HUP0500329A2 - Eljárás karbapenemvegyületek előállítására - Google Patents

Eljárás karbapenemvegyületek előállítására

Info

Publication number
HUP0500329A2
HUP0500329A2 HU0500329A HUP0500329A HUP0500329A2 HU P0500329 A2 HUP0500329 A2 HU P0500329A2 HU 0500329 A HU0500329 A HU 0500329A HU P0500329 A HUP0500329 A HU P0500329A HU P0500329 A2 HUP0500329 A2 HU P0500329A2
Authority
HU
Hungary
Prior art keywords
organic solvent
carbapenem
carbapenem solid
aryl
heteroaryl group
Prior art date
Application number
HU0500329A
Other languages
English (en)
Inventor
Raymond Cvetovich
Robert Wenslow
John M. Williams
Daniel Sidler
Louis Crocker
Hsien-Hsin Tung
Brian K. Johnson
Joseph Ii. Kukura
Ulf Dolling
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of HUP0500329A2 publication Critical patent/HUP0500329A2/hu
Publication of HUP0500329A3 publication Critical patent/HUP0500329A3/hu
Publication of HU230700B1 publication Critical patent/HU230700B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya eljárás szerves oldószerek szintjénekgyógyászatilag elfogadható szintre való csökkentésére (I) általánosképletű karbapenem szilárdanyagokban - a képletben R1 és R2 jelentéseazonosan vagy eltérően hidrogénatom, alkil-, aril- vagyheteroarilcsoport, ahol a fenti alkil-, aril- és heteroarilcsoportadott esetben szubsztituált - vagy azok sójában, oly módon, hogy aszerves oldószert tartalmazó karbapenem szilárdanyagot vizettartalmazó szerves oldószerrel mossák, és az így kapott, reziduálisszerves oldószert tartalmazó mosott karbapenem szilárdanyagban lévőreziduális szerves oldószert vákuum és/vagy (hidratált vagy száraz)inert gáz alkalmazásával, alacsony hőmérsékleten elpárologtatják, ilymódon kapják a gyógyászatilag elfogadható szintű szerves oldószerttartalmazó (I) általános képletű karbapenem szilárdanyagot vagy annaksóját, ahol a karbapenem szilárdanyag víztartalmát szerves oldószerrekorrigálva körülbelül 13% - körülbelül 25% között tartják az eljárássorán. Ó
HU0500329A 2001-09-26 2002-09-20 Eljárás karbapenemvegyületek előállítására HU230700B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32513001P 2001-09-26 2001-09-26
US60/325,130 2001-09-26
PCT/US2002/029879 WO2003027067A2 (en) 2001-09-26 2002-09-20 Process for making carbapenem compounds

Publications (3)

Publication Number Publication Date
HUP0500329A2 true HUP0500329A2 (hu) 2005-07-28
HUP0500329A3 HUP0500329A3 (en) 2012-09-28
HU230700B1 HU230700B1 (hu) 2017-09-28

Family

ID=23266556

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500329A HU230700B1 (hu) 2001-09-26 2002-09-20 Eljárás karbapenemvegyületek előállítására

Country Status (22)

