EA200100302A1 - Способы и композиции для протективной и терапевтической генетической иммунизации - Google Patents

Способы и композиции для протективной и терапевтической генетической иммунизации

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Publication number
EA200100302A1
EA200100302A1 EA200100302A EA200100302A EA200100302A1 EA 200100302 A1 EA200100302 A1 EA 200100302A1 EA 200100302 A EA200100302 A EA 200100302A EA 200100302 A EA200100302 A EA 200100302A EA 200100302 A1 EA200100302 A1 EA 200100302A1
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Eurasian Patent Office
Prior art keywords
cells
viral particles
lymphoid organs
present
transduction
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EA200100302A
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English (en)
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EA003554B1 (ru
Inventor
Джулианна Лисцивич
Франко Лори
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Джулианна Лисцивич
Франко Лори
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Application filed by Джулианна Лисцивич, Франко Лори filed Critical Джулианна Лисцивич
Publication of EA200100302A1 publication Critical patent/EA200100302A1/ru
Publication of EA003554B1 publication Critical patent/EA003554B1/ru

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Abstract

Описаны и заявлены способы и композиции для продуцирования протективного и терапевтического иммунитета у человека и животных путем генетической иммунизации. Настоящее изобретение обеспечивает как безопасность, так и эффективность лечения вирусных инфекций и связанных с ними заболеваний. Способы настоящего изобретения предусматривают трансдукцию клеток с использованием конструкции, которая направляет экспрессию аттенуированного вируса, не способного вызывать заболевание, например являющегося не компетентным по репликации. Обеспечиваемая настоящим изобретением повышенная эффективность в вырабатывании антивирусного иммунного ответа обусловлена отчасти уникальным способом «транспортировки» аттенуированных вирусных частиц в организм хозяина человека или животного. В частности, аттенуированные непатогенные вирусные частицы настоящего изобретения, которые продуцируют терапевтический или протективный иммунный ответ, экспрессируются клетками в лимфоидных органах так, что высвобождение вирусных частиц происходит в той области организма человека или животного, где антивирусный ответ обычно индуцируется клетками иммунной системы. Высвобождение вирусных частиц в лимфоидных органах достигается путем трансдукции клеток-хозяев в лимфоидных органах (или клеток, которые мигрируют предпочтительно в лимфоидные органы) с помощью генной конструкции, которая обеспечивает экспрессию аттенуированного вируса. Как подробно описано в заявке, особенно предпочтительной является трансдукция дендритных клеток.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100302A 1996-02-21 1997-02-20 Фармацевтическая композиция для генерации противовирусного иммунного ответа у человека и животного EA003554B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60462796A 1996-02-21 1996-02-21
PCT/US1997/002933 WO1997031119A1 (en) 1996-02-21 1997-02-20 Methods and compositions for protective and therapeutic genetic immunization

Publications (2)

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EA200100302A1 true EA200100302A1 (ru) 2001-10-22
EA003554B1 EA003554B1 (ru) 2003-06-26

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ID=24420371

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199800746A EA002020B1 (ru) 1996-02-21 1997-02-20 Способ генерации противовирусного иммунного ответа у человека или животного
EA200100302A EA003554B1 (ru) 1996-02-21 1997-02-20 Фармацевтическая композиция для генерации противовирусного иммунного ответа у человека и животного

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Application Number Title Priority Date Filing Date
EA199800746A EA002020B1 (ru) 1996-02-21 1997-02-20 Способ генерации противовирусного иммунного ответа у человека или животного

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EP (1) EP0882134B8 (ru)
JP (1) JP2000517290A (ru)
AP (1) AP964A (ru)
AT (1) ATE429505T1 (ru)
AU (1) AU726623B2 (ru)
CA (1) CA2246359A1 (ru)
DE (1) DE69739372D1 (ru)
EA (2) EA002020B1 (ru)
ES (1) ES2324745T3 (ru)
NZ (1) NZ331369A (ru)
OA (1) OA10842A (ru)
WO (1) WO1997031119A1 (ru)

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Publication number Publication date
AP9801320A0 (en) 1998-09-30
EA003554B1 (ru) 2003-06-26
DE69739372D1 (de) 2009-06-04
WO1997031119A1 (en) 1997-08-28
JP2000517290A (ja) 2000-12-26
ES2324745T3 (es) 2009-08-13
EP0882134A1 (en) 1998-12-09
NZ331369A (en) 2001-04-27
CA2246359A1 (en) 1997-08-28
EP0882134B8 (en) 2009-09-02
ATE429505T1 (de) 2009-05-15
EA199800746A1 (ru) 1999-02-25
EP0882134B1 (en) 2009-04-22
EA002020B1 (ru) 2001-12-24
AU726623B2 (en) 2000-11-16
AP964A (en) 2001-05-11
OA10842A (en) 2001-08-14
AU2136997A (en) 1997-09-10

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