TR199701073T1 - Protein kinaz C inhibit�rleri. - Google Patents
Protein kinaz C inhibit�rleri.Info
- Publication number
- TR199701073T1 TR199701073T1 TR97/01073T TR9701073T TR199701073T1 TR 199701073 T1 TR199701073 T1 TR 199701073T1 TR 97/01073 T TR97/01073 T TR 97/01073T TR 9701073 T TR9701073 T TR 9701073T TR 199701073 T1 TR199701073 T1 TR 199701073T1
- Authority
- TR
- Turkey
- Prior art keywords
- protein kinase
- inhibitors
- diseases
- compounds
- provides
- Prior art date
Links
- 229940123924 Protein kinase C inhibitor Drugs 0.000 title 1
- 239000003881 protein kinase C inhibitor Substances 0.000 title 1
- 102000003923 Protein Kinase C Human genes 0.000 abstract 3
- 108090000315 Protein Kinase C Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
- C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/413,735 US5624949A (en) | 1993-12-07 | 1995-03-30 | Protein kinase C inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199701073T1 true TR199701073T1 (xx) | 1998-02-21 |
Family
ID=23638401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR97/01073T TR199701073T1 (xx) | 1995-03-30 | 1996-03-28 | Protein kinaz C inhibit�rleri. |
Country Status (16)
Country | Link |
---|---|
US (10) | US5624949A (xx) |
EP (1) | EP0735038A1 (xx) |
JP (1) | JPH11507327A (xx) |
KR (1) | KR100319945B1 (xx) |
CN (1) | CN1093767C (xx) |
AU (1) | AU701988B2 (xx) |
CA (1) | CA2216535C (xx) |
CZ (1) | CZ286301B6 (xx) |
EA (1) | EA000598B1 (xx) |
HU (1) | HUP9801250A3 (xx) |
MX (1) | MX9707431A (xx) |
NO (1) | NO309271B1 (xx) |
NZ (1) | NZ305276A (xx) |
PL (1) | PL183600B1 (xx) |
TR (1) | TR199701073T1 (xx) |
WO (1) | WO1996030048A1 (xx) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5723456A (en) * | 1993-12-07 | 1998-03-03 | Eli Lilly & Company | Therapeutic treatment for cardiovascular diseases |
US5843935A (en) * | 1993-12-07 | 1998-12-01 | Eli Lilly And Company | Protein kinase C inhibitors |
ATE204579T1 (de) * | 1993-12-07 | 2001-09-15 | Lilly Co Eli | Proteinkinase c-inhibitoren |
PL184728B1 (pl) * | 1995-11-20 | 2002-12-31 | Lilly Co Eli | Nowe pochodne bisindolilomaleimidu z mostkiem N,N'i środek farmaceutyczny |
CA2237221C (en) * | 1995-11-20 | 2003-03-25 | Eli Lilly And Company | Protein kinase c inhibitor |
UA54427C2 (uk) * | 1996-05-01 | 2003-03-17 | Елі Ліллі Енд Компані | Спосіб лікування очних захворювань, які пов'язані з фактором васкулярного ендотеліального росту |
US5936084A (en) * | 1996-05-01 | 1999-08-10 | Eli Lilly And Company | Halo-substituted bisindolemaleimide protein kinase C inhibitors |
JP2002504086A (ja) * | 1996-05-01 | 2002-02-05 | イーライ・リリー・アンド・カンパニー | Vegf関連疾患の治療的処置 |
US6232299B1 (en) | 1996-05-01 | 2001-05-15 | Eli Lilly And Company | Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy |
US6093709A (en) * | 1996-08-22 | 2000-07-25 | Eli Lilly And Company | Therapeutic treatment for sexual dysfunctions |
EA001392B1 (ru) * | 1996-08-23 | 2001-02-26 | Эли Лилли Энд Компани | Синтез бисиндолилмалеимидов |
US6107327A (en) * | 1996-08-30 | 2000-08-22 | Eli Lilly And Company | Therapeutic treatment for HIV infection |
US5962446A (en) * | 1996-08-30 | 1999-10-05 | Eli Lilly And Company | Therapetutic treatment for human T cell lymphotrophic virus type 1 infection |
US6040152A (en) * | 1996-12-31 | 2000-03-21 | National Jewish Medical And Research Center | Method and assay for regulation of T cell proliferation |
US6093740A (en) * | 1997-04-30 | 2000-07-25 | Eli Lilly And Company | Therapeutic treatment for skin disorders |
JPH1180026A (ja) * | 1997-09-02 | 1999-03-23 | Yoshitomi Pharmaceut Ind Ltd | 新規免疫抑制剤、その使用方法およびその同定方法 |
