DK0812352T3 - Omdirigering af cellulær immunitet med proteintyrosinkinasekimærer - Google Patents
Omdirigering af cellulær immunitet med proteintyrosinkinasekimærerInfo
- Publication number
- DK0812352T3 DK0812352T3 DK96903666T DK96903666T DK0812352T3 DK 0812352 T3 DK0812352 T3 DK 0812352T3 DK 96903666 T DK96903666 T DK 96903666T DK 96903666 T DK96903666 T DK 96903666T DK 0812352 T3 DK0812352 T3 DK 0812352T3
- Authority
- DK
- Denmark
- Prior art keywords
- cell
- infective agent
- tyrosine kinase
- receptor
- protein tyrosine
- Prior art date
Links
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 title abstract 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 title abstract 2
- 230000007969 cellular immunity Effects 0.000 title 1
- 108700010039 chimeric receptor Proteins 0.000 abstract 4
- 230000001524 infective effect Effects 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000036755 cellular response Effects 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/394,177 US5912170A (en) | 1991-03-07 | 1995-02-24 | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0812352T3 true DK0812352T3 (da) | 2006-08-21 |
Family
ID=23557887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96903666T DK0812352T3 (da) | 1995-02-24 | 1996-01-24 | Omdirigering af cellulær immunitet med proteintyrosinkinasekimærer |
Country Status (19)
Country | Link |
---|---|
US (3) | US5912170A (da) |
EP (1) | EP0812352B1 (da) |
JP (1) | JP4170389B2 (da) |
KR (1) | KR100454396B1 (da) |
AT (1) | ATE323755T1 (da) |
AU (1) | AU703125C (da) |
CA (1) | CA2209301C (da) |
CZ (1) | CZ294909B6 (da) |
DE (1) | DE69636053T2 (da) |
DK (1) | DK0812352T3 (da) |
ES (1) | ES2258772T3 (da) |
FI (1) | FI121012B (da) |
HU (1) | HU225689B1 (da) |
NO (1) | NO321459B1 (da) |
NZ (2) | NZ501340A (da) |
PT (1) | PT812352E (da) |
RU (1) | RU2225870C2 (da) |
WO (1) | WO1996026265A1 (da) |
ZA (1) | ZA961476B (da) |
Families Citing this family (89)
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US5912170A (en) * | 1991-03-07 | 1999-06-15 | The General Hospital Corporation | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
US6004811A (en) | 1991-03-07 | 1999-12-21 | The Massachussetts General Hospital | Redirection of cellular immunity by protein tyrosine kinase chimeras |
US5851828A (en) | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
US6753162B1 (en) | 1991-03-07 | 2004-06-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
HU225688B1 (en) * | 1995-02-24 | 2007-06-28 | Gen Hospital Corp | Redirection of cellular immunity by receptor chimeras |
GB9526131D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Recombinant chimeric receptors |
IL137419A0 (en) * | 2000-07-20 | 2001-07-24 | Yissum Res Dev Co | Nk cells activating receptors and their therapeutic and diagnostic uses |
ES2384940T3 (es) * | 2004-01-16 | 2012-07-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Inmunoquinasas |
CA3065947C (en) | 2005-10-18 | 2023-03-07 | National Jewish Health | Conditionally immortalized long-term stem cells and methods of making and using such cells |
EP1800695A1 (en) * | 2005-12-21 | 2007-06-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Immuno-RNA-constructs |
PT2476435T (pt) | 2006-08-11 | 2018-03-05 | Life Sciences Res Partners Vzw | Péptidos imunogénicos e a sua utilização em distúrbios imunitários |
EP2587263A1 (en) * | 2007-07-25 | 2013-05-01 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Self coupling recombinant antibody fusion proteins |
US8450053B2 (en) * | 2007-09-11 | 2013-05-28 | University Of Maryland, Baltimore | ZAP-70 as predictor and modulator of effector function of T cells |
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FR2644463A1 (da) * | 1989-03-17 | 1990-09-21 | Pasteur Institut | |
EP0394827A1 (en) * | 1989-04-26 | 1990-10-31 | F. Hoffmann-La Roche Ag | Chimaeric CD4-immunoglobulin polypeptides |
WO1991010736A2 (en) * | 1990-01-19 | 1991-07-25 | Dana Farber Cancer Institute | CLONING AND CHARACTERIZATION OF THE CD3θ SUBUNIT |
DE69123241T2 (de) * | 1990-12-14 | 1997-04-17 | Cell Genesys Inc | Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen |
US5912170A (en) * | 1991-03-07 | 1999-06-15 | The General Hospital Corporation | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
IE920716A1 (en) * | 1991-03-07 | 1992-09-09 | Gen Hospital Corp | Redirection of cellular immunity by receptor chimeras |
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WO1993019163A1 (en) * | 1992-03-18 | 1993-09-30 | Yeda Research And Development Co, Ltd. | Chimeric receptor genes and cells transformed therewith |
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1995
- 1995-02-24 US US08/394,177 patent/US5912170A/en not_active Expired - Lifetime
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1996
- 1996-01-24 NZ NZ50134096A patent/NZ501340A/xx not_active IP Right Cessation
- 1996-01-24 EP EP96903666A patent/EP0812352B1/en not_active Expired - Lifetime
- 1996-01-24 NZ NZ302090A patent/NZ302090A/xx not_active IP Right Cessation
- 1996-01-24 CA CA2209301A patent/CA2209301C/en not_active Expired - Lifetime
- 1996-01-24 DK DK96903666T patent/DK0812352T3/da active
- 1996-01-24 DE DE69636053T patent/DE69636053T2/de not_active Expired - Lifetime
- 1996-01-24 CZ CZ19972601A patent/CZ294909B6/cs not_active IP Right Cessation
- 1996-01-24 ES ES96903666T patent/ES2258772T3/es not_active Expired - Lifetime
- 1996-01-24 JP JP52568396A patent/JP4170389B2/ja not_active Expired - Lifetime
- 1996-01-24 RU RU97115895/13A patent/RU2225870C2/ru active
- 1996-01-24 KR KR1019970705851A patent/KR100454396B1/ko not_active IP Right Cessation
- 1996-01-24 HU HU9800459A patent/HU225689B1/hu unknown
- 1996-01-24 PT PT96903666T patent/PT812352E/pt unknown
- 1996-01-24 AT AT96903666T patent/ATE323755T1/de active
- 1996-01-24 WO PCT/US1996/001001 patent/WO1996026265A1/en active IP Right Grant
- 1996-01-24 AU AU47675/96A patent/AU703125C/en not_active Expired
- 1996-02-23 ZA ZA961476A patent/ZA961476B/xx unknown
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1997
- 1997-08-22 NO NO19973863A patent/NO321459B1/no not_active IP Right Cessation
- 1997-08-22 FI FI973466A patent/FI121012B/fi not_active IP Right Cessation
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1999
- 1999-06-15 US US09/333,636 patent/US6410014B1/en not_active Expired - Lifetime
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2002
- 2002-02-25 US US10/179,778 patent/US20020176851A1/en not_active Abandoned
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