HUP9801599A3 - Use of imidazolin derivatives having alfa1l agonist effect for producing pharmaceutical compositions for treatment of incontinence, novel imidazolin derivatives and process for producing them - Google Patents
Use of imidazolin derivatives having alfa1l agonist effect for producing pharmaceutical compositions for treatment of incontinence, novel imidazolin derivatives and process for producing themInfo
- Publication number
- HUP9801599A3 HUP9801599A3 HU9801599A HUP9801599A HUP9801599A3 HU P9801599 A3 HUP9801599 A3 HU P9801599A3 HU 9801599 A HU9801599 A HU 9801599A HU P9801599 A HUP9801599 A HU P9801599A HU P9801599 A3 HUP9801599 A3 HU P9801599A3
- Authority
- HU
- Hungary
- Prior art keywords
- producing
- imidazolin
- derivatives
- imidazolin derivatives
- alfa1l
- Prior art date
Links
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical class C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 title 2
- 206010021639 Incontinence Diseases 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19514579A DE19514579A1 (de) | 1995-04-20 | 1995-04-20 | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9801599A2 HUP9801599A2 (hu) | 1999-01-28 |
HUP9801599A3 true HUP9801599A3 (en) | 1999-04-28 |
Family
ID=7759982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9801599A HUP9801599A3 (en) | 1995-04-20 | 1996-04-13 | Use of imidazolin derivatives having alfa1l agonist effect for producing pharmaceutical compositions for treatment of incontinence, novel imidazolin derivatives and process for producing them |
Country Status (31)
Country | Link |
---|---|
US (4) | US6268389B1 (hu) |
EP (2) | EP0821585B1 (hu) |
JP (2) | JP3379960B2 (hu) |
KR (1) | KR19990007985A (hu) |
CN (1) | CN1119148C (hu) |
AR (1) | AR002043A1 (hu) |
AU (1) | AU719710B2 (hu) |
BG (1) | BG64116B1 (hu) |
BR (1) | BR9608049A (hu) |
CA (1) | CA2214338C (hu) |
CZ (1) | CZ327197A3 (hu) |
DE (2) | DE19514579A1 (hu) |
EE (1) | EE04416B1 (hu) |
ES (1) | ES2279521T3 (hu) |
HR (1) | HRP960187A2 (hu) |
HU (1) | HUP9801599A3 (hu) |
IL (1) | IL117956A (hu) |
MX (1) | MX9707570A (hu) |
NO (1) | NO974821L (hu) |
NZ (1) | NZ307509A (hu) |
PE (1) | PE44297A1 (hu) |
PL (1) | PL184881B1 (hu) |
RU (2) | RU2230061C2 (hu) |
SK (1) | SK138097A3 (hu) |
TR (1) | TR199701212T1 (hu) |
TW (1) | TW403739B (hu) |
UA (1) | UA62913C2 (hu) |
UY (1) | UY24206A1 (hu) |
WO (1) | WO1996032939A1 (hu) |
YU (1) | YU24496A (hu) |
ZA (1) | ZA963131B (hu) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
US6503935B1 (en) | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
GB9906192D0 (en) | 1999-03-18 | 1999-05-12 | Medical Res Council | Photoreleasable compounds |
US6323231B1 (en) | 2000-02-17 | 2001-11-27 | Abbott Laboratories | Use of α1A adrenoceptor agonists with α1B and α1D antagonism for the treatment of stress urinary incontinence |
EP1328517A2 (de) * | 2000-10-14 | 2003-07-23 | Boehringer Ingelheim Pharma KG | Neue m-amino-phenylimino-imidazolidin-derivate zur behandlung der harninkontinenz |
US6602897B2 (en) | 2000-10-14 | 2003-08-05 | Boehringer Ingelheim Pharma Kg | m-Amino-phenylimino-imidazolidine derivatives for treating urinary incontinence |
