KR890011885A - 치환된 디벤조- 및 피리도벤조- 아제피논의 아미노케톤 및 약제학적 조성물 - Google Patents
치환된 디벤조- 및 피리도벤조- 아제피논의 아미노케톤 및 약제학적 조성물 Download PDFInfo
- Publication number
- KR890011885A KR890011885A KR1019890000676A KR890000676A KR890011885A KR 890011885 A KR890011885 A KR 890011885A KR 1019890000676 A KR1019890000676 A KR 1019890000676A KR 890000676 A KR890000676 A KR 890000676A KR 890011885 A KR890011885 A KR 890011885A
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- South Korea
- Prior art keywords
- compound
- formula
- methyl
- nitrogen
- salt
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (13)
- 일반식(Ⅰ)의 화합물 및 이의 산 부가염.상기식에서, R은 C1-4알킬을 나타내고, A 및 B는 독립적으로 질소 또는 탄소를 나타내며, 단 A 및 B는 동시에 질소일 수 없고, X는 융합된 환의 탄소원자에서의 치환체로서 수소, 할로겐 및 메틸중에서 선택된다.
- 제1항에 있어서, R이 메틸이고, X가 1,2,9 및 10- 위치에서 수소, 염소 또는 불소이며, A 및 B가 독립적으로 질소 또는 탄소이고 단 A 및 B가 동시에 질소일 수 없는 일반식 (Ⅰ)의 화합물.
- 6,11-디하이드로-11-[(1-메틸-4-피페리디닐)-카보닐]-5H-디벤조[b,e]-아제핀-6-온.
- 1-플루오로-6,11-디하이드로-11-[(1-메틸-4-피페리디닐)-카보닐]-5H-디벤조[b,e]-아제핀-6-온.
- 2-클로로-6,11-디하이드로-11-[(1-메틸-4-피페리디닐)-카보닐]-5H-피리도[2,3b]-벤즈아제핀-6-온.
- 제1항 내지 제5항중 어느 한 항에 따른 화합물의 생체혼화성 산 부가염.
- 제6항에 있어서, 생체 혼화성 산이 염산, 푸마르산 또는 말레산임을 특징으로 하는 염.
- 일반식(Ⅱ)의 화합물을 먼저 동일반응계내 -60℃내지 실온에서, 오가노리튬 화합물을 사용하여 불활성 유기용매중에서 이의 이리튬염으로 전환시키고, 이어서 이러한 리튬염을 일반식(Ⅲ)의 화합물과 반응시킴을 특징으로 하여, 제1항에 따른 일반식(Ⅰ)의 화합물을 제조하는 방법.상기식에서, A,B,X 및 R은 제1항에서 정의한 바와같고, Z는 시아노 또는 CO-Y 그룹[여기에서 Y는 염소, OR4또는 SR4(여기에서 R4는 C1-4알킬 또는 페닐이다)이다]을 나타낸다.
- 제8항에 있어서, 오가노리튬 화합물이 리튬알킬, 리튬아릴 및 리튬 디알킬아미드중에서 선택됨을 특징으로 하는 방법.
- 제8항 또는 제9항에 있어서, 불황성 유기용매가 테트라하이드로푸란, 디에틸에테르, 헥산 및 이들의 혼합물중에서 선택됨을 특징으로 하는 방법.
- 활성성분으로서 약제학적 담체 또는 부형제와 혼합된 하나이상의 제1항에 따른 일반식(Ⅰ)의 화합물 또는 이의 생체혼화성 산 부가염을 함유하는 약제학적 조성물.
- 제11항에 있어서, 궤양치료제-분비억제제로서의 약제학적 조성물.
- 제11항에 있어서, 위장관 질환 환자 치료용의 약제학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8819192A IT8819192A0 (it) | 1988-01-25 | 1988-01-25 | Amminochetoni di dibenzo e piridobenzo azepinoni sostituiti e composizioni farmaceutiche. |
IT19192A/88 | 1988-01-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890011885A true KR890011885A (ko) | 1989-08-23 |
Family
ID=11155667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890000676A KR890011885A (ko) | 1988-01-25 | 1989-01-23 | 치환된 디벤조- 및 피리도벤조- 아제피논의 아미노케톤 및 약제학적 조성물 |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0326526A1 (ko) |
JP (1) | JPH01216989A (ko) |
KR (1) | KR890011885A (ko) |
AU (1) | AU2880089A (ko) |
DD (1) | DD283387A5 (ko) |
DK (1) | DK29489A (ko) |
FI (1) | FI890324A (ko) |
HU (1) | HU199452B (ko) |
IL (1) | IL89061A0 (ko) |
IT (1) | IT8819192A0 (ko) |
NO (1) | NO890293L (ko) |
PL (1) | PL277329A1 (ko) |
PT (1) | PT89519B (ko) |
YU (1) | YU16389A (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100486316B1 (ko) * | 2002-07-06 | 2005-04-29 | 일동제약주식회사 | 5,11-디히드로-6에이치-디벤즈[비,이]아제핀-6-온의새로운 제조방법 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3402060A1 (de) * | 1984-01-21 | 1985-08-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1988
- 1988-01-25 IT IT8819192A patent/IT8819192A0/it unknown
-
1989
- 1989-01-23 DD DD89325189A patent/DD283387A5/de not_active IP Right Cessation
- 1989-01-23 PL PL27732989A patent/PL277329A1/xx unknown
- 1989-01-23 KR KR1019890000676A patent/KR890011885A/ko not_active Application Discontinuation
- 1989-01-23 FI FI890324A patent/FI890324A/fi not_active Application Discontinuation
- 1989-01-24 DK DK029489A patent/DK29489A/da not_active Application Discontinuation
- 1989-01-24 YU YU00163/89A patent/YU16389A/xx unknown
- 1989-01-24 PT PT89519A patent/PT89519B/pt active IP Right Grant
- 1989-01-24 IL IL89061A patent/IL89061A0/xx unknown
- 1989-01-24 EP EP89830023A patent/EP0326526A1/en not_active Withdrawn
- 1989-01-24 HU HU89296A patent/HU199452B/hu not_active IP Right Cessation
- 1989-01-24 JP JP1014942A patent/JPH01216989A/ja active Pending
- 1989-01-24 NO NO89890293A patent/NO890293L/no unknown
- 1989-01-25 AU AU28800/89A patent/AU2880089A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
FI890324A (fi) | 1989-07-26 |
HUT49130A (en) | 1989-08-28 |
DK29489A (da) | 1989-07-26 |
DD283387A5 (de) | 1990-10-10 |
PT89519B (pt) | 1994-02-28 |
NO890293D0 (no) | 1989-01-24 |
IL89061A0 (en) | 1989-08-15 |
YU16389A (en) | 1991-10-31 |
DK29489D0 (da) | 1989-01-24 |
PL277329A1 (en) | 1989-09-18 |
NO890293L (no) | 1989-07-26 |
JPH01216989A (ja) | 1989-08-30 |
IT8819192A0 (it) | 1988-01-25 |
FI890324A0 (fi) | 1989-01-23 |
AU2880089A (en) | 1989-07-27 |
HU199452B (en) | 1990-02-28 |
EP0326526A1 (en) | 1989-08-02 |
PT89519A (pt) | 1989-10-04 |
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