ID19599A - Turunan diamino-1,3,5-triazina tersubtitusi - Google Patents

Turunan diamino-1,3,5-triazina tersubtitusi

Info

Publication number
ID19599A
ID19599A IDP973312A ID973312A ID19599A ID 19599 A ID19599 A ID 19599A ID P973312 A IDP973312 A ID P973312A ID 973312 A ID973312 A ID 973312A ID 19599 A ID19599 A ID 19599A
Authority
ID
Indonesia
Prior art keywords
damuno
triazina
diamino
substituted
triazina substituted
Prior art date
Application number
IDP973312A
Other languages
English (en)
Indonesian (id)
Inventor
Michael Joseph Kukla
Donald W Ludovici
Paul Adriaan Jan Janssen
Jan Heeres
Henri Emiel Lodewijk Moereels
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ID19599A publication Critical patent/ID19599A/id

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D251/00Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D251/00Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40Nitrogen atoms
    • C07D251/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32Oxygen atoms
    • C07D307/33Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
IDP973312A 1996-10-01 1997-09-29 Turunan diamino-1,3,5-triazina tersubtitusi ID19599A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2726096P 1996-10-01 1996-10-01

Publications (1)

Publication Number Publication Date
ID19599A true ID19599A (id) 1998-07-23

Family

ID=21836641

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP973312A ID19599A (id) 1996-10-01 1997-09-29 Turunan diamino-1,3,5-triazina tersubtitusi

Country Status (34)

