HRP20010342B1 - Pharmaceutical composition for modified release insulin sensitiser - Google Patents
Pharmaceutical composition for modified release insulin sensitiserInfo
- Publication number
- HRP20010342B1 HRP20010342B1 HR20010342A HRP20010342A HRP20010342B1 HR P20010342 B1 HRP20010342 B1 HR P20010342B1 HR 20010342 A HR20010342 A HR 20010342A HR P20010342 A HRP20010342 A HR P20010342A HR P20010342 B1 HRP20010342 B1 HR P20010342B1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutical composition
- modified release
- pharmaceutically acceptable
- sustained release
- release insulin
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 231100000489 sensitizer Toxicity 0.000 title 1
- 238000013268 sustained release Methods 0.000 abstract 3
- 239000012730 sustained-release form Substances 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- -1 N-methyl-N- (2-pyridyl) amino Chemical group 0.000 abstract 1
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000003628 erosive effect Effects 0.000 abstract 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9824870.1A GB9824870D0 (en) | 1998-11-12 | 1998-11-12 | Novel composition and use |
| GBGB9912189.9A GB9912189D0 (en) | 1999-05-25 | 1999-05-25 | Novel composition and use |
| PCT/EP1999/009031 WO2000028990A1 (en) | 1998-11-12 | 1999-11-12 | Pharmaceutical composition for modified release insulin sensitiser |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20010342A2 HRP20010342A2 (en) | 2002-06-30 |
| HRP20010342B1 true HRP20010342B1 (en) | 2008-04-30 |
Family
ID=26314667
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010342A HRP20010342B1 (en) | 1998-11-12 | 2001-05-11 | Pharmaceutical composition for modified release insulin sensitiser |
| HR20080117A HRP20080117A2 (en) | 1998-11-12 | 2008-03-17 | Pharmaceutical composition for modified release insulin sensitiser |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080117A HRP20080117A2 (en) | 1998-11-12 | 2008-03-17 | Pharmaceutical composition for modified release insulin sensitiser |
Country Status (39)
| Country | Link |
|---|---|
| EP (3) | EP1128827B1 (xx) |
| JP (1) | JP2002529505A (xx) |
| KR (2) | KR20060097140A (xx) |
| CN (1) | CN1289081C (xx) |
| AP (2) | AP1901A (xx) |
| AR (2) | AR023700A1 (xx) |
| AT (1) | ATE382352T1 (xx) |
| AU (1) | AU768578B2 (xx) |
| BG (2) | BG65444B1 (xx) |
| BR (1) | BR9915215A (xx) |
| CA (1) | CA2350659C (xx) |
| CO (1) | CO5190673A1 (xx) |
| CY (1) | CY1107909T1 (xx) |
| CZ (1) | CZ20011628A3 (xx) |
| DE (1) | DE69937898T2 (xx) |
| DK (1) | DK1128827T3 (xx) |
| DZ (1) | DZ2937A1 (xx) |
| EA (3) | EA200702648A1 (xx) |
| EG (2) | EG22344A (xx) |
| ES (1) | ES2299269T3 (xx) |
| HK (1) | HK1040909B (xx) |
| HR (2) | HRP20010342B1 (xx) |
| HU (1) | HUP0104307A3 (xx) |
| ID (1) | ID29344A (xx) |
| IL (2) | IL143003A0 (xx) |
| MY (1) | MY135973A (xx) |
| NO (1) | NO20012351L (xx) |
| NZ (2) | NZ526440A (xx) |
| OA (1) | OA11676A (xx) |
| PE (1) | PE20001428A1 (xx) |
| PL (1) | PL198717B1 (xx) |
| PT (1) | PT1128827E (xx) |
| RS (1) | RS50208B (xx) |
| SI (1) | SI1128827T1 (xx) |
| SK (1) | SK286937B6 (xx) |
| TR (2) | TR200101337T2 (xx) |
| TW (2) | TWI257305B (xx) |
| UY (2) | UY25798A1 (xx) |
| WO (1) | WO2000028990A1 (xx) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6099862A (en) * | 1998-08-31 | 2000-08-08 | Andrx Corporation | Oral dosage form for the controlled release of a biguanide and sulfonylurea |
| MY125516A (en) | 1999-11-16 | 2006-08-30 | Smithkline Beecham Plc | Novel composition based on thiazolidinedione and metformin and use |
| EP1244468A2 (en) * | 2000-01-07 | 2002-10-02 | University Of Cincinnati | Selective activation of a th1 or th2 lymphocyte regulated immune response |
