HUP0401619A2 - Fenilanolamin-származékok, eljárás előállításukra, és az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Fenilanolamin-származékok, eljárás előállításukra, és az ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0401619A2
HUP0401619A2 HU0401619A HUP0401619A HUP0401619A2 HU P0401619 A2 HUP0401619 A2 HU P0401619A2 HU 0401619 A HU0401619 A HU 0401619A HU P0401619 A HUP0401619 A HU P0401619A HU P0401619 A2 HUP0401619 A2 HU P0401619A2
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Hungary
Prior art keywords
6alkyl
aryl
heteroaryl
xnr8c
group
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HU0401619A
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English (en)
Inventor
Philip Charles Box
Diane Mary Coe
Brian Edgar Looker
Inderjit Singh Mann
Panayiotis Alexandrou Procopiou
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Glaxo Group Limited
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Priority claimed from GB0122201A external-priority patent/GB0122201D0/en
Priority claimed from GB0126997A external-priority patent/GB0126997D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of HUP0401619A2 publication Critical patent/HUP0401619A2/hu
Publication of HUP0401619A3 publication Critical patent/HUP0401619A3/hu
Publication of HU228508B1 publication Critical patent/HU228508B1/hu
Priority to HUS1400025C priority Critical patent/HUS1400025I1/hu

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Abstract

A találmány tárgyát feniletanolaminszármazékok, eljárás ezekelőállítására; és az ezeket tartalmazó gyógyszerkészítmények képezik.A találmány tárgyát részletesebben az (I) általárnos képletűvegyületek képezik, és ezek sói, szolvátjai vagy gyógyászatilagelfogadható származékai, ahol a képletben m egész szám, értéke 2-8; negész szám, értéke 2-5; azzal a megkötéssel, hogy m+n értéke együtt 4-10; Rl jelentése hidrogénatom, C1-6 alkil, hidroxi, halogén, C1-6halogénalkil, -XC(O)NR9Rl0,-XNR8C(O)R9, -XNR8C(O)NR9R10, -XNR8SO2R9, -XSO2NR11Rl2, -XNR8SO2NR9R10 -XNR9R10, -XN+R8R9Rl0, -XNR8C(O)OR9, -XCO2R9, -XNR8C(O)NR8C(O)NR9Rl0, -XSR9,-XSOR9, és -XSO2R9; vagy Rljelentése -X-aril, -X-hetaroaril, vagy -X-(ariloxi), amelyekmindegyike adott esetben helyettesítve van 1 vagy 2 azonos vagykülönböző csoporttal a hidroxi, C1-6alkoxi, halogén, C1-6alkil, C1-6halogénalkil, -NHC(O)(C1-6alkil), -SO2(C1-6alkil), -SO2(aril), -SO2NH2, -SO2NH(C1-6alkil), -SO2NH(C3-7cikloalkil), -CO2H, -CO2(C1-6a1ki1), -SO2NH(C3-7cikloalkilC1-6alkil), -NH2, -NH(C1-6alkil); vagyheteroarilcsoport, amely adott esetben szubsztituálva van 1 vagy 2azonos vagy különböző csoporttal a hidroxi, C1-6alkoxi, halogénatom,C1-6alkil, vagy C1-6halogénalkilcsoportok közül; X jelentése-(CH2)p-vagy C2-6 alkeniléncsoport p egész szám, értéke 0-6 R8 és R9 jelentéseegymástól függetlenül hidrogénatom, C1-6alkil, C3-7cikloalkil, aril,heteroaril; heteroaril(C1-6alkil)- vagy aril(C1-6alkil)-csoport és R8és R9 egymástól függetlenül adott esetben szubsztituálva van 1 vagy 2csoporttal a halogénatom, Cl-6alkil, C1-6halogénalkil, -NHC(O)(C1-6alkil), -SO2(C1-6alkil), -SO2(aril), -CO2H, -CO2(C1-4alkil), -NH2, -NH(C1-6alkil), aril(C1-6alkil)-, aril(C2-6alkenil)-, aril(C2-6alkinil)-, heteroaril(C1-6 alkil)-, -NHSO2aril, -NH(heteroarilC1-6alkil), -NHSO2heteroaril, -NHSO2(Cl-6alkil),-NHC(O)aril,vagy-NHC(O)heteroarilcsoportok közül Rl0 jelentése hidrogénatom, C1-6alkil vagyC3-7 cikloalkilcsoport; R11 és R12 jelentése egymástól függetlenülhidrogénatom, C1-6alkil, C3-7cikloalkil, aril, heteroaril,heteroaril(C1-6-alkil)- vagy aril(C1-6alkil)-csoport, vagy R11 és R12jelentése azzal a nitrogénatommal együtt, amelyhez kapcsolódnak, 5, 6,vagy 7 tagú nitrogéntartalmú gyűrű; és Rl1 és Rl2 adott esetbenszubsztituálva van egy vagy kettő csoporttal a halogénatom, C1-6alkilés C1-6 halogénalkil-csoportok közül; ahol R1 jelentése -XNR8C(O)NR9R10 képletű csoport és R8 és R9 képezhet a hozzájukkapcsolódó Rl csoport -NC(O)N- részével együtt egy 5, 6 vagy 7 tagútelített vagy telítetlen gyűrűt; ahol R1 jelentése -XNR8C(O)OR9, és R8és R9 képezhet a hozzájuk kapcsolódó R1 csoport -NC(O)O- részévelegyütt egy 5, 6 vagy 7-tagú telített vagy telítetlen gyűrűt; ahol Rljelentése -XC(O)NR9R10 vagy -XNR8C(O)NR9R10 és R9 és Rl0 képezhet ahozzájuk kapcsolódó nitrogénatommal együtt egy 5, 6, v
HU0401619A 2001-09-14 2002-09-11 Phenethanolamine derivatives and pharmaceutical composition containing them HU228508B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HUS1400025C HUS1400025I1 (hu) 2001-09-14 2014-04-24 Feniletanolamin-származékok és az ezeket tartalmazó gyógyszerek

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0122201A GB0122201D0 (en) 2001-09-14 2001-09-14 Medicinal compounds
GB0126997A GB0126997D0 (en) 2001-11-09 2001-11-09 Medicinal Compounds
PCT/GB2002/004140 WO2003024439A1 (en) 2001-09-14 2002-09-11 Phenethanolamine derivatives for treatment of respiratory diseases

Publications (3)

Publication Number Publication Date
HUP0401619A2 true HUP0401619A2 (hu) 2004-11-29
HUP0401619A3 HUP0401619A3 (en) 2008-03-28
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