HUP9901299A2 - Attenuált, nemimmunogén poxvírusokból vagy parapoxvírusokból előállított multipotens parapox immunitást előidéző gyógyszerek használatának új indikációi - Google Patents
Attenuált, nemimmunogén poxvírusokból vagy parapoxvírusokból előállított multipotens parapox immunitást előidéző gyógyszerek használatának új indikációiInfo
- Publication number
- HUP9901299A2 HUP9901299A2 HU9901299A HUP9901299A HUP9901299A2 HU P9901299 A2 HUP9901299 A2 HU P9901299A2 HU 9901299 A HU9901299 A HU 9901299A HU P9901299 A HUP9901299 A HU P9901299A HU P9901299 A2 HUP9901299 A2 HU P9901299A2
- Authority
- HU
- Hungary
- Prior art keywords
- parapox
- viruses
- attenuated
- multipotent
- medicaments
- Prior art date
Links
- 241000700639 Parapoxvirus Species 0.000 title abstract 2
- 230000002238 attenuated effect Effects 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000036039 immunity Effects 0.000 title 1
- 239000000411 inducer Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 2
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 238000011360 adjunctive therapy Methods 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000024963 hair loss Diseases 0.000 abstract 1
- 230000003676 hair loss Effects 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 229940043274 prophylactic drug Drugs 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 239000000021 stimulant Substances 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
- 230000036642 wellbeing Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24211—Parapoxvirus, e.g. Orf virus
- C12N2710/24232—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány inaktivált, attenűált, nemimműnőgén pőx vagy parapőxvírűsőkból előállítőtt biőregűláló készítményekre vőnatkőzik. Ezek akészítmények - pőx indűcerek - aspecifikűsan stiműlálják a cellűlárisés hűmőrális imműnrendszert. A találmány szerint a pőx indűcerekalkalmazása a szőkásős prőfilaktikűs és terápiás gyógyszerekkiegészítésén, őlyan új indikációs területen is hatásősnak bizőnyűl,ahől eddig hasőnló ártalmatlan szer nem állt rendelkezésre. A pőxindűcerek hősszan tartó alkalmazás esetén is ártalmatlanők. Azadjűváló, kiegészítő terápiaként használt pőx indűcerek általábanpőzitív irányba tőlják el a betegek imműnőlógiai paramétereit, aminekkövetkeztében a súlyős betegeknél (példáűl rákős betegek, őperáltbetegek, HIV- és egyéb vírűssal fertőzött betegek, szklerózisműltiplexben szenvedők stb.) példáűl a közérzet javűlása, a fájdalőmenyhülése stb. érhető el. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19614810 | 1996-04-15 | ||
| PCT/DE1997/000761 WO1997038724A1 (de) | 1996-04-15 | 1997-04-14 | Neue indikationen für die verwendung von multipotenten paramunitätsinducern aus attenuierten, nicht-immunogenen pockenviren oder parapockenviren als arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9901299A2 true HUP9901299A2 (hu) | 1999-07-28 |
| HUP9901299A3 HUP9901299A3 (en) | 2000-03-28 |
| HU224308B1 HU224308B1 (hu) | 2005-07-28 |
Family
ID=7791302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901299A HU224308B1 (hu) | 1996-04-15 | 1997-04-14 | Attenuált, nem immunogén poxvírusokból vagy parapoxvírusokból származó multipotens parapox immunitás-inducerek alkalmazása gyógyszerkészítmények előállítására |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6162600A (hu) |
| EP (1) | EP0885013B1 (hu) |
| JP (1) | JP3568208B2 (hu) |
| KR (1) | KR100302994B1 (hu) |
| CN (1) | CN1165343C (hu) |
| AT (1) | ATE203678T1 (hu) |
| AU (1) | AU706729B2 (hu) |
| BR (1) | BR9708679A (hu) |
| CA (1) | CA2251690C (hu) |
| DE (2) | DE19780300D2 (hu) |
| DK (1) | DK0885013T3 (hu) |
| ES (1) | ES2125846T3 (hu) |
| GR (1) | GR3037049T3 (hu) |
| HU (1) | HU224308B1 (hu) |
| NO (1) | NO322176B1 (hu) |
| NZ (1) | NZ332243A (hu) |
| PL (1) | PL329353A1 (hu) |
| PT (1) | PT885013E (hu) |
| SI (1) | SI0885013T1 (hu) |
| WO (1) | WO1997038724A1 (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1303286B1 (de) * | 2000-07-11 | 2006-04-26 | Bayer HealthCare AG | Verwendung von stämmen des parapoxvirus ovis zur herstellung von antiviralen arzneimitteln und arzneimitteln gegen krebs |
| DE10122233A1 (de) * | 2000-07-11 | 2002-01-24 | Bayer Ag | Verwendung von Stämmen des Parapoxvirus ovis gegen Organfibrosen |