GB0030580D0 (en) * | 2000-12-15 | 2001-01-31 | Medicare Man Consultancy Ltd | Composition and method |
US6660772B2 (en) | 2001-02-01 | 2003-12-09 | Boehringer Ingelheim Pharma Kg | Use of 2-amino-1-(4-hydroxy-2-methanesulfonamidophenyl)ethanol for treating urinary incontinence |
DE10104369A1 (de) * | 2001-02-01 | 2002-08-08 | Boehringer Ingelheim Pharma | Verwendung von 2-Amino-(4-hydroxy-2-methansulfonamidophenyl)ethanol zur Behandlung der Harninkontinenz |
US20020169193A1 (en) * | 2001-02-10 | 2002-11-14 | Pascale Pouzet | Alkylphenyliminoimidazolidine derivatives for treating urinary incontinence |
DE10106214A1 (de) * | 2001-02-10 | 2002-08-14 | Boehringer Ingelheim Pharma | Neue Alkyl-phenylimino-imidazolidin-Derivate zur Behandlung der Harninkontinenz |
GB0114008D0 (en) * | 2001-06-08 | 2001-08-01 | Perry Robert E | New therapautic use |
US20040220240A1 (en) * | 2001-11-28 | 2004-11-04 | Pellegrini Cara A. | Method of increasing the extent of absorption of tizanidine |
US6455557B1 (en) | 2001-11-28 | 2002-09-24 | Elan Pharmaceuticals, Inc. | Method of reducing somnolence in patients treated with tizanidine |
EP1333028A1 (en) * | 2002-01-31 | 2003-08-06 | Boehringer Ingelheim Pharma GmbH & Co.KG | 2'-Halo-3',5'-dialkoxyphen-1'-yl-imino-2-imidazolidine derivatives and the use thereof for the treatment of urinary incontinence |
US6703409B2 (en) | 2002-01-31 | 2004-03-09 | Boehringer Ingelheim Pharma Gmbh & Co Kg | 2′-Halo-3′,5′-dialkoxyphen-1′-yl-imino-2-imidazolidine and the use thereof as a drug |
PL373410A1 (en) * | 2002-02-01 | 2005-08-22 | F.Hoffman-La Roche Ag | Substituted indoles as alpha-1 agonists |
DE10352132A1 (de) * | 2003-11-04 | 2005-06-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische Zusammensetzung aus einem Beta-3-Adrenozeptor-Agonisten und einem Alpha Agonisten |
KR101174191B1 (ko) * | 2007-02-02 | 2012-08-14 | 에프. 호프만-라 로슈 아게 | 중추 신경계 장애의 치료용 taar1 리간드로서 2-아미노옥사졸린 |
WO2008098857A1 (en) * | 2007-02-15 | 2008-08-21 | F. Hoffmann-La Roche Ag | 2-aminooxazolines as taar1 ligands |
CN101765425A (zh) * | 2007-08-02 | 2010-06-30 | 弗·哈夫曼-拉罗切有限公司 | 苯甲酰胺衍生物用于治疗cns障碍的用途 |
WO2009023757A1 (en) * | 2007-08-15 | 2009-02-19 | Allergan, Inc. | Therapeutic compounds |
BRPI0816158A2 (pt) * | 2007-08-15 | 2017-06-13 | Allergan Inc | composto carbociclo fundido substituído com heterociclila e uso do mesmo. |
JP4168086B1 (ja) * | 2008-04-16 | 2008-10-22 | 国立大学法人福井大学 | イミダゾリン誘導体 |
CA2728480A1 (en) * | 2008-07-24 | 2010-01-28 | F. Hoffmann-La Roche Ag | 4,5-dihydro-oxazol-2-yl derivatives |
US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
GB2466622A (en) * | 2008-12-23 | 2010-06-30 | Trinity College Dublin | Alpha2-Adrenoceptor Ligands |
US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
WO2012008565A1 (ja) * | 2010-07-16 | 2012-01-19 | 日本ケミファ株式会社 | イミダゾリン誘導体 |
DK2624696T3 (en) | 2010-10-06 | 2017-03-13 | Glaxosmithkline Llc Corp Service Company | BENZIMIDAZOLD DERIVATIVES AS PI3-KINASE INHIBITORS |
WO2015152196A1 (ja) * | 2014-03-31 | 2015-10-08 | 東レ株式会社 | イミダゾリン誘導体及びその医薬用途 |
WO2017157873A1 (en) | 2016-03-17 | 2017-09-21 | F. Hoffmann-La Roche Ag | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2899426A (en) * | 1959-08-11 | Synthesis of l | ||
DE71554C (de) * | B. BROCKHUES, in Firma BROCKHUES & ClE, in Köln a. Rh | Leicht transportable Nothlaschung für Schienenbrüche | ||
US2744910A (en) * | 1955-06-27 | 1956-05-08 | Bristol Lab Inc | 2-(ortho-benzylbenzyl)-imidazoline and acid addition salts |
US2915431A (en) * | 1956-07-17 | 1959-12-01 | Lab Robert & Carriere Sa Des | 2-(2'-isopropyl-4'-chloro-5'-methyl)-phenoxymethyl-2-imidazoline and its pharmaceutical uses |
US3081222A (en) * | 1960-03-11 | 1963-03-12 | Us Rubber Co | Fungicides |
US3202660A (en) | 1961-10-09 | 1965-08-24 | Boehringer Sohn Ingelheim | Process for the preparation of 3-arylamino-1, 3-diazacycloalkenes |
AT285599B (de) | 1968-06-21 | 1970-11-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen |
BE754820R (fr) * | 1969-08-13 | 1971-02-15 | Schering Ag | Nouveaux derives de pyrimidine, leurs procedes de preparation et leurs |
DE2316377C3 (de) | 1973-04-02 | 1978-11-02 | Lentia Gmbh, Chem. U. Pharm. Erzeugnisse - Industriebedarf, 8000 Muenchen | Verfahren zur Herstellung von 2-Phenyl-amino-2-imidazolin-Derivaten und von deren Salzen |
FR2269341B1 (hu) * | 1974-04-30 | 1978-07-28 | Castaigne Sa | |
MTP837B (en) * | 1977-11-07 | 1979-10-22 | Hoffman La Roche And Co Aktien | Derivatives 2 finino-imidazolidire |
DE2806775A1 (de) * | 1978-02-17 | 1979-08-30 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
DE2806811A1 (de) * | 1978-02-17 | 1979-08-23 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylimino- imidazolidine, deren saeureadditionssalze, diese enthaltene arzneimittel und verfahren zur herstellung derselben |
DE2811847A1 (de) | 1978-03-17 | 1979-09-20 | Lentia Gmbh | Neue arylaminoimidazolinderivate, deren herstellung und verwendung als arzneimittel |
US4226713A (en) | 1978-04-24 | 1980-10-07 | Goldberg Jack M | Diagnostic agents |
US4262005A (en) * | 1978-05-31 | 1981-04-14 | The Boots Company Limited | Compounds, compositions and methods for controlling pests |
US4323570A (en) * | 1978-11-15 | 1982-04-06 | Beiersdorf Aktiengesellschaft | Substituted aminopyrimidines |
DE2854659A1 (de) * | 1978-12-18 | 1980-07-10 | Boehringer Sohn Ingelheim | Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
US4226773A (en) * | 1979-05-07 | 1980-10-07 | Abbott Laboratories | Pyrazolyl amino imidazolines as diuretic agents |
DE2949287A1 (de) | 1979-12-07 | 1981-06-11 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
US4287201A (en) * | 1980-03-03 | 1981-09-01 | Merck & Co., Inc. | Anovulatory method and chicken feed compositions |
DE3168754D1 (en) * | 1980-07-09 | 1985-03-21 | Beecham Group Plc | Clonidine derivatives useful in the treatment of diarrhoea |
EP0070084A3 (en) * | 1981-04-24 | 1983-02-16 | Beecham Group Plc | Imidazoline derivatives |
DE3133886A1 (de) | 1981-08-27 | 1983-03-17 | Bayer Ag, 5090 Leverkusen | 2-arylazo-2-imidazoline, acylderivate derselben, verfahren zu ihrer herstellung und die verwendung zur bekaempfung von ekto- und/oder endoparasiten |
US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
CA1201066A (en) * | 1981-11-20 | 1986-02-25 | Alcon Laboratories, Inc. | N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure |
US4644007A (en) | 1981-11-20 | 1987-02-17 | Alcon Laboratories, Inc. | 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods |
FR2521140A1 (fr) | 1982-02-05 | 1983-08-12 | Synthelabo | Derives d'imidazolidine, leur preparation et leur application en therapeutique |
GB8304593D0 (en) * | 1983-02-18 | 1983-03-23 | Beecham Group Plc | Amidines |
GB8333835D0 (en) * | 1983-12-20 | 1984-02-01 | Beecham Group Plc | Compounds |
US4587257A (en) * | 1984-12-14 | 1986-05-06 | Alcon Laboratories, Inc. | Control of ocular bleeding using clonidine derivatives |
EP0236636A3 (en) * | 1986-02-07 | 1988-12-07 | Alcon Laboratories, Inc. | Use of clonidine derivatives for the preparation of ocular hemostatic agents |
US4861904A (en) * | 1986-04-17 | 1989-08-29 | Agency Of Industrial Science And Technology | Schiff base metal complex compounds, and organometallic ultrathin film composed thereof and oxygen separation films composed thereof |
GB8610909D0 (en) * | 1986-05-03 | 1986-06-11 | Beecham Group Plc | Compounds |
US4861189A (en) | 1987-02-26 | 1989-08-29 | Kajima Corporation | System for paving inclined and/or curved surfaces |
US4801617A (en) * | 1987-04-06 | 1989-01-31 | Leclerc Gerard | Iminoimidazolidines useful in lowering intraocular pressure |
DE3712385A1 (de) * | 1987-04-11 | 1988-10-27 | Boehringer Ingelheim Kg | 2-(phenylimino)imidazolidine |
JPH078795B2 (ja) * | 1989-09-06 | 1995-02-01 | 日立化成工業株式会社 | 排尿障害治療剤 |
US5130441A (en) * | 1990-02-06 | 1992-07-14 | Allergan, Inc. | Method for producing amino-2-imidazoline derivatives |
US5237072A (en) * | 1990-02-06 | 1993-08-17 | Allergan, Inc. | Method for producing amino-2-imidazoline derivatives |
IE911994A1 (en) * | 1990-07-03 | 1992-01-15 | Akzo Nv | 5-isothiazolamine derivatives |
WO1994008040A1 (en) * | 1992-09-25 | 1994-04-14 | Synaptic Pharmaceutical Corporation | Dna encoding human alpha 1 adrenergic receptors and uses thereof |
US5237032A (en) | 1992-09-30 | 1993-08-17 | Istituto Guido Donegani S.P.A. | Microwave processing of carbonate monomers |
EP0599697A1 (fr) * | 1992-11-24 | 1994-06-01 | Synthelabo | Dérivés de pyrrole, leur préparation et leur application en thérapeutique |
US5447916A (en) * | 1993-07-30 | 1995-09-05 | Chiron Corporation | Peptoid alpha-1 adrenergic receptor ligands |
CA2181909C (en) | 1994-01-24 | 2008-10-07 | Stephen A. Munk | Aromatic 2-amino-imidazole derivatives as alpha-2a adrenoceptor agonists |
FR2719844B1 (fr) * | 1994-05-10 | 1996-06-07 | Synthelabo | Dérivés de 5,6-dihydro-4h-thiéno[3,4-c]pyrrole, leur préparation et leur application en thérapeutique. |
DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
US5866579A (en) * | 1997-04-11 | 1999-02-02 | Synaptic Pharmaceutical Corporation | Imidazole and imidazoline derivatives and uses thereof |
US6602897B2 (en) * | 2000-10-14 | 2003-08-05 | Boehringer Ingelheim Pharma Kg | m-Amino-phenylimino-imidazolidine derivatives for treating urinary incontinence |
-
1995
- 1995-04-20 DE DE19514579A patent/DE19514579A1/de not_active Withdrawn
-
1996
- 1996-04-13 EP EP96914912A patent/EP0821585B1/de not_active Expired - Lifetime
- 1996-04-13 TR TR97/01212T patent/TR199701212T1/xx unknown
- 1996-04-13 CA CA2214338A patent/CA2214338C/en not_active Expired - Fee Related
- 1996-04-13 UA UA97115588A patent/UA62913C2/uk unknown
- 1996-04-13 CZ CZ973271A patent/CZ327197A3/cs unknown
- 1996-04-13 MX MX9707570A patent/MX9707570A/es not_active IP Right Cessation
- 1996-04-13 EE EE9700267A patent/EE04416B1/xx not_active IP Right Cessation
- 1996-04-13 JP JP53145596A patent/JP3379960B2/ja not_active Expired - Fee Related
- 1996-04-13 SK SK1380-97A patent/SK138097A3/sk unknown
- 1996-04-13 BR BR9608049A patent/BR9608049A/pt not_active Application Discontinuation
- 1996-04-13 KR KR1019970707509A patent/KR19990007985A/ko active IP Right Grant
- 1996-04-13 CN CN96193093A patent/CN1119148C/zh not_active Expired - Fee Related
- 1996-04-13 RU RU97119064/15A patent/RU2230061C2/ru not_active IP Right Cessation
- 1996-04-13 HU HU9801599A patent/HUP9801599A3/hu unknown
- 1996-04-13 PL PL96324041A patent/PL184881B1/pl not_active IP Right Cessation
- 1996-04-13 EP EP02025309A patent/EP1285653A1/de not_active Withdrawn
- 1996-04-13 NZ NZ307509A patent/NZ307509A/xx unknown
- 1996-04-13 DE DE59611411T patent/DE59611411D1/de not_active Expired - Lifetime
- 1996-04-13 ES ES96914912T patent/ES2279521T3/es not_active Expired - Lifetime
- 1996-04-13 AU AU56878/96A patent/AU719710B2/en not_active Ceased
- 1996-04-13 WO PCT/EP1996/001568 patent/WO1996032939A1/de active IP Right Grant
- 1996-04-14 UY UY24206A patent/UY24206A1/es not_active IP Right Cessation
- 1996-04-18 TW TW085104648A patent/TW403739B/zh not_active IP Right Cessation
- 1996-04-18 IL IL11795696A patent/IL117956A/en not_active IP Right Cessation
- 1996-04-19 YU YU24496A patent/YU24496A/sh unknown
- 1996-04-19 PE PE1996000273A patent/PE44297A1/es not_active Application Discontinuation
- 1996-04-19 ZA ZA963131A patent/ZA963131B/xx unknown
- 1996-04-19 HR HR19514579.8A patent/HRP960187A2/hr not_active Application Discontinuation
- 1996-04-22 AR ARP960102266A patent/AR002043A1/es unknown
-
1997
- 1997-10-15 BG BG101966A patent/BG64116B1/bg unknown
- 1997-10-17 NO NO974821A patent/NO974821L/no not_active Application Discontinuation
-
1999
- 1999-01-11 US US09/227,944 patent/US6268389B1/en not_active Expired - Lifetime
-
2000
- 2000-03-28 US US09/536,728 patent/US20020040150A1/en not_active Abandoned
-
2002
- 2002-08-14 JP JP2002236562A patent/JP4141763B2/ja not_active Expired - Fee Related
- 2002-11-15 US US10/295,460 patent/US6858594B2/en not_active Expired - Lifetime
-
2003
- 2003-02-07 RU RU2003104267/15A patent/RU2003104267A/ru not_active Application Discontinuation
-
2004
- 2004-04-19 US US10/827,408 patent/US7019021B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP9801599A3 (en) | Use of imidazolin derivatives having alfa1l agonist effect for producing pharmaceutical compositions for treatment of incontinence, novel imidazolin derivatives and process for producing them | |
HUP9802300A3 (en) | N-heteroaryl-pyridinesulfonamide derivatives, pharmaceutical compositions containing them, process for producing them and their use | |
HUP9802694A3 (en) | Benzamide derivatives, process for producing them and pharmaceutical compositions containing them | |
HUP9601492A3 (en) | Benzimidazol derivatives, process for producing them and pharmaceutical use of them | |
HUP9802839A3 (en) | Quinazoline derivatives, pharmaceutical compositions containing them and process for producing them | |
HUP0101599A3 (en) | Heterocyclically substituted amides, process for producing them, use of them and pharmaceutical compositions containing them | |
HUT76286A (en) | Quinoline derivatives, pharmaceutical compositions containing them, process for producing them and their use | |
HUP9602511A3 (en) | Aryl-diazinone derivatives, pharmaceutical compositions containing them, and process for producing all these | |
HUP9600071A3 (en) | Indolo-piperidine derivatives, pharmaceutical compositions containing them, process for producing them and their use | |
HUP9701265A3 (en) | Imidazoline derivatives, process for producing them and pharmaceutical compositions containing them | |
HUP9802315A3 (en) | Thrombin inhibitors, process for producing them and use of them for producing pharmaceutical compositions | |
HU9802653D0 (en) | Substituted imidazolidine derivatives, process for producing them, their use, and pharmaceutical compositions containing them | |
HU9402832D0 (en) | Imidazol-4-yl-piperidine derivatives, process for producing them and pharmaceutical use of them | |
HUP9602681A1 (en) | Hydroxy-pyridinone derivatives, process for producing them and pharmaceutical compositions containing them | |
CZ129596A3 (en) | Oxazolidinone derivative, process of its preparation and pharmaceutical composition containing thereof | |
HUP0002952A3 (en) | Benzimidazole derivatives, process for producing them, their use and pharmaceutical compositions containing them | |
HU9500434D0 (en) | 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one polysubstituted derivatives, process for producing them and pharmaceutical compositions containing them | |
HUT74187A (en) | 3-phenyl-izoquinolin-(2h)-one derivatives, process for producing them and use of them for producing pharmaceutical compositions | |
GB9617893D0 (en) | New pharmaceutical derivatives, process for obtaining them and pharmaceutical compositions containing them | |
PL312491A1 (en) | Novel benzoguanidine derivatives, method of obtaining them, their application for producing pharmaceutical agents, method of treating arrhytmia and pharmaceutical agent as such | |
HUP9600099A2 (en) | Process for producing flavano-lignane compositions of improved release and absorption, compositions produced this way find use of them for producing pharmaceutical compositions | |
HUT76641A (en) | Anti-helicobacter heterocyclic derivatives of azolones, pharmaceutical compositions containing them and process for producing them | |
CZ92295A3 (en) | Boronpeptide derivatives, process of their preparation and pharmaceutical composition containing thereof | |
HU9602640D0 (en) | Substituted benzoyl-guanidine derivatives, process for producing them and pharmaceutical compositions containing them | |
CZ346595A3 (en) | Substituted derivatives of 4-phenylthiazoles, process of their preparation and pharmaceutical compositions containing thereof |