ID27263A - Dihidropirimidina baru - Google Patents

Dihidropirimidina baru

Info

Publication number
ID27263A
ID27263A IDW20002111A ID20002111A ID27263A ID 27263 A ID27263 A ID 27263A ID W20002111 A IDW20002111 A ID W20002111A ID 20002111 A ID20002111 A ID 20002111A ID 27263 A ID27263 A ID 27263A
Authority
ID
Indonesia
Prior art keywords
hydropirimidine
new
new hydropirimidine
Prior art date
Application number
IDW20002111A
Other languages
English (en)
Indonesian (id)
Inventor
Jurgen Stoltefuss
Sirgfried Goldmann
Thomas Kramer
Karl-Heinz Schlemmer
Ulrich Niewohner
Arnold Paessens
Erwin Graef
Stefan Lottmann
Kark Deres
Olaf Weber
Jorn Stolting
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ID27263A publication Critical patent/ID27263A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
IDW20002111A 1998-04-18 1999-04-07 Dihidropirimidina baru ID27263A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19817264A DE19817264A1 (de) 1998-04-18 1998-04-18 Neue Dihydropyrimidine

Publications (1)

Publication Number Publication Date
ID27263A true ID27263A (id) 2001-03-22

Family

ID=7864972

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20002111A ID27263A (id) 1998-04-18 1999-04-07 Dihidropirimidina baru

Country Status (37)

