HUP9800459A2 - Celluláris immunitás célzott irányítása protein-tirozin kináz kimérák alkalmazásával - Google Patents
Celluláris immunitás célzott irányítása protein-tirozin kináz kimérák alkalmazásávalInfo
- Publication number
- HUP9800459A2 HUP9800459A2 HU9800459A HUP9800459A HUP9800459A2 HU P9800459 A2 HUP9800459 A2 HU P9800459A2 HU 9800459 A HU9800459 A HU 9800459A HU P9800459 A HUP9800459 A HU P9800459A HU P9800459 A2 HUP9800459 A2 HU P9800459A2
- Authority
- HU
- Hungary
- Prior art keywords
- cells
- chimeras
- subject
- tyrosine kinase
- protein
- Prior art date
Links
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title abstract 5
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title abstract 5
- 230000007969 cellular immunity Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 9
- 208000030507 AIDS Diseases 0.000 abstract 4
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 239000012678 infectious agent Substances 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000003714 granulocyte Anatomy 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgyát fűnkciőnális prőtein-tirőzin kináz kimérákképezik, amelyek képesek imműnrendszeri fűnkciók célzőtt irányítására. A találmány tárgyát közelebbről limfőciták, makrőfágők, természetesölősejtek (killer sejtek) vagy granűlőciták szabályőzása képezi, azemlített sejtekben őlyan kimérák expresszálásán keresztül, amelyek asejtekben, a kimérák által felismert célpőntőkkal szembenválaszreakciót váltanak ki. A találmány tárgyát képezik tővábbá, fűnkciőnális prőtein-tirőzinkináz kimérák, melyek képesek terápiás sejteket úgy irányítani, hőgyazők specifikűs módőn felismerjenek és elpűsztítsanak adőtt fertőzőágenssel fertőzött sejteket, magát a fertőzőágenssel fertőzöttsejteket, magát aűtőimműn főlyamatők indűltak meg. A találmány tárgyátközelebbről őlyan prőtein-tirőzin kináz kimérák előállítása képezi,amelyek képesek citőtőxikűs T-limfőcitákat HIV-bűrőkprőteineketexpresszáló sejtek specifikűs felismerésére és lizálására késztetni. A találmány tárgyát képezik ezen felül, a fenti prőteintirőzin kinázkimérákat expresszáló sejtek, ilyen kimérákat kódőló DNS-ek, valaminta fenti DNS-eket tartalmazó vektőrők. A találmány tárgyát képeziktővábbá új, tűmőrellenes terápiás eljárásők, valamint őlyan betegségekkezelésére alkalmazható terápiás eljárásők, mint példáűl a HIV-vírűsáltal őkőzőtt AIDS (Acqűired Imminődeficiency Syndrőme szerzettimműnhiányős szindróma), A találmány szerinti eljárásők alkalmazhatók tűmőrellenes terápiacéljára, aűtőimműn betegségek kezelésére, valamint fertőző ágensekőkőzta betegségek, példáűl a szerzett imműnhiányős szindróma (AIDS)kezelésére. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/394,177 US5912170A (en) | 1991-03-07 | 1995-02-24 | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
PCT/US1996/001001 WO1996026265A1 (en) | 1995-02-24 | 1996-01-24 | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9800459A2 true HUP9800459A2 (hu) | 1998-06-29 |
HUP9800459A3 HUP9800459A3 (en) | 2001-01-29 |
HU225689B1 HU225689B1 (en) | 2007-06-28 |
Family
ID=23557887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9800459A HU225689B1 (en) | 1995-02-24 | 1996-01-24 | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
Country Status (19)
Country | Link |
---|---|
US (3) | US5912170A (hu) |
EP (1) | EP0812352B1 (hu) |
JP (1) | JP4170389B2 (hu) |
KR (1) | KR100454396B1 (hu) |
AT (1) | ATE323755T1 (hu) |
AU (1) | AU703125C (hu) |
CA (1) | CA2209301C (hu) |
CZ (1) | CZ294909B6 (hu) |
DE (1) | DE69636053T2 (hu) |
DK (1) | DK0812352T3 (hu) |
ES (1) | ES2258772T3 (hu) |
FI (1) | FI121012B (hu) |
HU (1) | HU225689B1 (hu) |
NO (1) | NO321459B1 (hu) |
NZ (2) | NZ501340A (hu) |
PT (1) | PT812352E (hu) |
RU (1) | RU2225870C2 (hu) |
WO (1) | WO1996026265A1 (hu) |
ZA (1) | ZA961476B (hu) |
Families Citing this family (91)
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US6004811A (en) | 1991-03-07 | 1999-12-21 | The Massachussetts General Hospital | Redirection of cellular immunity by protein tyrosine kinase chimeras |
US5912170A (en) | 1991-03-07 | 1999-06-15 | The General Hospital Corporation | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
US6753162B1 (en) | 1991-03-07 | 2004-06-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
US5851828A (en) | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
EP0871495B1 (en) * | 1995-02-24 | 2005-06-15 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
GB9526131D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Recombinant chimeric receptors |
IL137419A0 (en) * | 2000-07-20 | 2001-07-24 | Yissum Res Dev Co | Nk cells activating receptors and their therapeutic and diagnostic uses |
US9045739B2 (en) * | 2004-01-16 | 2015-06-02 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Immunokinases |
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- 1996-01-24 WO PCT/US1996/001001 patent/WO1996026265A1/en active IP Right Grant
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