IE49577B1 - 8-substituted-4-amino-3-quinolinecarboxylic acids and esters-antisecretory,anti-ulcer compounds - Google Patents

8-substituted-4-amino-3-quinolinecarboxylic acids and esters-antisecretory,anti-ulcer compounds

Info

Publication number
IE49577B1
IE49577B1 IE605/80A IE60580A IE49577B1 IE 49577 B1 IE49577 B1 IE 49577B1 IE 605/80 A IE605/80 A IE 605/80A IE 60580 A IE60580 A IE 60580A IE 49577 B1 IE49577 B1 IE 49577B1
Authority
IE
Ireland
Prior art keywords
ethyl
amino
quinolinecarboxylate
methoxy
group
Prior art date
Application number
IE605/80A
Other languages
English (en)
Other versions
IE800605L (en
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of IE800605L publication Critical patent/IE800605L/xx
Publication of IE49577B1 publication Critical patent/IE49577B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IE605/80A 1979-03-26 1980-03-24 8-substituted-4-amino-3-quinolinecarboxylic acids and esters-antisecretory,anti-ulcer compounds IE49577B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2398179A 1979-03-26 1979-03-26
US06/127,153 US4343804A (en) 1979-03-26 1980-03-04 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds

Publications (2)

Publication Number Publication Date
IE800605L IE800605L (en) 1980-09-26
IE49577B1 true IE49577B1 (en) 1985-10-30

Family

ID=26697875

Family Applications (1)

Application Number Title Priority Date Filing Date
IE605/80A IE49577B1 (en) 1979-03-26 1980-03-24 8-substituted-4-amino-3-quinolinecarboxylic acids and esters-antisecretory,anti-ulcer compounds

Country Status (31)

Country Link
US (1) US4343804A (online.php)
JP (1) JPH02117663A (online.php)
AR (1) AR230268A1 (online.php)
AT (1) AT372373B (online.php)
AU (1) AU528388B2 (online.php)
BR (1) BR8001779A (online.php)
CA (1) CA1147338A (online.php)
CH (1) CH644105A5 (online.php)
DE (1) DE3011490A1 (online.php)
DK (1) DK156056C (online.php)
EG (1) EG15009A (online.php)
ES (1) ES489887A0 (online.php)
FI (1) FI77452C (online.php)
FR (1) FR2452485B1 (online.php)
GB (1) GB2047244B (online.php)
GR (1) GR68006B (online.php)
HK (1) HK67983A (online.php)
IE (1) IE49577B1 (online.php)
IL (1) IL59628A (online.php)
IN (1) IN151446B (online.php)
IT (1) IT1133079B (online.php)
MX (1) MX6264E (online.php)
NL (1) NL8001752A (online.php)
NO (1) NO153927C (online.php)
NZ (1) NZ193252A (online.php)
PH (1) PH16416A (online.php)
PL (1) PL125030B1 (online.php)
PT (1) PT71008B (online.php)
SE (1) SE435837B (online.php)
SG (1) SG33683G (online.php)
YU (1) YU41702B (online.php)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
GB8804448D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804444D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804445D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804447D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804446D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5432182A (en) * 1989-02-23 1995-07-11 Smithkline Beecham Intercredit B.V. Compounds substituted quinoline derivatives
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
DE3917233A1 (de) * 1989-05-26 1990-11-29 Basf Ag 8-substituierte 4-(heterocyclylmethylamino)-chinoline, ihre verwendung und daraus hergestellte arzneimittel
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
US5362743A (en) * 1993-03-09 1994-11-08 Pfizer Inc. Aminoquinoline derivatives
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
PT720601E (pt) * 1993-08-10 2001-02-28 Black James Foundation Ligandos de receptores de gastrina e cck
US5650415A (en) * 1995-06-07 1997-07-22 Sugen, Inc. Quinoline compounds
KR0169813B1 (ko) * 1995-07-12 1999-01-15 김종인 4-아미노-3-아실나프티리딘 유도체
US5760041A (en) * 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
US6875769B2 (en) * 1996-05-23 2005-04-05 Pfizer Inc. Substituted6,6-hetero-bicyclicderivatives
US5929080A (en) * 1997-05-06 1999-07-27 American Cyanamid Company Method of treating polycystic kidney disease
US6251912B1 (en) 1997-08-01 2001-06-26 American Cyanamid Company Substituted quinazoline derivatives
US6323209B1 (en) 1997-11-06 2001-11-27 American Cyanamid Company Method of treating or inhibiting colonic polyps
AU6159499A (en) 1998-09-29 2000-04-17 Wyeth Holdings Corporation Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors
MXPA02006474A (es) * 1999-12-28 2002-11-29 Eisai Co Ltd Compuestos heterociclicos que contienen sulfonamida.
US6521618B2 (en) * 2000-03-28 2003-02-18 Wyeth 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
US6576644B2 (en) * 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
CN102558155A (zh) 2003-01-14 2012-07-11 阿伦纳药品公司 作为代谢调节剂的芳基和杂芳基衍生物及其所涉及的疾病如糖尿病和高血糖症的预防和治疗
DK1606261T3 (da) 2003-03-10 2010-01-18 Nycomed Gmbh Hidtil ukendt fremgangsmåde til fremstilling af roflumilast
TWI335328B (en) * 2003-07-14 2011-01-01 Arena Pharm Inc Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related hereto
AU2006224619B2 (en) * 2005-03-16 2012-06-07 Takeda Gmbh Taste masked dosage form containing roflumilast
WO2011022216A1 (en) * 2009-08-17 2011-02-24 High Point Pharmaceuticals, Llc Substituted pyridine derivatives, pharmaceutical compositions, and methods of use to treat oxidative stress
CA2786994C (en) 2010-01-27 2018-01-16 Arena Pharmaceuticals, Inc. Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
MX2013003184A (es) 2010-09-22 2013-06-07 Arena Pharm Inc Moduladores del receptor gpr119 y el tratamiento de transtornos relacionados con el mismo.
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
PL3310760T3 (pl) 2015-06-22 2023-03-06 Arena Pharmaceuticals, Inc. Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
CN109890793B (zh) 2016-11-11 2022-11-18 拜耳动物保健有限责任公司 新的抗蠕虫药喹啉-3-甲酰胺衍生物
KR20190116416A (ko) 2017-02-16 2019-10-14 아레나 파마슈티칼스, 인크. 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
WO2019084271A1 (en) * 2017-10-25 2019-05-02 Children's Medical Center Corporation PAPD5 INHIBITORS AND METHODS OF USE
JP7403472B2 (ja) 2018-05-09 2023-12-22 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新規キノリン誘導体
AU2019280822A1 (en) 2018-06-06 2021-01-07 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
US12486234B2 (en) 2019-04-24 2025-12-02 Children's Medical Center Corporation PAPD5 inhibitors and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470186A (en) * 1967-06-02 1969-09-30 American Cyanamid Co Substituted 4-anilino-3-quinolinecarboxylic acids and esters
JPS4838712A (online.php) * 1971-09-18 1973-06-07

Also Published As

Publication number Publication date
EG15009A (en) 1985-03-31
GR68006B (online.php) 1981-10-26
NO800858L (no) 1980-09-29
US4343804A (en) 1982-08-10
SG33683G (en) 1985-03-29
IE800605L (en) 1980-09-26
NL8001752A (nl) 1980-09-30
FI800910A7 (fi) 1980-09-27
FI77452C (fi) 1989-03-10
DK156056C (da) 1989-11-06
MX6264E (es) 1985-02-19
FR2452485A1 (fr) 1980-10-24
PT71008B (en) 1981-06-25
SE435837B (sv) 1984-10-22
AR230268A1 (es) 1984-03-01
FR2452485B1 (fr) 1986-09-12
AU528388B2 (en) 1983-04-28
DE3011490A1 (de) 1981-03-12
SE8002292L (sv) 1980-09-27
YU41702B (en) 1987-12-31
PH16416A (en) 1983-09-29
NO153927B (no) 1986-03-10
AT372373B (de) 1983-09-26
DK128380A (da) 1980-09-27
CH644105A5 (fr) 1984-07-13
PT71008A (en) 1980-04-01
ATA156480A (de) 1983-02-15
GB2047244B (en) 1983-02-23
HK67983A (en) 1983-12-23
DK156056B (da) 1989-06-19
AU5684880A (en) 1980-10-02
IL59628A0 (en) 1980-06-30
JPH02117663A (ja) 1990-05-02
IT8067465A0 (it) 1980-03-26
CA1147338A (en) 1983-05-31
IT1133079B (it) 1986-07-09
IN151446B (online.php) 1983-04-23
NO153927C (no) 1986-06-18
PL125030B1 (en) 1983-03-31
NZ193252A (en) 1984-04-27
YU84480A (en) 1983-10-31
ES8103048A1 (es) 1981-02-16
BR8001779A (pt) 1980-11-18
ES489887A0 (es) 1981-02-16
GB2047244A (en) 1980-11-26
PL222993A1 (online.php) 1981-01-30
DE3011490C2 (online.php) 1988-12-22
FI77452B (fi) 1988-11-30
IL59628A (en) 1983-06-15

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