JP2001523707A (ja) * | 1997-11-26 | 2001-11-27 | イーライ・リリー・アンド・カンパニー | 慢性骨髄性白血病および急性リンパ性白血病のための治療的処置 |
CA2227688C (en) | 1998-01-16 | 2007-07-31 | James W. Critchfield | Methods and compositions for inhibition of viral replication |
US6103713A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for autoimmune diseases |
US6225301B1 (en) | 1998-03-05 | 2001-05-01 | Eli Lilly And Company | Therapeutic treatment for renal dysfunction |
US6291446B1 (en) * | 1998-03-05 | 2001-09-18 | Eli Lilly And Company | Therapeutic treatment for cytomegalovirus infection |
US6103712A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for asthma |
CA2245029A1 (en) | 1998-03-13 | 1999-09-13 | University Of British Columbia | Granulatimide compounds as g2 checkpoint inhibitors |
DE69911935T3 (de) * | 1998-03-13 | 2008-02-07 | The University Of British Columbia, Vancouver | Granulatimide-derivate zur behandlung von krebs |
US6127401A (en) | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
US6013646A (en) | 1998-07-02 | 2000-01-11 | Bayer Corporation | Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer |
US6841567B1 (en) * | 1999-02-12 | 2005-01-11 | Cephalon, Inc. | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
US6284783B1 (en) | 1999-06-09 | 2001-09-04 | The Uab Research Foundation | Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis |
US6399780B1 (en) | 1999-08-20 | 2002-06-04 | Cephalon, Inc. | Isomeric fused pyrrolocarbazoles and isoindolones |
US6852688B2 (en) | 2000-03-10 | 2005-02-08 | University Of Florida | Compositions for treating diabetic retinopathy and methods of using same |
EP1309680B1 (en) * | 2000-04-24 | 2006-04-19 | Yale University | Dna & protein binding miniature proteins |
US20020048581A1 (en) * | 2000-07-18 | 2002-04-25 | King George L. | Modulation of nitric oxide synthase by PKC |
US7425537B2 (en) | 2000-08-22 | 2008-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SH2 domain binding inhibitors |
JP2004526676A (ja) | 2000-12-08 | 2004-09-02 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | キナーゼ阻害剤として有用な大員複素環式化合物 |
US6849643B2 (en) * | 2000-12-08 | 2005-02-01 | Ortho-Mcneil Pharmaceutical, Inc. | Indazolyl-substituted pyrroline compounds as kinase inhibitors |
DE10109280A1 (de) * | 2001-02-26 | 2002-09-05 | Peter Mayser | Indolderivate mit inhibitorischer Wirkung auf Proteinkinasen |
US6559299B2 (en) * | 2001-03-29 | 2003-05-06 | Merck & Co., Inc. | Preparation and isolation of indolocarbazole glycosides |
GB0125659D0 (en) * | 2001-10-25 | 2001-12-19 | Ssl Int Plc | Spermicides |
GB0125658D0 (en) * | 2001-10-25 | 2001-12-19 | Ssl Int Plc | Medicaments |
WO2003059372A2 (en) * | 2001-12-29 | 2003-07-24 | Novo Nordisk A/S | Combined use of a glp-1 compound and a modulator of diabetic late complications |
JP2005531544A (ja) * | 2002-05-06 | 2005-10-20 | ワシントン・ユニバーシティ | Egfr経路の抑制による緑内障およびnos−2発現により媒介される他の状態の治療方法 |
CA2488602A1 (en) | 2002-06-05 | 2003-12-18 | Janssen Pharmaceutica N.V. | Substituted pyrrolines as kinase inhibitors |
ES2312785T3 (es) * | 2002-06-05 | 2009-03-01 | Janssen Pharmaceutica Nv | Pirrolinas sustituidas utiles como inhibidores de quinasa. |
CA2393720C (en) * | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
US20040175384A1 (en) * | 2003-12-12 | 2004-09-09 | Mohapatra Shyam S. | Protein kinase C as a target for the treatment of respiratory syncytial virus |
CN1832940A (zh) * | 2003-06-13 | 2006-09-13 | 詹森药业有限公司 | 用作激酶抑制剂的取代的吲唑基(吲哚基)马来酰亚胺衍生物 |
ES2338789T3 (es) | 2003-06-18 | 2010-05-12 | Tranzyme Pharma Inc. | Antagonistas macrociclicos del receptor de motilina. |
CA2526284C (en) | 2003-06-25 | 2014-11-18 | Crucell Holland B.V. | Binding molecules for the treatment of myeloid cell malignancies |
