HUP0500329A2 - Eljárás karbapenemvegyületek előállítására - Google Patents

Eljárás karbapenemvegyületek előállítására

Info

Publication number
HUP0500329A2
HUP0500329A2 HU0500329A HUP0500329A HUP0500329A2 HU P0500329 A2 HUP0500329 A2 HU P0500329A2 HU 0500329 A HU0500329 A HU 0500329A HU P0500329 A HUP0500329 A HU P0500329A HU P0500329 A2 HUP0500329 A2 HU P0500329A2
Authority
HU
Hungary
Prior art keywords
organic solvent
carbapenem
carbapenem solid
aryl
heteroaryl group
Prior art date
Application number
HU0500329A
Other languages
English (en)
Inventor
Raymond Cvetovich
Robert Wenslow
John M. Williams
Daniel Sidler
Louis Crocker
Hsien-Hsin Tung
Brian K. Johnson
Joseph Ii. Kukura
Ulf Dolling
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of HUP0500329A2 publication Critical patent/HUP0500329A2/hu
Publication of HUP0500329A3 publication Critical patent/HUP0500329A3/hu
Publication of HU230700B1 publication Critical patent/HU230700B1/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02Preparation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya eljárás szerves oldószerek szintjénekgyógyászatilag elfogadható szintre való csökkentésére (I) általánosképletű karbapenem szilárdanyagokban - a képletben R1 és R2 jelentéseazonosan vagy eltérően hidrogénatom, alkil-, aril- vagyheteroarilcsoport, ahol a fenti alkil-, aril- és heteroarilcsoportadott esetben szubsztituált - vagy azok sójában, oly módon, hogy aszerves oldószert tartalmazó karbapenem szilárdanyagot vizettartalmazó szerves oldószerrel mossák, és az így kapott, reziduálisszerves oldószert tartalmazó mosott karbapenem szilárdanyagban lévőreziduális szerves oldószert vákuum és/vagy (hidratált vagy száraz)inert gáz alkalmazásával, alacsony hőmérsékleten elpárologtatják, ilymódon kapják a gyógyászatilag elfogadható szintű szerves oldószerttartalmazó (I) általános képletű karbapenem szilárdanyagot vagy annaksóját, ahol a karbapenem szilárdanyag víztartalmát szerves oldószerrekorrigálva körülbelül 13% - körülbelül 25% között tartják az eljárássorán. Ó
HU0500329A 2001-09-26 2002-09-20 Eljárás karbapenemvegyületek előállítására HU230700B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32513001P 2001-09-26 2001-09-26
US60/325,130 2001-09-26
PCT/US2002/029879 WO2003027067A2 (en) 2001-09-26 2002-09-20 Process for making carbapenem compounds

Publications (3)

Publication Number Publication Date
HUP0500329A2 true HUP0500329A2 (hu) 2005-07-28
HUP0500329A3 HUP0500329A3 (en) 2012-09-28
HU230700B1 HU230700B1 (hu) 2017-09-28

Family

ID=23266556

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0500329A HU230700B1 (hu) 2001-09-26 2002-09-20 Eljárás karbapenemvegyületek előállítására

Country Status (22)