Country Link
US (3) US6696451B1 (zh)
EP (1) EP1080086B1 (zh)
JP (2) JP4590097B2 (zh)
KR (1) KR100636771B1 (zh)
CN (1) CN1159311C (zh)
AR (1) AR018187A1 (zh)
AT (1) ATE223401T1 (zh)
AU (1) AU740318B2 (zh)
BG (1) BG64649B1 (zh)
BR (2) BRPI9917862B8 (zh)
CA (1) CA2328780C (zh)
CO (1) CO5021127A1 (zh)
CU (1) CU23049A3 (zh)
CZ (1) CZ293482B6 (zh)
DE (2) DE19817264A1 (zh)
DK (1) DK1080086T3 (zh)
ES (1) ES2183548T3 (zh)
GT (1) GT199900056A (zh)
HK (1) HK1039119A1 (zh)
HU (1) HUP0102372A3 (zh)
ID (1) ID27263A (zh)
IL (2) IL138584A0 (zh)
MY (1) MY126527A (zh)
NO (2) NO321985B1 (zh)
NZ (1) NZ507569A (zh)
PE (1) PE20000427A1 (zh)
PL (1) PL193898B1 (zh)
PT (1) PT1080086E (zh)
RU (1) RU2245881C9 (zh)
SI (1) SI1080086T1 (zh)
SK (1) SK286407B6 (zh)
SV (1) SV1999000047A (zh)
TR (1) TR200003011T2 (zh)
TW (1) TW548274B (zh)
UA (1) UA63998C2 (zh)
WO (1) WO1999054326A1 (zh)
ZA (1) ZA200005136B (zh)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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AU4289100A (en) * 1999-03-25 2000-10-16 Bayer Aktiengesellschaft Dihydropyrimidines and their use in the treatment of hepatitis
WO2000078730A1 (fr) 1999-06-23 2000-12-28 Ajinomoto Co., Inc. Nouveaux derives dihydropyrimidiniques
AU3009801A (en) * 1999-12-22 2001-07-03 Bayer Aktiengesellschaft Combinations of medicaments for treating viral diseases
DE10012823A1 (de) 2000-03-16 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013125A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10013126A1 (de) * 2000-03-17 2001-09-20 Bayer Ag Arzneimittel gegen virale Erkrankungen
DE10125131A1 (de) 2001-05-23 2002-12-05 Bayer Ag Verfahren zur Spaltung des Methyl 4-(2-chlor-4-fluorphenyl)-2-(3,5-difluor-2-pyridinyl)-6-methyl-1,4-dihydro-5-pyrmidincarboxylat-Racemats
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
CN101104617B (zh) * 2006-07-10 2010-06-23 北京摩力克科技有限公司 二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
CN101104604B (zh) * 2006-07-10 2011-03-02 北京摩力克科技有限公司 光学纯二氢嘧啶类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
RU2452733C2 (ru) * 2007-04-27 2012-06-10 Пэдью Фарма Л.П. Антагонисты trpv1 и их применение
DK2514750T5 (en) * 2007-06-18 2014-02-17 Sunshine Lake Pharma Co Ltd BROMPHENYL-SUBSTITUTED THIAZOLYLDIHYDROPYRIMIDINES
NZ582443A (en) 2007-07-12 2011-04-29 Novartis Ag Oral pharmaceutical solutions containing telbivudine
US20130267517A1 (en) 2012-03-31 2013-10-10 Hoffmann-La Roche Inc. Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
HUE034919T2 (en) * 2012-08-24 2018-03-28 Sunshine Lake Pharma Co Ltd 2,4,5,6-substituted 3,6-dihydropyrimidine derivatives such as hepatitis B virus (HBV) polymerase inhibitors, for example, for the treatment of chronic hepatitis
WO2014037480A1 (en) 2012-09-10 2014-03-13 F. Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN103664899B (zh) * 2012-09-11 2017-06-16 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
AU2013342164A1 (en) * 2012-11-09 2015-06-04 Assembly Biosciences, Inc. Alternative uses for HBV assembly effectors
EP2968823B8 (en) 2013-03-15 2022-02-16 Fisher & Paykel Healthcare Limited Components for medical circuits
TW201609652A (zh) * 2013-11-12 2016-03-16 陶氏農業科學公司 用於氟化化合物之過程（三）
EP3071564B1 (en) 2013-11-19 2020-08-05 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
CN104672223B (zh) 2013-11-27 2018-03-13 广东东阳光药业有限公司 二氢嘧啶衍生物的制备方法及其中间体
US9771358B2 (en) 2014-03-28 2017-09-26 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
US9938301B2 (en) * 2014-05-30 2018-04-10 Qilu Pharmaceutical Co., Ltd. Dihydropyrimido fused ring derivative as HBV inhibitor
CN105153164B (zh) * 2014-05-30 2018-10-30 齐鲁制药有限公司 作为hbv抑制剂的二氢嘧啶并环衍生物
RU2017127611A (ru) 2015-02-07 2019-03-07 Саншайн Лейк Фарма Ко., Лтд. Комплексные соединения и соли производных дигидропиримидина и их применение в фармацевтических препаратах
KR20200020887A (ko) 2017-06-27 2020-02-26 얀센 파마슈티카 엔.브이. 헤테로아릴디히드로피리미딘 유도체 및 b형 간염 감염의 치료 방법
US10759774B2 (en) 2017-09-28 2020-09-01 The Curators Of The University Of Missouri Inhibitors of hepatitis B virus targeting capsid assembly
MA50520A (fr) 2017-11-02 2020-09-09 Aicuris Gmbh & Co Kg Nouveaux indole-2-carboxamides à substitution pyrazolo-pipéridine hautement actifs agissant contre le virus de l'hépatite b (vhb)
WO2019086141A1 (en) 2017-11-02 2019-05-09 Aicuris Gmbh & Co. Kg Novel, highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis b virus (hbv)
EP3790866A4 (en) * 2018-05-08 2022-03-02 Janssen Sciences Ireland Unlimited Company DIHYDROPYRIMIDE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR HBV-INDUCED DISEASE
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
UY38435A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas urea 6,7-dihidro-4h-pirazol[1,5-a] pirazinas activas contra el virus de la hepatitis b (vhb)
AR117189A1 (es) 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)
WO2020089460A1 (en) * 2018-11-02 2020-05-07 Aicuris Gmbh & Co. Kg Novel urea 6,7-dihydro-4h-thiazolo[5,4-c]pyridines active against the hepatitis b virus (hbv)
UY38437A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv)
UY38436A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas 6,7-dihidro-4h-pirazolo[1,5-a] pirazinindol-2-carboxamidas activas contra el virus de la hepatitis b (vhb)
UY38439A (es) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Novedosas urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb)
CN113227090A (zh) 2018-12-20 2021-08-06 詹森药业有限公司 杂芳基二氢嘧啶衍生物和治疗乙型肝炎感染的方法
CN113767101A (zh) 2019-04-30 2021-12-07 艾库里斯有限及两合公司 具有抗乙型肝炎病毒(hbv)活性的新的吲哚-2-甲酰胺类化合物
KR20220003023A (ko) 2019-04-30 2022-01-07 아이쿠리스 게엠베하 운트 코. 카게 B형 간염 바이러스 (hbv)에 대해 활성인 신규 옥살릴 피페라진
EP3962913A1 (en) 2019-04-30 2022-03-09 AiCuris GmbH & Co. KG Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv)
CA3138384A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv)
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators

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JPS60185764A (ja) * 1984-03-05 1985-09-21 Wako Pure Chem Ind Ltd ピリジン誘導体の新規な製造法
US4698340A (en) * 1984-07-19 1987-10-06 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine derivatives, processes for preparation thereof and composition containing the same
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GB8906168D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
AR010061A1 (es) 1996-11-12 2000-05-17 Garcia Cattebeke Cybele Carina Derivado de 3-(2-piridil)-pirazol substituidos, un proceso para su preparacion, compuestos intermediarios, una composicion herbicida e inhibidoradel crecimiento de plantas, un metodo para controlar e inhibir el crecimiento de las plantas y el uso de dicha composicion
SE9702564D0 (sv) * 1997-07-02 1997-07-02 Astra Ab New compounds

Also Published As

Publication number Publication date
TW548274B (en) 2003-08-21
DE59902573D1 (en) 2002-10-10
BRPI9917862B8 (pt) 2021-05-25
CA2328780C (en) 2008-09-23
NO20045259L (no) 2000-12-13
TR200003011T2 (tr) 2001-01-22
JP5237332B2 (ja) 2013-07-17
BRPI9917862A2 (zh) 2010-12-07
AR018187A1 (es) 2001-10-31
PL193898B1 (pl) 2007-03-30
US6696451B1 (en) 2004-02-24
EP1080086B1 (de) 2002-09-04
SK15652000A3 (sk) 2001-04-09
MY126527A (en) 2006-10-31
JP2002512243A (ja) 2002-04-23
EP1080086A1 (de) 2001-03-07
CU23049A3 (es) 2005-06-24
PT1080086E (pt) 2002-12-31
ZA200005136B (en) 2001-03-02
CA2328780A1 (en) 1999-10-28
US7514565B2 (en) 2009-04-07
US20070117812A1 (en) 2007-05-24
NO20005215D0 (no) 2000-10-17
SV1999000047A (es) 2000-06-23
WO1999054326A1 (de) 1999-10-28
BG64649B1 (bg) 2005-10-31
BR9909730A (pt) 2000-12-19
JP2010241837A (ja) 2010-10-28
DE19817264A1 (de) 1999-10-21
SK286407B6 (sk) 2008-09-05
US20040167135A1 (en) 2004-08-26
WO1999054326A8 (de) 1999-12-29
BG104812A (en) 2001-06-29
NO329020B1 (no) 2010-07-26
HUP0102372A3 (en) 2003-01-28
RU2245881C9 (ru) 2006-02-10
HK1039119A1 (en) 2002-04-12
CZ293482B6 (cs) 2004-05-12
BRPI9917862B1 (pt) 2013-05-07
AU740318B2 (en) 2001-11-01
DK1080086T3 (da) 2002-12-23
NO321985B1 (no) 2006-07-31
CN1159311C (zh) 2004-07-28
GT199900056A (es) 2000-10-07
CZ20003871A3 (cs) 2001-01-17
KR100636771B1 (ko) 2006-10-23
JP4590097B2 (ja) 2010-12-01
CO5021127A1 (es) 2001-03-27
ES2183548T3 (es) 2003-03-16
CN1305471A (zh) 2001-07-25
PE20000427A1 (es) 2000-06-25
IL138584A0 (en) 2001-10-31
RU2245881C2 (ru) 2005-02-10
SI1080086T1 (en) 2003-02-28
HUP0102372A2 (hu) 2001-12-28
IL138584A (en) 2006-09-05
KR20010042788A (ko) 2001-05-25
ATE223401T1 (de) 2002-09-15
NZ507569A (en) 2002-04-26
PL343481A1 (en) 2001-08-27
BR9909730B1 (pt) 2012-09-04
AU3813399A (en) 1999-11-08
NO20005215L (no) 2000-12-13
UA63998C2 (uk) 2004-02-16

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