GB0407315D0 (en) * | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
WO2005012360A2 (en) * | 2003-07-22 | 2005-02-10 | Crucell Holland B.V. | Binding molecules against sars-coronavirus and uses thereof |
US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
US8592368B2 (en) | 2003-12-19 | 2013-11-26 | University Of South Florida | JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection |
EP1727529B1 (en) * | 2004-03-17 | 2016-03-02 | Lars Michael Larsen | Prevention of retinopathy by inhibition of the visual cycle |
NZ550366A (en) | 2004-05-27 | 2009-11-27 | Crucell Holland Bv | Binding molecules capable of neutralizing rabies virus and uses thereof |
JP2008504292A (ja) | 2004-06-24 | 2008-02-14 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 免疫増強用の化合物 |
US20080096923A1 (en) * | 2004-07-23 | 2008-04-24 | Aniz Girach | Methods For Diagnosing And Treating Diabetic Microvascular Complications |
JP4852046B2 (ja) | 2004-10-12 | 2012-01-11 | クルセル ホランド ベー ヴェー | 癌の治療及び検出に用いる結合分子 |
US8106170B2 (en) | 2004-11-11 | 2012-01-31 | Crucell Holland B.V. | Compositions against SARS-coronavirus and uses thereof |
WO2006068988A1 (en) * | 2004-12-20 | 2006-06-29 | Eli Lilly And Company | Combination therapy for vascular complications associated with hyperglycemia |
US8158586B2 (en) * | 2005-04-11 | 2012-04-17 | Pharmagap Inc. | Inhibitors of protein kinases and uses thereof |
EP1879921B1 (en) | 2005-05-12 | 2011-04-27 | Crucell Holland B.V. | Host cell specific binding molecules capable of neutralizing viruses and uses thereof |
EP2305697A3 (en) | 2005-07-25 | 2011-07-27 | Intermune, Inc. | Macrocyclic inhibitors of Hepatitis C virus replication |
US20070112053A1 (en) | 2005-09-16 | 2007-05-17 | Pickett Cecil B | Pharmaceutical compositions and methods using temozolomide and a protein kinase inhibitor |
US20070088019A1 (en) * | 2005-09-29 | 2007-04-19 | Han-Cheng Zhang | Macroheterocyclic compounds as kinase inhibitors |
NZ568135A (en) | 2005-10-11 | 2011-06-30 | Array Biopharma Inc | Macrocyclic compounds and methods for inhibiting hepatitis C viral replication |
EP1998776A4 (en) * | 2006-03-10 | 2009-07-08 | Janssen Pharmaceutica Nv | MACRO-HETEROCYL COMPOUNDS CONTAINING PYRIDINE AS KINASE INHIBITORS |
US8426355B2 (en) * | 2006-03-15 | 2013-04-23 | Theralogics, Inc. | Methods of treating muscular wasting diseases using NF-κB activation inhibitors |
EP2027155B1 (en) | 2006-06-06 | 2016-01-27 | Crucell Holland B.V. | Human binding molecules having killing activity against staphylococci and uses thereof |
WO2007141278A2 (en) | 2006-06-06 | 2007-12-13 | Crucell Holland B.V. | Human binding molecules having killing activity against enterococci and staphylococcus aureus and uses thereof |
KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
US8445437B2 (en) * | 2006-07-27 | 2013-05-21 | The Brigham And Women's Hospital, Inc. | Treatment and prevention of cardiovascular disease using mast cell stabilizers |
EP2450376B1 (en) | 2006-09-07 | 2018-02-28 | Janssen Vaccines & Prevention B.V. | Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof |
MX2009002174A (es) | 2006-09-07 | 2009-03-12 | Crucell Holland Bv | Moleculas de union humanas capaces de neutralizar el virus de la influenza h5n1 y usos de las mismas. |
NZ581606A (en) * | 2007-05-03 | 2012-06-29 | Intermune Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
AP2009005057A0 (en) * | 2007-05-10 | 2009-12-31 | Array Biopharma Inc | Novel peptide inhibitors of hepatitis c virus replication |
JP5460600B2 (ja) | 2007-09-28 | 2014-04-02 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 肥満症治療における肥満細胞安定化薬 |