| IL151150A0 (en) * | 2001-01-31 | 2003-04-10 | Roehm Gmbh | Multiparticulate drug form comprising at least two differently coated pellet forms |
| JP2005514399A (ja) * | 2001-12-21 | 2005-05-19 | スミスクライン ビーチャム コーポレーション | ＰＰＡＲγアクチベーターの投薬法 |
| PE20030800A1 (es) * | 2002-02-12 | 2003-10-31 | Glaxo Group Ltd | Forma de dosificacion oral de liberacion controlada |
| US20060286168A1 (en) * | 2002-07-11 | 2006-12-21 | Masahiko Koike | Process for producing coated preparation |
| US7018658B2 (en) * | 2002-11-14 | 2006-03-28 | Synthon Bv | Pharmaceutical pellets comprising tamsulosin |
| EP1589951B1 (en) * | 2003-01-03 | 2017-08-09 | Supernus Pharmaceuticals, Inc. | Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics |
| EP1588708A4 (en) | 2003-01-29 | 2006-03-01 | Takeda Pharmaceutical | METHOD FOR PRODUCING COATED PREPARATION |
| ES2241478B1 (es) * | 2004-02-13 | 2006-11-16 | Lacer S.A. | Preparacion farmaceutica para la liberacion sostenida de un principio farmaceuticamente activo. |
| FI20060501L (fi) * | 2006-05-22 | 2007-11-23 | Biohit Oyj | Koostumus ja menetelmä asetaldehydin sitomiseksi vatsassa |
| WO2013010137A2 (en) * | 2011-07-14 | 2013-01-17 | Jacks Health Technologies Llc | A composition, device and method for delayed and sustained release of brain energy molecules |
| CA2936746C (en) | 2014-10-31 | 2017-06-27 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522636A (en) | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| JPS5697277A (en) | 1980-01-07 | 1981-08-05 | Takeda Chem Ind Ltd | Thiazolidine derivative |
| JPS6051189A (ja) | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| US4582839A (en) | 1984-03-21 | 1986-04-15 | Takeda Chemical Industries, Ltd. | 2,4-thiazolidinediones |
| CN1003445B (zh) | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| DK173350B1 (da) | 1985-02-26 | 2000-08-07 | Sankyo Co | Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem |
| JPH06779B2 (ja) | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | チアゾリジオン誘導体およびそれを含んでなる医薬組成物 |
| US4812570A (en) | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
| ATE186724T1 (de) | 1987-09-04 | 1999-12-15 | Beecham Group Plc | Substituierte thiazolidindionderivate |
| US4791125A (en) | 1987-12-02 | 1988-12-13 | Pfizer Inc. | Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents |
| WO1989008651A1 (en) | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Hypoglycemic thiazolidinedione derivatives |
| US5061717A (en) | 1988-03-08 | 1991-10-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| WO1991007107A1 (en) | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
| US5089514A (en) | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| WO1992000967A1 (fr) | 1990-07-03 | 1992-01-23 | Yamanouchi Pharmaceutical Co., Ltd. | Compose biheterocyclique |
| EP0544696B1 (en) | 1990-08-23 | 1995-01-11 | Pfizer Inc. | Hypoglycemic hydroxyurea derivatives |
| JPH04210683A (ja) | 1990-12-06 | 1992-07-31 | Terumo Corp | チアゾリジン−２，４−ジオン誘導体およびこれを含有する糖尿病合併症治療薬 |
| US5183823A (en) | 1991-04-11 | 1993-02-02 | Takeda Chemical Industries, Ltd. | Pyridine n-oxide compounds which are useful as hypoglycemic and hypolipidemic agents |
| KR100249988B1 (ko) | 1991-04-11 | 2000-04-01 | 로렌스 티. 마이젠헬더 | 티아졸리딘디온 유도체, 그의 제조방법 및 용도 |
| US5502078A (en) * | 1991-05-28 | 1996-03-26 | Zeneca Limited | Chemical compounds |
| TW222626B (xx) | 1991-07-22 | 1994-04-21 | Pfizer | |
| FR2680512B1 (fr) | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH05271204A (ja) | 1992-03-26 | 1993-10-19 | Japan Tobacco Inc | 新規なトリアジン誘導体 |
| US5264451A (en) | 1992-04-07 | 1993-11-23 | American Home Products Corporation | Process for treating hyperglycemia using trifluoromethyl substituted 3H-pyrazol-3-ones |
| WO1993021166A1 (en) | 1992-04-10 | 1993-10-28 | Smithkline Beecham Plc | Heterocyclic compounds and their use in the treatment of type ii-diabetes |
| AU4104593A (en) | 1992-05-05 | 1993-11-29 | Upjohn Company, The | A process for producing pioglitazone metabolite |
| PL174610B1 (pl) | 1992-07-03 | 1998-08-31 | Smithkline Beecham Plc | Nowe związki heterocykliczne |
| US5326770A (en) * | 1992-07-17 | 1994-07-05 | The Du Pont Merck Pharmaceutical Company | Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals |
| US5232945A (en) | 1992-07-20 | 1993-08-03 | Pfizer Inc. | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives |
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| US5457109A (en) * | 1993-09-15 | 1995-10-10 | Warner-Lambert Company | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
| DE4432757A1 (de) * | 1994-09-14 | 1996-03-21 | Boehringer Mannheim Gmbh | Pharmazeutische Zubereitung enthaltend Metformin und Verfahren zu deren Herstellung |
| TW438587B (en) * | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| JP3256841B2 (ja) * | 1996-06-27 | 2002-02-18 | 武田薬品工業株式会社 | ベンズアルデヒド化合物の製造法 |
| US5952509A (en) * | 1996-06-27 | 1999-09-14 | Takeda Chemical Industries, Ltd. | Production of benzaldehyde compounds |
| GB9619757D0 (en) * | 1996-09-21 | 1996-11-06 | Knoll Ag | Chemical process |
| CA2284192A1 (en) * | 1997-03-24 | 1998-10-01 | Galderma Research & Development, S.N.C. | Retinoid related molecules for the treatment of non-insulin dependent diabetes mellitus |
-
1999
- 1999-11-10 DZ DZ990237A patent/DZ2937A1/xx active
- 1999-11-10 AR ARP990105699A patent/AR023700A1/es unknown
- 1999-11-10 AR ARP990105698A patent/AR023699A1/es unknown
- 1999-11-11 CO CO99070989A patent/CO5190673A1/es not_active Application Discontinuation
- 1999-11-11 EG EG142899A patent/EG22344A/xx active
- 1999-11-11 MY MYPI99004894A patent/MY135973A/en unknown
- 1999-11-11 EG EG142999A patent/EG24463A/xx active
- 1999-11-12 SI SI9931001T patent/SI1128827T1/sl unknown
- 1999-11-12 KR KR1020067017464A patent/KR20060097140A/ko not_active Application Discontinuation
- 1999-11-12 RS YU36401A patent/RS50208B/sr unknown
- 1999-11-12 DE DE69937898T patent/DE69937898T2/de not_active Expired - Lifetime
- 1999-11-12 UY UY25798A patent/UY25798A1/es not_active Application Discontinuation
- 1999-11-12 CZ CZ20011628A patent/CZ20011628A3/cs unknown
- 1999-11-12 AP APAP/P/2001/002135A patent/AP1901A/en active
- 1999-11-12 EP EP99956029A patent/EP1128827B1/en not_active Expired - Lifetime
- 1999-11-12 AU AU12729/00A patent/AU768578B2/en not_active Ceased
- 1999-11-12 DK DK99956029T patent/DK1128827T3/da active
- 1999-11-12 CN CNB998154946A patent/CN1289081C/zh not_active Expired - Fee Related
- 1999-11-12 EA EA200702648A patent/EA200702648A1/ru unknown
- 1999-11-12 AT AT99956029T patent/ATE382352T1/de not_active IP Right Cessation
- 1999-11-12 SK SK643-2001A patent/SK286937B6/sk not_active IP Right Cessation
- 1999-11-12 TR TR2001/01337T patent/TR200101337T2/xx unknown
- 1999-11-12 EA EA200601144A patent/EA200601144A1/ru unknown
- 1999-11-12 HU HU0104307A patent/HUP0104307A3/hu unknown
- 1999-11-12 NZ NZ526440A patent/NZ526440A/en not_active IP Right Cessation
- 1999-11-12 OA OA1200100116A patent/OA11676A/en unknown
- 1999-11-12 NZ NZ511611A patent/NZ511611A/en not_active IP Right Cessation
- 1999-11-12 EP EP07105991A patent/EP1815855A1/en not_active Withdrawn
- 1999-11-12 PE PE1999001147A patent/PE20001428A1/es not_active Application Discontinuation
- 1999-11-12 KR KR1020017005949A patent/KR100732599B1/ko not_active IP Right Cessation
- 1999-11-12 PL PL348153A patent/PL198717B1/pl not_active IP Right Cessation
- 1999-11-12 PT PT99956029T patent/PT1128827E/pt unknown
- 1999-11-12 TR TR2005/03846T patent/TR200503846T2/xx unknown
- 1999-11-12 JP JP2000582037A patent/JP2002529505A/ja active Pending
- 1999-11-12 WO PCT/EP1999/009031 patent/WO2000028990A1/en active Application Filing
- 1999-11-12 BR BR9915215-0A patent/BR9915215A/pt not_active Application Discontinuation
- 1999-11-12 EA EA200100540A patent/EA007608B1/ru not_active IP Right Cessation
- 1999-11-12 ID IDW00200101047A patent/ID29344A/id unknown
- 1999-11-12 EP EP07150269A patent/EP1917962A1/en not_active Withdrawn
- 1999-11-12 ES ES99956029T patent/ES2299269T3/es not_active Expired - Lifetime
- 1999-11-12 IL IL14300399A patent/IL143003A0/xx unknown
- 1999-11-12 CA CA002350659A patent/CA2350659C/en not_active Expired - Fee Related
- 1999-11-12 AP AP2008004490A patent/AP2008004490A0/xx unknown
- 1999-11-15 UY UY25800A patent/UY25800A1/es not_active Application Discontinuation
- 1999-12-24 TW TW093132308A patent/TWI257305B/zh active
- 1999-12-24 TW TW088122852A patent/TWI246920B/zh not_active IP Right Cessation
-
2001
- 2001-05-11 NO NO20012351A patent/NO20012351L/no not_active Application Discontinuation
- 2001-05-11 HR HR20010342A patent/HRP20010342B1/xx not_active IP Right Cessation
- 2001-06-07 BG BG105570A patent/BG65444B1/bg unknown
- 2001-06-07 BG BG109893A patent/BG109893A/bg unknown
-
2002
- 2002-02-08 HK HK02101021.9A patent/HK1040909B/zh not_active IP Right Cessation
-
2007
- 2007-06-14 IL IL183972A patent/IL183972A0/en unknown
-
2008
- 2008-03-17 HR HR20080117A patent/HRP20080117A2/xx not_active Application Discontinuation
- 2008-03-19 CY CY20081100310T patent/CY1107909T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20010342B1 (en) | Pharmaceutical composition for modified release insulin sensitiser | |
| HRP20010343B1 (en) | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent | |
| HRP20020416B1 (en) | Novel composition and use | |
| NO944803D0 (no) | Farmasöytisk preparat for kontrollert frigivelse | |
| DE60032749D1 (de) | Stabilisierte pharmazeutische zusammensetzung enthaltend einen nichtsteroiden entzündungshemmenden wirkstoff und prostaglandin | |
| YU23402A (sh) | Kompozicije sa kontrolisanim oslobađanjem koje sadrže nimezulid | |
| DE60038536D1 (de) | Matrixsystem mit verzögerter freisetzung für hochlösliche wirkstoffe | |
| MA29281B1 (fr) | Forme posologique orale au rosiglitazone | |
| AR015120A1 (es) | Composicion farmaceutica que comprende 5-[4-[2-(n-metil-n-(2-piridil)amino) etoxi]bencil]-tiazolidin-2,4-diona, un procedimiento para su preparacion, y unacomposicion para la pre-administracion farmaceutica | |
| AR015894A1 (es) | Uso de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona e insulina para la preparacion de un medicamento y composicion farmaceuticaque contiene dichos compuestos | |
| NZ515555A (en) | Treatment of diabetes with thiazolidinedione and sulphonylurea | |
| RS50130B (sr) | Farmaceutska kompozicija 5-(4-(2-(n-metil-n-(2-piridil)amino)etoksi)benzil) tiazolidin-2,4-diona | |
| AP1715A (en) | The hydrochloride salt of 5-[ 4 -[2 -(n-methyl-n- (2-pyridyl) amino) ethoxy]benzyl]thiazolidine -2,4-dione | |
| PT1446404E (pt) | Edisilatos de rosiglitazona e sua utilizacao como antidiabeticos | |
| PE20020324A1 (es) | Nuevas composiciones farmaceuticas que contienen epinastina y pseudoefedrina | |
| GB0021784D0 (en) | Novel pharmaceutical | |
| AP1738A (en) | Sodium salts of 5-[4-[2-(N-Methyl -N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione. | |
| ECSP034467A (es) | Farmaceutico novedoso | |
| AP1841A (en) | A thiazolidinedione derivative and its use as antidiabetic. | |
| ECSP003434A (es) | Nuevos compuestos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| B1PR | Patent granted | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20091026 Year of fee payment: 11 |
|
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20101113 |