EA200100540A1 - Фармацевтическая композиция с модифицированным высвобождением сенсибилизатора к инсулину - Google Patents

Фармацевтическая композиция с модифицированным высвобождением сенсибилизатора к инсулину

Info

Publication number
EA200100540A1
EA200100540A1 EA200100540A EA200100540A EA200100540A1 EA 200100540 A1 EA200100540 A1 EA 200100540A1 EA 200100540 A EA200100540 A EA 200100540A EA 200100540 A EA200100540 A EA 200100540A EA 200100540 A1 EA200100540 A1 EA 200100540A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical composition
sensitizer
insulin
composition
modified
Prior art date
Application number
EA200100540A
Other languages
English (en)
Other versions
EA007608B1 (ru
Inventor
Роберт Глайнек
Сьюзн Мари Милосович
Уилльям Малдун
Винченцо Ре
Джозеф Соер
Джанет Луиз Скиннер
Original Assignee
Смитклайн Бичам Плс
Смитклайн Бичам Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9824870.1A external-priority patent/GB9824870D0/en
Priority claimed from GBGB9912189.9A external-priority patent/GB9912189D0/en
Application filed by Смитклайн Бичам Плс, Смитклайн Бичам Корпорейшн filed Critical Смитклайн Бичам Плс
Publication of EA200100540A1 publication Critical patent/EA200100540A1/ru
Publication of EA007608B1 publication Critical patent/EA007608B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Фармацевтическая композиция, которая содержит сенсибилизатор к инсулину и фармацевтически приемлемый носитель для него, где композиция составлена так, чтобы обеспечить модифицированное высвобождение сенсибилизатора к инсулину, а также применение такой композиции в медицине.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100540A 1998-11-12 1999-11-12 Таблетка с энтеропокрытием EA007608B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9824870.1A GB9824870D0 (en) 1998-11-12 1998-11-12 Novel composition and use
GBGB9912189.9A GB9912189D0 (en) 1999-05-25 1999-05-25 Novel composition and use
PCT/EP1999/009031 WO2000028990A1 (en) 1998-11-12 1999-11-12 Pharmaceutical composition for modified release insulin sensitiser

Publications (2)

Publication Number Publication Date
EA200100540A1 true EA200100540A1 (ru) 2001-10-22
EA007608B1 EA007608B1 (ru) 2006-12-29

Family

ID=26314667

Family Applications (3)

Application Number Title Priority Date Filing Date
EA200601144A EA200601144A1 (ru) 1998-11-12 1999-11-12 Таблетка замедленного высвобождения сенсибилизатора к инсулину
EA200100540A EA007608B1 (ru) 1998-11-12 1999-11-12 Таблетка с энтеропокрытием
EA200702648A EA200702648A1 (ru) 1998-11-12 1999-11-12 Фармацевтическая композиция, пригодная для введения один раз в день

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200601144A EA200601144A1 (ru) 1998-11-12 1999-11-12 Таблетка замедленного высвобождения сенсибилизатора к инсулину

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200702648A EA200702648A1 (ru) 1998-11-12 1999-11-12 Фармацевтическая композиция, пригодная для введения один раз в день

Country Status (39)

Country Link
EP (3) EP1917962A1 (ru)
JP (1) JP2002529505A (ru)
KR (2) KR100732599B1 (ru)
CN (1) CN1289081C (ru)
AP (2) AP1901A (ru)
AR (2) AR023700A1 (ru)
AT (1) ATE382352T1 (ru)
AU (1) AU768578B2 (ru)
BG (2) BG65444B1 (ru)
BR (1) BR9915215A (ru)
CA (1) CA2350659C (ru)
CO (1) CO5190673A1 (ru)
CY (1) CY1107909T1 (ru)
CZ (1) CZ20011628A3 (ru)
DE (1) DE69937898T2 (ru)
DK (1) DK1128827T3 (ru)
DZ (1) DZ2937A1 (ru)
EA (3) EA200601144A1 (ru)
EG (2) EG22344A (ru)
ES (1) ES2299269T3 (ru)
HK (1) HK1040909B (ru)
HR (2) HRP20010342B1 (ru)
HU (1) HUP0104307A3 (ru)
ID (1) ID29344A (ru)
IL (2) IL143003A0 (ru)
MY (1) MY135973A (ru)
NO (1) NO20012351L (ru)
NZ (2) NZ526440A (ru)
OA (1) OA11676A (ru)
PE (1) PE20001428A1 (ru)
PL (1) PL198717B1 (ru)
PT (1) PT1128827E (ru)
RS (1) RS50208B (ru)
SI (1) SI1128827T1 (ru)
SK (1) SK286937B6 (ru)
TR (2) TR200101337T2 (ru)
TW (2) TWI246920B (ru)
UY (2) UY25798A1 (ru)
WO (1) WO2000028990A1 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6099862A (en) * 1998-08-31 2000-08-08 Andrx Corporation Oral dosage form for the controlled release of a biguanide and sulfonylurea
AR030920A1 (es) 1999-11-16 2003-09-03 Smithkline Beecham Plc Composiciones farmaceuticas para el tratamiento de la diabetes mellitus y condiciones asociadas con la diabetes mellitus, y procedimientos para preparar dichas composiciones
JP2004504264A (ja) * 2000-01-07 2004-02-12 ユニバーシティ　オブ　シンシナティ Ｔｈ１又はｔｈ２リンパ球に制御される免疫応答の選択的活性化
ATE380022T1 (de) * 2001-01-31 2007-12-15 Evonik Roehm Gmbh Multipartikuläre arzneiform, enthaltend mindestens zwei unterschiedlich überzogene pelletformen
AU2002367154A1 (en) * 2001-12-21 2003-07-15 Smithkline Beecham Corporation Dosing regimen for ppar-gamma activators
PE20030800A1 (es) * 2002-02-12 2003-10-31 Glaxo Group Ltd Forma de dosificacion oral de liberacion controlada
CN100367960C (zh) * 2002-07-11 2008-02-13 武田药品工业株式会社 包衣制剂的制备方法
US7018658B2 (en) * 2002-11-14 2006-03-28 Synthon Bv Pharmaceutical pellets comprising tamsulosin
WO2004062577A2 (en) 2003-01-03 2004-07-29 Shire Laboratories Inc. Two or more enteric materials to regulate drug release
KR101114808B1 (ko) 2003-01-29 2012-02-15 다케다 야쿠힌 고교 가부시키가이샤 피복 제제의 제조법
ES2241478B1 (es) * 2004-02-13 2006-11-16 Lacer S.A. Preparacion farmaceutica para la liberacion sostenida de un principio farmaceuticamente activo.
FI20060501L (fi) * 2006-05-22 2007-11-23 Biohit Oyj Koostumus ja menetelmä asetaldehydin sitomiseksi vatsassa
CA2878866C (en) * 2011-07-14 2021-02-23 Able Cerebral, Llc A composition, device and method for delayed and sustained release of brain energy molecules
CA2936746C (en) 2014-10-31 2017-06-27 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS5697277A (en) 1980-01-07 1981-08-05 Takeda Chem Ind Ltd Thiazolidine derivative
JPS6051189A (ja) 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
US4582839A (en) 1984-03-21 1986-04-15 Takeda Chemical Industries, Ltd. 2,4-thiazolidinediones
CN1003445B (zh) 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
DK173350B1 (da) 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem
JPH06779B2 (ja) 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
US4812570A (en) 1986-07-24 1989-03-14 Takeda Chemical Industries, Ltd. Method for producing thiazolidinedione derivatives
EP0842925A1 (en) 1987-09-04 1998-05-20 Beecham Group Plc Substituted thiazolidinedione derivatives
US4791125A (en) 1987-12-02 1988-12-13 Pfizer Inc. Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents
WO1989008651A1 (en) 1988-03-08 1989-09-21 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
WO1989008650A1 (en) 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione hypoglycemic agents
WO1991007107A1 (en) 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
US5089514A (en) 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
EP0533933A4 (en) 1990-07-03 1993-05-05 Yamanouchi Pharmaceutical Co. Ltd. Bisheterocyclic compound
AU645112B2 (en) 1990-08-23 1994-01-06 Pfizer Inc. Hypoglycemic hydroxyurea derivatives
JPH04210683A (ja) 1990-12-06 1992-07-31 Terumo Corp チアゾリジン−２，４−ジオン誘導体およびこれを含有する糖尿病合併症治療薬
SK109993A3 (en) 1991-04-11 1994-12-07 Upjohn Co Thiazolidinedione derivatives producing and use thereof
US5183823A (en) 1991-04-11 1993-02-02 Takeda Chemical Industries, Ltd. Pyridine n-oxide compounds which are useful as hypoglycemic and hypolipidemic agents
US5502078A (en) * 1991-05-28 1996-03-26 Zeneca Limited Chemical compounds
TW222626B (ru) 1991-07-22 1994-04-21 Pfizer
FR2680512B1 (fr) 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
JPH05271204A (ja) 1992-03-26 1993-10-19 Japan Tobacco Inc 新規なトリアジン誘導体
US5264451A (en) 1992-04-07 1993-11-23 American Home Products Corporation Process for treating hyperglycemia using trifluoromethyl substituted 3H-pyrazol-3-ones
WO1993021166A1 (en) 1992-04-10 1993-10-28 Smithkline Beecham Plc Heterocyclic compounds and their use in the treatment of type ii-diabetes
WO1993022445A1 (en) 1992-05-05 1993-11-11 The Upjohn Company A process for producing pioglitazone metabolite
EP0648212B1 (en) 1992-07-03 2001-10-24 Smithkline Beecham Plc Benzoxazole and benzothiazole derivatives as pharmaceutical
US5326770A (en) * 1992-07-17 1994-07-05 The Du Pont Merck Pharmaceutical Company Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals
US5232945A (en) 1992-07-20 1993-08-03 Pfizer Inc. 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives
GB9218830D0 (en) 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
US5457109A (en) 1993-09-15 1995-10-10 Warner-Lambert Company Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus
DE4432757A1 (de) * 1994-09-14 1996-03-21 Boehringer Mannheim Gmbh Pharmazeutische Zubereitung enthaltend Metformin und Verfahren zu deren Herstellung
TWI238064B (en) * 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
US5840332A (en) * 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
US5952509A (en) * 1996-06-27 1999-09-14 Takeda Chemical Industries, Ltd. Production of benzaldehyde compounds
JP3256841B2 (ja) * 1996-06-27 2002-02-18 武田薬品工業株式会社 ベンズアルデヒド化合物の製造法
GB9619757D0 (en) * 1996-09-21 1996-11-06 Knoll Ag Chemical process
AU6576398A (en) * 1997-03-24 1998-10-20 Galderma Research & Development, S.N.C. Retinoid related molecules for the treatment of non-insulin dependent diabetes mellitus