US20090130195A1 (en) | 2007-10-17 | 2009-05-21 | Mildred Acevedo-Duncan | Prostate carcinogenesis predictor |
US8419332B2 (en) * | 2007-10-19 | 2013-04-16 | Atlas Bolt & Screw Company Llc | Non-dimpling fastener |
EA201071034A1 (ru) * | 2008-04-15 | 2011-06-30 | Интермьюн, Инк. | Новые макроциклические ингибиторы репликаций вируса гепатита с |
EP2181999A1 (en) | 2008-11-03 | 2010-05-05 | Zentiva, A.S. | Method of manufacturing ruboxistarin |
AR075584A1 (es) * | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
NZ596032A (en) | 2009-05-11 | 2013-09-27 | Crucell Holland Bv | Human binding molecules capable of neutralizing influenza virus h3n2 and uses thereof |
WO2011038293A1 (en) * | 2009-09-28 | 2011-03-31 | Intermune, Inc. | Cyclic peptide inhibitors of hepatitis c virus replication |
ES2385157B1 (es) * | 2010-02-25 | 2013-07-08 | Universidad Del País Vasco | Compuestos para el tratamiento de alzheimer. |
US8785648B1 (en) | 2010-08-10 | 2014-07-22 | The Regents Of The University Of California | PKC-epsilon inhibitors |
EP3180003B1 (en) | 2014-07-01 | 2022-01-12 | The Regents of the University of California | Pkc-epsilon inhibitors |
WO2018118874A1 (en) | 2016-12-19 | 2018-06-28 | Chromaderm, Inc. | Methods of treating hyperpigmentation disorders |
WO2019000224A1 (zh) * | 2017-06-27 | 2019-01-03 | 中国海洋大学 | 双吲哚马来酰亚胺衍生物及其制备方法和用途 |
US11590131B2 (en) | 2017-07-28 | 2023-02-28 | Applied Therapeutics, Inc. | Compositions and methods for treating galactosemia |
EP4135674A1 (en) | 2020-05-01 | 2023-02-22 | Applied Therapeutics Inc. | Aldose reductase inhibitors for treating sorbitol dehydrogenase deficiency |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4785085A (en) * | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
US4808613A (en) * | 1986-11-21 | 1989-02-28 | Bristol-Myers Company | Rebeccamycin derivative containing pharmaceutical composition |
DE3752123T2 (de) * | 1987-03-09 | 1998-05-14 | Kyowa Hakko Kogyo Kk | Derivate des physiologisch aktiven mittels k-252 |
JPH07113027B2 (ja) * | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | K−252誘導体 |
US5438050A (en) * | 1988-02-06 | 1995-08-01 | Godecke Aktiengesellschaft | Indolocarbazole derivatives, processes for their preparation and compositions containing them |
DE3803620A1 (de) * | 1988-02-06 | 1989-08-17 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
NZ227850A (en) * | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
MC2096A1 (fr) * | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
DE3914764A1 (de) * | 1989-05-05 | 1990-11-08 | Goedecke Ag | Maleinimid-derivate und deren verwendung als arzneimittel |
PT93947B (pt) * | 1989-05-05 | 1996-11-29 | Goedecke Ag | Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem |
US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
DE3924538A1 (de) * | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
DE3942296A1 (de) * | 1989-12-21 | 1991-06-27 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung |
DE4005969A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
DE4005970A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
JPH06503837A (ja) * | 1991-04-11 | 1994-04-28 | シェリング・コーポレーション | 抗腫瘍および抗乾癬薬 |
GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
DE69326388T2 (de) * | 1992-06-22 | 1999-12-30 | Kyowa Hakko Kogyo Co., Ltd. | Verfahren zur Herstellung von Staurosporin-Derivaten |
US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
US5589472A (en) * | 1992-09-25 | 1996-12-31 | Vice; Susan F. | Diindolo compounds and pharmaceutical compositions containing them |
DE4243321A1 (de) * | 1992-12-21 | 1994-06-23 | Goedecke Ag | Aminosäurederivate von Heterocyclen als PKC-Inhibitoren |
