CY1112092T1 - Διεργασια για την κατασκευη ενωσεων καρβαπενεμης - Google Patents
Διεργασια για την κατασκευη ενωσεων καρβαπενεμηςInfo
- Publication number
- CY1112092T1 CY1112092T1 CY20111101043T CY111101043T CY1112092T1 CY 1112092 T1 CY1112092 T1 CY 1112092T1 CY 20111101043 T CY20111101043 T CY 20111101043T CY 111101043 T CY111101043 T CY 111101043T CY 1112092 T1 CY1112092 T1 CY 1112092T1
- Authority
- CY
- Cyprus
- Prior art keywords
- organic solvents
- carbapenem
- pharmaceutically acceptable
- formula
- organic solvent
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000010276 construction Methods 0.000 title 1
- 239000003960 organic solvent Substances 0.000 abstract 5
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 abstract 3
- 239000007787 solid Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση αφορά διεργασία για την ελάττωση των επιπέδων των οργανικών διαλυτών σε φαρμακευτικώς αποδεκτά επίπεδα σε θερμικώς ασταθή στερεά κρυσταλλικής καρβαπενέμης που αντιπροσωπεύονται από τον τύπο (I), ή ένα άλας αυτών, όπου τα R1 και R2 είναι τα ίδια ή διαφορετικά, και επιλέγονται από Η, αλκυλ, αρυλ, και ετεροαρυλ, που περιλαμβάνει πλύση ενός στερεού καρβαπενέμης που περιέχει οργανικό διαλύτη με οργανικό διαλύτη που περιέχει νερό, και χρήση κενού ή/και αδρανούς αερίου (ενυδατωμένου ή ξηρού) σε χαμηλή θερμοκρασία ώστε να παραχθεί ένωση του τύπου (I) που περιέχει φαρμακευτικώς αποδεκτά επίπεδα οργανικών διαλυτών, όπου η περιεκτικότητα σε νερό του στερεού κρυσταλλικής καρβαπενέμης, διορθώνοντας για τους οργανικούς διαλύτες, διατηρείται περίπου στο 13% έως περίπου 25% κατά τη διάρκεια της διεργασίας.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32513001P | 2001-09-26 | 2001-09-26 | |
| EP02775896A EP1474426B8 (en) | 2001-09-26 | 2002-09-20 | Process for making carbapenem compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1112092T1 true CY1112092T1 (el) | 2015-11-04 |
Family
ID=23266556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111101043T CY1112092T1 (el) | 2001-09-26 | 2011-10-31 | Διεργασια για την κατασκευη ενωσεων καρβαπενεμης |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7022841B2 (el) |
| EP (1) | EP1474426B8 (el) |
| JP (1) | JP4480396B2 (el) |
| KR (1) | KR100628676B1 (el) |
| CN (2) | CN100338064C (el) |
| AT (1) | ATE518864T1 (el) |
| AU (1) | AU2002341747B2 (el) |
| BR (1) | BRPI0212411B8 (el) |
| CA (1) | CA2461565C (el) |
| CY (1) | CY1112092T1 (el) |
| DK (1) | DK1474426T3 (el) |
| EA (1) | EA008168B1 (el) |
| ES (1) | ES2368997T3 (el) |
| HU (1) | HU230700B1 (el) |
| IL (1) | IL160413A0 (el) |
| MX (1) | MXPA04002797A (el) |
| NZ (1) | NZ531174A (el) |
| PL (1) | PL218808B1 (el) |
| PT (1) | PT1474426E (el) |
| RS (1) | RS52410B (el) |
| UA (1) | UA78524C2 (el) |
| WO (1) | WO2003027067A2 (el) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE40794E1 (en) | 2001-09-26 | 2009-06-23 | Merck & Co., Inc. | Crystalline forms of carbapenem antibiotics and methods of preparation |
| CN1608066A (zh) * | 2001-11-16 | 2005-04-20 | 兰贝克赛实验室有限公司 | 结晶亚胺培南的制备方法 |
| MX2007006018A (es) * | 2004-11-30 | 2007-06-07 | Astellas Pharma Inc | Suspension farmaceutica oral novedosa de cristal de cefdinir. |
| CN100457760C (zh) * | 2005-10-20 | 2009-02-04 | 上海交通大学 | 尔他培南钠盐的制备方法 |
| US8293894B2 (en) * | 2006-11-20 | 2012-10-23 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of carbapenem antibiotic |
| CN101367812B (zh) * | 2007-06-28 | 2011-04-27 | 山东轩竹医药科技有限公司 | 被巯基吡咯烷甲酰胺基环戊烯酸取代的培南衍生物 |
| CN101372490B (zh) * | 2007-08-15 | 2011-02-09 | 山东轩竹医药科技有限公司 | 含有巯基氮杂环乙烯基氮杂环的培南衍生物 |
| EP2505190A1 (en) | 2008-06-11 | 2012-10-03 | Ranbaxy Laboratories Limited | Polymorphic forms of ertapenem monosodium salt and process for it's preparation |
