DE69714841T2 - Ein 1-methylcarbapenem-derivat - Google Patents

Ein 1-methylcarbapenem-derivat

Info

Publication number
DE69714841T2
DE69714841T2 DE69714841T DE69714841T DE69714841T2 DE 69714841 T2 DE69714841 T2 DE 69714841T2 DE 69714841 T DE69714841 T DE 69714841T DE 69714841 T DE69714841 T DE 69714841T DE 69714841 T2 DE69714841 T2 DE 69714841T2
Authority
DE
Germany
Prior art keywords
lower alkyl
alkyl group
hydrogen atom
group
methylcarbapenem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69714841T
Other languages
English (en)
Other versions
DE69714841D1 (de
Inventor
Isao Kawamoto
Munetsugu Morimoto
Katsuya Ishikawa
Katsuhiko Kojima
Yasuo Shimoji
Satoshi Ohya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of DE69714841D1 publication Critical patent/DE69714841D1/de
Application granted granted Critical
Publication of DE69714841T2 publication Critical patent/DE69714841T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69714841T 1996-04-26 1997-04-25 Ein 1-methylcarbapenem-derivat Expired - Fee Related DE69714841T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10736496 1996-04-26
PCT/JP1997/001452 WO1997041123A1 (fr) 1996-04-26 1997-04-25 Derives de 1-methylcarbapeneme

Publications (2)

Publication Number Publication Date
DE69714841D1 DE69714841D1 (de) 2002-09-26
DE69714841T2 true DE69714841T2 (de) 2003-05-28

Family

ID=14457217

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69714841T Expired - Fee Related DE69714841T2 (de) 1996-04-26 1997-04-25 Ein 1-methylcarbapenem-derivat

Country Status (18)

Country Link
US (1) US5977097A (de)
EP (1) EP0900797B1 (de)
KR (1) KR20000064997A (de)
CN (1) CN1093861C (de)
AT (1) ATE222588T1 (de)
AU (1) AU710881B2 (de)
CA (1) CA2252723A1 (de)
CZ (1) CZ342098A3 (de)
DE (1) DE69714841T2 (de)
DK (1) DK0900797T3 (de)
ES (1) ES2180977T3 (de)
HK (1) HK1018260A1 (de)
HU (1) HUP9902149A3 (de)
NO (1) NO312900B1 (de)
NZ (1) NZ332453A (de)
PT (1) PT900797E (de)
RU (1) RU2162088C2 (de)
WO (1) WO1997041123A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9901376A3 (en) * 1995-12-21 2000-03-28 Sankyo Company Ltd Chuo Ku 1-methylcarbapenem derivatives, their use, production thereof and medicaments containing the same
AU1415500A (en) * 1998-12-07 2000-06-26 Sankyo Company Limited 1-methylcarbapenem derivatives
EP1194151A4 (de) * 1999-06-23 2003-01-15 Merck & Co Inc Antagonisten der integrin rezeptoren
JP4480396B2 (ja) * 2001-09-26 2010-06-16 メルク・シャープ・エンド・ドーム・コーポレイション カルバペネム化合物の製造方法
JPWO2008026527A1 (ja) * 2006-08-28 2010-01-21 株式会社カネカ ３−シアノピロリジン誘導体およびその塩の製造方法
CN101357917B (zh) * 2007-06-22 2011-03-23 山东轩竹医药科技有限公司 含有甲酰肼基的碳青霉烯化合物
CN101367809B (zh) * 2007-06-28 2011-04-27 山东轩竹医药科技有限公司 含有巯基吡咯烷甲酰肼的培南衍生物
CN101362760B (zh) * 2007-08-07 2010-12-15 山东轩竹医药科技有限公司 1β-甲基碳代青霉烯化合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JP2752143B2 (ja) * 1988-04-01 1998-05-18 三共株式会社 カルバペネム誘導体
IE950607L (en) * 1988-04-01 1989-10-01 Sankyo Co 2-(heterocyclylthio) carbapenem derivatives, their¹preparation and their use as antibiotics
JPH023687A (ja) * 1988-06-22 1990-01-09 Sankyo Co Ltd １−メチルカルバペネム誘導体
JPH04211083A (ja) * 1990-02-23 1992-08-03 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体
FI96863C (fi) * 1990-02-23 1996-09-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten /2-(1-homopiperatsiinikarbonyyli)pyrrolidin-4-yylitio/-6-(1-hydroksietyyli)-1-karbapen-2-eemi-3-karboksylaattisuolojen valmistamiseksi
FI101226B (fi) * 1991-06-04 1998-05-15 Sankyo Co Menetelmä lääkeaineena käyttökelpoisten 2-£2-(karbonyyli)pyrrolidin-4- yylitio|-6-(1-hydroksietyyli)-1-metyylikarbapen-2-eemi-3-karboksyyliha ppojohdannaisten valmistamiseksi
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
FI103046B (fi) * 1992-03-11 1999-04-15 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten pyrrolidinyylitiokarbapeneemij ohdannaisten valmistamiseksi
JP3411589B2 (ja) * 1992-05-11 2003-06-03 第一製薬株式会社 カルバペネム誘導体
JP3344662B2 (ja) * 1992-09-14 2002-11-11 三共株式会社 カルバペネム−３−カルボン酸誘導体
JPH06199860A (ja) * 1992-09-16 1994-07-19 Sankyo Co Ltd カルバペネム誘導体
JPH07228570A (ja) * 1993-12-22 1995-08-29 Sankyo Co Ltd ４−メルカプトピロリジン誘導体
JP3199300B2 (ja) * 1994-05-09 2001-08-13 三共株式会社 １−メチルカルバペネム誘導体
JPH0848667A (ja) * 1994-06-03 1996-02-20 Sankyo Co Ltd ４−メルカプトピロリジン誘導体

Also Published As

Publication number Publication date
CA2252723A1 (en) 1997-11-06
ES2180977T3 (es) 2003-02-16
AU710881B2 (en) 1999-09-30
US5977097A (en) 1999-11-02
CN1093861C (zh) 2002-11-06
NZ332453A (en) 2000-09-29
RU2162088C2 (ru) 2001-01-20
KR20000064997A (ko) 2000-11-06
DK0900797T3 (da) 2002-09-09
EP0900797A1 (de) 1999-03-10
HK1018260A1 (en) 1999-12-17
DE69714841D1 (de) 2002-09-26
NO984948D0 (no) 1998-10-23
HUP9902149A3 (en) 2002-01-28
NO984948L (no) 1998-12-21
NO312900B1 (no) 2002-07-15
PT900797E (pt) 2002-11-29
EP0900797B1 (de) 2002-08-21
WO1997041123A1 (fr) 1997-11-06
CZ342098A3 (cs) 1999-02-17
AU2407697A (en) 1997-11-19
EP0900797A4 (de) 2000-07-19
CN1223655A (zh) 1999-07-21
ATE222588T1 (de) 2002-09-15
HUP9902149A2 (hu) 1999-10-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee