HUP0401536A2 - Peptidek és/vagy proteinek, valamint terápiás és/vagy megelőző gyógyszerkészítmény előállítására történő alkalmazásuk - Google Patents

Peptidek és/vagy proteinek, valamint terápiás és/vagy megelőző gyógyszerkészítmény előállítására történő alkalmazásuk

Info

Publication number
HUP0401536A2
HUP0401536A2 HU0401536A HUP0401536A HUP0401536A2 HU P0401536 A2 HUP0401536 A2 HU P0401536A2 HU 0401536 A HU0401536 A HU 0401536A HU P0401536 A HUP0401536 A HU P0401536A HU P0401536 A2 HUP0401536 A2 HU P0401536A2
Authority
HU
Hungary
Prior art keywords
residue
peptides
proteins
therapeutic
production
Prior art date
Application number
HU0401536A
Other languages
English (en)
Inventor
Peter Petzelbauer
Original Assignee
Fibrex Medical Research & Development Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fibrex Medical Research & Development Gmbh filed Critical Fibrex Medical Research & Development Gmbh
Publication of HUP0401536A2 publication Critical patent/HUP0401536A2/hu
Publication of HUP0401536A3 publication Critical patent/HUP0401536A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A találmány (I) általános képletű peptidek vagy proteinek gyógyászatialkalmazására vonatkozik. Az (I) általános képletben Rl és R2jelentése egymástól függetlenül hidrogénatom, telített vagytelítetlen, 1-3 szénatomos, különösen 1-10 szénatomosszénhidrogéncsoport, Z1 hisztidin- vagy prolinmaradék, Z2 jelentéseargininmaradék vagy terminális argininmaradékot hordozó peptid- vagyproteinmaradék, különösen 2-30 aminosavból álló maradék. A vegyületekgyulladások ellen a humán és állatgyógyászatban alkalmazhatók. Ó
HU0401536A 2000-12-12 2001-12-07 Peptides and/or proteins and use thereof for the production of a therapeutic and/or prophylactic medicament HUP0401536A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT20632000 2000-12-12
PCT/AT2001/000387 WO2002048180A2 (de) 2000-12-12 2001-12-07 Peptide und/oder proteine sowie verwendung desselben zur herstellung eines therapeutischen und/oder präventiven arzneimittels

Publications (2)

Publication Number Publication Date
HUP0401536A2 true HUP0401536A2 (hu) 2004-11-29
HUP0401536A3 HUP0401536A3 (en) 2008-09-29

Family

ID=3689750

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401536A HUP0401536A3 (en) 2000-12-12 2001-12-07 Peptides and/or proteins and use thereof for the production of a therapeutic and/or prophylactic medicament

Country Status (31)

