EA200400474A1 - Способ получения карбапенемовых соединений - Google Patents
Способ получения карбапенемовых соединенийInfo
- Publication number
- EA200400474A1 EA200400474A1 EA200400474A EA200400474A EA200400474A1 EA 200400474 A1 EA200400474 A1 EA 200400474A1 EA 200400474 A EA200400474 A EA 200400474A EA 200400474 A EA200400474 A EA 200400474A EA 200400474 A1 EA200400474 A1 EA 200400474A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- organic solvents
- carbapenem
- pharmaceutically acceptable
- formula
- obtaining
- Prior art date
Links
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000003960 organic solvent Substances 0.000 abstract 5
- 239000007787 solid Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229940041011 carbapenems Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Данное изобретение относится к способу снижения уровней органических растворителей до фармацевтически приемлемых уровней в твердых веществах термически нестабильных кристаллических карбапенемах, представляемых формулой I, или их солях, где Rи Rявляются одинаковыми или разными и выбраны из H, алкила, арила и гетероарила, включающему промывание твердого вещества карбапенема, содержащего органический растворитель, органическим растворителем, содержащим воду; и с использованием вакуума и/или инертного газа (гидратированного или сухого) при низкой температуре с получением соединения формулы I, содержащего фармацевтически приемлемые уровни органических растворителей, причем в течение данного процесса содержание воды в твердом веществе кристаллического карбапенема с поправкой на органические растворители поддерживают на уровне от примерно 13 до примерно 25%.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32513001P | 2001-09-26 | 2001-09-26 | |
PCT/US2002/029879 WO2003027067A2 (en) | 2001-09-26 | 2002-09-20 | Process for making carbapenem compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200400474A1 true EA200400474A1 (ru) | 2004-08-26 |
EA008168B1 EA008168B1 (ru) | 2007-04-27 |
Family
ID=23266556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400474A EA008168B1 (ru) | 2001-09-26 | 2002-09-20 | Способ получения карбапенемовых соединений |
Country Status (22)
Country | Link |
---|---|
US (1) | US7022841B2 (ru) |
EP (1) | EP1474426B8 (ru) |
JP (1) | JP4480396B2 (ru) |
KR (1) | KR100628676B1 (ru) |
CN (2) | CN100338064C (ru) |
AT (1) | ATE518864T1 (ru) |
AU (1) | AU2002341747B2 (ru) |
BR (1) | BRPI0212411B8 (ru) |
CA (1) | CA2461565C (ru) |
CY (1) | CY1112092T1 (ru) |
DK (1) | DK1474426T3 (ru) |
EA (1) | EA008168B1 (ru) |
ES (1) | ES2368997T3 (ru) |
HU (1) | HU230700B1 (ru) |
IL (1) | IL160413A0 (ru) |
MX (1) | MXPA04002797A (ru) |
NZ (1) | NZ531174A (ru) |
PL (1) | PL218808B1 (ru) |
PT (1) | PT1474426E (ru) |
RS (1) | RS52410B (ru) |
UA (1) | UA78524C2 (ru) |
WO (1) | WO2003027067A2 (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003026572A2 (en) * | 2001-09-26 | 2003-04-03 | Merck & Co., Inc. | Crystalline forms of ertapenem sodium |
PL368984A1 (en) * | 2001-11-16 | 2005-04-04 | Ranbaxy Laboratories Limited | Process for the preparation of crystalline imipenem |
MX2007006018A (es) * | 2004-11-30 | 2007-06-07 | Astellas Pharma Inc | Suspension farmaceutica oral novedosa de cristal de cefdinir. |
CN100457760C (zh) * | 2005-10-20 | 2009-02-04 | 上海交通大学 | 尔他培南钠盐的制备方法 |
US8293894B2 (en) * | 2006-11-20 | 2012-10-23 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of carbapenem antibiotic |
CN101367812B (zh) * | 2007-06-28 | 2011-04-27 | 山东轩竹医药科技有限公司 | 被巯基吡咯烷甲酰胺基环戊烯酸取代的培南衍生物 |
CN101372490B (zh) * | 2007-08-15 | 2011-02-09 | 山东轩竹医药科技有限公司 | 含有巯基氮杂环乙烯基氮杂环的培南衍生物 |
US20110172201A1 (en) * | 2008-06-11 | 2011-07-14 | Ranbaxy Laboratories Limited | Process for preparing a carbapenem antibiotic composition |
CN102558182B (zh) | 2010-12-31 | 2015-02-11 | 石药集团中奇制药技术(石家庄)有限公司 | 一种厄他培南钠晶型及其制备方法 |
CN102363617B (zh) * | 2011-11-09 | 2013-09-18 | 上海希迈医药科技有限公司 | 一种厄他培南单钠盐结晶体及其制备方法 |
US20150038726A1 (en) * | 2012-04-04 | 2015-02-05 | Hospira, Inc. | Process for the preparation of carbapenem antibiotic |
IN2013MU03862A (ru) | 2013-12-11 | 2015-07-31 | Unimark Remedies Ltd | |
CN113416193B (zh) * | 2021-08-23 | 2021-12-17 | 凯莱英医药集团(天津)股份有限公司 | 厄他培南钠新晶型及其制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
IE60588B1 (en) | 1986-07-30 | 1994-07-27 | Sumitomo Pharma | Carbapenem compound in crystalline form, and its production and use |
JP3048196B2 (ja) * | 1991-06-20 | 2000-06-05 | 第一製薬株式会社 | カルバペネム誘導体 |
GB9202298D0 (en) | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
CZ290002B6 (cs) * | 1992-03-11 | 2002-05-15 | Sankyo Company Limited | Antimikrobiální karbapenemové deriváty, způsob výroby a farmaceutický prostředek |
ZA938438B (en) * | 1992-11-17 | 1994-06-20 | Sankyo Co | Crystalline carbapenem derivative |
DE69714841T2 (de) * | 1996-04-26 | 2003-05-28 | Sankyo Co | Ein 1-methylcarbapenem-derivat |
US6180783B1 (en) | 1997-06-16 | 2001-01-30 | Merck & Co., Inc. | Stabilized carbapenem intermediates and improved process for carbapenem synthesis |
US5872250A (en) | 1997-07-30 | 1999-02-16 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
JP3953274B2 (ja) | 1998-03-02 | 2007-08-08 | メルク エンド カムパニー インコーポレーテッド | カルバペネム抗生物質の合成方法 |
TWI250160B (en) * | 1999-07-06 | 2006-03-01 | Sankyo Co | Crystalline 1-methylcarbapenem compound |
AR035728A1 (es) * | 2001-01-16 | 2004-07-07 | Merck & Co Inc | Proceso perfeccionado para la sintesis de carbapenem |
WO2003026572A2 (en) * | 2001-09-26 | 2003-04-03 | Merck & Co., Inc. | Crystalline forms of ertapenem sodium |
-
2002
- 2002-09-20 PL PL371666A patent/PL218808B1/pl unknown
- 2002-09-20 US US10/485,134 patent/US7022841B2/en not_active Expired - Lifetime
- 2002-09-20 CA CA002461565A patent/CA2461565C/en not_active Expired - Lifetime
- 2002-09-20 ES ES02775896T patent/ES2368997T3/es not_active Expired - Lifetime
- 2002-09-20 EP EP02775896A patent/EP1474426B8/en not_active Expired - Lifetime
- 2002-09-20 JP JP2003530658A patent/JP4480396B2/ja not_active Expired - Lifetime
- 2002-09-20 KR KR1020047004533A patent/KR100628676B1/ko active IP Right Grant
- 2002-09-20 IL IL16041302A patent/IL160413A0/xx unknown
- 2002-09-20 BR BRPI0212411A patent/BRPI0212411B8/pt not_active IP Right Cessation
- 2002-09-20 UA UA20040403037A patent/UA78524C2/uk unknown
- 2002-09-20 RS YU22404A patent/RS52410B/en unknown
- 2002-09-20 AU AU2002341747A patent/AU2002341747B2/en not_active Expired
- 2002-09-20 NZ NZ531174A patent/NZ531174A/en not_active IP Right Cessation
- 2002-09-20 DK DK02775896.0T patent/DK1474426T3/da active
- 2002-09-20 WO PCT/US2002/029879 patent/WO2003027067A2/en active IP Right Grant
- 2002-09-20 AT AT02775896T patent/ATE518864T1/de active
- 2002-09-20 MX MXPA04002797A patent/MXPA04002797A/es active IP Right Grant
- 2002-09-20 HU HU0500329A patent/HU230700B1/hu unknown
- 2002-09-20 EA EA200400474A patent/EA008168B1/ru unknown
- 2002-09-20 PT PT02775896T patent/PT1474426E/pt unknown
- 2002-09-20 CN CNB028184319A patent/CN100338064C/zh not_active Expired - Lifetime
- 2002-09-20 CN CNB2006100043356A patent/CN100387599C/zh not_active Expired - Lifetime
-
2011
- 2011-10-31 CY CY20111101043T patent/CY1112092T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title | ||
PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title |