PE20050253A1 - Modificaciones estables de maleato de hidrogeno de tegaserod - Google Patents
Modificaciones estables de maleato de hidrogeno de tegaserodInfo
- Publication number
- PE20050253A1 PE20050253A1 PE2004000706A PE2004000706A PE20050253A1 PE 20050253 A1 PE20050253 A1 PE 20050253A1 PE 2004000706 A PE2004000706 A PE 2004000706A PE 2004000706 A PE2004000706 A PE 2004000706A PE 20050253 A1 PE20050253 A1 PE 20050253A1
- Authority
- PE
- Peru
- Prior art keywords
- hydrogen maleate
- tegaserod
- ray
- stable modifications
- tegaserod hydrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Glass Compositions (AREA)
- Liquid Crystal Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Abstract
REFERIDA A UNA MODIFICACION ESENCIALMENTE PURA DEL CRISTAL A DE MALEATO DE H DE TEGASEROD PRESENTANDO DETERMINADOS VALORES EN EL ANALISIS DE CRISTAL DE RAYOS X, UN PATRON DE DIFRACCIONDE POLVOS DE RAYOS X CUYOS VALORES q SON: 5.4 ± 0.3°, 6.4 ± 0.3°, 10.8 ± 0.3°, 16.2 ± 0.3°, ENTRE OTROS; UNA SENAL ENDORTERMICA DE APROX. 190°C EN EL TERMOGRAMA EN CALORIMETRIA DE EXPLORACION DIFERENCIAL. TAMBIEN REFERIDA A UNA PROCESO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA QUE COMPRENDA UN VEHICULO ADEMAS. DICHO MEDICAMENTO ES UTIL PARA EL TRATAMIENTO DE SINDROME DE INTESTINO IRRITABLE, REFLUJO GASTROESOFAGICO, CONSTIPACION CRONICA, DIARREA, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48963803P | 2003-07-24 | 2003-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050253A1 true PE20050253A1 (es) | 2005-06-03 |
Family
ID=34135099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2004000706A PE20050253A1 (es) | 2003-07-24 | 2004-07-22 | Modificaciones estables de maleato de hidrogeno de tegaserod |
Country Status (24)
Country | Link |
---|---|
US (1) | US20070112056A1 (es) |
EP (2) | EP1651601A1 (es) |
JP (1) | JP2006528609A (es) |
KR (1) | KR20060040710A (es) |
CN (1) | CN1826318A (es) |
AR (1) | AR045081A1 (es) |
AU (1) | AU2004263285A1 (es) |
BR (1) | BRPI0412830A (es) |
CA (1) | CA2532351A1 (es) |
CO (1) | CO5680418A2 (es) |
EC (1) | ECSP066306A (es) |
IL (1) | IL172914A0 (es) |
IS (1) | IS8321A (es) |
MA (1) | MA27935A1 (es) |
MX (1) | MXPA06000917A (es) |
MY (1) | MY137386A (es) |
NO (1) | NO20060915L (es) |
NZ (1) | NZ544596A (es) |
PE (1) | PE20050253A1 (es) |
RU (1) | RU2349585C2 (es) |
SG (1) | SG144944A1 (es) |
TN (1) | TNSN06024A1 (es) |
TW (1) | TW200510302A (es) |
WO (1) | WO2005014544A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006045120A2 (en) * | 2004-10-19 | 2006-04-27 | Teva Pharmaceutical Industries Ltd. | Purification of tegaserod maleate |
BRPI0606898A2 (pt) * | 2005-01-31 | 2009-07-21 | Novartis Ag | uso de agonista de 5-ht4 na preparação de medicamentos e método útil no esvaziamento gástrico retardado |
CZ298399B6 (cs) * | 2005-05-02 | 2007-09-19 | Zentiva, A. S. | Zpusob prípravy 2-[(5-methoxy-1 H-indol-3-yl) methylen]-N-pentylkarbazimidamidu (tegaserodu) |
EP1893195A2 (en) * | 2005-06-22 | 2008-03-05 | Teva Pharmaceutical Industries Ltd | Polymorphic forms of tegaserod maleate |
WO2007119109A2 (en) * | 2005-10-06 | 2007-10-25 | Medichem, S.A. | Processes for preparing tegaserod maleate and pharmaceutical compositions containing it |
GB0524668D0 (en) * | 2005-12-02 | 2006-01-11 | Novartis Ag | Organic compounds |
WO2007120924A1 (en) * | 2006-04-17 | 2007-10-25 | Teva Pharmaceutical Industries Ltd. | Preparation of tegaserod maleate free of iodide |
EP1956002A1 (en) * | 2007-02-07 | 2008-08-13 | Chemo Ibérica, S.A. | New tegaserod maleate polymorphs and process for their preparation |
AU2008252604A1 (en) * | 2007-05-17 | 2008-11-27 | Generics [Uk] Limited | Process for the preparation of form A of tegaserod |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01242588A (ja) * | 1988-03-25 | 1989-09-27 | Chiba Gosei Kenkyusho:Kk | 7―シアノメチルチオアセトアミド―7α―メトキシ―3―(1―メチル―1H―テトラゾール―5―イル)チオメチル―3―セフェム―4―カルボン酸の結晶及びその製造方法 |
HUT64023A (en) * | 1991-03-22 | 1993-11-29 | Sandoz Ag | Process for producing aminoguanidine derivatives and pharmaceutical compositions comprising such compounds |
JPH08291140A (ja) * | 1995-04-20 | 1996-11-05 | Teikoku Chem Ind Corp Ltd | 易吸収性結晶 |
CN1165293C (zh) * | 1998-08-21 | 2004-09-08 | 诺瓦提斯公司 | 5ht4激动剂或拮抗剂的新型口服制剂 |
EP1321142A1 (en) * | 2001-12-21 | 2003-06-25 | Novartis AG | Solid pharmaceutical composition for oral administration of Tegaserod |
CN1176077C (zh) * | 2003-01-07 | 2004-11-17 | 江苏省药物研究所 | 马来酸替加色罗一水结晶 |
US20050119328A1 (en) * | 2003-03-25 | 2005-06-02 | Hetero Drugs Limited | Novel crysalline forms of tegaserod maleate |
JP2007514000A (ja) * | 2003-12-16 | 2007-05-31 | テバ ファーマシューティカル インダストリーズ リミティド | テガセロッド塩基及びその塩の多形現象形 |
US20050272802A1 (en) * | 2004-04-22 | 2005-12-08 | Sundaram Venkataraman | Process for preparing form I of tegaserod maleate |
EP1893195A2 (en) * | 2005-06-22 | 2008-03-05 | Teva Pharmaceutical Industries Ltd | Polymorphic forms of tegaserod maleate |
-
2004
- 2004-07-22 AR ARP040102610A patent/AR045081A1/es not_active Application Discontinuation
- 2004-07-22 TW TW093121920A patent/TW200510302A/zh unknown
- 2004-07-22 MY MYPI20042945A patent/MY137386A/en unknown
- 2004-07-22 PE PE2004000706A patent/PE20050253A1/es not_active Application Discontinuation
- 2004-07-23 CN CNA2004800213549A patent/CN1826318A/zh active Pending
- 2004-07-23 JP JP2006520806A patent/JP2006528609A/ja active Pending
- 2004-07-23 RU RU2006105481/04A patent/RU2349585C2/ru not_active IP Right Cessation
- 2004-07-23 SG SG200805476-9A patent/SG144944A1/en unknown
- 2004-07-23 BR BRPI0412830-3A patent/BRPI0412830A/pt not_active IP Right Cessation
- 2004-07-23 NZ NZ544596A patent/NZ544596A/en unknown
- 2004-07-23 US US10/565,454 patent/US20070112056A1/en not_active Abandoned
- 2004-07-23 EP EP04763452A patent/EP1651601A1/en not_active Withdrawn
- 2004-07-23 EP EP07117155A patent/EP1880992A1/en not_active Withdrawn
- 2004-07-23 KR KR1020067001500A patent/KR20060040710A/ko not_active Application Discontinuation
- 2004-07-23 AU AU2004263285A patent/AU2004263285A1/en not_active Abandoned
- 2004-07-23 WO PCT/EP2004/008281 patent/WO2005014544A1/en not_active Application Discontinuation
- 2004-07-23 CA CA002532351A patent/CA2532351A1/en not_active Abandoned
- 2004-07-23 MX MXPA06000917A patent/MXPA06000917A/es unknown
-
2005
- 2005-12-29 IL IL172914A patent/IL172914A0/en unknown
-
2006
- 2006-01-23 TN TNP2006000024A patent/TNSN06024A1/en unknown
- 2006-01-24 EC EC2006006306A patent/ECSP066306A/es unknown
- 2006-01-27 MA MA28759A patent/MA27935A1/fr unknown
- 2006-02-21 CO CO06016978A patent/CO5680418A2/es not_active Application Discontinuation
- 2006-02-22 IS IS8321A patent/IS8321A/is unknown
- 2006-02-24 NO NO20060915A patent/NO20060915L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20070112056A1 (en) | 2007-05-17 |
IL172914A0 (en) | 2006-06-11 |
EP1880992A1 (en) | 2008-01-23 |
AU2004263285A1 (en) | 2005-02-17 |
MXPA06000917A (es) | 2006-03-30 |
AR045081A1 (es) | 2005-10-12 |
WO2005014544A1 (en) | 2005-02-17 |
NO20060915L (no) | 2006-04-24 |
CA2532351A1 (en) | 2005-02-17 |
KR20060040710A (ko) | 2006-05-10 |
MY137386A (en) | 2009-01-30 |
CO5680418A2 (es) | 2006-09-29 |
ECSP066306A (es) | 2006-07-28 |
JP2006528609A (ja) | 2006-12-21 |
TW200510302A (en) | 2005-03-16 |
BRPI0412830A (pt) | 2006-09-26 |
SG144944A1 (en) | 2008-08-28 |
MA27935A1 (fr) | 2006-06-01 |
NZ544596A (en) | 2009-01-31 |
IS8321A (is) | 2006-02-22 |
TNSN06024A1 (en) | 2007-10-03 |
RU2006105481A (ru) | 2007-09-20 |
RU2349585C2 (ru) | 2009-03-20 |
CN1826318A (zh) | 2006-08-30 |
EP1651601A1 (en) | 2006-05-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal | ||
FG | Grant, registration | ||
FD | Application declared void or lapsed |