ID23375A - Metode pengobatan penyakit mata kering dengan agonist-agonist reseptor purinergik - Google Patents
Metode pengobatan penyakit mata kering dengan agonist-agonist reseptor purinergikInfo
- Publication number
- ID23375A ID23375A IDW990977A ID990977A ID23375A ID 23375 A ID23375 A ID 23375A ID W990977 A IDW990977 A ID W990977A ID 990977 A ID990977 A ID 990977A ID 23375 A ID23375 A ID 23375A
- Authority
- ID
- Indonesia
- Prior art keywords
- triphosphate
- purinergic receptor
- subject
- agonistics
- disclosed
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/797,472 US5900407A (en) | 1997-02-06 | 1997-02-06 | Method of treating dry eye disease with uridine triphosphates and related compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ID23375A true ID23375A (id) | 2000-04-20 |
Family
ID=25170925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW990977A ID23375A (id) | 1997-02-06 | 1998-02-06 | Metode pengobatan penyakit mata kering dengan agonist-agonist reseptor purinergik |
Country Status (20)
Country | Link |
---|---|
US (6) | US5900407A (fr) |
EP (1) | EP1003474B1 (fr) |
JP (3) | JP3652707B2 (fr) |
KR (1) | KR100378443B1 (fr) |
CN (1) | CN1151775C (fr) |
AT (1) | ATE428400T1 (fr) |
AU (1) | AU735684B2 (fr) |
BR (1) | BR9809562A (fr) |
CA (1) | CA2280183C (fr) |
DE (1) | DE69840746D1 (fr) |
DK (1) | DK1003474T3 (fr) |
ES (1) | ES2325892T3 (fr) |
HK (1) | HK1025915A1 (fr) |
ID (1) | ID23375A (fr) |
MY (1) | MY120023A (fr) |
NO (1) | NO329118B1 (fr) |
NZ (1) | NZ337405A (fr) |
PT (1) | PT1003474E (fr) |
WO (1) | WO1998034593A1 (fr) |
ZA (1) | ZA98979B (fr) |
Families Citing this family (85)
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US6423694B1 (en) * | 1996-02-21 | 2002-07-23 | Inspire Pharmaceuticals, Inc. | Method of treating otitis media with uridine triphosphates and related compounds |
US6420347B1 (en) * | 1997-03-27 | 2002-07-16 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with uridine triphosphates and related compounds |
US6673779B2 (en) * | 1996-03-27 | 2004-01-06 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues |
US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
US5763447C1 (en) * | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
US6921755B2 (en) * | 1998-02-06 | 2005-07-26 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
US6696425B2 (en) * | 1997-02-06 | 2004-02-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
US7223744B2 (en) * | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
US7078391B2 (en) | 1997-02-10 | 2006-07-18 | Inspire Pharmaceuticals, Inc. | Method of treating edematous retinal disorders |
US6596725B2 (en) | 1997-02-10 | 2003-07-22 | Inspire Pharmaceuticals, Inc. | Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema |
TW593331B (en) * | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
US6872710B2 (en) * | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
US6462028B2 (en) | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
JP3723227B2 (ja) * | 1997-07-25 | 2005-12-07 | インスパイアー ファーマシューティカルズ,インコーポレイティド | ジ(ウリジン5’)−テトラホスフェート及びその塩の大規模生産のための方法 |
US6548658B2 (en) * | 1997-07-25 | 2003-04-15 | Inspire Pharmaceuticals, Inc. | Di-(uridine 5′)-tetraphosphate and salts thereof |
EP1087777B1 (fr) * | 1998-05-22 | 2003-02-19 | Inspire Pharmaceuticals, Inc. | Dinucleotides therapeutiques et leurs derives |
WO2000039145A1 (fr) * | 1998-12-23 | 2000-07-06 | The University Of North Carolina At Chapel Hill | Transfert genique cible utilisant des recepteurs couples a une proteine g |
CA2359891A1 (fr) * | 1999-02-26 | 2000-08-31 | Inspire Pharmaceuticals, Inc. | Methode favorisant l'hydratation des muqueuses a l'aide de certains uridine, adenine et cytidine diphosphates et de leurs analogues |