Also Published As

Publication number Publication date
TWI257305B (en) 2006-07-01
AP2008004490A0 (en) 2008-06-30
SI1128827T1 (sl) 2008-06-30
HUP0104307A3 (en) 2003-12-29
PL348153A1 (en) 2002-05-06
ES2299269T3 (es) 2008-05-16
HUP0104307A2 (hu) 2002-07-29
MY135973A (en) 2008-07-31
EP1128827B1 (en) 2008-01-02
RS50208B (sr) 2009-07-15
UY25798A1 (es) 2000-12-29
KR100732599B1 (ko) 2007-06-27
PE20001428A1 (es) 2001-02-08
BR9915215A (pt) 2001-07-31
DE69937898D1 (de) 2008-02-14
PT1128827E (pt) 2008-03-10
NZ526440A (en) 2005-01-28
PL198717B1 (pl) 2008-07-31
BG65444B1 (bg) 2008-08-29
NO20012351D0 (no) 2001-05-11
IL183972A0 (en) 2007-10-31
TR200101337T2 (tr) 2001-11-21
CA2350659C (en) 2009-06-09
BG109893A (bg) 2008-11-28
HK1040909B (zh) 2008-08-01
DZ2937A1 (fr) 2004-03-15
WO2000028990A1 (en) 2000-05-25
SK286937B6 (sk) 2009-07-06
KR20060097140A (ko) 2006-09-13
CN1333683A (zh) 2002-01-30
AR023700A1 (es) 2002-09-04
EG22344A (en) 2002-12-31
KR20010073229A (ko) 2001-07-31
EP1917962A1 (en) 2008-05-07
EA200702648A1 (ru) 2008-10-30
EA007608B1 (ru) 2006-12-29
CZ20011628A3 (cs) 2001-12-12
AU768578B2 (en) 2003-12-18
JP2002529505A (ja) 2002-09-10
AU1272900A (en) 2000-06-05
NZ511611A (en) 2003-10-31
TWI246920B (en) 2006-01-11
TW200505436A (en) 2005-02-16
DK1128827T3 (da) 2008-04-28
CN1289081C (zh) 2006-12-13
OA11676A (en) 2005-01-12
DE69937898T2 (de) 2009-01-02
CO5190673A1 (es) 2002-08-29
YU36401A (sh) 2004-05-12
IL143003A0 (en) 2002-04-21
NO20012351L (no) 2001-07-04
AP1901A (en) 2008-10-24
CA2350659A1 (en) 2000-05-25
CY1107909T1 (el) 2013-09-04
HK1040909A1 (en) 2002-06-28
HRP20010342B1 (en) 2008-04-30
HRP20010342A2 (en) 2002-06-30
ID29344A (id) 2001-08-23
EG24463A (en) 2009-07-16
EP1128827A1 (en) 2001-09-05
EA200601144A1 (ru) 2007-02-27
BG105570A (en) 2002-02-28
SK6432001A3 (en) 2001-12-03
AR023699A1 (es) 2002-09-04
TR200503846T2 (tr) 2007-01-22
HRP20080117A2 (en) 2008-10-31
UY25800A1 (es) 2000-08-21
EP1815855A1 (en) 2007-08-08
ATE382352T1 (de) 2008-01-15

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