ID22643A - Steroid-steroid aktif secara antigestagenik dengan rantai 17 -alkilterfluorinasi - Google Patents

Steroid-steroid aktif secara antigestagenik dengan rantai 17 -alkilterfluorinasi

Info

Publication number
ID22643A
ID22643A IDW990831A ID990831A ID22643A ID 22643 A ID22643 A ID 22643A ID W990831 A IDW990831 A ID W990831A ID 990831 A ID990831 A ID 990831A ID 22643 A ID22643 A ID 22643A
Authority
ID
Indonesia
Prior art keywords
alkilterfluorination
antigestagenic
chain
active steroids
steroids
Prior art date
Application number
IDW990831A
Other languages
English (en)
Indonesian (id)
Inventor
Arwed Cleve
Ulrich Klar
Gunter Neep
Kristof Chwalisz
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ID22643A publication Critical patent/ID22643A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IDW990831A 1997-02-07 1998-02-09 Steroid-steroid aktif secara antigestagenik dengan rantai 17 -alkilterfluorinasi ID22643A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19706061A DE19706061A1 (de) 1997-02-07 1997-02-07 Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette

Publications (1)

Publication Number Publication Date
ID22643A true ID22643A (id) 1999-12-02

Family

ID=7820508

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW990831A ID22643A (id) 1997-02-07 1998-02-09 Steroid-steroid aktif secara antigestagenik dengan rantai 17 -alkilterfluorinasi

Country Status (35)

Country Link
US (4) US6316432B1 (fr)
EP (1) EP0970103B1 (fr)
JP (1) JP4324249B2 (fr)
KR (1) KR100511815B1 (fr)
CN (2) CN1246865A (fr)
AR (1) AR010887A1 (fr)
AT (1) ATE216397T1 (fr)
AU (1) AU742834B2 (fr)
BG (1) BG63875B1 (fr)
BR (1) BR9807667A (fr)
CA (1) CA2280041C (fr)
CL (1) CL2004001191A1 (fr)
CZ (1) CZ296328B6 (fr)
DE (2) DE19706061A1 (fr)
DK (1) DK0970103T3 (fr)
EA (1) EA003092B1 (fr)
EE (1) EE03831B1 (fr)
ES (1) ES2175673T3 (fr)
HK (1) HK1040718B (fr)
HU (1) HUP0000968A3 (fr)
ID (1) ID22643A (fr)
IL (1) IL131226A (fr)
IS (1) IS2190B (fr)
MY (1) MY118508A (fr)
NO (1) NO313554B1 (fr)
NZ (1) NZ336989A (fr)
PL (1) PL191808B1 (fr)
PT (1) PT970103E (fr)
SI (1) SI0970103T1 (fr)
SK (1) SK283155B6 (fr)
TR (1) TR199901855T2 (fr)
TW (1) TW499434B (fr)
UA (1) UA66783C2 (fr)
WO (1) WO1998034947A1 (fr)
ZA (1) ZA98985B (fr)

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DE19706061A1 (de) * 1997-02-07 1998-08-13 Schering Ag Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette
DE10049736A1 (de) * 2000-09-29 2002-04-18 Jenapharm Gmbh 17alpha-Fluoralkylsteroide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE10051609A1 (de) * 2000-10-18 2002-05-02 Schering Ag Hemmung der Wachstumsfaktorabhängigkeit von Tumorzellen
UY26965A1 (es) * 2000-10-18 2002-06-20 Schering Ag Uso de antiprogestinas para la profilaxis y el tratamiento de enfermedades dependientes de hormonas
UY26966A1 (es) * 2000-10-18 2002-06-20 Schering Ag Uso de antiprogestinas para la inducción de apoptosis en una célula
MXPA03002954A (es) * 2000-10-18 2003-08-07 Schering Ag Uso de antiprogestinas para profilaxis y tratamiento de enfermedades dependientes de las hormonas.
AU1595802A (en) * 2000-10-18 2002-04-29 Schering Ag Inhibition of the growth factor dependency of tumor cells
MXPA03002955A (es) * 2000-10-18 2003-08-07 Schering Ag Uso de antiprogestinas para la induccion de apoptosis en una celula.
CZ20031864A3 (en) * 2001-01-09 2004-03-17 Schering Aktiengesellschaft The use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment
US20020143000A1 (en) * 2001-01-09 2002-10-03 Christa Hegele-Hartung Use of antigestagens for inhibiting accelerated endometrial maturation during infertility treatment
UY27301A1 (es) * 2001-05-25 2003-02-28 Schering Ag Uso y composiciones de antiprogestinas para el tratamiento de enfermedades de la próstata
US20030013694A1 (en) * 2001-05-25 2003-01-16 Jens Hoffmann Use and compositions of antiprogestins for treatment of prostate diseases
DE10159217A1 (de) 2001-11-27 2003-06-05 Schering Ag 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate
AU2003227717A1 (en) * 2002-05-03 2003-11-17 Schering Ag 17Alpha-FLUOROALKYL-11Beta-BENZALDOXIME-STEROIDS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING SAID STEROIDS AND THE USE THEREOF IN THE PRODUCTION OF MEDICAMENTS
DE10221034A1 (de) 2002-05-03 2003-11-20 Schering Ag 17alpha-Fluoralkyl-11ß-benzaldoxim-Steroide, Verfahren zu deren Herstellung, diese Steroide enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
US20040242551A1 (en) * 2003-05-28 2004-12-02 Schering Ag Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
ME00294B (fr) 2003-07-23 2011-05-10 Bayer Pharmaceuticals Corp Omega-carboxyaryldiphenyluree fluoro-subtituee pour le traitement et la prevention de maladies et d'etats pathologiques
US7593347B2 (en) * 2003-12-29 2009-09-22 Intel Corporation Method and apparatus to exchange channel information
EP1862468A1 (fr) * 2006-06-02 2007-12-05 Bayer Schering Pharma Aktiengesellschaft 11beta-(4-Acetylphenyle)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-one crystalline
MX343130B (es) 2006-10-24 2016-10-26 Repros Therapeutics Inc Composiciones y métodos para suprimir la proliferación endometrial.
DE102006054535A1 (de) * 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesteronrezeptorantagonisten
US20080268041A1 (en) * 2007-04-23 2008-10-30 Jens Hoffmann Combination of progesterone-receptor antagonist together with none-steroidal antiestrogen for use in brca mediated diseases
US20090029954A1 (en) * 2007-04-23 2009-01-29 Jens Hoffmann Progesterone-receptor antagonist for use in brca alone or as combination with antiestrogen
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
EP2123279A1 (fr) * 2008-05-14 2009-11-25 Bayer Schering Pharma Aktiengesellschaft Administration séquentielle de 20,20,21,21,21-Ppentafluor-17-hydroxy-1 1bêta-[4-(hydroxyacétyl) phényl]-19-nor-17alpha-pregna-4,9-dien-3-on et un ou plusieurs gestagènes destinés au traitement de maladies gynécologiques
US20100087402A1 (en) * 2008-09-29 2010-04-08 Vivus, Inc. Methods and compositions for the treatment of estrogen-dependent hyperproliferative uterine disorders
DE102009034362A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
US20130018027A1 (en) 2010-03-22 2013-01-17 Repros Therapeutics Inc. Compositions and methods for non-toxic delivery of antiprogestins
DE102010030538A1 (de) 2010-06-25 2011-12-29 Bayer Schering Pharma Aktiengesellschaft 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
DE102011004899A1 (de) 2011-03-01 2012-09-06 Bayer Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
US20130029953A1 (en) * 2011-07-28 2013-01-31 Klaus Nickisch Progesterone antagonists
DE102011087987A1 (de) 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
EP2983671B1 (fr) 2013-04-11 2018-10-24 Bayer Pharma Aktiengesellschaft Forme posologique de l'antagoniste du récepteur de la progestérone
US9096641B2 (en) 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
EP2868323A1 (fr) 2013-11-03 2015-05-06 Flamina Holding AG Composition ou groupe de compositions pharmaceutiques pour utilisation dans un procédé d'inhibition de la production de HCG autocrine dans des cellules humaines adultes
EP2868321A1 (fr) * 2013-11-03 2015-05-06 Flamina Holding AG Composition ou groupe des compositions pour l'inhibitation de la production de HCG autocrine dans la cellulse adulte humain
EA035567B1 (ru) 2015-05-18 2020-07-08 Байер Фарма Акциенгезельшафт Режим приема селективного модулятора рецептора прогестерона (sprm)
EP3214092A1 (fr) 2016-03-04 2017-09-06 Bayer Pharma Aktiengesellschaft Promédicaments du modulateur du récepteur de progesterone (sprm) (11.bêta.,17.bêta.)-17-hydroxy-11-[4-(méthylsulphonyle)phenyle]-17-(pentafluoroéthyl)estra-4,9-dièn-3-one

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DE310541C (fr) * 1915-12-19 1919-01-30
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2639045B2 (fr) 1982-03-01 1994-07-29 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto-delta-4,9-19-nor steroides et leur application comme medicaments
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
FR2598421B1 (fr) * 1986-05-06 1988-08-19 Roussel Uclaf Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
US5272140A (en) * 1987-01-23 1993-12-21 Akzo N.V. 11-aryl steroid derivatives
DE3723788A1 (de) * 1987-07-16 1989-01-26 Schering Ag 11(beta)-phenyl-4,9,15-estratriene, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3733478A1 (de) 1987-10-01 1989-04-13 Schering Ag Antigestagen- und antioestrogenwirksame verbindungen zur geburtseinleitung und zum schwangerschaftsabbruch sowie zur behandlung gynaekologischer stoerungen und hormonabhaengiger tumore
BE1004905A4 (fr) * 1987-12-30 1993-02-23 Roussel Uclaf Nouveaux derives 17beta-oh 19-nor steroides substitues en 17alpha, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
JPH02188599A (ja) * 1988-11-16 1990-07-24 Roussel Uclaf ３―ケト―デルタ―４，９―１９―ノルステロイドから誘導される新物質及びそれらよりなる薬剤
DE3921059A1 (de) * 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
CN1055929C (zh) * 1993-09-20 2000-08-30 中国科学院上海有机化学研究所 三氟甲基甾体化合物及其制备方法
DE19706061A1 (de) * 1997-02-07 1998-08-13 Schering Ag Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette

Also Published As

Publication number Publication date
BG63875B1 (bg) 2003-04-30
AU6100598A (en) 1998-08-26
CL2004001191A1 (es) 2005-03-28
EE03831B1 (et) 2002-08-15
EE9900339A (et) 2000-02-15
US6503895B2 (en) 2003-01-07
IS5147A (is) 1999-08-04
HK1040718B (zh) 2005-12-09
IS2190B (is) 2007-01-15
CN1324802A (zh) 2001-12-05
US20030134834A1 (en) 2003-07-17
ATE216397T1 (de) 2002-05-15
JP4324249B2 (ja) 2009-09-02
PT970103E (pt) 2002-09-30
EA199900644A1 (ru) 2000-04-24
CN1246865A (zh) 2000-03-08
NO313554B1 (no) 2002-10-21
SK283155B6 (sk) 2003-03-04
US20020045774A1 (en) 2002-04-18
KR100511815B1 (ko) 2005-09-05
AU742834B2 (en) 2002-01-10
DE59803856D1 (de) 2002-05-23
JP2001510479A (ja) 2001-07-31
DK0970103T3 (da) 2002-07-22
KR20000070835A (ko) 2000-11-25
IL131226A0 (en) 2001-01-28
HUP0000968A2 (hu) 2000-10-28
WO1998034947A1 (fr) 1998-08-13
CA2280041A1 (fr) 1998-08-13
BR9807667A (pt) 2000-02-15
HK1040718A1 (en) 2002-06-21
EP0970103A1 (fr) 2000-01-12
AR010887A1 (es) 2000-07-12
DE19706061A1 (de) 1998-08-13
IL131226A (en) 2004-12-15
BG103603A (en) 2000-06-30
ZA98985B (en) 1999-08-03
HUP0000968A3 (en) 2001-03-28
US6316432B1 (en) 2001-11-13
NO993811D0 (no) 1999-08-06
SK103899A3 (en) 2000-05-16
US7148213B2 (en) 2006-12-12
SI0970103T1 (en) 2002-10-31
US20050080060A1 (en) 2005-04-14
CN1202120C (zh) 2005-05-18
EP0970103B1 (fr) 2002-04-17
UA66783C2 (en) 2004-06-15
NO993811L (no) 1999-10-04
NZ336989A (en) 2001-04-27
PL334878A1 (en) 2000-03-27
PL191808B1 (pl) 2006-07-31
US6806263B2 (en) 2004-10-19
CA2280041C (fr) 2007-10-23
ES2175673T3 (es) 2002-11-16
MY118508A (en) 2004-11-30
CZ296328B6 (cs) 2006-02-15
TW499434B (en) 2002-08-21
EA003092B1 (ru) 2002-12-26
CZ280599A3 (cs) 2000-01-12
TR199901855T2 (xx) 2000-04-21

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