Country Link
US (1) US7022841B2 (hu)
EP (1) EP1474426B8 (hu)
JP (1) JP4480396B2 (hu)
KR (1) KR100628676B1 (hu)
CN (2) CN100387599C (hu)
AT (1) ATE518864T1 (hu)
AU (1) AU2002341747B2 (hu)
BR (1) BRPI0212411B8 (hu)
CA (1) CA2461565C (hu)
CY (1) CY1112092T1 (hu)
DK (1) DK1474426T3 (hu)
EA (1) EA008168B1 (hu)
ES (1) ES2368997T3 (hu)
HU (1) HU230700B1 (hu)
IL (1) IL160413A0 (hu)
MX (1) MXPA04002797A (hu)
NZ (1) NZ531174A (hu)
PL (1) PL218808B1 (hu)
PT (1) PT1474426E (hu)
RS (1) RS52410B (hu)
UA (1) UA78524C2 (hu)
WO (1) WO2003027067A2 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002331885B2 (en) 2001-09-26 2007-07-26 Merck & Co., Inc. Crystalline forms of ertapenem sodium
JP2005509037A (ja) * 2001-11-16 2005-04-07 ランバクシー ラボラトリーズ リミテッド 結晶イミペネム製造方法
WO2006059753A1 (en) * 2004-11-30 2006-06-08 Astellas Pharma Inc. Novel oral pharmaceutical suspension of cefdinir crystal
CN100457760C (zh) * 2005-10-20 2009-02-04 上海交通大学 尔他培南钠盐的制备方法
WO2008062279A2 (en) * 2006-11-20 2008-05-29 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of carbapenem antibiotic
CN101367812B (zh) * 2007-06-28 2011-04-27 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰胺基环戊烯酸取代的培南衍生物
CN101372490B (zh) * 2007-08-15 2011-02-09 山东轩竹医药科技有限公司 含有巯基氮杂环乙烯基氮杂环的培南衍生物
EP2303225B1 (en) 2008-06-11 2013-11-20 Ranbaxy Laboratories Limited Compositions of Carbon Dioxide Adduct of Ertapenem and Polymorphic Forms of Ertapenem Monosodium Salt
CN102558182B (zh) * 2010-12-31 2015-02-11 石药集团中奇制药技术(石家庄)有限公司 一种厄他培南钠晶型及其制备方法
CN102363617B (zh) * 2011-11-09 2013-09-18 上海希迈医药科技有限公司 一种厄他培南单钠盐结晶体及其制备方法
US20150038726A1 (en) * 2012-04-04 2015-02-05 Hospira, Inc. Process for the preparation of carbapenem antibiotic
WO2015087245A1 (en) 2013-12-11 2015-06-18 Unimark Remedies Ltd. Process for preparation of ertapenem and salts thereof
CN113416193B (zh) * 2021-08-23 2021-12-17 凯莱英医药集团(天津)股份有限公司 厄他培南钠新晶型及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
IE60588B1 (en) 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
JP3048196B2 (ja) * 1991-06-20 2000-06-05 第一製薬株式会社 カルバペネム誘導体
GB9202298D0 (en) 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CZ290002B6 (cs) * 1992-03-11 2002-05-15 Sankyo Company Limited Antimikrobiální karbapenemové deriváty, způsob výroby a farmaceutický prostředek
ZA938438B (en) * 1992-11-17 1994-06-20 Sankyo Co Crystalline carbapenem derivative
WO1997041123A1 (fr) * 1996-04-26 1997-11-06 Sankyo Company, Limited Derives de 1-methylcarbapeneme
US6180783B1 (en) * 1997-06-16 2001-01-30 Merck & Co., Inc. Stabilized carbapenem intermediates and improved process for carbapenem synthesis
US5872250A (en) 1997-07-30 1999-02-16 Merck & Co., Inc. Process for synthesizing carbapenem antibiotics
ES2260900T3 (es) 1998-03-02 2006-11-01 MERCK & CO., INC. Procedimiento para sintetizar antibioticos de carbapenem.
TWI250160B (en) * 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
AR035728A1 (es) * 2001-01-16 2004-07-07 Merck & Co Inc Proceso perfeccionado para la sintesis de carbapenem
AU2002331885B2 (en) * 2001-09-26 2007-07-26 Merck & Co., Inc. Crystalline forms of ertapenem sodium