Country Link
US (1) US7022841B2 (hu)
EP (1) EP1474426B8 (hu)
JP (1) JP4480396B2 (hu)
KR (1) KR100628676B1 (hu)
CN (2) CN100387599C (hu)
AT (1) ATE518864T1 (hu)
AU (1) AU2002341747B2 (hu)
BR (1) BRPI0212411B8 (hu)
CA (1) CA2461565C (hu)
CY (1) CY1112092T1 (hu)
DK (1) DK1474426T3 (hu)
EA (1) EA008168B1 (hu)
ES (1) ES2368997T3 (hu)
HU (1) HU230700B1 (hu)
IL (1) IL160413A0 (hu)
MX (1) MXPA04002797A (hu)
NZ (1) NZ531174A (hu)
PL (1) PL218808B1 (hu)
PT (1) PT1474426E (hu)
RS (1) RS52410B (hu)
UA (1) UA78524C2 (hu)
WO (1) WO2003027067A2 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7145002B2 (en) * 2001-09-26 2006-12-05 Merck & Co. Inc. Crystalline forms of carbapenem antibiotics and methods of preparation
JP2005509037A (ja) * 2001-11-16 2005-04-07 ランバクシー ラボラトリーズ リミテッド 結晶イミペネム製造方法
MX2007006018A (es) * 2004-11-30 2007-06-07 Astellas Pharma Inc Suspension farmaceutica oral novedosa de cristal de cefdinir.
CN100457760C (zh) * 2005-10-20 2009-02-04 上海交通大学 尔他培南钠盐的制备方法
US8293894B2 (en) * 2006-11-20 2012-10-23 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
CN101367812B (zh) * 2007-06-28 2011-04-27 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰胺基环戊烯酸取代的培南衍生物
CN101372490B (zh) * 2007-08-15 2011-02-09 山东轩竹医药科技有限公司 含有巯基氮杂环乙烯基氮杂环的培南衍生物
EP2505190A1 (en) * 2008-06-11 2012-10-03 Ranbaxy Laboratories Limited Polymorphic forms of ertapenem monosodium salt and process for it's preparation
CN102558182B (zh) * 2010-12-31 2015-02-11 石药集团中奇制药技术（石家庄）有限公司 一种厄他培南钠晶型及其制备方法
CN102363617B (zh) * 2011-11-09 2013-09-18 上海希迈医药科技有限公司 一种厄他培南单钠盐结晶体及其制备方法
EP2834242A4 (en) * 2012-04-04 2016-01-06 Hospira Inc IMPROVED PROCESS FOR THE PREPARATION OF CARBAPENEM ANTIBIOTICS
IN2013MU03862A (hu) 2013-12-11 2015-07-31 Unimark Remedies Ltd
CN113416193B (zh) * 2021-08-23 2021-12-17 凯莱英医药集团（天津）股份有限公司 厄他培南钠新晶型及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
IE60588B1 (en) 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
JP3048196B2 (ja) * 1991-06-20 2000-06-05 第一製薬株式会社 カルバペネム誘導体
GB9202298D0 (en) 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CZ290002B6 (cs) * 1992-03-11 2002-05-15 Sankyo Company Limited Antimikrobiální karbapenemové deriváty, způsob výroby a farmaceutický prostředek
ZA938438B (en) * 1992-11-17 1994-06-20 Sankyo Co Crystalline carbapenem derivative
ES2180977T3 (es) * 1996-04-26 2003-02-16 Sankyo Co Un derivado de 1-metilcarbapenem.
US6180783B1 (en) * 1997-06-16 2001-01-30 Merck & Co., Inc. Stabilized carbapenem intermediates and improved process for carbapenem synthesis
US5872250A (en) * 1997-07-30 1999-02-16 Merck & Co., Inc. Process for synthesizing carbapenem antibiotics
AU749234B2 (en) * 1998-03-02 2002-06-20 Merck Sharp & Dohme Corp. Process for synthesizing carbapenem antibiotics
TWI250160B (en) * 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
AR035728A1 (es) * 2001-01-16 2004-07-07 Merck & Co Inc Proceso perfeccionado para la sintesis de carbapenem
US7145002B2 (en) * 2001-09-26 2006-12-05 Merck & Co. Inc. Crystalline forms of carbapenem antibiotics and methods of preparation

Also Published As

Publication number Publication date
CN100338064C (zh) 2007-09-19
EP1474426A2 (en) 2004-11-10
WO2003027067A3 (en) 2004-09-10
PL371666A1 (en) 2005-06-27
US20040176351A1 (en) 2004-09-09
RS52410B (en) 2013-02-28
ES2368997T3 (es) 2011-11-24
US7022841B2 (en) 2006-04-04
MXPA04002797A (es) 2004-07-02
EP1474426A4 (en) 2005-01-05
CY1112092T1 (el) 2015-11-04
PL218808B1 (pl) 2015-01-30
CN100387599C (zh) 2008-05-14
RS22404A (en) 2007-02-05
EA200400474A1 (ru) 2004-08-26
ATE518864T1 (de) 2011-08-15
EP1474426B8 (en) 2011-10-12
JP2005508334A (ja) 2005-03-31
KR100628676B1 (ko) 2006-09-27
CN1821248A (zh) 2006-08-23
NZ531174A (en) 2005-09-30
EP1474426B1 (en) 2011-08-03
EA008168B1 (ru) 2007-04-27
UA78524C2 (en) 2007-04-10
AU2002341747B2 (en) 2007-10-18
BRPI0212411B8 (pt) 2021-07-27
BR0212411A (pt) 2004-08-03
DK1474426T3 (da) 2011-11-21
PT1474426E (pt) 2011-10-07
WO2003027067A2 (en) 2003-04-03
CA2461565C (en) 2009-09-15
HUP0500329A3 (en) 2012-09-28
CN1602312A (zh) 2005-03-30
JP4480396B2 (ja) 2010-06-16
BRPI0212411B1 (pt) 2015-10-27
KR20040039437A (ko) 2004-05-10
CA2461565A1 (en) 2003-04-03
HU230700B1 (hu) 2017-09-28
IL160413A0 (en) 2004-07-25

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US

GB9A Succession in title

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK SHARP & DOHME CORP., US; SCHERING CORPORATION, US

HC9A Change of name, address

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK SHARP & DOHME CORP., US; SCHERING CORPORATION, US

GB9A Succession in title

Owner name: MERCK SHARP & DOHME LLC, US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK SHARP & DOHME CORP., US; MERCK SHARP & DOHME CORP., US; SCHERING CORPORATION, US