Country Link
US (4) US6380194B1 (zh)
EP (1) EP0834507B1 (zh)
JP (1) JP4127882B2 (zh)
KR (1) KR100478846B1 (zh)
CN (1) CN1083438C (zh)
AP (1) AP914A (zh)
AR (1) AR008864A1 (zh)
AT (1) ATE267179T1 (zh)
AU (1) AU740809B2 (zh)
BR (1) BR9704937A (zh)
CA (1) CA2216486A1 (zh)
CZ (1) CZ297333B6 (zh)
DE (1) DE69729153T2 (zh)
DK (1) DK0834507T3 (zh)
EE (1) EE03826B1 (zh)
ES (1) ES2221679T3 (zh)
HK (1) HK1009676A1 (zh)
HR (1) HRP970526B1 (zh)
HU (1) HU225270B1 (zh)
ID (1) ID19599A (zh)
IL (1) IL121849A (zh)
MY (1) MY123803A (zh)
NO (1) NO311614B1 (zh)
NZ (1) NZ328854A (zh)
OA (1) OA10620A (zh)
PL (1) PL190155B1 (zh)
PT (1) PT834507E (zh)
RU (1) RU2186774C2 (zh)
SG (1) SG53075A1 (zh)
SI (1) SI0834507T1 (zh)
SK (1) SK285241B6 (zh)
TR (1) TR199701070A2 (zh)
TW (1) TW411335B (zh)
ZA (1) ZA978766B (zh)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO311614B1 (no) 1996-10-01 2001-12-17 Janssen Pharmaceutica Nv Substituerte diamino-1,3,5-triazinderivater
TR200101319T2 (tr) 1998-11-10 2001-10-22 Janssen Pharmaceutica N.V. 2,4-Disübstitüe triazin türevleri.
SK287270B6 (sk) * 1998-11-10 2010-05-07 Janssen Pharmaceutica N. V. Derivát pyrimidínu
DE19945982A1 (de) * 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
CZ300712B6 (cs) * 1999-09-24 2009-07-22 Janssen Pharmaceutica N. V. Cásticová farmaceutická kompozice, pevná disperze a farmaceutická dávková forma, zpusoby jejich prípravy a použití a obchodní balení s jejich obsahem
US6906067B2 (en) 1999-12-28 2005-06-14 Bristol-Myers Squibb Company N-heterocyclic inhibitors of TNF-α expression
IL150420A0 (en) * 1999-12-28 2002-12-01 Pharmacopeia Inc Pyrimidine and triazine kinase inhibitors
ES2559273T3 (es) 2000-05-08 2016-02-11 Janssen Pharmaceutica Nv Profármacos de pirimidinas que inhiben la replicación del VIH
US7276510B2 (en) 2000-05-08 2007-10-02 Janssen Pharmaceutica, Inc. HIV replication inhibitors
DE60235470D1 (de) * 2001-06-26 2010-04-08 Pharmacopeia Inc N-heterocyclische inhibitoren der expression von tnf-alpha
US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
WO2003037891A1 (en) 2001-11-01 2003-05-08 Janssen Pharmaceutica N.V. Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors)
EA007578B1 (ru) 2001-11-01 2006-12-29 Янссен Фармацевтика Н.В. Производные амидов в качестве ингибиторов гликогенсинтаза-киназы 3-бета
US7528164B2 (en) 2002-05-16 2009-05-05 Cytovia, Inc. Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
US7476741B2 (en) * 2002-05-16 2009-01-13 Cytovia, Inc. Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
AU2002350719A1 (en) 2002-11-29 2004-06-23 Janssen Pharmaceutica N.V. Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
KR20050105190A (ko) * 2003-02-07 2005-11-03 얀센 파마슈티카 엔.브이. Hiv를 저해하는 1,2,4-트리아진
CL2004000303A1 (es) * 2003-02-20 2005-04-08 Tibotec Pharm Ltd Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih.
WO2005003103A2 (en) * 2003-06-30 2005-01-13 Astrazeneca Ab 2, 4, 6-tri-substituted 6-membered heterocycles and their use in the treatment of neurodegenerative diseases
CN101035773B (zh) 2004-08-10 2012-06-06 詹森药业有限公司 抑制hiv的1,2,4-三嗪-6-酮衍生物
US20090068169A1 (en) * 2004-09-03 2009-03-12 Christopher Penney 2,4,6-triamino-s-triazine-based compounds which bind to the tail (fc) portion of immunoglobulins and their use
TW200626561A (en) 2004-09-30 2006-08-01 Tibotec Pharm Ltd HIV inhibiting 5-substituted pyrimidines
KR20070057899A (ko) 2004-09-30 2007-06-07 티보텍 파마슈티칼즈 리미티드 Hiv를 억제하는 5-헤테로사이클릴피리미딘
KR20070057798A (ko) 2004-09-30 2007-06-07 티보텍 파마슈티칼즈 리미티드 Hiv를 저해하는 5-탄소환 또는 복소환으로 치환된피리미딘
RU2403254C2 (ru) 2004-10-29 2010-11-10 Тиботек Фармасьютикалз Лтд. Бициклические производные пиримидина, ингибирующие вич
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
US7589197B2 (en) 2005-06-14 2009-09-15 Taigen Biotechnology Pyrimidine compounds
BRPI0709690B8 (pt) 2006-03-30 2021-05-25 Janssen R & D Ireland 5-amido pirimidinas substituídas e composição farmacêutica que as compreende
KR20090094084A (ko) * 2006-12-29 2009-09-03 티보텍 파마슈티칼즈 리미티드 Hiv를 억제하는 5,6-치환된 피리미딘
DK2114901T3 (da) 2006-12-29 2014-06-30 Janssen R & D Ireland Hiv-inhiberende 6-substituerede pyrimidiner
US8258295B2 (en) 2007-04-30 2012-09-04 Prometic Biosciences Inc. Triazine derivatives, compositions containing such derivatives, and methods of treatment of cancer and autoimmune diseases using such derivatives
EP2268635B1 (en) * 2008-04-21 2015-06-10 Taigen Biotechnology Co., Ltd. Heterocyclic compounds
TW201021855A (en) 2008-11-13 2010-06-16 Taigen Biotechnology Co Ltd Lyophilization formulation
US9058223B2 (en) * 2011-04-22 2015-06-16 Microsoft Technology Licensing Llc Parallel entropy encoding on GPU
CA2888413C (en) * 2012-10-24 2021-11-16 Basf Se Herbicidal azines
CN106458937A (zh) * 2014-04-11 2017-02-22 巴斯夫欧洲公司 作为除草剂的二氨基三嗪衍生物
WO2016059647A2 (en) * 2014-10-13 2016-04-21 SHRI CHHATRAPTI SHIVAJI COLLEGE Maharashtra, India) Triaminotriazine picolinonitrile derivatives as potent reverse transcriptase inhibitor of hiv-1
CN105837525B (zh) * 2016-03-25 2019-05-28 浙江工业大学 2,4-二胺-1,3,5-三嗪类化合物及其制备方法与应用

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US2817814A (en) 1953-08-13 1957-12-24 Gen Electric Corona detection probe
GB771327A (en) 1953-10-26 1957-03-27 Monsanto Chemicals Production of heat hardenable melamine-formaldehyde condensation products
US2817614A (en) * 1953-10-26 1957-12-24 Monsanto Chemicals Internally plasticized melamine resins and laminates made therewith
JPS4927592B1 (zh) * 1970-05-13 1974-07-18
GB1390235A (en) 1971-08-07 1975-04-09 Kakenyaku Kako Kk 2-amino-4,6substituted-s triazines and methods for their preparation
DE3724379A1 (de) * 1987-07-23 1989-02-02 Bayer Ag Verfahren zur herstellung feinteiliger magnetischer hexaferritpigmente
WO1993010116A1 (en) * 1991-11-12 1993-05-27 Pfizer Inc. Triazine derivatives for enhancing antitumor activity
US5516775A (en) 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
JP3398152B2 (ja) * 1993-10-12 2003-04-21 ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー 1n−アルキル−n−アリールピリミジンアミンおよびその誘導体
NO311614B1 (no) * 1996-10-01 2001-12-17 Janssen Pharmaceutica Nv Substituerte diamino-1,3,5-triazinderivater

Also Published As

Publication number Publication date
CZ299397A3 (cs) 1998-11-11
US6380194B1 (en) 2002-04-30
HK1009676A1 (en) 1999-06-04
SK285241B6 (sk) 2006-09-07
BR9704937A (pt) 2000-06-06
PL322369A1 (en) 1998-04-14
DE69729153T2 (de) 2005-01-27
NZ328854A (en) 2000-10-27
AU3926697A (en) 1998-04-09
AP914A (en) 2000-12-18
EP0834507A1 (en) 1998-04-08
JP4127882B2 (ja) 2008-07-30
ATE267179T1 (de) 2004-06-15
TW411335B (en) 2000-11-11
MX9707511A (es) 1998-06-30
EP0834507B1 (en) 2004-05-19
EE03826B1 (et) 2002-08-15
US7449575B2 (en) 2008-11-11
SG53075A1 (en) 1998-09-28
ES2221679T3 (es) 2005-01-01
HRP970526B1 (en) 2002-10-31
DE69729153D1 (de) 2004-06-24
SI0834507T1 (en) 2004-10-31
DK0834507T3 (da) 2004-09-06
CN1083438C (zh) 2002-04-24
HUP9701596A3 (en) 2000-04-28
ZA978766B (en) 1999-03-30
AP9701109A0 (en) 1997-10-31
NO974368D0 (no) 1997-09-22
US20060189614A1 (en) 2006-08-24
HRP970526A2 (en) 1998-10-31
JPH10114759A (ja) 1998-05-06
IL121849A (en) 2001-08-26
HU225270B1 (en) 2006-08-28
US20020147181A1 (en) 2002-10-10
KR100478846B1 (ko) 2006-06-13
PT834507E (pt) 2004-10-29
AU740809B2 (en) 2001-11-15
CA2216486A1 (en) 1998-04-01
RU2186774C2 (ru) 2002-08-10
US20030199473A1 (en) 2003-10-23
KR19980032428A (ko) 1998-07-25
EE9700253A (et) 1998-04-15
AR008864A1 (es) 2000-02-23
OA10620A (en) 2002-09-03
HUP9701596A2 (hu) 1999-06-28
MY123803A (en) 2006-06-30
CN1180698A (zh) 1998-05-06
CZ297333B6 (cs) 2006-11-15
NO974368L (no) 1998-04-02
TR199701070A2 (xx) 1998-04-21
HU9701596D0 (en) 1997-11-28
IL121849A0 (en) 1998-02-22
NO311614B1 (no) 2001-12-17
US6962916B2 (en) 2005-11-08
SK131997A3 (en) 1999-06-11
PL190155B1 (pl) 2005-11-30
US6858609B2 (en) 2005-02-22

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