Also Published As

Publication number Publication date
IL160413A0 (en) 2004-07-25
EP1474426B8 (en) 2011-10-12
UA78524C2 (en) 2007-04-10
ATE518864T1 (de) 2011-08-15
BRPI0212411B1 (pt) 2015-10-27
CN1602312A (zh) 2005-03-30
CN100338064C (zh) 2007-09-19
JP4480396B2 (ja) 2010-06-16
HU230700B1 (hu) 2017-09-28
EP1474426B1 (en) 2011-08-03
PT1474426E (pt) 2011-10-07
EA200400474A1 (ru) 2004-08-26
WO2003027067A3 (en) 2004-09-10
DK1474426T3 (da) 2011-11-21
PL371666A1 (en) 2005-06-27
KR100628676B1 (ko) 2006-09-27
EP1474426A4 (en) 2005-01-05
EA008168B1 (ru) 2007-04-27
CY1112092T1 (el) 2015-11-04
US20040176351A1 (en) 2004-09-09
CN1821248A (zh) 2006-08-23
CA2461565C (en) 2009-09-15
HUP0500329A3 (en) 2012-09-28
WO2003027067A2 (en) 2003-04-03
BR0212411A (pt) 2004-08-03
AU2002341747B2 (en) 2007-10-18
PL218808B1 (pl) 2015-01-30
ES2368997T3 (es) 2011-11-24
KR20040039437A (ko) 2004-05-10
CA2461565A1 (en) 2003-04-03
MXPA04002797A (es) 2004-07-02
JP2005508334A (ja) 2005-03-31
NZ531174A (en) 2005-09-30
EP1474426A2 (en) 2004-11-10
RS52410B (en) 2013-02-28
US7022841B2 (en) 2006-04-04
BRPI0212411B8 (pt) 2021-07-27
RS22404A (en) 2007-02-05
CN100387599C (zh) 2008-05-14

Similar Documents

Publication Publication Date Title
HUP0500329A2 (hu) Eljárás karbapenemvegyületek előállítására
CA2269053A1 (en) Crystals of benzimidazole derivatives and their production
JP2010184925A (ja) セフジニルの新規な結晶形
EA200601830A1 (ru) Ортозамещённые арильные или гетероарильные амидные соединения
NO940261L (no) 5-leddete heterocykler, fremgangsmåte ved fremstilling derav og legemidler som inneholder disse forbindelser
WO2009077874A3 (en) A pharmaceutical composition for treating esophageal cancer
JP2006509707A5 (hu)
HUP0401575A2 (hu) Új vinil-karbonsav-származékok és ezek alkalmazása cukorbetegség ellen és ezeket tartalmazó gyógyszerkészítmények
WO2003070665A3 (en) Desolvating solvates of atorvastatin hemi-calcium
NO903532L (no) Fremgangsmaate for behandling av kardiell, saavel som vaskulaer hypertropi og hyperplasi.
KR920021502A (ko) α-디아조-β-케토 에스테르 단위 및 설포네이트 단위를 함유하는 다작용성 화합물, 이의 제조방법 및 이의 용도
RU97107992A (ru) Производные хинолина
CA2048243A1 (en) 4-amino- 4,6-steroids and their use as 5-.alpha.-reductase inhibitors
WO2003080631A3 (en) Plasma carboxypeptidase b inhibitors
HUP9903424A1 (hu) Új eritromicinszármazékok,eljárás előállításukra és gyógyszerként való alkalmazásuk
HUP0300816A2 (hu) Folyamatos eljárás peszticid hatású klór-tiazol-származékok elżállítására
HUP0402101A2 (hu) Vajsavszármazékok, előállításuk és alkalmazásuk
KR970074781A (ko) 황 함유 헤테로사이클릭 브라디키닌 길항제, 이의 제조방법 및 이의 용도
HUP9901070A2 (hu) Eljárás 1-(3-trialkil-szilil-fenil)-2,2,2-trifluor-metil-etanon-származékok előállítására
NO983656L (no) Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander
DE50000808D1 (de) Verfahren zur Herstellung von 3-Isochromanonen durch Cyclisierung von o-Chlormehtylphenylessigsäuren
HUP0202335A2 (hu) Eljárás optikailag aktív, vinil-szubsztituált ciklopropánkarbonsavak racemizálására
JP2002514634A5 (hu)
KR890011885A (ko) 치환된 디벤조- 및 피리도벤조- 아제피논의 아미노케톤 및 약제학적 조성물
AU2003278193A1 (en) Method of obtaining polymorphic form i of finasteride

Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US

GB9A Succession in title

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK SHARP & DOHME CORP., US; SCHERING CORPORATION, US

HC9A Change of name, address

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK SHARP & DOHME CORP., US; SCHERING CORPORATION, US

GB9A Succession in title

Owner name: MERCK SHARP & DOHME LLC, US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US; MERCK SHARP & DOHME CORP., US; MERCK SHARP & DOHME CORP., US; SCHERING CORPORATION, US