060A patent/FI20010060A/fi unknown
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