| CN102558182B (zh) * | 2010-12-31 | 2015-02-11 | 石药集团中奇制药技术（石家庄）有限公司 | 一种厄他培南钠晶型及其制备方法 |
| CN102363617B (zh) * | 2011-11-09 | 2013-09-18 | 上海希迈医药科技有限公司 | 一种厄他培南单钠盐结晶体及其制备方法 |
| EP2834242A4 (en) * | 2012-04-04 | 2016-01-06 | Hospira Inc | IMPROVED PROCESS FOR THE PREPARATION OF CARBAPENEM ANTIBIOTICS |
| WO2015087245A1 (en) | 2013-12-11 | 2015-06-18 | Unimark Remedies Ltd. | Process for preparation of ertapenem and salts thereof |
| CN113416193B (zh) | 2021-08-23 | 2021-12-17 | 凯莱英医药集团（天津）股份有限公司 | 厄他培南钠新晶型及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283906C (en) | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| IE60588B1 (en) * | 1986-07-30 | 1994-07-27 | Sumitomo Pharma | Carbapenem compound in crystalline form, and its production and use |
| JP3048196B2 (ja) * | 1991-06-20 | 2000-06-05 | 第一製薬株式会社 | カルバペネム誘導体 |
| GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| HU218676B (hu) * | 1992-03-11 | 2000-10-28 | Sankyo Co. Ltd. | Antimikrobiális karbapenemszármazékok, ilyen vegyületeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására |
| ZA938438B (en) * | 1992-11-17 | 1994-06-20 | Sankyo Co | Crystalline carbapenem derivative |
| CN1093861C (zh) * | 1996-04-26 | 2002-11-06 | 三共株式会社 | 1－甲基碳青霉烯衍生物 |
| US6180783B1 (en) | 1997-06-16 | 2001-01-30 | Merck & Co., Inc. | Stabilized carbapenem intermediates and improved process for carbapenem synthesis |
| US5872250A (en) * | 1997-07-30 | 1999-02-16 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
| EP1060180B1 (en) * | 1998-03-02 | 2006-03-29 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
| TWI250160B (en) * | 1999-07-06 | 2006-03-01 | Sankyo Co | Crystalline 1-methylcarbapenem compound |
| AR035728A1 (es) * | 2001-01-16 | 2004-07-07 | Merck & Co Inc | Proceso perfeccionado para la sintesis de carbapenem |
| USRE40794E1 (en) * | 2001-09-26 | 2009-06-23 | Merck & Co., Inc. | Crystalline forms of carbapenem antibiotics and methods of preparation |
-
2002
- 2002-09-20 ES ES02775896T patent/ES2368997T3/es not_active Expired - Lifetime
- 2002-09-20 EA EA200400474A patent/EA008168B1/ru unknown
- 2002-09-20 CN CNB028184319A patent/CN100338064C/zh not_active Expired - Lifetime
- 2002-09-20 HU HU0500329A patent/HU230700B1/hu unknown
- 2002-09-20 DK DK02775896.0T patent/DK1474426T3/da active
- 2002-09-20 CA CA002461565A patent/CA2461565C/en not_active Expired - Lifetime
- 2002-09-20 BR BRPI0212411A patent/BRPI0212411B8/pt not_active IP Right Cessation
- 2002-09-20 AT AT02775896T patent/ATE518864T1/de active
- 2002-09-20 WO PCT/US2002/029879 patent/WO2003027067A2/en active IP Right Grant
- 2002-09-20 US US10/485,134 patent/US7022841B2/en not_active Expired - Lifetime
- 2002-09-20 NZ NZ531174A patent/NZ531174A/en not_active IP Right Cessation
- 2002-09-20 KR KR1020047004533A patent/KR100628676B1/ko active IP Right Grant
- 2002-09-20 RS YU22404A patent/RS52410B/en unknown
- 2002-09-20 MX MXPA04002797A patent/MXPA04002797A/es active IP Right Grant
- 2002-09-20 JP JP2003530658A patent/JP4480396B2/ja not_active Expired - Lifetime
- 2002-09-20 PL PL371666A patent/PL218808B1/pl unknown
- 2002-09-20 IL IL16041302A patent/IL160413A0/xx unknown
- 2002-09-20 PT PT02775896T patent/PT1474426E/pt unknown
- 2002-09-20 EP EP02775896A patent/EP1474426B8/en not_active Expired - Lifetime
- 2002-09-20 AU AU2002341747A patent/AU2002341747B2/en not_active Expired
- 2002-09-20 UA UA20040403037A patent/UA78524C2/uk unknown
- 2002-09-20 CN CNB2006100043356A patent/CN100387599C/zh not_active Expired - Lifetime
-
2011
- 2011-10-31 CY CY20111101043T patent/CY1112092T1/el unknown
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