CZ303172B6 (cs) * | 1999-06-30 | 2012-05-09 | Inspire Pharmaceuticals, Inc. | Krystalická forma P1-(2'-deoxycytidin-5'-)P4-(uridin-5'-)tetrafosfátu |
US6576224B1 (en) * | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
US20020061281A1 (en) * | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
WO2001028528A1 (fr) * | 1999-10-20 | 2001-04-26 | Eliezer Rapaport | Procedes, compositions pharmaceutiques et therapeutiques destines a l'administration d'adenosine |
US6723737B1 (en) * | 1999-10-20 | 2004-04-20 | Eliezer Rapaport | Methods, pharmaceutical and therapeutic compostions for administering adenosine |
US6277855B1 (en) | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
US6864243B1 (en) * | 2000-05-12 | 2005-03-08 | Inspire Pharmaceuticals, Inc. | Method for treating retinal degeneration with purinergic receptor agonists |
CA2413928C (fr) * | 2000-05-30 | 2011-01-25 | Santen Pharmaceutical Co., Ltd. | Promoteurs de l'extension de l'epithelium corneen |
US7115585B2 (en) | 2000-08-21 | 2006-10-03 | Inspire Pharmaceuticals, Inc. | Compositions for treating epithelial and retinal tissue diseases |
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US7018985B1 (en) | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
US6867199B2 (en) | 2000-08-21 | 2005-03-15 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapeutic use |
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CN106729718A (zh) * | 2010-09-10 | 2017-05-31 | 参天制药株式会社 | 以组合p2y2受体激动剂和透明质酸或其盐为特征的干眼症治疗剂 |
US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
AU2011328900B2 (en) | 2010-11-16 | 2015-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for treatment of dry eye |
EP2659894A4 (fr) * | 2010-12-28 | 2014-12-10 | Santen Pharmaceutical Co Ltd | Solution ophtalmique contenant du diquafosol, son procédé de production, et procédé de prévention de la formation d'un précipité insoluble |
EP2694983B1 (fr) * | 2011-04-06 | 2020-06-03 | KLA-Tencor Corporation | Procédé et système pour produire une métrique de qualité pour commande de processus améliorée |
UA113981C2 (xx) | 2012-03-26 | 2017-04-10 | Офтальмологічний розчин, що містить диквафасол | |
EP2967817B1 (fr) | 2013-03-12 | 2021-03-10 | Oculeve, Inc. | Dispositifs et systèmes de pose d'implant |
CA2883874A1 (fr) | 2013-04-19 | 2014-10-23 | Oculeve, Inc. | Dispositifs et procedes de stimulation nasale |
ES2812752T3 (es) | 2014-02-25 | 2021-03-18 | Oculeve Inc | Formulaciones de polímeros para estimulación nasolagrimal |
EP3171928B1 (fr) | 2014-07-25 | 2020-02-26 | Oculeve, Inc. | Stimulation pulsée pour traiter l'oeil sec |
EP3209371A4 (fr) | 2014-10-22 | 2018-10-24 | Oculeve, Inc. | Systèmes et procédés de stimulateur nasal implantable |
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CN107106843A (zh) | 2014-10-22 | 2017-08-29 | 奥库利维公司 | 用于治疗干眼症的刺激装置和方法 |
KR20180014768A (ko) | 2015-06-05 | 2018-02-09 | 산텐 세이야꾸 가부시키가이샤 | 소프트 콘택트렌즈가 착용된 드라이아이 환자의 눈에 점안되도록 이용되는 것을 특징으로 하는 드라이아이 치료제 |
US10426958B2 (en) | 2015-12-04 | 2019-10-01 | Oculeve, Inc. | Intranasal stimulation for enhanced release of ocular mucins and other tear proteins |
US10252048B2 (en) | 2016-02-19 | 2019-04-09 | Oculeve, Inc. | Nasal stimulation for rhinitis, nasal congestion, and ocular allergies |
CA3022683A1 (fr) | 2016-05-02 | 2017-11-09 | Oculeve, Inc. | Stimulation intranasale pour le traitement de la maladie de la glande de meibomius et de la blepharite |
JP2020500609A (ja) | 2016-12-02 | 2020-01-16 | オキュリーブ, インコーポレイテッド | ドライアイ予測及び治療勧告のための装置及び方法 |
MX2020008925A (es) | 2018-02-28 | 2020-10-01 | Santen Pharmaceutical Co Ltd | Composicion oftalmica que comprende dicuafosol y polimero cationico. |
JPWO2020175525A1 (ja) | 2019-02-27 | 2021-12-23 | 参天製薬株式会社 | ジクアホソルまたはその塩、ビニル系高分子およびセルロース系高分子を含有する眼科用組成物 |
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WO2021039748A1 (fr) * | 2019-08-27 | 2021-03-04 | 参天製薬株式会社 | Diquafosol ou sel correspondant et composition ophtalmique aqueuse contenant de la polyvinylpyrrolidone |
KR20210110055A (ko) * | 2020-02-28 | 2021-09-07 | 주식회사 종근당바이오 | P1, p4-디(우리딘 5'-)테트라포스페이트 나트륨염 4 수화물 결정형 a의 제조방법 |
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US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
US5789391A (en) | 1996-07-03 | 1998-08-04 | Inspire Pharmaceuticals, Inc. | Method of treating sinusitis with uridine triphosphates and related compounds |
US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
US6696425B2 (en) | 1997-02-06 | 2004-02-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
US6921755B2 (en) | 1998-02-06 | 2005-07-26 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
TW567456B (en) * | 2001-02-15 | 2003-12-21 | Au Optronics Corp | Apparatus capable of improving flicker of thin film transistor liquid crystal display |
FR2904554B1 (fr) * | 2006-08-04 | 2010-11-05 | Zheng Xu | Lipides moleculaires heterogenes cytotropes (lmhc), procede de preparation, et methodes de traitement de patients porteurs de cancers multiples |
-
1997
- 1997-02-06 US US08/797,472 patent/US5900407A/en not_active Expired - Lifetime
-
1998
- 1998-02-06 AT AT98907434T patent/ATE428400T1/de active
- 1998-02-06 NZ NZ337405A patent/NZ337405A/en not_active IP Right Cessation
- 1998-02-06 MY MYPI98000483A patent/MY120023A/en unknown
- 1998-02-06 US US09/171,169 patent/US6887858B1/en not_active Expired - Lifetime
- 1998-02-06 CA CA002280183A patent/CA2280183C/fr not_active Expired - Lifetime
- 1998-02-06 DK DK98907434T patent/DK1003474T3/da active
- 1998-02-06 DE DE69840746T patent/DE69840746D1/de not_active Expired - Lifetime
- 1998-02-06 EP EP98907434A patent/EP1003474B1/fr not_active Expired - Lifetime
- 1998-02-06 CN CNB988032619A patent/CN1151775C/zh not_active Expired - Lifetime
- 1998-02-06 JP JP53505498A patent/JP3652707B2/ja not_active Expired - Lifetime
- 1998-02-06 AU AU63241/98A patent/AU735684B2/en not_active Expired
- 1998-02-06 PT PT98907434T patent/PT1003474E/pt unknown
- 1998-02-06 BR BR9809562-5A patent/BR9809562A/pt not_active Application Discontinuation
- 1998-02-06 KR KR10-1999-7007113A patent/KR100378443B1/ko active IP Right Review Request
- 1998-02-06 ID IDW990977A patent/ID23375A/id unknown
- 1998-02-06 ZA ZA98979A patent/ZA98979B/xx unknown
- 1998-02-06 ES ES98907434T patent/ES2325892T3/es not_active Expired - Lifetime
- 1998-02-06 WO PCT/US1998/002701 patent/WO1998034593A1/fr active IP Right Grant
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1999
- 1999-08-04 NO NO19993777A patent/NO329118B1/no not_active IP Right Cessation
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2000
- 2000-08-25 HK HK00105346A patent/HK1025915A1/xx not_active IP Right Cessation
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2002
- 2002-01-03 US US10/041,826 patent/US6916794B2/en not_active Expired - Lifetime
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2004
- 2004-09-13 JP JP2004265998A patent/JP4664027B2/ja not_active Expired - Lifetime
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2005
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2007
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2009
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2010
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