| CZ200372A3 (cs) * | 2000-07-11 | 2003-05-14 | Bayer Aktiengesellschaft | Použití kmenů Parapoxvirus ovis pro výrobu léku k léčení orgánových fibróz |
| US6844000B2 (en) | 2001-12-07 | 2005-01-18 | Bayer Pharmaceuticals Corporation | Use of Parapox B2L protein to treat cancer and modify immune responses |
| BRPI0513321B1 (pt) * | 2004-07-13 | 2022-03-08 | Aicuris Gmbh & Co. Kg | Vírus parapox em combinação com outros agentes antivirais para o tratamento de doenças virais |
| DE102004045758A1 (de) * | 2004-09-21 | 2006-04-06 | Toximed Gmbh | Pharmazeutischer Wirkstoff gegen das HIV-Syndrom |
| DE102005027956B4 (de) * | 2005-06-16 | 2009-10-22 | Mayr, Anton, Prof. Dr. Dr. h.c. mult. | Hochattenuierte Poxvirusstämme, Verfahren zu ihrer Herstellung und deren Verwendung als Paramunitätsinducer oder zur Herstellung von Vektor-Vakzinen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3504940C2 (de) * | 1984-02-17 | 1997-11-06 | Bayer Ag | Multipotente Paramunitätsmediatoren, Verfahren zu ihrer Herstellung und diese Mediatoren enthaltende Arzneimittel |
| US6290962B1 (en) * | 1992-11-03 | 2001-09-18 | Oravax, Inc. | Urease-based vaccine and treatment for helicobacter infection |
| DE4405841C1 (de) * | 1994-02-23 | 1995-01-05 | Mayr Anton Prof Dr Med Vet Dr | Multipotente Paramunitätsinducer auf der Basis von Kombinationen von Pockenviruskomponenten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
-
1997
- 1997-04-14 AT AT97922838T patent/ATE203678T1/de not_active IP Right Cessation
- 1997-04-14 DE DE19780300T patent/DE19780300D2/de not_active Expired - Lifetime
- 1997-04-14 JP JP53664997A patent/JP3568208B2/ja not_active Expired - Lifetime
- 1997-04-14 WO PCT/DE1997/000761 patent/WO1997038724A1/de active IP Right Grant
- 1997-04-14 NZ NZ332243A patent/NZ332243A/xx unknown
- 1997-04-14 HU HU9901299A patent/HU224308B1/hu not_active IP Right Cessation
- 1997-04-14 EP EP97922838A patent/EP0885013B1/de not_active Expired - Lifetime
- 1997-04-14 PT PT97922838T patent/PT885013E/pt unknown
- 1997-04-14 PL PL97329353A patent/PL329353A1/xx unknown
- 1997-04-14 CA CA002251690A patent/CA2251690C/en not_active Expired - Fee Related
- 1997-04-14 CN CNB971938202A patent/CN1165343C/zh not_active Expired - Fee Related
- 1997-04-14 KR KR1019980708260A patent/KR100302994B1/ko not_active IP Right Cessation
- 1997-04-14 DK DK97922838T patent/DK0885013T3/da active
- 1997-04-14 BR BR9708679-7A patent/BR9708679A/pt not_active Application Discontinuation
- 1997-04-14 SI SI9730186T patent/SI0885013T1/xx unknown
- 1997-04-14 ES ES97922838T patent/ES2125846T3/es not_active Expired - Lifetime
- 1997-04-14 AU AU28858/97A patent/AU706729B2/en not_active Ceased
- 1997-04-14 DE DE59704194T patent/DE59704194D1/de not_active Expired - Fee Related
-
1998
- 1998-10-14 US US09/171,269 patent/US6162600A/en not_active Expired - Fee Related
- 1998-10-14 NO NO19984782A patent/NO322176B1/no unknown
-
2001
- 2001-10-30 GR GR20010401921T patent/GR3037049T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2125846T3 (es) | 2001-12-16 |
| KR20000005479A (ko) | 2000-01-25 |
| US6162600A (en) | 2000-12-19 |
| DE19780300D2 (de) | 1999-06-17 |
| PL329353A1 (en) | 1999-03-29 |
| ATE203678T1 (de) | 2001-08-15 |
| AU706729B2 (en) | 1999-06-24 |
| EP0885013B1 (de) | 2001-08-01 |
| DE59704194D1 (de) | 2001-09-06 |
| HUP9901299A3 (en) | 2000-03-28 |
| HU224308B1 (hu) | 2005-07-28 |
| GR3037049T3 (en) | 2002-01-31 |
| SI0885013T1 (hu) | 2001-12-31 |
| NO984782L (no) | 1998-12-15 |
| NZ332243A (en) | 2000-10-27 |
| JP3568208B2 (ja) | 2004-09-22 |
| ES2125846T1 (es) | 1999-03-16 |
| CA2251690C (en) | 2005-11-08 |
| AU2885897A (en) | 1997-11-07 |
| NO984782D0 (no) | 1998-10-14 |
| KR100302994B1 (ko) | 2001-11-30 |
| CN1215996A (zh) | 1999-05-05 |
| CN1165343C (zh) | 2004-09-08 |
| JP2000501114A (ja) | 2000-02-02 |
| WO1997038724A1 (de) | 1997-10-23 |
| PT885013E (pt) | 2002-01-30 |
| NO322176B1 (no) | 2006-08-21 |
| EP0885013A1 (de) | 1998-12-23 |
| DK0885013T3 (da) | 2001-11-05 |
| CA2251690A1 (en) | 1997-10-23 |
| BR9708679A (pt) | 2000-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HFG4 | Patent granted, date of granting |
Effective date: 20050610 |
|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |