HUP9801250A2 - Makrociklusos 3,4-bisz(3,3'-indolil)-pirrolin-2,5-dion-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Makrociklusos 3,4-bisz(3,3'-indolil)-pirrolin-2,5-dion-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP9801250A2
HUP9801250A2 HU9801250A HUP9801250A HUP9801250A2 HU P9801250 A2 HUP9801250 A2 HU P9801250A2 HU 9801250 A HU9801250 A HU 9801250A HU P9801250 A HUP9801250 A HU P9801250A HU P9801250 A2 HUP9801250 A2 HU P9801250A2
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HU
Hungary
Prior art keywords
atom
alkyl
carbon
macrocyclic
indolyl
Prior art date
Application number
HU9801250A
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English (en)
Inventor
William F. Heath
Michael R. Jirousek
John H. Mcdonald
Christopher J. Rito
Original Assignee
Eli Lilly And Co.
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Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP9801250A2 publication Critical patent/HUP9801250A2/hu
Publication of HUP9801250A3 publication Critical patent/HUP9801250A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgyát (I) általánős képletű vegyületek, azelőállításűkra szőlgáló eljárás és az azőkat tartalmazógyógyszerkészítmények képezik. Az (I) általánős képletben W jelentése őxigénatőm, kénatőm vagy NH képletű csőpőrt, R1 jelentése hidrőgénatőm, halőgénatőm, 1-4 szénatőmős alkil-,hidrőxil-, 1-4 szénatőmős alkőxi-, halő-alkil-, nitrőcsőpőrt, -NH-(1-4szénatőmős)-alkil-, -N-di(1-4 szénatőmős)-alkil- vagy -NHCO-(1-4szénatőmős)-alkil általánős képletű csőpőrt. R2 jelentése hidrőgénatőm, CH3CO-, NH2 képletű csőpőrt vagyhidrőxilcsőpőrt, Z jelentése -(CH2)p- vagy -(CH2)p-O-(CH2)p- általánős képletű csőpőrt, R8 jelentése -NH(CF3) vagy -N(CF3)(CH3) képletű csőpőrt, m jelentése 0, 1, 2 vagy 3, és p jelentése 0, 1 vagy 2. A találmány szerinti vegyületek prőtein-kináz C gátló hatásúak. ŕ
HU9801250A 1995-03-30 1996-03-28 Macrocyclic 3,4-bis(3,31-indolyl)-pyrrole-2,5-dione derivatives, process for their preparation and pharmaceutical compositions containing them HUP9801250A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/413,735 US5624949A (en) 1993-12-07 1995-03-30 Protein kinase C inhibitors

Publications (2)

Publication Number Publication Date
HUP9801250A2 true HUP9801250A2 (hu) 1998-09-28
HUP9801250A3 HUP9801250A3 (en) 1998-12-28

Family

ID=23638401

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801250A HUP9801250A3 (en) 1995-03-30 1996-03-28 Macrocyclic 3,4-bis(3,31-indolyl)-pyrrole-2,5-dione derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (10) US5624949A (hu)
EP (1) EP0735038A1 (hu)
JP (1) JPH11507327A (hu)
KR (1) KR100319945B1 (hu)
CN (1) CN1093767C (hu)
AU (1) AU701988B2 (hu)
CA (1) CA2216535C (hu)
CZ (1) CZ286301B6 (hu)
EA (1) EA000598B1 (hu)
HU (1) HUP9801250A3 (hu)
MX (1) MX9707431A (hu)
NO (1) NO309271B1 (hu)
NZ (1) NZ305276A (hu)
PL (1) PL183600B1 (hu)
TR (1) TR199701073T1 (hu)
WO (1) WO1996030048A1 (hu)

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US5624949A (en) 1997-04-29
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CZ305197A3 (cs) 1998-05-13
AU5324996A (en) 1996-10-16
WO1996030048A1 (en) 1996-10-03
NZ305276A (en) 1999-02-25
CA2216535C (en) 2002-05-07
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NO974453D0 (no) 1997-09-26
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US5739322A (en) 1998-04-14
US5674862A (en) 1997-10-07
NO974453L (no) 1997-11-19
US5780461A (en) 1998-07-14
KR100319945B1 (ko) 2002-03-08
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AU701988B2 (en) 1999-02-11
US6057440A (en) 2000-05-02
CN1185742A (zh) 1998-06-24
CN1093767C (zh) 2002-11-06
JPH11507327A (ja) 1999-06-29
US5821365A (en) 1998-10-13
CZ286301B6 (cs) 2000-03-15
EA199700280A1 (ru) 1998-02-26
EA000598B1 (ru) 1999-12-29
CA2216535A1 (en) 1996-10-03
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US5621098A (en) 1997-04-15

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