Country Link
US (4) US7271144B2 (hu)
EP (2) EP1586586B1 (hu)
JP (1) JP4181874B2 (hu)
KR (1) KR100864069B1 (hu)
CN (2) CN101676299A (hu)
AT (2) ATE425184T1 (hu)
AU (1) AU2002221316A1 (hu)
BG (1) BG107891A (hu)
BR (1) BR0116122A (hu)
CA (1) CA2430972C (hu)
CY (2) CY1106108T1 (hu)
CZ (1) CZ20031630A3 (hu)
DE (2) DE50114771D1 (hu)
DK (2) DK1586586T3 (hu)
EA (1) EA005576B1 (hu)
EE (1) EE200300283A (hu)
ES (2) ES2266093T3 (hu)
HK (1) HK1084400A1 (hu)
HR (1) HRP20030564A2 (hu)
HU (1) HUP0401536A3 (hu)
IL (2) IL156360A0 (hu)
MX (1) MXPA03005218A (hu)
NO (1) NO330767B1 (hu)
NZ (1) NZ550619A (hu)
PL (2) PL209752B1 (hu)
PT (2) PT1341819E (hu)
SI (2) SI1586586T1 (hu)
SK (1) SK7062003A3 (hu)
WO (1) WO2002048180A2 (hu)
YU (1) YU53803A (hu)
ZA (1) ZA200304545B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1586586T3 (da) 2000-12-12 2009-06-29 Fibrex Medical Res & Dev Gmbh Peptider og/eller proteiner og deres anvendelse til fremstilling af et terapeutisk og/eller præventivt lægemiddel
PT1691827E (pt) * 2004-06-25 2009-11-23 Fibrex Medical Res & Dev Gmbh Utilização de péptidos derivados da cadeia b beta de fibrinogénio humano para o tratamento do choque
FR2879604B1 (fr) * 2004-12-22 2010-08-13 Biomerieux Sa Peptides citrullines derives de la fibrine reconnus par des auto-anticorps specifiques de la polyarthrite rhumatoide, et leurs utilisations
AT502987A1 (de) 2005-12-23 2007-07-15 Fibrex Medical Res & Dev Gmbh Pharmazeutische zusammensetzung zur behandlung von hämorrhagischem schock und seinen folgeerscheinungen
JP2009527503A (ja) * 2006-02-23 2009-07-30 ファイブレックス メディカル リサーチ アンド デベロップメント ゲーエムベーハー ペプチドおよびペプチド誘導体、それらの製造ならびに治療上および／または予防上使用可能な医薬組成物を調製するためのそれらの使用
WO2007095659A1 (de) * 2006-02-23 2007-08-30 Fibrex Medical Research & Development Gmbh Peptide und peptid-derivate, herstellun derselben sowie deren verwendung zur herstellung eines therapeutisch und/oder präventiv wirkenden arzneimittels
WO2007095660A1 (en) 2006-02-23 2007-08-30 Fibrex Medical Research & Development Gmbh Peptides and peptide derivatives as well as pharmaceutical compositions containing the same
FR2900657B1 (fr) * 2006-05-03 2009-04-17 Univ Toulouse Identification de modulateurs de l'activation des macrophages, utilisables pour le traitement de la polyarthrite rhumatoide
WO2009038729A2 (en) 2007-09-17 2009-03-26 Regenerx Biopharmaceuticals, Inc. Compositions and methods utilizing fibrin beta chain fragments of the bbeta chain of fibrinogen
FR2908134B1 (fr) * 2007-12-04 2012-10-12 Univ Toulouse 3 Paul Sabatier Identification de modulateurs de l'activation des macrophages, utilisables pour le traitement de la polyarthrite rhumatoide
JP5410997B2 (ja) * 2008-01-31 2014-02-05 則行 川村 うつ病およびうつ状態のマーカーおよびそれを用いた検出・診断
US20090286725A1 (en) * 2008-05-15 2009-11-19 Fibrex Medical Research & Development Gmbh Peptides and derivatives thereof, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition
US8088890B2 (en) 2008-09-26 2012-01-03 Fibrex Medical Research & Development Gmbh Peptides and peptidomimetic compounds, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition
WO2010043444A2 (en) * 2008-10-15 2010-04-22 Fibrex Medical Research & Development Gmbh Pharmaceutical preparation for the treatment and/or prevention of ischemia/reperfusion injury and the sequels thereof
US20100152832A1 (en) * 2008-12-12 2010-06-17 Medtronic Vascular, Inc. Apparatus and Methods for Treatment of Aneurysms With Fibrin Derived Peptide B-Beta
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927916A (en) * 1984-04-23 1990-05-22 The General Hospital Corporation Method of producing fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity using fibrin-specific peptides
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
DE19729591A1 (de) * 1997-07-10 1999-02-11 Therasorb Medizinische Systeme Mittel zur Behandlung und/oder Prophylaxe von Mikrozirkulationsstörungen
FR2795735B1 (fr) * 1999-07-01 2001-09-07 Univ Toulouse Derives citrullines de la fibrine et leur utilisation pour le diagnostic ou le traitement de la polyarthrite rhumatoide
DK1586586T3 (da) * 2000-12-12 2009-06-29 Fibrex Medical Res & Dev Gmbh Peptider og/eller proteiner og deres anvendelse til fremstilling af et terapeutisk og/eller præventivt lægemiddel
US7201763B2 (en) * 2001-10-24 2007-04-10 Boston Scientific Scimed, Inc. Distal balloon waist material relief and method of manufacture

Also Published As

Publication number Publication date
NZ550619A (en) 2008-06-30
NO20032656L (no) 2003-06-12
IL156360A (en) 2012-12-31
KR20030060988A (ko) 2003-07-16
ATE329614T1 (de) 2006-07-15
EE200300283A (et) 2003-10-15
KR100864069B1 (ko) 2008-10-16
PL362924A1 (en) 2004-11-02
AU2002221316A1 (en) 2002-06-24
DK1341819T3 (da) 2006-10-16
CN1518558B (zh) 2010-06-16
ZA200304545B (en) 2004-09-13
PT1341819E (pt) 2006-10-31
JP4181874B2 (ja) 2008-11-19
CA2430972A1 (en) 2002-06-20
SI1341819T1 (sl) 2006-10-31
CZ20031630A3 (cs) 2003-10-15
CN1518558A (zh) 2004-08-04
WO2002048180A3 (de) 2003-01-30
DK1586586T3 (da) 2009-06-29
CA2430972C (en) 2014-08-05
WO2002048180A2 (de) 2002-06-20
NO330767B1 (no) 2011-07-11
US20090137464A1 (en) 2009-05-28
US20070037749A1 (en) 2007-02-15
NO20032656D0 (no) 2003-06-12
US7494973B2 (en) 2009-02-24
PL209419B1 (pl) 2011-08-31
US20040192596A1 (en) 2004-09-30
US20090088384A1 (en) 2009-04-02
EA005576B1 (ru) 2005-04-28
US8067373B2 (en) 2011-11-29
YU53803A (sh) 2006-03-03
CY1109107T1 (el) 2014-07-02
ES2323963T3 (es) 2009-07-28
EP1586586A3 (de) 2006-03-29
US7811985B2 (en) 2010-10-12
MXPA03005218A (es) 2004-12-03
US7271144B2 (en) 2007-09-18
SI1586586T1 (sl) 2009-08-31
EP1341819B1 (de) 2006-06-14
SK7062003A3 (en) 2003-11-04
EP1341819A2 (de) 2003-09-10
ATE425184T1 (de) 2009-03-15
HRP20030564A2 (en) 2005-06-30
EP1586586A2 (de) 2005-10-19
ES2266093T3 (es) 2007-03-01
IL156360A0 (en) 2004-01-04
CN101676299A (zh) 2010-03-24
HUP0401536A3 (en) 2008-09-29
JP2004527469A (ja) 2004-09-09
DE50114771D1 (de) 2009-04-23
DE50110182D1 (de) 2006-07-27
EA200300678A1 (ru) 2003-10-30
CY1106108T1 (el) 2011-06-08
PL209752B1 (pl) 2011-10-31
PT1586586E (pt) 2010-05-28
BG107891A (bg) 2004-08-31
BR0116122A (pt) 2003-10-14
HK1084400A1 (en) 2006-07-28
EP1586586B1 (de) 2009-03-11

Similar Documents

Publication Publication Date Title
HUP0401536A2 (hu) Peptidek és/vagy proteinek, valamint terápiás és/vagy megelőző gyógyszerkészítmény előállítására történő alkalmazásuk
Vigneaud et al. The synthesis of an octapeptide amide with the hormonal activity of oxytocin
DE69326064D1 (de) Peptide des menschlichen Proteins P53 zum Gebrauch in menschlichen-zytotoxischen-T-Zell-Antwort-induzierenden Kompositionen sowie menschliche P53-Protein-spezifische T-Lymphocyten
HUP0202512A2 (hu) Fehérjék polimerizációját gátló anyagok és eljárások ezek alkalmazására
PT593754E (pt) Peptidos do virus do papiloma humano para uso em composicoes indutoras de uma reaccao das celulas t no homem
MX361694B (es) Fragmentos de peptidos para inducir sintesis de proteinas de matriz extra-celular.
NZ592510A (en) HLA-A*1101-restricted WTI peptide and pharmaceutical composition comprising the same
BR0109494A (pt) Produção de fatores recombinantes de coagulação do sangue em linhas celulares humanas
RU2010111139A (ru) Комбинированная терапия рака поджелудочной железы с использованием антигенного пептида и химиотерапевтического средства
ATE213499T1 (de) Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose
DE60135996D1 (de) Peptidzusammensetzungen zur behandlung periodontaler krankheiten und prävention der hautalterung
ATE392428T1 (de) Arzneimittel enthaltend analgetische peptide
DK1173476T3 (da) Funktionelle sojabönneproteiner
AU2003292326A1 (en) Cosmetic or pharmaceutical composition comprising peptides with the sequence arg-gly-ser
DK0759772T3 (da) Tri-, tetra-, penta- og polypeptider og deres terapeutiske anvendelse som antidepressiva
ATE3416T1 (de) Pharmakologisch aktive peptide und diese enthaltende arzneimittel.
ATE510008T1 (de) Entzündungshemmende peptide
HUP9602024A2 (hu) Aminosavtartalmú, külsőlegesen használható, gyógyhatású készítmény
DE60036199D1 (de) Proteaseresistente flint-analoge
BR0014803A (pt) Peptìdeo, composição farmacêutica, uso de um ou mais dos peptìdeos, e, composição de diagnóstico
HUP0300787A2 (hu) Új interferon a sclerosis multiplex kezelésére
RU95120588A (ru) Циклогексапептиды, их смеси, способ их получения и применения
KR20140084191A (ko) 멜라노트란스페린으로부터 유도된 펩티드 화합물 및 이의 용도
DE602004019141D1 (de) Isoleucyl-valyl-threonyl-asparaginyl-threonyl-threonin (ivtntt) enthaltende biologisch wirksame peptide
MX2023005395A (es) Formulaciones de peptidos y metodos de uso.

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees