IE45253B1 - 1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxylic acid derivaties and process for the production thereof - Google Patents

1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxylic acid derivaties and process for the production thereof

Info

Publication number
IE45253B1
IE45253B1 IE1423/77A IE142377A IE45253B1 IE 45253 B1 IE45253 B1 IE 45253B1 IE 1423/77 A IE1423/77 A IE 1423/77A IE 142377 A IE142377 A IE 142377A IE 45253 B1 IE45253 B1 IE 45253B1
Authority
IE
Ireland
Prior art keywords
compound
dihydro
pyrrole
pyrrolo
carboxylic acid
Prior art date
Application number
IE1423/77A
Other languages
English (en)
Other versions
IE45253L (en
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107410&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE45253(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US05/771,286 external-priority patent/US4089969A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of IE45253L publication Critical patent/IE45253L/xx
Publication of IE45253B1 publication Critical patent/IE45253B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
IE1423/77A 1976-07-14 1977-07-08 1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxylic acid derivaties and process for the production thereof IE45253B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70490976A 1976-07-14 1976-07-14
US05/771,286 US4089969A (en) 1976-07-14 1977-02-23 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof

Publications (2)

Publication Number Publication Date
IE45253L IE45253L (en) 1978-01-14
IE45253B1 true IE45253B1 (en) 1982-07-14

Family

ID=27107410

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1423/77A IE45253B1 (en) 1976-07-14 1977-07-08 1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxylic acid derivaties and process for the production thereof

Country Status (27)

Country Link
JP (1) JPS539788A (ja)
AR (1) AR224997A1 (ja)
CA (1) CA1102809A (ja)
CH (3) CH641458A5 (ja)
CS (1) CS204954B2 (ja)
DE (2) DE2760330C2 (ja)
DK (1) DK151886C (ja)
ES (2) ES460706A1 (ja)
FI (1) FI63406C (ja)
FR (2) FR2358406A1 (ja)
GB (1) GB1554075A (ja)
GR (1) GR61111B (ja)
HK (1) HK15981A (ja)
HU (1) HU174224B (ja)
IE (1) IE45253B1 (ja)
IL (2) IL52493A (ja)
IT (1) IT1117313B (ja)
MX (1) MX163202B (ja)
MY (1) MY8100357A (ja)
NL (2) NL186318C (ja)
NO (1) NO147564C (ja)
NZ (1) NZ184610A (ja)
PL (4) PL124711B1 (ja)
PT (1) PT66780B (ja)
SE (1) SE434643B (ja)
SU (1) SU695558A3 (ja)
YU (1) YU40816B (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
JPS55124633A (en) * 1979-03-19 1980-09-25 Sohachi Takeuchi Manufacturing method of tubular vessel
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
JPS5910589A (ja) * 1982-06-10 1984-01-20 メルク　エンド　カムパニー　インコーポレーテツド 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JPH0739418B2 (ja) * 1987-09-10 1995-05-01 久光製薬株式会社 新規な３−アロイル−６，７−ジヒドロ−５Ｈ−ピロロ〔１，２−ｃ〕イミダゾール−７−カルボン酸誘導体
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
IT1250691B (it) * 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
WO1993009768A1 (en) * 1991-11-11 1993-05-27 Hisamitsu Pharmaceutical Co., Inc. Fomentation containing ketorolac
DE4300697C1 (de) * 1993-01-13 1994-05-19 Roemmers Sa Keterolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
JP2008210666A (ja) * 2007-02-27 2008-09-11 Okamura Corp 商品陳列棚における照明装置

Also Published As

Publication number Publication date
FR2358406B1 (ja) 1981-04-17
HK15981A (en) 1981-05-01
PT66780B (fr) 1978-12-18
HU174224B (hu) 1979-11-28
DK151886C (da) 1988-06-06
IL58779A0 (en) 1980-02-29
IT1117313B (it) 1986-02-17
FR2375234A1 (fr) 1978-07-21
JPS539788A (en) 1978-01-28
IL52493A0 (en) 1977-10-31
YU172177A (en) 1983-09-30
PL124445B1 (en) 1983-01-31
NO147564B (no) 1983-01-24
FI63406B (fi) 1983-02-28
FR2375234B1 (ja) 1980-11-07
MY8100357A (en) 1981-12-31
SU695558A3 (ru) 1979-10-30
CH646972A5 (en) 1984-12-28
CH646973A5 (en) 1984-12-28
NZ184610A (en) 1979-03-28
CA1102809A (en) 1981-06-09
AU2697577A (en) 1979-01-18
CH641458A5 (en) 1984-02-29
AR224997A1 (es) 1982-02-15
DK307577A (da) 1978-01-15
NL7707651A (nl) 1978-01-17
NL930021I2 (nl) 1997-03-03
MX163202B (es) 1992-02-20
NL186318B (nl) 1990-06-01
PL124711B1 (en) 1983-02-28
YU40816B (en) 1986-06-30
ES460706A1 (es) 1978-12-01
PL199603A1 (pl) 1978-04-24
AU513384B2 (en) 1980-11-27
NL186318C (nl) 1990-11-01
DE2731678C2 (ja) 1989-06-08
FR2358406A1 (fr) 1978-02-10
SE7708141L (sv) 1978-01-15
NO772494L (no) 1978-01-17
DE2731678A1 (de) 1978-03-16
IE45253L (en) 1978-01-14
GB1554075A (en) 1979-10-17
JPS6254109B2 (ja) 1987-11-13
NO147564C (no) 1983-05-18
GR61111B (en) 1978-09-12
FI772153A (ja) 1978-01-15
IL52493A (en) 1982-02-28
DK151886B (da) 1988-01-11
CS204954B2 (en) 1981-04-30
DE2760330C2 (ja) 1989-06-15
PL109390B1 (en) 1980-05-31
ES470214A1 (es) 1979-09-16
SE434643B (sv) 1984-08-06
NL930021I1 (nl) 1993-05-03
PL124444B1 (en) 1983-01-31
PT66780A (fr) 1977-08-01
FI63406C (fi) 1983-06-10

Similar Documents

Publication Publication Date Title
US4089969A (en) 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4097579A (en) 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4087539A (en) 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4232038A (en) 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
IE45253B1 (en) 1,2-dihydro-3h-pyrrolo (1,2-a)pyrrole-1-carboxylic acid derivaties and process for the production thereof
US4344943A (en) 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
NO874834L (no) Fremgangsmaate for fremstilling av terapeutisk aktive tienopyridinoner.
US4560699A (en) 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
IE45302B1 (en) 5-(2-furoyl)-,5-(2-thenoyl)-,5(3-furoyl)-and 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo,2-a)pyrrole-1-carboxylic acid derivatives and process for the production thereof
GB1586655A (en) Pyrido-indole transquilising agents
US4410534A (en) 3-Substituted-5,6,7,8-tetrahydropyrrolo[1,2-a]-pyridine-and 6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]-azepine carboxylic acid derivatives useful as blood platelet aggregation inhibitors
EP0284076A1 (en) Process for preparing (+)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
US4000288A (en) 6,11-dihydrodibenzo-thiepin-11-ones, compositions and uses thereof
US4816461A (en) 7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b] indole, a process for their preparation and medicaments containing them
DK151336B (da) Analogifremgangsmaade til fremstilling af en (dl)- eller (l)-5-benzoyl-1,2-dihydro-3h-pyrrol(1,2-a)pyrrol-1-carboxylsyre
CH641461A5 (en) 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives
DK152654B (da) Analogifremgangsmaade til fremstilling af (dl)- eller (l)-5-(2-furoyl)-, 5-(2-thenoyl)-, 5-(furoyl)- eller 5-(3-thenoyl)-1,2-dihydro-3h-pyrrol-oe1,2-aaa-pyrrol-1-carboxylsyre
JPS5865280A (ja) ５―（アミノアルキル）―１１―フェニル―５Ｈ―ジベンゾ〔ｂ，ｅ〕〔１，４〕ジアゼピン類
CH644862A5 (en) 5-(2- and 3-furoyl)- and 5-(2- and 3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and their salts and esters

Legal Events

Date Code Title Description
MK9A Patent expired