PH30300A (en) * | 1993-05-07 | 1997-01-20 | Ciba Geigy Ag | Polycyclic compounds and processes for the preparation thereof |
AU678435B2 (en) * | 1993-05-10 | 1997-05-29 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
FI945705A (fi) * | 1993-12-07 | 1996-06-03 | Lilly Co Eli | Bisindolyylimaleimidien parannettu synteesi |
ATE204579T1 (de) * | 1993-12-07 | 2001-09-15 | Lilly Co Eli | Proteinkinase c-inhibitoren |
US5481003A (en) * | 1994-06-22 | 1996-01-02 | Eli Lilly And Company | Protein kinase C inhibitors |
CA2237221C (en) * | 1995-11-20 | 2003-03-25 | Eli Lilly And Company | Protein kinase c inhibitor |
-
1995
- 1995-03-30 US US08/413,735 patent/US5624949A/en not_active Expired - Fee Related
- 1995-06-01 US US08/457,657 patent/US5621098A/en not_active Expired - Fee Related
- 1995-06-01 US US08/457,000 patent/US5552396A/en not_active Expired - Lifetime
- 1995-06-01 US US08/457,060 patent/US5674862A/en not_active Expired - Lifetime
-
1996
- 1996-03-28 CZ CZ19973051A patent/CZ286301B6/cs not_active IP Right Cessation
- 1996-03-28 WO PCT/US1996/004245 patent/WO1996030048A1/en active IP Right Grant
- 1996-03-28 HU HU9801250A patent/HUP9801250A3/hu unknown
- 1996-03-28 AU AU53249/96A patent/AU701988B2/en not_active Ceased
- 1996-03-28 PL PL96322584A patent/PL183600B1/pl unknown
- 1996-03-28 JP JP8529640A patent/JPH11507327A/ja not_active Withdrawn
- 1996-03-28 NZ NZ305276A patent/NZ305276A/xx unknown
- 1996-03-28 EA EA199700280A patent/EA000598B1/ru not_active IP Right Cessation
- 1996-03-28 EP EP96302142A patent/EP0735038A1/en not_active Withdrawn
- 1996-03-28 CN CN96194257A patent/CN1093767C/zh not_active Expired - Fee Related
- 1996-03-28 CA CA002216535A patent/CA2216535C/en not_active Expired - Fee Related
- 1996-03-28 MX MX9707431A patent/MX9707431A/es unknown
- 1996-03-28 KR KR1019970706785A patent/KR100319945B1/ko not_active IP Right Cessation
- 1996-03-28 TR TR97/01073T patent/TR199701073T1/xx unknown
- 1996-05-06 US US08/646,708 patent/US5719175A/en not_active Expired - Fee Related
- 1996-05-06 US US08/643,710 patent/US5780461A/en not_active Expired - Fee Related
- 1996-05-06 US US08/646,703 patent/US5696108A/en not_active Expired - Fee Related
-
1997
- 1997-03-20 US US08/822,255 patent/US5739322A/en not_active Expired - Fee Related
- 1997-09-26 NO NO974453A patent/NO309271B1/no not_active IP Right Cessation
- 1997-11-14 US US08/971,115 patent/US5821365A/en not_active Expired - Fee Related
- 1997-11-14 US US08/970,891 patent/US6057440A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5621098A (en) | 1997-04-15 |
US5780461A (en) | 1998-07-14 |
HUP9801250A3 (en) | 1998-12-28 |
US5624949A (en) | 1997-04-29 |
PL183600B1 (pl) | 2002-06-28 |
US5739322A (en) | 1998-04-14 |
NO974453D0 (no) | 1997-09-26 |
CZ305197A3 (cs) | 1998-05-13 |
MX9707431A (es) | 1997-12-31 |
US5719175A (en) | 1998-02-17 |
JPH11507327A (ja) | 1999-06-29 |
US5821365A (en) | 1998-10-13 |
EA000598B1 (ru) | 1999-12-29 |
WO1996030048A1 (en) | 1996-10-03 |
NO974453L (no) | 1997-11-19 |
CN1185742A (zh) | 1998-06-24 |
PL322584A1 (en) | 1998-02-02 |
CA2216535A1 (en) | 1996-10-03 |
US6057440A (en) | 2000-05-02 |
NO309271B1 (no) | 2001-01-08 |
US5552396A (en) | 1996-09-03 |
US5674862A (en) | 1997-10-07 |
KR100319945B1 (ko) | 2002-03-08 |
KR19980703380A (ko) | 1998-10-15 |
HUP9801250A2 (hu) | 1998-09-28 |
AU701988B2 (en) | 1999-02-11 |
NZ305276A (en) | 1999-02-25 |
CZ286301B6 (cs) | 2000-03-15 |
EA199700280A1 (ru) | 1998-02-26 |
AU5324996A (en) | 1996-10-16 |
CA2216535C (en) | 2002-05-07 |
CN1093767C (zh) | 2002-11-06 |
US5696108A (en) | 1997-12-09 |
EP0735038A1 (en) | 1996-10-02 |
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